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Aliases for MIR212 Gene

Subcategory (RNA class) for MIR212 Gene

miRNA

Quality Score for this RNA gene is

4.2

Aliases for MIR212 Gene

  • MicroRNA 212 2 3 5
  • Hsa-Mir-212 3
  • Mir-212 3
  • MIRN212 3

External Ids for MIR212 Gene

Previous HGNC Symbols for MIR212 Gene

  • MIRN212

Previous GeneCards Identifiers for MIR212 Gene

  • GC17M001928
  • GC17M001931
  • GC17M001954
  • GC17M001959
  • GC17M001962

Summaries for MIR212 Gene

Entrez Gene Summary for MIR212 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR212 Gene

MIR212 (MicroRNA 212) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR212 include Postpartum Psychosis. Among its related pathways are Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR212 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR212

Additional gene information for MIR212 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR212 Gene

Genomics for MIR212 Gene

GeneHancer (GH) Regulatory Elements for MIR212 Gene

Promoters and enhancers for MIR212 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I002049 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 550.8 +0.3 341 2.1 ATF1 SIN3A GLIS2 ELK1 ZNF207 ZNF143 SP3 NCOA1 ZHX2 MXD4 MIR132 MIR212 RTN4RL1 TSR1 PITPNA SGSM2 SLC43A2 SMG6 GC17M002005
GH17I002051 Enhancer 0.7 ENCODE dbSUPER 550.8 -1.5 -1450 0.6 ZKSCAN8 ZNF175 BCL11B EZH2 ZBTB17 MIR132 MIR212 HNRNPA1P16 SMG6 DPH1 METTL16 ENSG00000263345 SMYD4 PRPF8 HIC1
GH17I002052 Enhancer 0.6 ENCODE 550.8 -0.8 -842 0.2 L3MBTL2 PYGO2 ZNF335 ZKSCAN8 GLIS1 CREB1 CREM ZBTB26 EZH2 MIR132 MIR212 HIC1 GC17M002005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR212 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR212 Gene

Genomic Locations for MIR212 Gene
chr17:2,050,271-2,050,380
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr17:1,953,565-1,953,674
(GRCh37/hg19)

Genomic View for MIR212 Gene

Genes around MIR212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR212 Gene

ORGUL Member Location for MIR212 Gene

ORGUL Member Location for MIR212 gene

Proteins for MIR212 Gene

Post-translational modifications for MIR212 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR212 Gene

Domains & Families for MIR212 Gene

Gene Families for MIR212 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR212: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR212 Gene

Function for MIR212 Gene

Gene Ontology (GO) - Molecular Function for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22880819
genes like me logo Genes that share ontologies with MIR212: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR212 Gene

Localization for MIR212 Gene

Gene Ontology (GO) - Cellular Components for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR212: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR212 Gene

Pathways & Interactions for MIR212 Gene

SuperPathways for MIR212 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR212: view

Pathways by source for MIR212 Gene

1 BioSystems pathway for MIR212 Gene

Interacting Proteins for MIR212 Gene

Gene Ontology (GO) - Biological Process for MIR212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 25217442
GO:0010628 positive regulation of gene expression IDA 25217442
GO:0010629 negative regulation of gene expression IDA 25217442
GO:0016525 negative regulation of angiogenesis IDA 25217442
GO:0035195 gene silencing by miRNA IDA 25217442
genes like me logo Genes that share ontologies with MIR212: view

No data available for SIGNOR curated interactions for MIR212 Gene

Drugs & Compounds for MIR212 Gene

No Compound Related Data Available

Transcripts for MIR212 Gene

fRNAdb Secondary structures for MIR212 Gene

  • hsa-miR-212-5p_MIMAT0022695_Homo_sapiens_miR-212-5p_mature
  • hsa-miR-212-3p_MIMAT0000269_Homo_sapiens_miR-212-3p_mature

mRNA/cDNA for MIR212 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR212 Gene

No ASD Table

Relevant External Links for MIR212 Gene

GeneLoc Exon Structure for
MIR212
ECgene alternative splicing isoforms for
MIR212

Expression for MIR212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR212 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR212 Gene:

MIR212
genes like me logo Genes that share expression patterns with MIR212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR212 Gene

Orthologs for MIR212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR212 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-212 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-212 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir212 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-212 34
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-212 34
  • 70 (a)
OneToMany
BX663516.1 34
  • 69 (a)
OneToMany
CU459076.1 34
  • 69 (a)
OneToMany
Species where no ortholog for MIR212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR212 Gene

ENSEMBL:
Gene Tree for MIR212 (if available)
TreeFam:
Gene Tree for MIR212 (if available)

Paralogs for MIR212 Gene

No data available for Paralogs for MIR212 Gene

Variants for MIR212 Gene

Sequence variations from dbSNP and Humsavar for MIR212 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000289205 -- 2,051,474(-) G/C upstream_transcript_variant
rs1000719068 -- 2,050,231(-) T/C/G downstream_transcript_variant
rs1000894579 -- 2,050,551(-) G/C upstream_transcript_variant
rs1001166349 -- 2,051,308(-) C/T upstream_transcript_variant
rs1001263117 -- 2,050,708(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR212 Gene

Variant ID Type Subtype PubMed ID
dgv1403n106 CNV deletion 24896259
esv33884 CNV gain 17666407
nsv1070376 CNV deletion 25765185
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138
nsv952103 CNV deletion 24416366

Additional Variant Information for MIR212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR212 Gene

Disorders for MIR212 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR212 Gene - From: GeneCards

Disorder Aliases PubMed IDs
postpartum psychosis
  • puerperal psychosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR212

genes like me logo Genes that share disorders with MIR212: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR212 Gene

Publications for MIR212 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 58
  2. SRSF3-regulated miR-132/212 controls cell migration and invasion by targeting YAP1. (PMID: 28624413) Kim HR … Kim HH (Experimental cell research 2017) 3 58
  3. Synergy of circulating miR-212 with markers for cardiovascular risks to enhance estimation of atherosclerosis presence. (PMID: 28557988) Jeong HS … Kim J (PloS one 2017) 3 58
  4. Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease. (PMID: 28089352) Wang Y … Krichevsky AM (Neurobiology of aging 2017) 3 58
  5. MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers. (PMID: 27999212) Li C … Chu X (Oncotarget 2017) 3 58

Products for MIR212 Gene

Sources for MIR212 Gene

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