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Aliases for MIR215 Gene

Subcategory (RNA class) for MIR215 Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR215 Gene

  • MicroRNA 215 2 3
  • Hsa-Mir-215 3
  • MiRNA215 3
  • Mir-215 3
  • MIRN215 3

External Ids for MIR215 Gene

Previous HGNC Symbols for MIR215 Gene

  • MIRN215

Previous GeneCards Identifiers for MIR215 Gene

  • GC01M218359
  • GC01M220291

Summaries for MIR215 Gene

Entrez Gene Summary for MIR215 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR215 Gene

MIR215 (MicroRNA 215) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR215 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR215

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR215 Gene

Genomics for MIR215 Gene

Genomic Location for MIR215 Gene

Chromosome:
1
Start:
220,117,853 bp from pter
End:
220,117,962 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR215 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR215 Gene

ORGUL Member Location for MIR215 Gene

ORGUL Member Location for MIR215 gene

No data available for Regulatory Elements for MIR215 Gene

Proteins for MIR215 Gene

Post-translational modifications for MIR215 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR215 Gene

Domains & Families for MIR215 Gene

Gene Families for MIR215 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR215: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR215 Gene

Function for MIR215 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR215 Gene

Localization for MIR215 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR215 Gene

Pathways & Interactions for MIR215 Gene

SuperPathways for MIR215 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR215: view

Pathways by source for MIR215 Gene

1 KEGG pathway for MIR215 Gene

Interacting Proteins for MIR215 Gene

Gene Ontology (GO) - Biological Process for MIR215 Gene

None

No data available for SIGNOR curated interactions for MIR215 Gene

Drugs & Compounds for MIR215 Gene

No Compound Related Data Available

Transcripts for MIR215 Gene

fRNAdb Secondary structures for MIR215 Gene

  • hsa-miR-215-3p_MIMAT0026476_Homo_sapiens_miR-215-3p_mature

mRNA/cDNA for MIR215 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR215 Gene

No ASD Table

Relevant External Links for MIR215 Gene

GeneLoc Exon Structure for
MIR215
ECgene alternative splicing isoforms for
MIR215

Expression for MIR215 Gene

mRNA expression in normal human tissues for MIR215 Gene

genes like me logo Genes that share expression patterns with MIR215: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR215 Gene

Orthologs for MIR215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR215 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-215 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-215 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-215 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir215 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
oan-mir-215 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-215 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-215 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-215 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-192 36
  • 66 (a)
OneToMany
Species with no ortholog for MIR215:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR215 Gene

ENSEMBL:
Gene Tree for MIR215 (if available)
TreeFam:
Gene Tree for MIR215 (if available)

Paralogs for MIR215 Gene

No data available for Paralogs for MIR215 Gene

Variants for MIR215 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR215 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897
esv2665152 CNV Deletion 23128226

Relevant External Links for MIR215 Gene

HapMap Linkage Disequilibrium report
MIR215

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR215 Gene

Disorders for MIR215 Gene

Relevant External Links for MIR215

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR215
genes like me logo Genes that share disorders with MIR215: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR215 Gene

Publications for MIR215 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 67
  2. Nidogen-1 (NID1) is a common target of microRNAs MiR-192/215 in the pathogenesis of Hirschsprung's disease. (PMID: 25857602) Zhu D. … Tang W. (J. Neurochem. 2015) 67
  3. The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. (PMID: 25775580) Jones M.F. … Lal A. (Proc. Natl. Acad. Sci. U.S.A. 2015) 67
  4. MiR-215/192 participates in gastric cancer progression. (PMID: 24981590) Xu Y.J. … Fan Y. (Clin Transl Oncol 2015) 67
  5. Serum microRNA 143 and microRNA 215 as potential biomarkers for the diagnosis of chronic hepatitis and hepatocellular carcinoma. (PMID: 24993656) Zhang Z.Q. … Luan Y. (Diagn Pathol 2014) 67

Products for MIR215 Gene

Sources for MIR215 Gene

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