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Aliases for MIR215 Gene

Subcategory (RNA class) for MIR215 Gene


Quality Score for this RNA gene is


Aliases for MIR215 Gene

  • MicroRNA 215 2 3 5
  • Hsa-Mir-215 3
  • MiRNA215 3
  • Mir-215 3
  • MIRN215 3

External Ids for MIR215 Gene

Previous HGNC Symbols for MIR215 Gene

  • MIRN215

Previous GeneCards Identifiers for MIR215 Gene

  • GC01M218359
  • GC01M220291

Summaries for MIR215 Gene

Entrez Gene Summary for MIR215 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR215 Gene

MIR215 (MicroRNA 215) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR215 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR215

Additional gene information for MIR215 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR215 Gene

Genomics for MIR215 Gene

Regulatory Elements for MIR215 Gene

Enhancers for MIR215 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H220158 0.4 ENCODE 12.4 -41.6 -41593 1.7 CEBPG IARS2 MIR194-1 MIR215 EPRS RAB3GAP2 GC01P220165 RPS15AP12
GH01H220113 0.6 dbSUPER 0.7 +4.4 4401 0.9 HDGF CTCF TRIM22 RAD21 CHAMP1 KLF16 ZNF143 CUX1 HOMEZ ZHX1 EPRS RPS15AP12 LOC105373475 MIR215
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR215 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR215 Gene

Genomic Locations for MIR215 Gene
110 bases
Minus strand

Genomic View for MIR215 Gene

Genes around MIR215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR215 Gene

ORGUL Member Location for MIR215 Gene

ORGUL Member Location for MIR215 gene

Proteins for MIR215 Gene

Post-translational modifications for MIR215 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR215 Gene

Domains & Families for MIR215 Gene

Gene Families for MIR215 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR215: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR215 Gene

Function for MIR215 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR215 Gene

Localization for MIR215 Gene

Gene Ontology (GO) - Cellular Components for MIR215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR215: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR215 Gene

Pathways & Interactions for MIR215 Gene

SuperPathways for MIR215 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR215: view

Pathways by source for MIR215 Gene

1 KEGG pathway for MIR215 Gene

Interacting Proteins for MIR215 Gene

Gene Ontology (GO) - Biological Process for MIR215 Gene


No data available for SIGNOR curated interactions for MIR215 Gene

Drugs & Compounds for MIR215 Gene

No Compound Related Data Available

Transcripts for MIR215 Gene

fRNAdb Secondary structures for MIR215 Gene

  • hsa-miR-215-3p_MIMAT0026476_Homo_sapiens_miR-215-3p_mature

mRNA/cDNA for MIR215 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR215 Gene

No ASD Table

Relevant External Links for MIR215 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR215 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR215 Gene:

genes like me logo Genes that share expression patterns with MIR215: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR215 Gene

Orthologs for MIR215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR215 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-215 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-215 34
  • 89 (a)
(Bos Taurus)
Mammalia bta-mir-215 34
  • 87 (a)
(Monodelphis domestica)
Mammalia mdo-mir-215 34
  • 83 (a)
(Mus musculus)
Mammalia Mir215 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
oan-mir-215 34
  • 72 (a)
(Gallus gallus)
Aves gga-mir-215 34
  • 75 (a)
(Anolis carolinensis)
Reptilia aca-mir-215 34
  • 66 (a)
(Danio rerio)
Actinopterygii dre-mir-192 34
  • 66 (a)
Species where no ortholog for MIR215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR215 Gene

Gene Tree for MIR215 (if available)
Gene Tree for MIR215 (if available)

Paralogs for MIR215 Gene

No data available for Paralogs for MIR215 Gene

Variants for MIR215 Gene

Sequence variations from dbSNP and Humsavar for MIR215 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000510918 -- 220,119,793(+) AAAAT(A/G)TCAGC intron-variant, upstream-variant-2KB
rs1003012789 -- 220,119,271(+) ATAAG(G/T)CCTTT intron-variant, upstream-variant-2KB
rs1003759254 -- 220,117,538(+) CTAGG(A/G)AATTT intron-variant, downstream-variant-500B
rs1004488327 -- 220,117,620(+) TATGT(A/G)TTAGT intron-variant, downstream-variant-500B
rs1004985583 -- 220,118,074(+) AAATC(-/T)TTTTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR215 Gene

Variant ID Type Subtype PubMed ID
nsv947468 CNV deletion 23825009
nsv832636 CNV loss 17160897
esv3588893 CNV loss 21293372
esv3547011 CNV deletion 23714750
esv2665152 CNV deletion 23128226

Relevant External Links for MIR215 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR215 Gene

Disorders for MIR215 Gene

Relevant External Links for MIR215

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR215 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR215 Gene

Publications for MIR215 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 60
  2. MicroRNA-215 enhances invasion and migration by targeting retinoblastoma tumor suppressor gene 1 in high-grade glioma. (PMID: 27837373) Wei Y … Li X (Biotechnology letters 2017) 3 60
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  4. miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis. (PMID: 26676658) Ge G … Zou Y (Oncology reports 2016) 3 60
  5. miR-215 promotes malignant progression of gastric cancer by targeting RUNX1. (PMID: 26716895) Li N … Shen L (Oncotarget 2016) 3 60

Products for MIR215 Gene

Sources for MIR215 Gene

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