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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR21 Gene

  • MicroRNA 21 2 3 5
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3
  • MIRN21 3

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918
  • GC17P059708

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Chromosome 17P Deletion. Among its related pathways are Autophagy Pathway and MicroRNAs in cancer.

Gene Wiki entry for MIR21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

Regulatory Elements for MIR21 Gene

Enhancers for MIR21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G059781 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.8 -53.6 -53592 11.9 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 LOC101927755 DHX40 SKA2 RPS6KB1 LOC100996660 MIR21 RNU6-450P PPM1D TRIM37 VMP1
GH17G059751 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -79.8 -79782 20.4 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A YBX1 DMAP1 FEZF1 RPS6KB1 NDUFB8P2 LOC101927755 MIR21 RNU6-450P TUBD1 PPM1D SMG8 CA4 DHX40
GH17G059705 1.4 ENCODE dbSUPER 10.6 -133.4 -133394 5.2 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC GLIS1 SKA2 LOC101927755 LOC100996660 TUBD1 RPS6KB1 MIR21 RNU6-450P TRIM37 DHX40 PTRH2
GH17G059773 1.1 dbSUPER 13 -67.4 -67405 1.3 FOXA2 ARID4B DMAP1 ZNF766 ZNF263 SP3 SP5 ZHX2 KAT8 ZNF592 MIR21 RNU6-450P RPS6KB1 TUBD1 DHX40 USP32 ENSG00000267637 GC17M059723
GH17G059778 1.1 ENCODE dbSUPER 12.5 -62.2 -62188 0.6 HDAC1 SIN3A ZBTB40 SCRT2 FOS ZNF362 CEBPB ZEB2 MEF2D SMARCA4 MIR21 RNU6-450P ENSG00000267637 GC17M059723
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR21 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR21 Gene

Chromosome:
17
Start:
59,841,266 bp from pter
End:
59,841,337 bp from pter
Size:
72 bases
Orientation:
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

2 KEGG pathways for MIR21 Gene

Interacting Proteins for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene

None

No data available for SIGNOR curated interactions for MIR21 Gene

Drugs & Compounds for MIR21 Gene

No Compound Related Data Available

Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR21

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
MIR21
ECgene alternative splicing isoforms for
MIR21

Expression for MIR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR21 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR21 Gene:

MIR21
genes like me logo Genes that share expression patterns with MIR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR21 Gene

Orthologs for MIR21 Gene

Evolution for MIR21 Gene

ENSEMBL:
Gene Tree for MIR21 (if available)
TreeFam:
Gene Tree for MIR21 (if available)

No data available for Orthologs for MIR21 Gene

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000220885 -- 59,840,566(+) AACTT(C/T)ATAAA upstream-variant-2KB, utr-variant-3-prime
rs1003071912 -- 59,840,891(+) AAAAC(C/T)ACACT upstream-variant-2KB, utr-variant-3-prime
rs1003528503 -- 59,841,239(+) ACCAT(C/T)GTGAC upstream-variant-2KB, utr-variant-3-prime
rs1004420391 -- 59,841,371(+) ATCCA(A/G)TGTTC downstream-variant-500B, utr-variant-3-prime
rs1004802057 -- 59,839,516(+) AAGAG(C/T)TAACC intron-variant, upstream-variant-2KB

Relevant External Links for MIR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR21 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chromosome 17p deletion
  • 17p deletion
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR21

Genetic Association Database (GAD)
MIR21
Human Genome Epidemiology (HuGE) Navigator
MIR21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR21
genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  3. Dysregulation of urinary miR-21 and miR-200b associated with interstitial fibrosis and tubular atrophy (IFTA) in renal transplant recipients. (PMID: 27521993) Zununi Vahed S. … Samadi N. (Clin. Biochem. 2017) 3 64
  4. Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics. (PMID: 27867039) Szeto C.C. … Li P.K. (Clin. Chim. Acta 2017) 3 64
  5. miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. (PMID: 28006751) Sheng B. … Chen W. (Biomed. Pharmacother. 2017) 3 64

Products for MIR21 Gene

Sources for MIR21 Gene

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