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Aliases for MIR210 Gene

Subcategory (RNA class) for MIR210 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR210 Gene

  • MicroRNA 210 2 3 5
  • Hsa-Mir-210 3
  • Mir-210 3
  • MIRN210 3

External Ids for MIR210 Gene

Previous HGNC Symbols for MIR210 Gene

  • MIRN210

Previous GeneCards Identifiers for MIR210 Gene

  • GC11M000561
  • GC11M000570
  • GC11M000575
  • GC11M000582
  • GC11M000581
  • GC11M000585
  • GC11M000589
  • GC11M000591

Summaries for MIR210 Gene

Entrez Gene Summary for MIR210 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR210 Gene

MIR210 (MicroRNA 210) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and SIDS Susceptibility Pathways.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR210 Gene

Genomics for MIR210 Gene

Regulatory Elements for MIR210 Gene

Enhancers for MIR210 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000775 1 ENCODE 4.9 -209.1 -209137 3.9 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 FOS ZNF488 REST SREBF1 TALDO1 TMEM80 MIR210 PDDC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR210 on UCSC Golden Path with GeneCards custom track

Promoters for MIR210 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000556858 -202 2401 ATF1 CREB3L1 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF143 FOS PAF1

Genomic Location for MIR210 Gene

Chromosome:
11
Start:
568,089 bp from pter
End:
568,198 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR210 Gene

Genes around MIR210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR210 Gene

Proteins for MIR210 Gene

Post-translational modifications for MIR210 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR210 Gene

Domains & Families for MIR210 Gene

Gene Families for MIR210 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR210: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR210 Gene

Function for MIR210 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR210 Gene

Localization for MIR210 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR210 Gene

Pathways & Interactions for MIR210 Gene

genes like me logo Genes that share pathways with MIR210: view

Pathways by source for MIR210 Gene

1 KEGG pathway for MIR210 Gene

Interacting Proteins for MIR210 Gene

Gene Ontology (GO) - Biological Process for MIR210 Gene

None

No data available for SIGNOR curated interactions for MIR210 Gene

Transcripts for MIR210 Gene

mRNA/cDNA for MIR210 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR210 Gene

No ASD Table

Relevant External Links for MIR210 Gene

GeneLoc Exon Structure for
MIR210
ECgene alternative splicing isoforms for
MIR210

Expression for MIR210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR210 Gene

mRNA differential expression in normal tissues according to GTEx for MIR210 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.4) and Skin - Sun Exposed (Lower leg) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR210 Gene:

MIR210
genes like me logo Genes that share expression patterns with MIR210: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR210 Gene

Orthologs for MIR210 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-210 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-210 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-210 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir210 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-210 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-210 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-210 35
  • 68 (a)
OneToOne
Species where no ortholog for MIR210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR210 Gene

ENSEMBL:
Gene Tree for MIR210 (if available)
TreeFam:
Gene Tree for MIR210 (if available)

Paralogs for MIR210 Gene

No data available for Paralogs for MIR210 Gene

Variants for MIR210 Gene

Sequence variations from dbSNP and Humsavar for MIR210 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1062099 -- 567,627(+) AGAAG(C/G)CAGGC nc-transcript-variant, downstream-variant-500B
rs10902173 -- 570,072(+) ATCTG(C/T)AGTGA upstream-variant-2KB
rs111534861 -- 569,878(+) GGAGC(C/T)TCTAA upstream-variant-2KB
rs111655589 -- 568,945(+) CCCCC(C/G)AACCC upstream-variant-2KB
rs111782423 -- 569,162(+) GGTCC(C/T)TCCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR210 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv951270 CNV deletion 24416366
nsv552856 CNV gain 21841781
nsv552854 CNV loss 21841781
nsv528415 CNV loss 19592680
nsv527327 CNV loss 19592680
nsv518824 CNV loss 19592680
nsv469924 CNV gain 18288195

Relevant External Links for MIR210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR210 Gene

Disorders for MIR210 Gene

Relevant External Links for MIR210

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR210

No disorders were found for MIR210 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR210 Gene

Publications for MIR210 Gene

  1. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J. … Ries C. (Toxicol. Lett. 2016) 3 64
  2. Involvement of MicroRNA-210 Demethylation in Steroid-associated Osteonecrosis of the Femoral Head. (PMID: 26805628) Yuan H.F. … Yan Z.Q. (Sci Rep 2016) 3 64
  3. MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation. (PMID: 25044272) Jin Y. … Zhao C. (Cell Biol. Int. 2015) 3 64
  4. Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids. (PMID: 25586423) Rosenberg T. … Kristensen B.W. (CNS Oncol 2015) 3 64
  5. Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells. (PMID: 25849663) Bianchi N. … Gambari R. (PLoS ONE 2015) 3 64

Products for MIR210 Gene

Sources for MIR210 Gene

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