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Aliases for MIR217 Gene

Subcategory (RNA class) for MIR217 Gene

miRNA

Quality Score for this RNA gene is

9

Aliases for MIR217 Gene

  • MicroRNA 217 2 3 5
  • Hsa-Mir-217 3
  • Mir-217 3
  • MIRN217 3

External Ids for MIR217 Gene

Previous HGNC Symbols for MIR217 Gene

  • MIRN217

Previous GeneCards Identifiers for MIR217 Gene

  • GC02M056064
  • GC02M056210

Summaries for MIR217 Gene

Entrez Gene Summary for MIR217 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR217 Gene

MIR217 (MicroRNA 217) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR217 include Pancreatic Ductal Adenocarcinoma and Pancreas Adenocarcinoma.

fRNAdb sequence ontologies for MIR217 Gene

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR217

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR217 Gene

Genomics for MIR217 Gene

Regulatory Elements for MIR217 Gene

Enhancers for MIR217 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F056008 1.2 Ensembl ENCODE 11.3 -26.1 -26061 2.0 CTCF ZNF654 RFX1 JUN BHLHE40 MAX MNT REST RAD21 POLR2A MIR217 MIR216A EFEMP1 MIR216B MIR217HG
GH02F056012 0.4 FANTOM5 11.3 -29.3 -29311 0.1 ZNF335 JUND SCRT2 FEZF1 EFEMP1 MIR217 MIR216A MIR216B MIR217HG
GH02F055957 1.2 Ensembl ENCODE 11.3 +24.4 24392 1.4 PKNOX1 SIN3A RAD21 RFX5 ZNF335 GLIS2 SCRT2 RCOR1 DEK ZNF263 EFEMP1 MIR217 MIR216A ENSG00000240401 ENSG00000272180 GC02P055982
GH02F055961 0.6 ENCODE 11 +21.6 21596 0.2 GTF2F1 CTCF ZNF654 REST ZNF2 RAD21 RFX5 SMC3 MIR216A MIR217 ENSG00000272180 GC02P055982
GH02F055947 0.2 ENCODE 10.8 +35.1 35146 0.1 OSR2 CEBPB EP300 WT1 ZKSCAN1 EFEMP1 MIR217 MIR216A GC02M055952 LOC105374690 RN7SKP208
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR217 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR217 Gene

Chromosome:
2
Start:
55,982,967 bp from pter
End:
55,983,076 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR217 Gene

Genes around MIR217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR217 Gene

ORGUL Member Location for MIR217 Gene

ORGUL Member Location for MIR217 gene

Proteins for MIR217 Gene

Post-translational modifications for MIR217 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR217 Gene

Domains & Families for MIR217 Gene

Gene Families for MIR217 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR217: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR217 Gene

Function for MIR217 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR217 Gene

Localization for MIR217 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR217 Gene

Pathways & Interactions for MIR217 Gene

SuperPathways for MIR217 Gene

No Data Available

Interacting Proteins for MIR217 Gene

Gene Ontology (GO) - Biological Process for MIR217 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR217 Gene

Transcripts for MIR217 Gene

fRNAdb Secondary structures for MIR217 Gene

  • FR232136

mRNA/cDNA for MIR217 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR217 Gene

No ASD Table

Relevant External Links for MIR217 Gene

GeneLoc Exon Structure for
MIR217
ECgene alternative splicing isoforms for
MIR217

Expression for MIR217 Gene

mRNA expression in normal human tissues for MIR217 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR217 Gene:

MIR217
genes like me logo Genes that share expression patterns with MIR217: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR217 Gene

Orthologs for MIR217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-217 35
  • 100 (a)
OneToMany
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia cfa-mir-217 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-217 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-217 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir217 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-217 35 35
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-217 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-217 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-217 35
  • 80 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-217 35
  • 51 (a)
OneToOne
Species where no ortholog for MIR217 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR217 Gene

ENSEMBL:
Gene Tree for MIR217 (if available)
TreeFam:
Gene Tree for MIR217 (if available)

Paralogs for MIR217 Gene

No data available for Paralogs for MIR217 Gene

Variants for MIR217 Gene

Sequence variations from dbSNP and Humsavar for MIR217 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10204798 -- 55,982,662(+) AAACC(A/G)ACAAA intron-variant, downstream-variant-500B
rs10695015 -- 55,983,940(+) CACAC(-/ACACAC)TGATA intron-variant, upstream-variant-2KB
rs111274244 -- 55,983,928(+) ATATA(C/T)ATATA intron-variant, upstream-variant-2KB
rs111712148 -- 55,983,345(+) ATTCT(A/G)TATCT intron-variant, upstream-variant-2KB
rs111857538 -- 55,983,330(+) AAATA(-/G)CTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR217 Gene

Variant ID Type Subtype PubMed ID
esv2759051 CNV gain 17122850
esv3575244 CNV gain 25503493

Relevant External Links for MIR217 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR217 Gene

Disorders for MIR217 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR217 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR217

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR217
genes like me logo Genes that share disorders with MIR217: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR217 Gene

Publications for MIR217 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  2. MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2. (PMID: 26826389) Zhu H. … Li Z. (Biochem. Biophys. Res. Commun. 2016) 3 64
  3. Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R. (PMID: 26708715) Li J. … Zhang W. (Oncol. Rep. 2016) 3 64
  4. Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. (PMID: 25538231) Wang X. … Yang M. (J. Biol. Chem. 2015) 3 64
  5. microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer. (PMID: 25869101) Chen D.L. … Xu R.H. (Oncotarget 2015) 3 64

Products for MIR217 Gene

Sources for MIR217 Gene

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