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Aliases for MIR214 Gene

Subcategory (RNA class) for MIR214 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR214 Gene

  • MicroRNA 214 2 3
  • MIRN214 3 6
  • Hsa-Mir-214 3
  • MiRNA214 3
  • Mir-214 3

External Ids for MIR214 Gene

Previous HGNC Symbols for MIR214 Gene

  • MIRN214

Previous GeneCards Identifiers for MIR214 Gene

  • GC01M170375
  • GC01M172180
  • GC01M172182
  • GC01M172188
  • GC01M172192

Summaries for MIR214 Gene

Entrez Gene Summary for MIR214 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR214 Gene

MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR214 include intrahepatic cholangiocarcinoma and pediatric osteosarcoma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR214 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR214

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR214 Gene

Genomics for MIR214 Gene

Genomic Location for MIR214 Gene

Start:
172,138,798 bp from pter
End:
172,138,907 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR214 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR214 Gene

ORGUL Member Location for MIR214 Gene

ORGUL Member Location for MIR214 gene

No data available for Regulatory Elements for MIR214 Gene

Proteins for MIR214 Gene

Post-translational modifications for MIR214 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR214 Gene

Domains for MIR214 Gene

Gene Families for MIR214 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR214: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR214 Gene

Function for MIR214 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR214 Gene

Localization for MIR214 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR214 Gene

Pathways for MIR214 Gene

genes like me logo Genes that share pathways with MIR214: view

Pathways by source for MIR214 Gene

Interacting Proteins for MIR214 Gene

Gene Ontology (GO) - Biological Process for MIR214 Gene

None

Transcripts for MIR214 Gene

fRNAdb Secondary structures for MIR214 Gene

  • hsa-mir-214_MI0000290_Homo_sapiens_miR-214_stem-loop_hairpin

mRNA/cDNA for MIR214 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR214

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR214 Gene

No ASD Table

Relevant External Links for MIR214 Gene

GeneLoc Exon Structure for
MIR214
ECgene alternative splicing isoforms for
MIR214

Expression for MIR214 Gene

mRNA expression in normal human tissues for MIR214 Gene

mRNA differential expression in normal tissues according to GTEx for MIR214 Gene

This gene is overexpressed in Spleen (6.0) and Ovary (5.4).
genes like me logo Genes that share expressions with MIR214: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MIR214 Gene

Orthologs for MIR214 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR214 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-214 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-214 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-214 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir214 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-214 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-214 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-214 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-214 36
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-214 36
  • 87 (a)
OneToOne
Species with no ortholog for MIR214:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR214 Gene

ENSEMBL:
Gene Tree for MIR214 (if available)
TreeFam:
Gene Tree for MIR214 (if available)

Paralogs for MIR214 Gene

No data available for Paralogs for MIR214 Gene

Variants for MIR214 Gene

Relevant External Links for MIR214 Gene

HapMap Linkage Disequilibrium report
MIR214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR214 Gene

Disorders for MIR214 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MIR214 Gene including...

Search for MIR214 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR214: view

No data available for UniProtKB/Swiss-Prot for MIR214 Gene

Publications for MIR214 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. (PMID: 17108080) van Rooij E. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. (PMID: 18199536) Yang H. … Cheng J.Q. (Cancer Res. 2008) 3

Products for MIR214 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR214
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR214
    • Block miRNA regulation of MIR214 using miScript Target Protectors

    Sources for MIR214 Gene

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