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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene


Quality Score for this RNA gene is


Aliases for MIR21 Gene

  • MicroRNA 21 2 3 5
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3
  • MIRN21 3

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918
  • GC17P059708

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Chromosome 17P Deletion. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Proteoglycans in cancer.

Gene Wiki entry for MIR21 Gene

Additional gene information for MIR21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

Regulatory Elements for MIR21 Gene

Enhancers for MIR21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H059781 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.8 -53.6 -53592 11.9 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A RPS6KB1 TUBD1 LOC101927755 SKA2 LOC100996660 HEATR6 MIR21 RNU6-450P PPM1D TRIM37
GH17H059751 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -79.8 -79782 20.4 HDGF PKNOX1 FOXA2 MLX ARID4B YBX1 FEZF1 DMAP1 SLC30A9 ZNF207 RPS6KB1 TUBD1 NDUFB8P2 PPM1D LOC101927755 ENSG00000274378 ENSG00000224738 MIR21 RNU6-450P HEATR6
GH17H059705 1.4 ENCODE dbSUPER 10.6 -133.4 -133394 5.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 SLC30A9 PPM1D RPS6KB1 TUBD1 RNFT1 SKA2 NDUFB8P2 LOC101927755 LOC100996660 RNU6-450P MIR21
GH17H059725 1.2 Ensembl ENCODE 10.9 -115.5 -115521 1.5 HDGF FOXA2 ARID4B YY1 ZNF121 REST PPARG ZNF592 KAT8 NFIL3 TUBD1 RPS6KB1 MIR21 RNU6-450P HEATR6 GC17M059723 PTRH2
GH17H059746 1 ENCODE dbSUPER 12.3 -94.2 -94232 0.2 CTCF NFXL1 RAD21 GATA3 SMC3 ZNF143 MAFK MIXL1 SMARCA5 ZNF654 MIR21 RNU6-450P RPS6KB1 TUBD1 VMP1 PTRH2 GC17M059723 ENSG00000267637
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR21 Gene

Genomic Locations for MIR21 Gene
72 bases
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

Proteins for MIR21 Gene

Post-translational modifications for MIR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR21 Gene

Function for MIR21 Gene

Gene Ontology (GO) - Molecular Function for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 21376256
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 18372920
genes like me logo Genes that share ontologies with MIR21: view

Animal Model Products

Clone Products

  • Addgene plasmids for MIR21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

Gene Ontology (GO) - Cellular Components for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
GO:0005737 cytoplasm IDA 23657402
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

2 KEGG pathways for MIR21 Gene

Interacting Proteins for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 21347332
GO:0007179 transforming growth factor beta receptor signaling pathway ISS --
GO:0007566 embryo implantation NAS 18556655
GO:0008284 positive regulation of cell proliferation IMP 16762633
genes like me logo Genes that share ontologies with MIR21: view

No data available for SIGNOR curated interactions for MIR21 Gene

Drugs & Compounds for MIR21 Gene

No Compound Related Data Available

Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • Addgene plasmids for MIR21

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR21 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR21 Gene:

genes like me logo Genes that share expression patterns with MIR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR21 Gene

Orthologs for MIR21 Gene

Evolution for MIR21 Gene

Gene Tree for MIR21 (if available)
Gene Tree for MIR21 (if available)

No data available for Orthologs for MIR21 Gene

Paralogs for MIR21 Gene

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000220885 -- 59,840,566(+) AACTT(C/T)ATAAA upstream-variant-2KB, utr-variant-3-prime
rs1003071912 -- 59,840,891(+) AAAAC(C/T)ACACT upstream-variant-2KB, utr-variant-3-prime
rs1003528503 -- 59,841,239(+) ACCAT(C/T)GTGAC upstream-variant-2KB, utr-variant-3-prime
rs1004420391 -- 59,841,371(+) ATCCA(A/G)TGTTC downstream-variant-500B, utr-variant-3-prime
rs1004802057 -- 59,839,516(+) AAGAG(C/T)TAACC intron-variant, upstream-variant-2KB

Relevant External Links for MIR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR21 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chromosome 17p deletion
  • 17p deletion
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 45 60
  3. Dysregulation of urinary miR-21 and miR-200b associated with interstitial fibrosis and tubular atrophy (IFTA) in renal transplant recipients. (PMID: 27521993) Zununi Vahed S … Samadi N (Clinical biochemistry 2017) 3 60
  4. Adrenaline inhibits osteogenesis via repressing miR-21 expression. (PMID: 27671240) Chen D … Wang Z (Cell biology international 2017) 3 60
  5. The role of miRNA-21 and epithelial mesenchymal transition (EMT) process in colorectal cancer. (PMID: 27672217) Jaca A … Naidoo R (Journal of clinical pathology 2017) 3 60

Products for MIR21 Gene

  • Addgene plasmids for MIR21

Sources for MIR21 Gene

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