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Aliases for MIR217 Gene

Subcategory (RNA class) for MIR217 Gene

miRNA

Quality Score for this RNA gene is

11

Aliases for MIR217 Gene

  • MicroRNA 217 2 3
  • Hsa-Mir-217 3
  • Mir-217 3
  • MIRN217 3

External Ids for MIR217 Gene

Previous HGNC Symbols for MIR217 Gene

  • MIRN217

Previous GeneCards Identifiers for MIR217 Gene

  • GC02M056064
  • GC02M056210

Summaries for MIR217 Gene

Entrez Gene Summary for MIR217 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR217 Gene

MIR217 (MicroRNA 217) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR217 include pancreatic ductal adenocarcinoma and pancreas adenocarcinoma.

fRNAdb sequence ontologies for MIR217 Gene

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR217

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR217 Gene

Genomics for MIR217 Gene

Genomic Location for MIR217 Gene

Chromosome:
2
Start:
55,982,952 bp from pter
End:
55,983,076 bp from pter
Size:
125 bases
Orientation:
Minus strand

Genomic View for MIR217 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR217 Gene

ORGUL Member Location for MIR217 Gene

ORGUL Member Location for MIR217 gene

No data available for Regulatory Elements for MIR217 Gene

Proteins for MIR217 Gene

Post-translational modifications for MIR217 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR217 Gene

Domains & Families for MIR217 Gene

Gene Families for MIR217 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR217: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR217 Gene

Function for MIR217 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR217 Gene

Localization for MIR217 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR217 Gene

Pathways & Interactions for MIR217 Gene

SuperPathways for MIR217 Gene

No Data Available

Interacting Proteins for MIR217 Gene

Gene Ontology (GO) - Biological Process for MIR217 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR217 Gene

Drugs & Compounds for MIR217 Gene

No Compound Related Data Available

Transcripts for MIR217 Gene

fRNAdb Secondary structures for MIR217 Gene

  • FR232136

mRNA/cDNA for MIR217 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR217 Gene

No ASD Table

Relevant External Links for MIR217 Gene

GeneLoc Exon Structure for
MIR217
ECgene alternative splicing isoforms for
MIR217

Expression for MIR217 Gene

mRNA expression in normal human tissues for MIR217 Gene

genes like me logo Genes that share expression patterns with MIR217: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR217 Gene

Orthologs for MIR217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR217 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-217 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-217 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-217 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir217 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-217 36
  • 85 (a)
OneToMany
oan-mir-217 36
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
ptr-mir-217 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-217 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-217 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-217 36
  • 80 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-217 36
  • 51 (a)
OneToOne
Species with no ortholog for MIR217:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR217 Gene

ENSEMBL:
Gene Tree for MIR217 (if available)
TreeFam:
Gene Tree for MIR217 (if available)

Paralogs for MIR217 Gene

No data available for Paralogs for MIR217 Gene

Variants for MIR217 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR217 Gene

Variant ID Type Subtype PubMed ID
dgv1186e1 CNV Complex 17122850

Relevant External Links for MIR217 Gene

HapMap Linkage Disequilibrium report
MIR217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR217 Gene

Disorders for MIR217 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR217 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association

Relevant External Links for MIR217

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR217
genes like me logo Genes that share disorders with MIR217: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR217 Gene

Publications for MIR217 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 67
  2. Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. (PMID: 25538231) Wang X. … Yang M. (J. Biol. Chem. 2015) 67
  3. MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells. (PMID: 25801876) Han F. … Armando I. (Hypertension 2015) 67
  4. Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway. (PMID: 25172416) Deng S. … Zhao G. (Cancer Lett. 2014) 67
  5. MicroRNA-217 regulates WASF3 expression and suppresses tumor growth and metastasis in osteosarcoma. (PMID: 25289936) Shen L. … Li X. (PLoS ONE 2014) 67

Products for MIR217 Gene

Sources for MIR217 Gene

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