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Aliases for MIR216A Gene

Subcategory (RNA class) for MIR216A Gene


Quality Score for this RNA gene is


Aliases for MIR216A Gene

  • MicroRNA 216a 2 3 5
  • MicroRNA 216 2 3
  • Hsa-Mir-216a 3
  • Hsa-Mir-216 3
  • MiRNA216 3
  • Mir-216a 3
  • MIRN216A 3
  • Mir-216 3
  • MIRN216 3
  • MIR216 3

External Ids for MIR216A Gene

Previous HGNC Symbols for MIR216A Gene

  • MIRN216
  • MIRN216A

Previous GeneCards Identifiers for MIR216A Gene

  • GC02M056072
  • GC02M056216

Summaries for MIR216A Gene

Entrez Gene Summary for MIR216A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216A Gene

MIR216A (MicroRNA 216a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR216A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR216A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR216A Gene

Genomics for MIR216A Gene

Regulatory Elements for MIR216A Gene

Enhancers for MIR216A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F055957 1.1 Ensembl ENCODE 10.9 +30.4 30375 1.4 PKNOX1 SIN3A RAD21 RFX5 ZNF335 GLIS2 SCRT2 RCOR1 DEK ZNF263 EFEMP1 MIR217 MIR216A ENSG00000240401 ENSG00000272180 GC02P055982
GH02F056008 0.9 Ensembl ENCODE 11.1 -20.1 -20078 2.0 CTCF ZNF654 RFX1 JUN BHLHE40 MAX MNT REST RAD21 POLR2A MIR217 MIR216A EFEMP1 MIR216B MIR217HG
GH02F055965 0.8 Ensembl ENCODE 11.8 +22.8 22809 1.8 JUN IKZF1 MNT RAD21 NR2F2 MIR216A EFEMP1 ENSG00000240401 ENSG00000272180 GC02P055982
GH02F056015 0.7 Ensembl ENCODE 11.1 -26.9 -26892 0.9 ZNF692 REST PRDM1 MIR216A MIR217 MIR216B MIR217HG
GH02F056013 0.6 ENCODE 11.1 -25.2 -25157 0.5 PKNOX1 ZNF146 SMARCA4 POLR2A ZIC2 MIR216A MIR217 MIR216B MIR217HG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR216A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR216A Gene

55,988,950 bp from pter
55,989,059 bp from pter
110 bases
Minus strand

Genomic View for MIR216A Gene

Genes around MIR216A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR216A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR216A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216A Gene

ORGUL Member Location for MIR216A Gene

ORGUL Member Location for MIR216A gene

Proteins for MIR216A Gene

Post-translational modifications for MIR216A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216A Gene

Domains & Families for MIR216A Gene

Gene Families for MIR216A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR216A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR216A Gene

Function for MIR216A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR216A Gene

Localization for MIR216A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR216A Gene

Pathways & Interactions for MIR216A Gene

SuperPathways for MIR216A Gene

No Data Available

Interacting Proteins for MIR216A Gene

Gene Ontology (GO) - Biological Process for MIR216A Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR216A Gene

Transcripts for MIR216A Gene

fRNAdb Secondary structures for MIR216A Gene

  • FR306832

mRNA/cDNA for MIR216A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216A Gene

No ASD Table

Relevant External Links for MIR216A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR216A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR216A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR216A Gene:

genes like me logo Genes that share expression patterns with MIR216A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR216A Gene

Orthologs for MIR216A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-216a 35
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-216a 35
  • 97 (a)
(Monodelphis domestica)
Mammalia mdo-mir-216 35
  • 96 (a)
(Bos Taurus)
Mammalia bta-mir-216a 35
  • 94 (a)
(Mus musculus)
Mammalia Mir216a 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-216a 35
  • 73 (a)
(Gallus gallus)
Aves gga-mir-216a 35
  • 87 (a)
(Anolis carolinensis)
Reptilia aca-mir-216a 35
  • 84 (a)
(Danio rerio)
Actinopterygii dre-mir-216a 35
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 35
  • 58 (a)
Species where no ortholog for MIR216A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216A Gene

Gene Tree for MIR216A (if available)
Gene Tree for MIR216A (if available)

Paralogs for MIR216A Gene

No data available for Paralogs for MIR216A Gene

Variants for MIR216A Gene

Sequence variations from dbSNP and Humsavar for MIR216A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10865292 -- 55,988,917(+) TTGGT(A/G)TTTAA intron-variant, downstream-variant-500B
rs112803313 -- 55,990,394(+) ATAAA(C/G)TTACA intron-variant, upstream-variant-2KB
rs113990686 -- 55,989,882(+) CATTG(C/T)AGACT intron-variant, upstream-variant-2KB
rs11682464 -- 55,988,472(+) AGTTG(A/C)TTCTA intron-variant, downstream-variant-500B
rs11695578 -- 55,989,784(+) cagta(G/T)gtctg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR216A Gene

Variant ID Type Subtype PubMed ID
esv2759051 CNV gain 17122850
esv3575244 CNV gain 25503493

Relevant External Links for MIR216A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR216A Gene

Disorders for MIR216A Gene

Relevant External Links for MIR216A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR216A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR216A Gene

Publications for MIR216A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma. (PMID: 26989293) Dong S. … He F. (Dis. Markers 2016) 3 64
  3. Cystathionine I^-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway. (PMID: 26772887) Gong D. … Tang C.K. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B. (PMID: 25955794) Li L. … Ma H.Q. (Mol Med Rep 2015) 3 64
  5. MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy. (PMID: 26134156) Zhang X. … Cui S. (Oncol. Rep. 2015) 3 64

Products for MIR216A Gene

Sources for MIR216A Gene

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