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Aliases for MIR2110 Gene

Subcategory (RNA class) for MIR2110 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR2110 Gene

  • MicroRNA 2110 2 3
  • CCDC186 4 5
  • CTCL Tumor Antigen HD-CL-01/L14-2 4
  • Coiled-Coil Domain Containing 186 5
  • Hsa-Mir-2110 3
  • C10orf118 4
  • Mir-2110 3

External Ids for MIR2110 Gene

Previous GeneCards Identifiers for MIR2110 Gene

  • GC00U923218
  • GC10M115933
  • GC10M114174

Summaries for MIR2110 Gene

Entrez Gene Summary for MIR2110 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2110 Gene

MIR2110 (MicroRNA 2110) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR2110 Gene

Genomics for MIR2110 Gene

Regulatory Elements for MIR2110 Gene

Enhancers for MIR2110 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F114647 1.3 Ensembl ENCODE 36.5 -474.5 -474455 3.1 ZFP64 ZNF493 FEZF1 ZNF48 BRCA1 ZNF2 YY1 ZNF121 ZNF302 KLF7 MIR2110 NHLRC2 UBE2V1P5 FAM160B1 PPIAP19 ENSG00000229668
GH10F114879 1.1 Ensembl ENCODE 16.6 -706.7 -706736 3.1 PKNOX1 INSM2 ZNF76 FEZF1 ZNF2 RAD21 GTF3C2 ZNF366 SCRT2 ZNF143 ATRNL1 FAM160B1 MIR2110 UBE2V1P5 RPL15P13
GH10F113851 1.1 ENCODE 13.7 +320.1 320081 5.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 ZHX2 JUNB MIR2110 DCLRE1A ENSG00000212589
GH10F114779 1.1 Ensembl ENCODE 13.4 -606.1 -606112 1.9 INSM2 KLF17 FEZF1 RAD21 BRCA1 ZEB1 SMARCC2 RCOR1 FOS SMARCC1 MIR2110 ABLIM1 NHLRC2 LOC101927692 TAF9BP2
GH10F114042 0.9 ENCODE 13.8 +129.2 129190 5.1 ZNF76 ZNF2 GLIS2 ZNF202 SP3 ZNF341 GLIS1 IKZF1 KDM1A ZBTB26 MIR2110 ADRB1 GC10P114045 GC10M114041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR2110 on UCSC Golden Path with GeneCards custom track

Promoters for MIR2110 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001427374 619 3599 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1

Genomic Location for MIR2110 Gene

Chromosome:
10
Start:
114,120,862 bp from pter
End:
114,174,220 bp from pter
Size:
53,359 bases
Orientation:
Minus strand

Genomic View for MIR2110 Gene

Genes around MIR2110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR2110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2110 Gene

Proteins for MIR2110 Gene

  • Protein details for MIR2110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E2-CC186_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 186
    Protein Accession:
    Q7Z3E2
    Secondary Accessions:
    • Q2M2V6
    • Q3ZB81
    • Q6NS91
    • Q7RTP1
    • Q8N117
    • Q8N3G3
    • Q8N6C2
    • Q9NWA3

    Protein attributes for MIR2110 Gene

    Size:
    898 amino acids
    Molecular mass:
    103687 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305}; Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for MIR2110 Gene

Post-translational modifications for MIR2110 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR2110 Gene

No data available for DME Specific Peptides for MIR2110 Gene

Domains & Families for MIR2110 Gene

Gene Families for MIR2110 Gene

Protein Domains for MIR2110 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR2110: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR2110 Gene

Function for MIR2110 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2110 Gene

Localization for MIR2110 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR2110 Gene

Pathways & Interactions for MIR2110 Gene

SuperPathways for MIR2110 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR2110 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR2110 Gene

Transcripts for MIR2110 Gene

mRNA/cDNA for MIR2110 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2110 Gene

No ASD Table

Relevant External Links for MIR2110 Gene

GeneLoc Exon Structure for
MIR2110
ECgene alternative splicing isoforms for
MIR2110

Expression for MIR2110 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR2110 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR2110 Gene:

MIR2110
genes like me logo Genes that share expression patterns with MIR2110: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR2110 Gene

Orthologs for MIR2110 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR2110 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10orf118 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10orf118 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10orf118 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A630007B06Rik 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf118 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf118 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10orf118 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf118 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C12H10orf118 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4925 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cccp-1 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for MIR2110 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR2110 Gene

ENSEMBL:
Gene Tree for MIR2110 (if available)
TreeFam:
Gene Tree for MIR2110 (if available)

Paralogs for MIR2110 Gene

No data available for Paralogs for MIR2110 Gene

Variants for MIR2110 Gene

Sequence variations from dbSNP and Humsavar for MIR2110 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs112630549 -- 114,173,637(+) ATAGG(A/C)GATTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs113997717 -- 114,174,694(+) CTGGG(G/T)GTTCC upstream-variant-2KB, utr-variant-5-prime
rs114530801 -- 114,174,163(+) CGGCC(A/C/G)TTTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs115703478 -- 114,175,623(+) TGATT(C/T)CCAGT intron-variant, upstream-variant-2KB
rs116205658 -- 114,175,770(+) CAAAT(A/T)TAGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR2110 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER inversion 18451855

Relevant External Links for MIR2110 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR2110 Gene

Disorders for MIR2110 Gene

Relevant External Links for MIR2110

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR2110

No disorders were found for MIR2110 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2110 Gene

Publications for MIR2110 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. (PMID: 19144710) Zhu J.Y. … Meister G. (J. Virol. 2009) 3 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR2110 Gene

Sources for MIR2110 Gene

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