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Aliases for MIR216A Gene

Subcategory (RNA class) for MIR216A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR216A Gene

  • MicroRNA 216a 2 3
  • MicroRNA 216 2 3
  • MIRN216 3 6
  • MIR216 3 6
  • Hsa-Mir-216a 3
  • Hsa-Mir-216 3
  • MiRNA216 3
  • MIRN216A 3
  • Mir-216 3

External Ids for MIR216A Gene

Previous Symbols for MIR216A Gene

  • MIRN216
  • MIRN216A

Summaries for MIR216A Gene

Entrez Gene Summary for MIR216A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216A Gene

MIR216A (MicroRNA 216a) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR216A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR216A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR216A Gene

Genomics for MIR216A Gene

Genomic Location for MIR216A Gene

Start:
55,988,950 bp from pter
End:
55,989,059 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR216A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR216A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216A Gene

ORGUL Member Location for MIR216A Gene

ORGUL Member Location for MIR216A gene

No data available for Regulatory Elements for MIR216A Gene

Proteins for MIR216A Gene

Post-translational modifications for MIR216A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216A Gene

Domains for MIR216A Gene

Gene Families for MIR216A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR216A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR216A Gene

Function for MIR216A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR216A Gene

Localization for MIR216A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR216A Gene

Pathways for MIR216A Gene

SuperPathways for MIR216A Gene

No Data Available

Interacting Proteins for MIR216A Gene

Gene Ontology (GO) - Biological Process for MIR216A Gene

None

No data available for Pathways by source for MIR216A Gene

Transcripts for MIR216A Gene

fRNAdb Secondary structures for MIR216A Gene

  • FR306832

mRNA/cDNA for MIR216A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216A Gene

No ASD Table

Relevant External Links for MIR216A Gene

GeneLoc Exon Structure for
MIR216A
ECgene alternative splicing isoforms for
MIR216A

Expression for MIR216A Gene

mRNA expression in normal human tissues for MIR216A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR216A: view

Orthologs for MIR216A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-216a 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-216a 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-216a 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir216a 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-216 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-216a 37
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-216a 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-216a 37
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-216a 37
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 37
  • 58 (a)
OneToMany
Species with no ortholog for MIR216A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216A Gene

ENSEMBL:
Gene Tree for MIR216A (if available)
TreeFam:
Gene Tree for MIR216A (if available)

Paralogs for MIR216A Gene

No data available for Paralogs for MIR216A Gene

Variants for MIR216A Gene

Sequence variations from dbSNP and Humsavar for MIR216A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6545536 -- 55,990,592(+) ACAAG(A/G)GCTTC upstream-variant-2KB
rs6545537 -- 55,990,699(+) ATAGA(A/G)AAGTG upstream-variant-2KB
rs6545538 -- 55,990,765(+) AATGG(A/G)AACAT upstream-variant-2KB
rs6752420 -- 55,990,727(+) TTCTT(C/G)CCTCT upstream-variant-2KB
rs7558150 -- 55,989,769(+) CTCTA(G/T)ATTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR216A Gene

Variant ID Type Subtype PubMed ID
dgv1186e1 CNV Complex 17122850

Relevant External Links for MIR216A Gene

HapMap Linkage Disequilibrium report
MIR216A

Disorders for MIR216A Gene

Relevant External Links for MIR216A

Genetic Association Database (GAD)
MIR216A
Human Genome Epidemiology (HuGE) Navigator
MIR216A
genes like me logo Genes that share disorders with MIR216A: view

No data available for UniProtKB/Swiss-Prot for MIR216A Gene

Publications for MIR216A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C. … Martelli F. (RNA 2012) 3
  3. Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. (PMID: 22392644) Chen P.J. … Chen P.J. (Hepatology 2012) 3
  4. Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases. (PMID: 22960330) Szeto C.C. … Kam-Tao L.P. (Dis. Markers 2012) 3
  5. [Expression of miR-216a in pancreatic cancer and its clinical significance]. (PMID: 23174591) Hou B. … Ou J. (Nan Fang Yi Ke Da Xue Xue Bao 2012) 3

Products for MIR216A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR216A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR216A
    • Block miRNA regulation of MIR216A using miScript Target Protectors

    Sources for MIR216A Gene

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