Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR216B Gene

Subcategory (RNA class) for MIR216B Gene


Quality Score for this RNA gene is


Aliases for MIR216B Gene

  • MicroRNA 216b 2 3
  • Hsa-Mir-216b 3
  • MIRN216B 3

External Ids for MIR216B Gene

Previous HGNC Symbols for MIR216B Gene

  • MIRN216B

Previous GeneCards Identifiers for MIR216B Gene

  • GC02M056083
  • GC02M056227

Summaries for MIR216B Gene

Entrez Gene Summary for MIR216B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216B Gene

MIR216B (MicroRNA 216b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR216B Gene

Genomics for MIR216B Gene

Genomic Location for MIR216B Gene

56,000,714 bp from pter
56,000,795 bp from pter
82 bases
Minus strand

Genomic View for MIR216B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR216B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216B Gene

No data available for Regulatory Elements for MIR216B Gene

Proteins for MIR216B Gene

Post-translational modifications for MIR216B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216B Gene

Domains for MIR216B Gene

Gene Families for MIR216B Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR216B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR216B Gene

Function for MIR216B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR216B Gene

Localization for MIR216B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR216B Gene

Pathways for MIR216B Gene

SuperPathways for MIR216B Gene

No Data Available

Interacting Proteins for MIR216B Gene

Gene Ontology (GO) - Biological Process for MIR216B Gene


No data available for Pathways by source for MIR216B Gene

Transcripts for MIR216B Gene

mRNA/cDNA for MIR216B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216B Gene

No ASD Table

Relevant External Links for MIR216B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR216B Gene

mRNA expression in normal human tissues for MIR216B Gene

genes like me logo Genes that share expressions with MIR216B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR216B Gene

Orthologs for MIR216B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-216b 36
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
(Mus musculus)
Mammalia Mir216b 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-216b 36
  • 77 (a)
(Pan troglodytes)
Mammalia ptr-mir-216b 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-216b 36
  • 79 (a)
(Anolis carolinensis)
Reptilia aca-mir-216b 36
  • 73 (a)
(Danio rerio)
Actinopterygii dre-mir-216b 36
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 36
  • 42 (a)
Species with no ortholog for MIR216B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216B Gene

Gene Tree for MIR216B (if available)
Gene Tree for MIR216B (if available)

Paralogs for MIR216B Gene

No data available for Paralogs for MIR216B Gene

Variants for MIR216B Gene

Sequence variations from dbSNP and Humsavar for MIR216B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4672084 -- 56,002,249(+) ACTTC(C/T)ATCCT upstream-variant-2KB
rs13029542 -- 56,001,216(+) TCTAA(C/T)GTTAG upstream-variant-2KB
rs13418127 -- 56,001,519(+) AACAT(C/T)TTCCT upstream-variant-2KB
rs34775141 -- 56,001,018(+) TTCCC(-/A/C)AAGCC upstream-variant-2KB
rs35263642 -- 56,001,029(+) CAACC(-/C)AGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR216B Gene

Variant ID Type Subtype PubMed ID
dgv1186e1 CNV Complex 17122850

Relevant External Links for MIR216B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR216B Gene

Disorders for MIR216B Gene

No disorders were found for MIR216B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR216B Gene

Publications for MIR216B Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3
  5. MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure. (PMID: 24681041) Xu X. … Ge Y. (Exp. Eye Res. 2014) 3

Products for MIR216B Gene

Sources for MIR216B Gene

Back to Top