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Aliases for MIR211 Gene

Subcategory (RNA class) for MIR211 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR211 Gene

  • MicroRNA 211 2 3 5
  • Hsa-Mir-211 3
  • Mir-211 3
  • MIRN211 3

External Ids for MIR211 Gene

Previous HGNC Symbols for MIR211 Gene

  • MIRN211

Previous GeneCards Identifiers for MIR211 Gene

  • GC15M029147
  • GC15M031357

Summaries for MIR211 Gene

Entrez Gene Summary for MIR211 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR211 Gene

MIR211 (MicroRNA 211) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR211 Gene

Genomics for MIR211 Gene

Regulatory Elements for MIR211 Gene

Enhancers for MIR211 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G031049 0.9 Ensembl ENCODE 0.4 +15.3 15267 1.7 CTCF IRF2 RFX1 MXI1 ELF1 NR2F2 CREB3 IRF1 ETV6 FOS MTMR10 OTUD7A MIR211 GC15M031066 LOC105370752
GH15G031031 1.2 Ensembl ENCODE 0.3 +32.5 32470 2.5 ATF1 PKNOX1 CREB3L1 SIN3A DMAP1 YY1 GLIS2 GATA2 ZNF207 FOS MTMR10 CHRNA7 LOC105370752 MIR211 GC15M031066
GH15G031034 1 ENCODE 0.3 +30.8 30809 0.2 ATF1 PKNOX1 CREB3L1 SIN3A DMAP1 FEZF1 YY1 GLIS2 ELK1 ZNF143 MTMR10 ENSG00000215302 LOC105370752 MIR211 GC15M031066
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR211 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR211 Gene

Chromosome:
15
Start:
31,065,032 bp from pter
End:
31,065,141 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR211 Gene

Genes around MIR211 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR211 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR211 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR211 Gene

Proteins for MIR211 Gene

Post-translational modifications for MIR211 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR211 Gene

Domains & Families for MIR211 Gene

Gene Families for MIR211 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR211: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR211 Gene

Function for MIR211 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR211 Gene

Localization for MIR211 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR211 Gene

Pathways & Interactions for MIR211 Gene

SuperPathways for MIR211 Gene

No Data Available

Interacting Proteins for MIR211 Gene

Gene Ontology (GO) - Biological Process for MIR211 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR211 Gene

Drugs & Compounds for MIR211 Gene

No Compound Related Data Available

Transcripts for MIR211 Gene

mRNA/cDNA for MIR211 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR211 Gene

No ASD Table

Relevant External Links for MIR211 Gene

GeneLoc Exon Structure for
MIR211
ECgene alternative splicing isoforms for
MIR211

Expression for MIR211 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR211 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR211 Gene:

MIR211
genes like me logo Genes that share expression patterns with MIR211: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR211 Gene

Orthologs for MIR211 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR211 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-211 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-211 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-211 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-204 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir211 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-204 35 35
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-204-2 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-204a-1 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01083725.1 35
  • 77 (a)
OneToMany
dre-mir-204-2 35
  • 56 (a)
OneToMany
Species where no ortholog for MIR211 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR211 Gene

ENSEMBL:
Gene Tree for MIR211 (if available)
TreeFam:
Gene Tree for MIR211 (if available)

Paralogs for MIR211 Gene

No data available for Paralogs for MIR211 Gene

Variants for MIR211 Gene

Sequence variations from dbSNP and Humsavar for MIR211 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs869312176 Likely pathogenic 31,066,093(-) CTCCC(C/T)GCAGA upstream-variant-2KB, reference, missense
rs376701394 Uncertain significance 31,066,120(+) GCCTT(C/T)GCAGC upstream-variant-2KB, reference, missense
rs1002518815 -- 31,066,738(+) AACCT(C/T)CTTGA intron-variant, upstream-variant-2KB
rs1003941992 -- 31,066,931(+) ATGTT(A/G)CCATT intron-variant, upstream-variant-2KB
rs1004651242 -- 31,065,533(+) TAGTT(C/T)GACCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR211 Gene

Variant ID Type Subtype PubMed ID
dgv2534n100 CNV loss 25217958
dgv4428n54 CNV loss 21841781
esv2761861 CNV loss 21179565
esv33507 CNV loss 17666407
nsv456746 CNV loss 19166990
nsv520825 CNV loss 19592680
nsv568767 CNV loss 21841781

Relevant External Links for MIR211 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR211

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR211 Gene

Disorders for MIR211 Gene

Relevant External Links for MIR211

Human Genome Epidemiology (HuGE) Navigator
MIR211
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR211

No disorders were found for MIR211 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR211 Gene

Publications for MIR211 Gene

  1. miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1. (PMID: 26277787) Ye L. … Liu B. (Tumour Biol. 2016) 3 64
  2. MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells. (PMID: 26787841) Mazar J. … Perera R.J. (Mol. Cell. Biol. 2016) 3 64
  3. Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer. (PMID: 26974151) Wu X. … Zhu H. (PLoS ONE 2016) 3 64
  4. MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration. (PMID: 25680404) Song G.Q. … Zhao Y. (Tumour Biol. 2015) 3 64
  5. miR-211 suppresses hepatocellular carcinoma by downregulating SATB2. (PMID: 25888635) Jiang G. … Cao L. (Oncotarget 2015) 3 64

Products for MIR211 Gene

Sources for MIR211 Gene

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