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Aliases for MIR212 Gene

Subcategory (RNA class) for MIR212 Gene

miRNA

Quality Score for this RNA gene is

4.2

Aliases for MIR212 Gene

  • MicroRNA 212 2 3
  • MIRN212 3 6
  • Hsa-Mir-212 3
  • Mir-212 3

External Ids for MIR212 Gene

Previous HGNC Symbols for MIR212 Gene

  • MIRN212

Previous GeneCards Identifiers for MIR212 Gene

  • GC17M001928
  • GC17M001931
  • GC17M001954
  • GC17M001959
  • GC17M001962

Summaries for MIR212 Gene

Entrez Gene Summary for MIR212 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR212 Gene

MIR212 (MicroRNA 212) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR212 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR212

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR212 Gene

Genomics for MIR212 Gene

Genomic Location for MIR212 Gene

Start:
2,050,271 bp from pter
End:
2,050,380 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR212 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR212 Gene

ORGUL Member Location for MIR212 Gene

ORGUL Member Location for MIR212 gene

No data available for Regulatory Elements for MIR212 Gene

Proteins for MIR212 Gene

Post-translational modifications for MIR212 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR212 Gene

Domains for MIR212 Gene

Gene Families for MIR212 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR212: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR212 Gene

Function for MIR212 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR212 Gene

Localization for MIR212 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR212 Gene

Pathways for MIR212 Gene

SuperPathways for MIR212 Gene

No Data Available

Interacting Proteins for MIR212 Gene

Gene Ontology (GO) - Biological Process for MIR212 Gene

None

No data available for Pathways by source for MIR212 Gene

Transcripts for MIR212 Gene

fRNAdb Secondary structures for MIR212 Gene

  • hsa-miR-212-5p_MIMAT0022695_Homo_sapiens_miR-212-5p_mature
  • hsa-miR-212-3p_MIMAT0000269_Homo_sapiens_miR-212-3p_mature

mRNA/cDNA for MIR212 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR212

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR212 Gene

No ASD Table

Relevant External Links for MIR212 Gene

GeneLoc Exon Structure for
MIR212
ECgene alternative splicing isoforms for
MIR212

Expression for MIR212 Gene

mRNA expression in normal human tissues for MIR212 Gene

genes like me logo Genes that share expressions with MIR212: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR212 Gene

Orthologs for MIR212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR212 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-212 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-212 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-212 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir212 36
  • 98 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX663516.1 36
  • 69 (a)
OneToMany
CU459076.1 36
  • 69 (a)
OneToMany
dre-mir-212 36
  • 70 (a)
OneToMany
Species with no ortholog for MIR212:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR212 Gene

ENSEMBL:
Gene Tree for MIR212 (if available)
TreeFam:
Gene Tree for MIR212 (if available)

Paralogs for MIR212 Gene

No data available for Paralogs for MIR212 Gene

Variants for MIR212 Gene

Sequence variations from dbSNP and Humsavar for MIR212 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7212720 -- 2,052,374(+) CCTCA(C/G)CCTGC upstream-variant-2KB
rs7212723 -- 2,052,375(+) CTCAC(A/C)CTGCC upstream-variant-2KB
rs7225200 -- 2,052,368(+) GGCGG(C/T)CCTCA upstream-variant-2KB
rs56697120 -- 2,052,081(+) AGGGG(A/C)CCCCA upstream-variant-2KB
rs114252787 -- 2,052,299(+) GTGCA(A/C)GGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR212 Gene

Variant ID Type Subtype PubMed ID
nsv907523 CNV Loss 21882294
nsv827857 CNV Gain 20364138
nsv907526 CNV Loss 21882294
dgv3035n71 CNV Loss 21882294
esv33884 CNV Gain 17666407

Relevant External Links for MIR212 Gene

HapMap Linkage Disequilibrium report
MIR212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR212 Gene

Disorders for MIR212 Gene

No disorders were found for MIR212 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR212 Gene

Publications for MIR212 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. (PMID: 18162065) Tang Y. … Keshavarzian A. (Alcohol. Clin. Exp. Res. 2008) 3
  4. miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. (PMID: 20020497) Wada R. … Yuasa Y. (Int. J. Cancer 2010) 3
  5. Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. (PMID: 20856931) Hatakeyama H. … Chung C.H. (PLoS ONE 2010) 3

Products for MIR212 Gene

Sources for MIR212 Gene

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