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Aliases for MIR216A Gene

Subcategory (RNA class) for MIR216A Gene


Quality Score for this RNA gene is


Aliases for MIR216A Gene

  • MicroRNA 216a 2 3 5
  • MicroRNA 216 2 3
  • Hsa-Mir-216a 3
  • Hsa-Mir-216 3
  • MiRNA216 3
  • Mir-216a 3
  • MIRN216A 3
  • Mir-216 3
  • MIRN216 3
  • MIR216 3

External Ids for MIR216A Gene

Previous HGNC Symbols for MIR216A Gene

  • MIRN216
  • MIRN216A

Previous GeneCards Identifiers for MIR216A Gene

  • GC02M056072
  • GC02M056216

Summaries for MIR216A Gene

Entrez Gene Summary for MIR216A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR216A Gene

MIR216A (MicroRNA 216a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR216A Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR216A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR216A Gene

Genomics for MIR216A Gene

Regulatory Elements for MIR216A Gene

Enhancers for MIR216A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR216A on UCSC Golden Path with GeneCards custom track

Promoters for MIR216A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR216A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR216A Gene

55,988,950 bp from pter
55,989,059 bp from pter
110 bases
Minus strand

Genomic View for MIR216A Gene

Genes around MIR216A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR216A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR216A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR216A Gene

ORGUL Member Location for MIR216A Gene

ORGUL Member Location for MIR216A gene

Proteins for MIR216A Gene

Post-translational modifications for MIR216A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR216A Gene

Domains & Families for MIR216A Gene

Gene Families for MIR216A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR216A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR216A Gene

Function for MIR216A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR216A Gene

Localization for MIR216A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR216A Gene

Pathways & Interactions for MIR216A Gene

SuperPathways for MIR216A Gene

No Data Available

Interacting Proteins for MIR216A Gene

Gene Ontology (GO) - Biological Process for MIR216A Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR216A Gene

Drugs & Compounds for MIR216A Gene

No Compound Related Data Available

Transcripts for MIR216A Gene

fRNAdb Secondary structures for MIR216A Gene

  • FR306832

mRNA/cDNA for MIR216A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR216A Gene

No ASD Table

Relevant External Links for MIR216A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR216A Gene

mRNA expression in normal human tissues for MIR216A Gene

genes like me logo Genes that share expression patterns with MIR216A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR216A Gene

Orthologs for MIR216A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR216A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-216a 36
  • 94 (a)
(Canis familiaris)
Mammalia cfa-mir-216a 36
  • 97 (a)
(Monodelphis domestica)
Mammalia mdo-mir-216 36
  • 96 (a)
(Mus musculus)
Mammalia Mir216a 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-216a 36
  • 73 (a)
(Pan troglodytes)
Mammalia ptr-mir-216a 36
  • 98 (a)
(Gallus gallus)
Aves gga-mir-216a 36
  • 87 (a)
(Anolis carolinensis)
Reptilia aca-mir-216a 36
  • 84 (a)
(Danio rerio)
Actinopterygii dre-mir-216a 36
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-216a 36
  • 58 (a)
Species with no ortholog for MIR216A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR216A Gene

Gene Tree for MIR216A (if available)
Gene Tree for MIR216A (if available)

Paralogs for MIR216A Gene

No data available for Paralogs for MIR216A Gene

Variants for MIR216A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR216A Gene

Variant ID Type Subtype PubMed ID
dgv1186e1 CNV Complex 17122850

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR216A Gene

Disorders for MIR216A Gene

Relevant External Links for MIR216A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR216A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR216A Gene

Publications for MIR216A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B. (PMID: 25955794) Li L. … Ma H.Q. (Mol Med Rep 2015) 3
  3. miR-216a may inhibit pancreatic tumor growth by targeting JAK2. (PMID: 26149212) Hou B.H. … Ou J.R. (FEBS Lett. 2015) 3
  4. MiR-216a: a link between endothelial dysfunction and autophagy. (PMID: 24481443) Menghini R. … Federici M. (Cell Death Dis 2014) 3
  5. miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. (PMID: 24895996) Bofill-De Ros X. … Fillat C. (Mol. Ther. 2014) 3

Products for MIR216A Gene

Sources for MIR216A Gene