Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR2116 Gene

Subcategory (RNA class) for MIR2116 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR2116 Gene

  • MicroRNA 2116 2 3 5
  • Hsa-Mir-2116 3
  • Mir-2116 3

External Ids for MIR2116 Gene

Previous GeneCards Identifiers for MIR2116 Gene

  • GC00U923641
  • GC15U901171
  • GC15M059463
  • GC15M036285

Summaries for MIR2116 Gene

Entrez Gene Summary for MIR2116 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2116 Gene

MIR2116 (MicroRNA 2116) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR2116 Gene

Genomics for MIR2116 Gene

Regulatory Elements for MIR2116 Gene

Enhancers for MIR2116 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G059290 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -127.7 -127733 17.6 HDGF FOXA2 WRNIP1 SIN3A FEZF1 ZNF2 ZNF416 FOS DEK SP3 MINDY2 MYO1E PIGHP1 RPS3AP6 MIR2116 BNIP2 RNF111 GC15M059271 GC15M059344
GH15G059270 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -107.7 -107674 16.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS DEK MYO1E FAM81A PIGHP1 RPS3AP6 MIR2116 ENSG00000259250 GCNT3 GC15M059271 GC15M059344
GH15G059236 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -66.1 -66145 2.1 TBP PKNOX1 TBL1XR1 RB1 SIN3A RAD21 ZBTB40 ZNF335 ZNF121 FOS RNU4-80P MYO1E MIR2116 BNIP2 RNF111 ADAM10 SLTM GC15M059055 GC15M059213
GH15G059190 1.3 Ensembl ENCODE dbSUPER 11 -20.6 -20587 2.9 NFIB JUN BACH1 CHD4 SIN3A BMI1 ARID3A EED ZNF207 ETV6 LDHAL6B MIR2116 FAM81A
GH15G059250 1.4 Ensembl ENCODE dbSUPER 10.2 -80.2 -80180 1.1 TBP TBL1XR1 BMI1 ETV6 RELB IKZF2 CREM CBFB JUNB ZEB2 MYO1E MIR2116 GC15M059055 ENSG00000259771
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR2116 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR2116 Gene

Chromosome:
15
Start:
59,171,183 bp from pter
End:
59,171,262 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR2116 Gene

Genes around MIR2116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR2116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2116 Gene

ORGUL Member Location for MIR2116 Gene

ORGUL Member Location for MIR2116 gene

Proteins for MIR2116 Gene

Post-translational modifications for MIR2116 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR2116 Gene

Domains & Families for MIR2116 Gene

Gene Families for MIR2116 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR2116: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR2116 Gene

Function for MIR2116 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2116 Gene

Localization for MIR2116 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR2116 Gene

Pathways & Interactions for MIR2116 Gene

SuperPathways for MIR2116 Gene

No Data Available

Interacting Proteins for MIR2116 Gene

Gene Ontology (GO) - Biological Process for MIR2116 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR2116 Gene

Drugs & Compounds for MIR2116 Gene

No Compound Related Data Available

Transcripts for MIR2116 Gene

mRNA/cDNA for MIR2116 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2116 Gene

No ASD Table

Relevant External Links for MIR2116 Gene

GeneLoc Exon Structure for
MIR2116
ECgene alternative splicing isoforms for
MIR2116

Expression for MIR2116 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR2116 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR2116 Gene:

MIR2116
genes like me logo Genes that share expression patterns with MIR2116: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR2116 Gene

Orthologs for MIR2116 Gene

Evolution for MIR2116 Gene

ENSEMBL:
Gene Tree for MIR2116 (if available)
TreeFam:
Gene Tree for MIR2116 (if available)

No data available for Orthologs for MIR2116 Gene

Paralogs for MIR2116 Gene

No data available for Paralogs for MIR2116 Gene

Variants for MIR2116 Gene

Sequence variations from dbSNP and Humsavar for MIR2116 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000166543 -- 59,172,083(+) CAGGC(A/T)TGGTG intron-variant, upstream-variant-2KB
rs1000669010 -- 59,172,806(+) CTACT(G/T)GGGAA intron-variant, upstream-variant-2KB
rs1002485591 -- 59,171,309(+) TCTGC(A/C)GAGAG intron-variant, upstream-variant-2KB
rs1006928815 -- 59,172,235(+) GCCTG(C/T)AATCC intron-variant, upstream-variant-2KB
rs1008662300 -- 59,170,810(+) AAATC(C/T)GTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR2116 Gene

Variant ID Type Subtype PubMed ID
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv833025 CNV gain 17160897

Relevant External Links for MIR2116 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2116

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR2116 Gene

Disorders for MIR2116 Gene

Relevant External Links for MIR2116

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR2116

No disorders were found for MIR2116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2116 Gene

Publications for MIR2116 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries. (PMID: 19390579) Wyman S.K. … Tewari M. (PLoS ONE 2009) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR2116 Gene

Sources for MIR2116 Gene

Content
Loading form....