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Aliases for MIR212 Gene

Subcategory (RNA class) for MIR212 Gene

miRNA

Quality Score for this RNA gene is

4.2

Aliases for MIR212 Gene

  • MicroRNA 212 2 3 5
  • Hsa-Mir-212 3
  • Mir-212 3
  • MIRN212 3

External Ids for MIR212 Gene

Previous HGNC Symbols for MIR212 Gene

  • MIRN212

Previous GeneCards Identifiers for MIR212 Gene

  • GC17M001928
  • GC17M001931
  • GC17M001954
  • GC17M001959
  • GC17M001962

Summaries for MIR212 Gene

Entrez Gene Summary for MIR212 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR212 Gene

MIR212 (MicroRNA 212) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR212 include Postpartum Psychosis. Among its related pathways are Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR212 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR212

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR212 Gene

Genomics for MIR212 Gene

Regulatory Elements for MIR212 Gene

Enhancers for MIR212 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G002049 1.4 FANTOM5 ENCODE 0.7 +0.3 342 2.1 ATF1 SIN3A GLIS2 ELK1 ZNF143 ZNF207 KLF13 SP3 ZHX2 MXD4 RTN4RL1 TSR1 PITPNA SGSM2 SLC43A2 SMG6 MIR132 MIR212
GH17G002051 0.8 ENCODE dbSUPER 0.7 -1.5 -1451 0.6 PKNOX1 SUZ12 ZKSCAN8 ZNF175 ZNF24 BCL11B EZH2 MIR212 HIC1
GH17G002052 0.7 ENCODE 0.7 -0.8 -842 0.2 PKNOX1 L3MBTL2 SUZ12 BHLHE40 REST GLIS1 ZKSCAN8 ZNF24 CREM ZBTB26 MIR212 HIC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR212 on UCSC Golden Path with GeneCards custom track

Promoters for MIR212 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090179 180 1201 ATF1 SIN3A GLIS2 ELK1 ZNF143 ZNF207 KLF13 SP3 ZHX2 NCOA1

Genomic Location for MIR212 Gene

Chromosome:
17
Start:
2,050,271 bp from pter
End:
2,050,380 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR212 Gene

Genes around MIR212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR212 Gene

ORGUL Member Location for MIR212 Gene

ORGUL Member Location for MIR212 gene

Proteins for MIR212 Gene

Post-translational modifications for MIR212 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR212 Gene

Domains & Families for MIR212 Gene

Gene Families for MIR212 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR212: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR212 Gene

Function for MIR212 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR212 Gene

Localization for MIR212 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR212 Gene

Pathways & Interactions for MIR212 Gene

SuperPathways for MIR212 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR212: view

Pathways by source for MIR212 Gene

1 BioSystems pathway for MIR212 Gene

Interacting Proteins for MIR212 Gene

Gene Ontology (GO) - Biological Process for MIR212 Gene

None

No data available for SIGNOR curated interactions for MIR212 Gene

Transcripts for MIR212 Gene

fRNAdb Secondary structures for MIR212 Gene

  • hsa-miR-212-5p_MIMAT0022695_Homo_sapiens_miR-212-5p_mature
  • hsa-miR-212-3p_MIMAT0000269_Homo_sapiens_miR-212-3p_mature

mRNA/cDNA for MIR212 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR212 Gene

No ASD Table

Relevant External Links for MIR212 Gene

GeneLoc Exon Structure for
MIR212
ECgene alternative splicing isoforms for
MIR212

Expression for MIR212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR212 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR212 Gene:

MIR212
genes like me logo Genes that share expression patterns with MIR212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR212 Gene

Orthologs for MIR212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR212 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-212 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-212 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir212 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-212 35
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-212 35
  • 70 (a)
OneToMany
BX663516.1 35
  • 69 (a)
OneToMany
CU459076.1 35
  • 69 (a)
OneToMany
Species where no ortholog for MIR212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR212 Gene

ENSEMBL:
Gene Tree for MIR212 (if available)
TreeFam:
Gene Tree for MIR212 (if available)

Paralogs for MIR212 Gene

No data available for Paralogs for MIR212 Gene

Variants for MIR212 Gene

Sequence variations from dbSNP and Humsavar for MIR212 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000289205 -- 2,051,474(+) CCTTC(C/G)AGCTT upstream-variant-2KB
rs1000719068 -- 2,050,231(+) GGGGG(C/G/T)CCCCG downstream-variant-500B, upstream-variant-2KB
rs1000894579 -- 2,050,551(+) GGCGG(C/G)ACCTG upstream-variant-2KB
rs1001166349 -- 2,051,308(+) AGTGG(C/T)GAGGC upstream-variant-2KB
rs1001263117 -- 2,050,708(+) CGGGG(G/T)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR212 Gene

Variant ID Type Subtype PubMed ID
dgv1403n106 CNV deletion 24896259
esv33884 CNV gain 17666407
nsv1070376 CNV deletion 25765185
nsv574216 CNV gain 21841781
nsv827857 CNV gain 20364138
nsv952103 CNV deletion 24416366

Relevant External Links for MIR212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR212 Gene

Disorders for MIR212 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR212 Gene - From: GeneCards

Disorder Aliases PubMed IDs
postpartum psychosis
  • puerperal psychosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR212

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR212
genes like me logo Genes that share disorders with MIR212: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR212 Gene

Publications for MIR212 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  2. Overexpressions of miR-212 are associated with poor prognosis of patients with pancreatic ductal adenocarcinoma. (PMID: 27814273) Wu Z. … Cao L. (Cancer Biomark 2017) 3 64
  3. Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis. (PMID: 26692142) Yin Y. … Huang Z. (Gene 2016) 3 64
  4. Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer. (PMID: 26553749) Yang Y. … Abdel-Mageed A.B. (Clin. Cancer Res. 2016) 3 64
  5. MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence. (PMID: 26439987) Ramalinga M. … Kumar D. (Oncotarget 2015) 3 64

Products for MIR212 Gene

Sources for MIR212 Gene

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