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Aliases for MIR218-2 Gene

Subcategory (RNA class) for MIR218-2 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR218-2 Gene

  • MicroRNA 218-2 2 3 5
  • Hsa-Mir-218-2 3
  • Mir-218-2 3
  • MIRN218-2 3

External Ids for MIR218-2 Gene

Previous HGNC Symbols for MIR218-2 Gene

  • MIRN218-2

Previous GeneCards Identifiers for MIR218-2 Gene

  • GC05M168130
  • GC05M168195

Summaries for MIR218-2 Gene

Entrez Gene Summary for MIR218-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR218-2 Gene

MIR218-2 (MicroRNA 218-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR218-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR218-2

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR218-2 Gene

Genomics for MIR218-2 Gene

Regulatory Elements for MIR218-2 Gene

Enhancers for MIR218-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G168793 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -26.0 -25951 1.6 ATF1 GLI4 GLIS2 ZNF263 SP3 REST TSHZ1 ZNF518A WT1 PRDM4 ENSG00000254192 RARS MIR218-2 ENSG00000202345 LOC105377713
GH05G168817 0.9 dbSUPER 11.1 -52.6 -52557 6.5 PKNOX1 YY1 ZNF366 CBX5 ZSCAN5C ETV6 FOS CREM JUNB TBX21 MIR218-2 LOC101927969 SLIT3 ENSG00000202345 LOC105377713
GH05G168851 1 Ensembl ENCODE 9.8 -84.1 -84061 1.7 ESRRA ZBTB21 EBF1 BMI1 GATA3 GATA2 ZSCAN5C PATZ1 ZNF263 RFX1 MIR218-2 LOC105377713 ENSG00000202345
GH05G168787 0.6 dbSUPER 12.2 -21.5 -21495 4.0 PKNOX1 ZNF157 HLF ZSCAN4 ATF2 SP7 NR2C2 ZBTB20 MIR218-2 LOC101927969 ENSG00000248965 SLIT3 GC05P168792 GC05M168784
GH05G168797 0.6 ENCODE dbSUPER 11 -28.6 -28576 0.2 PRDM1 MIR218-2 ENSG00000202345 LOC105377713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR218-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR218-2 Gene

Chromosome:
5
Start:
168,768,146 bp from pter
End:
168,768,255 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR218-2 Gene

Genes around MIR218-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR218-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR218-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR218-2 Gene

ORGUL Member Location for MIR218-2 Gene

ORGUL Member Location for MIR218-2 gene

Proteins for MIR218-2 Gene

Post-translational modifications for MIR218-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR218-2 Gene

Domains & Families for MIR218-2 Gene

Gene Families for MIR218-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR218-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR218-2 Gene

Function for MIR218-2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR218-2 Gene

Localization for MIR218-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR218-2 Gene

Pathways & Interactions for MIR218-2 Gene

genes like me logo Genes that share pathways with MIR218-2: view

Pathways by source for MIR218-2 Gene

1 BioSystems pathway for MIR218-2 Gene

Interacting Proteins for MIR218-2 Gene

Gene Ontology (GO) - Biological Process for MIR218-2 Gene

None

No data available for SIGNOR curated interactions for MIR218-2 Gene

Drugs & Compounds for MIR218-2 Gene

No Compound Related Data Available

Transcripts for MIR218-2 Gene

fRNAdb Secondary structures for MIR218-2 Gene

  • hsa-miR-218-5p_MIMAT0000275_Homo_sapiens_miR-218-5p_mature
  • hsa-miR-218-2-3p_MIMAT0004566_Homo_sapiens_miR-218-2-3p_mature

mRNA/cDNA for MIR218-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR218-2 Gene

No ASD Table

Relevant External Links for MIR218-2 Gene

GeneLoc Exon Structure for
MIR218-2
ECgene alternative splicing isoforms for
MIR218-2

Expression for MIR218-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR218-2 Gene

genes like me logo Genes that share expression patterns with MIR218-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR218-2 Gene

Orthologs for MIR218-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR218-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-218-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-218-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-218-2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir218-2 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-218-2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-218-2 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-218-2 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-218a-2 35
  • 73 (a)
OneToMany
Species where no ortholog for MIR218-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR218-2 Gene

ENSEMBL:
Gene Tree for MIR218-2 (if available)
TreeFam:
Gene Tree for MIR218-2 (if available)

Paralogs for MIR218-2 Gene

No data available for Paralogs for MIR218-2 Gene

Variants for MIR218-2 Gene

Sequence variations from dbSNP and Humsavar for MIR218-2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000966654 -- 168,767,991(+) CCAGA(C/T)CCATT intron-variant, downstream-variant-500B
rs1001251795 -- 168,767,725(+) GGGGT(C/T)GGGGG intron-variant, downstream-variant-500B
rs1003409949 -- 168,769,443(+) TAGAT(A/G)GTCTC intron-variant, upstream-variant-2KB
rs1003565153 -- 168,770,015(+) TCTGT(A/G)CTTTT intron-variant, upstream-variant-2KB
rs1004022113 -- 168,768,067(+) GGTGG(C/G)TCTGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR218-2 Gene

Variant ID Type Subtype PubMed ID
nsv1028080 CNV gain 25217958
nsv462513 CNV loss 19166990
nsv600258 CNV loss 21841781

Relevant External Links for MIR218-2 Gene

Human Gene Mutation Database (HGMD)
MIR218-2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR218-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR218-2 Gene

Disorders for MIR218-2 Gene

Relevant External Links for MIR218-2

Human Genome Epidemiology (HuGE) Navigator
MIR218-2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR218-2

No disorders were found for MIR218-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR218-2 Gene

Publications for MIR218-2 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  2. miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer. (PMID: 28323002) Zhang X. … Tie J. (Gene 2017) 3 64
  3. miR-218 suppressed the growth of lung carcinoma by reducing MEF2D expression. (PMID: 26409449) Song L. … Peng L. (Tumour Biol. 2016) 3 64
  4. MiR-218-5p inhibits the stem cell properties and invasive ability of the A2B5a8_CD133a8> subgroup of human glioma stem cells. (PMID: 26572167) Wu Z. … Du Z. (Oncol. Rep. 2016) 3 64
  5. Tumor-suppressing roles of miR-214 and miR-218 in breast cancer. (PMID: 27109339) Liu B. … Zhang L. (Oncol. Rep. 2016) 3 64

Products for MIR218-2 Gene

Sources for MIR218-2 Gene

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