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Aliases for MIR214 Gene

Subcategory (RNA class) for MIR214 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR214 Gene

  • MicroRNA 214 2 3
  • DNM3 Opposite Strand/Antisense RNA 5
  • Hsa-Mir-214 3
  • MiRNA214 3
  • Mir-214 3
  • MIRN214 3
  • DNM3OS 5

External Ids for MIR214 Gene

Previous HGNC Symbols for MIR214 Gene

  • MIRN214

Previous GeneCards Identifiers for MIR214 Gene

  • GC01M170375
  • GC01M172180
  • GC01M172182
  • GC01M172188
  • GC01M172192
  • GC01M172198

Summaries for MIR214 Gene

Entrez Gene Summary for MIR214 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR214 Gene

MIR214 (MicroRNA 214) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR214 Gene

Genomics for MIR214 Gene

Regulatory Elements for MIR214 Gene

Enhancers for MIR214 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F172179 1.4 FANTOM5 Ensembl ENCODE 11.7 -38.9 -38894 8.0 TBP TBL1XR1 SIN3A ASH2L BMI1 EBF1 RAD21 GATA3 POLR2A CBX5 DNM3OS MIR199A2 MIR214 RNU6-157P GC01P172160 GC01P172209
GH01F172210 0.7 ENCODE 10.6 -66.6 -66601 2.7 SIN3A RAD21 ZBTB40 GATA3 CREM MTA2 CBFB TRIM22 JUNB KLF4 DNM3OS MIR199A2 MIR214 GC01P172209 GC01P172216
GH01F171434 1.3 FANTOM5 Ensembl ENCODE 5 +709.8 709797 2.2 CTCF TAF1 JUN MAX ZIC2 RAD21 GTF3C2 CTBP1 SCRT2 SMC3 PRRC2C FMO4 MIR214 CYCSP53 GC01M171420
GH01F172108 0.5 ENCODE 11.5 +35.2 35206 1.7 JUND FOXP2 RAD21 DNM3OS MIR199A2 MIR214 GC01P172124 GC01M171926
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR214 on UCSC Golden Path with GeneCards custom track

Promoters for MIR214 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001526005 1993 6000 ZNF680 JUN SIN3A RAD21 NR2F2 ZFHX2 JUND ZNF366 POLR2A GLIS1

Genomic Location for MIR214 Gene

Chromosome:
1
Start:
172,136,531 bp from pter
End:
172,144,794 bp from pter
Size:
8,264 bases
Orientation:
Minus strand

Genomic View for MIR214 Gene

Genes around MIR214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR214 Gene

Proteins for MIR214 Gene

Post-translational modifications for MIR214 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR214 Gene

Domains & Families for MIR214 Gene

Gene Families for MIR214 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR214: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR214 Gene

Function for MIR214 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR214 Gene

Localization for MIR214 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR214 Gene

Pathways & Interactions for MIR214 Gene

SuperPathways for MIR214 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR214: view

Pathways by source for MIR214 Gene

1 KEGG pathway for MIR214 Gene

Interacting Proteins for MIR214 Gene

Gene Ontology (GO) - Biological Process for MIR214 Gene

None

No data available for SIGNOR curated interactions for MIR214 Gene

Transcripts for MIR214 Gene

mRNA/cDNA for MIR214 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR214 Gene

No ASD Table

Relevant External Links for MIR214 Gene

GeneLoc Exon Structure for
MIR214
ECgene alternative splicing isoforms for
MIR214

Expression for MIR214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR214 Gene

mRNA differential expression in normal tissues according to GTEx for MIR214 Gene

This gene is overexpressed in Spleen (x6.0) and Ovary (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR214 Gene:

MIR214
genes like me logo Genes that share expression patterns with MIR214: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR214 Gene

Orthologs for MIR214 Gene

Evolution for MIR214 Gene

ENSEMBL:
Gene Tree for MIR214 (if available)
TreeFam:
Gene Tree for MIR214 (if available)

No data available for Orthologs for MIR214 Gene

Paralogs for MIR214 Gene

No data available for Paralogs for MIR214 Gene

Variants for MIR214 Gene

Sequence variations from dbSNP and Humsavar for MIR214 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs115132259 -- 172,139,197(+) TTCAT(A/G)TTATT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs115605846 -- 172,140,284(+) TTCCG(A/T)TTCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs117110263 -- 172,139,677(+) TCACA(G/T)TGATG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs139031456 -- 172,139,210(+) TGGCC(A/C)ACATG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs139689939 -- 172,139,644(+) GAATC(A/G)AAAGG intron-variant, nc-transcript-variant, upstream-variant-2KB

Relevant External Links for MIR214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR214 Gene

Disorders for MIR214 Gene

Relevant External Links for MIR214

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR214

No disorders were found for MIR214 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR214 Gene

Publications for MIR214 Gene

  1. A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson's disease. (PMID: 26631297) Dong H. … Zhang C.Y. (Biomarkers 2016) 3 64
  2. MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). (PMID: 26973267) Yang X. … Dong S. (Int Heart J 2016) 3 64
  3. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. (PMID: 26947250) Li D. … Zhang G. (Nat Commun 2016) 3 64
  4. miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2. (PMID: 26791102) Gao M. … Liu S. (Free Radic. Biol. Med. 2016) 3 64
  5. miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators. (PMID: 26498144) Wang P. … Xie C. (Oncotarget 2016) 3 64

Products for MIR214 Gene

Sources for MIR214 Gene

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