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Aliases for MIR218-2 Gene

Subcategory (RNA class) for MIR218-2 Gene


Quality Score for this RNA gene is


Aliases for MIR218-2 Gene

  • MicroRNA 218-2 2 3
  • Hsa-Mir-218-2 3
  • Mir-218-2 3
  • MIRN218-2 3

External Ids for MIR218-2 Gene

Previous HGNC Symbols for MIR218-2 Gene

  • MIRN218-2

Previous GeneCards Identifiers for MIR218-2 Gene

  • GC05M168130
  • GC05M168195

Summaries for MIR218-2 Gene

Entrez Gene Summary for MIR218-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR218-2 Gene

MIR218-2 (MicroRNA 218-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR218-2 include lung squamous cell carcinoma.

fRNAdb sequence ontologies for MIR218-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR218-2

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR218-2 Gene

Genomics for MIR218-2 Gene

Genomic Location for MIR218-2 Gene

168,768,146 bp from pter
168,768,255 bp from pter
110 bases
Minus strand

Genomic View for MIR218-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR218-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR218-2 Gene

ORGUL Member Location for MIR218-2 Gene

ORGUL Member Location for MIR218-2 gene

No data available for Regulatory Elements for MIR218-2 Gene

Proteins for MIR218-2 Gene

Post-translational modifications for MIR218-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR218-2 Gene

Domains for MIR218-2 Gene

Gene Families for MIR218-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR218-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR218-2 Gene

Function for MIR218-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR218-2 Gene

Localization for MIR218-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR218-2 Gene

Pathways for MIR218-2 Gene

SuperPathways for MIR218-2 Gene

No Data Available

Interacting Proteins for MIR218-2 Gene

Gene Ontology (GO) - Biological Process for MIR218-2 Gene


No data available for Pathways by source for MIR218-2 Gene

Transcripts for MIR218-2 Gene

fRNAdb Secondary structures for MIR218-2 Gene

  • hsa-miR-218-5p_MIMAT0000275_Homo_sapiens_miR-218-5p_mature
  • hsa-miR-218-2-3p_MIMAT0004566_Homo_sapiens_miR-218-2-3p_mature

mRNA/cDNA for MIR218-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR218-2 Gene

No ASD Table

Relevant External Links for MIR218-2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR218-2 Gene

mRNA expression in normal human tissues for MIR218-2 Gene

genes like me logo Genes that share expressions with MIR218-2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR218-2 Gene

Orthologs for MIR218-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR218-2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-218-2 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-218-2 36
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-218-2 36
  • 92 (a)
(Mus musculus)
Mammalia Mir218-2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-218-2 36
  • 90 (a)
(Pan troglodytes)
Mammalia ptr-mir-218-2 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-218-2 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
(Danio rerio)
Actinopterygii dre-mir-218a-2 36
  • 73 (a)
Species with no ortholog for MIR218-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR218-2 Gene

Gene Tree for MIR218-2 (if available)
Gene Tree for MIR218-2 (if available)

Paralogs for MIR218-2 Gene

No data available for Paralogs for MIR218-2 Gene

Variants for MIR218-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR218-2 Gene

Variant ID Type Subtype PubMed ID
nsv462513 CNV Loss 19166990

Relevant External Links for MIR218-2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR218-2 Gene

Disorders for MIR218-2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR218-2 Gene in MalaCards »

(1) Disease for MIR218-2 Gene

Relevant External Links for MIR218-2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR218-2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR218-2 Gene

Publications for MIR218-2 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  5. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. (PMID: 20838434) Davidson M.R. … Fong K.M. (PLoS ONE 2010) 3

Products for MIR218-2 Gene

Sources for MIR218-2 Gene

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