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Aliases for MIR211 Gene

Subcategory (RNA class) for MIR211 Gene

miRNA

Quality Score for this RNA gene is

4.2

Aliases for MIR211 Gene

  • MicroRNA 211 2 3
  • MIRN211 3 6
  • Hsa-Mir-211 3
  • Mir-211 3

External Ids for MIR211 Gene

Previous Symbols for MIR211 Gene

  • MIRN211

Summaries for MIR211 Gene

Entrez Gene Summary for MIR211 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR211 Gene

MIR211 (MicroRNA 211) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR211 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR211

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR211 Gene

Genomics for MIR211 Gene

Genomic Location for MIR211 Gene

Start:
31,065,032 bp from pter
End:
31,065,141 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR211 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR211 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR211 Gene

ORGUL Member Location for MIR211 Gene

ORGUL Member Location for MIR211 gene

No data available for Regulatory Elements for MIR211 Gene

Proteins for MIR211 Gene

Post-translational modifications for MIR211 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR211 Gene

Domains for MIR211 Gene

Gene Families for MIR211 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR211: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR211 Gene

Function for MIR211 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR211 Gene

Localization for MIR211 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR211 Gene

Pathways for MIR211 Gene

SuperPathways for MIR211 Gene

No Data Available

Interacting Proteins for MIR211 Gene

Gene Ontology (GO) - Biological Process for MIR211 Gene

None

No data available for Pathways by source for MIR211 Gene

Transcripts for MIR211 Gene

fRNAdb Secondary structures for MIR211 Gene

  • hsa-miR-211-5p_MIMAT0000268_Homo_sapiens_miR-211-5p_mature

mRNA/cDNA for MIR211 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR211 Gene

No ASD Table

Relevant External Links for MIR211 Gene

GeneLoc Exon Structure for
MIR211
ECgene alternative splicing isoforms for
MIR211

Expression for MIR211 Gene

mRNA expression in normal human tissues for MIR211 Gene

genes like me logo Genes that share expressions with MIR211: view

Orthologs for MIR211 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR211 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-211 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-211 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-211 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir211 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-204 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-204 37
  • 64 (a)
OneToMany
oan-mir-204 37
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-204-2 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-204a-1 37
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01083725.1 37
  • 77 (a)
OneToMany
dre-mir-204-2 37
  • 56 (a)
OneToMany
Species with no ortholog for MIR211:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR211 Gene

ENSEMBL:
Gene Tree for MIR211 (if available)
TreeFam:
Gene Tree for MIR211 (if available)

Paralogs for MIR211 Gene

No data available for Paralogs for MIR211 Gene

Variants for MIR211 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR211 Gene

Variant ID Type Subtype PubMed ID
nsv903831 CNV Gain 21882294
esv33507 CNV Loss 17666407
nsv903835 CNV Gain 21882294
nsv903836 CNV Gain 21882294
nsv520825 CNV Loss 19592680
nsv456746 CNV Loss 19166990

Relevant External Links for MIR211 Gene

HapMap Linkage Disequilibrium report
MIR211

No data available for Sequence variations from dbSNP and Humsavar for MIR211 Gene

Disorders for MIR211 Gene

Relevant External Links for MIR211

Human Genome Epidemiology (HuGE) Navigator
MIR211
genes like me logo Genes that share disorders with MIR211: view

No data available for UniProtKB/Swiss-Prot for MIR211 Gene

Publications for MIR211 Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. (PMID: 18946016) Chang K.W. … Lin S.C. (J. Dent. Res. 2008) 3
  4. MicroRNA-204/211 alters epithelial physiology. (PMID: 20056717) Wang F.E. … Miller S.S. (FASEB J. 2010) 3
  5. A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. (PMID: 20378606) Chen J. … Hui R. (Hum. Mol. Genet. 2010) 3

Products for MIR211 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR211
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR211
    • Block miRNA regulation of MIR211 using miScript Target Protectors

    Sources for MIR211 Gene

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