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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIR21 Gene

RNA gene GIFtS: 26
GCID: GC17P057918

microRNA 21

(Previous symbol: MIRN21)

Explore 59 diseases affiliated with
MIR21 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 13

Aliases
MicroRNA 21¹ ²		MiR-21¹
MIRN21¹ ² ⁵		MiRNA21¹
Hsa-Mir-21¹		Mir-21¹
MIR-21¹

External Ids:	HGNC: 31586¹	Entrez Gene: 406991²	Ensembl: ENSG00000199004⁷	OMIM: 611020⁵

ORGUL members:	fRNAdb¹⁰:FR284618
	miRBase: MI0000077

Export aliases for MIR21 gene to outside databases

Previous GC identifer: GC17P055276

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR21:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene

expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed

by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either

protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an

approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer

ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated

into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the

miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq

represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

Gene Wiki entry for MIR21 (MIRN21)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIR21
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1 Ensembl cytogenetic band: 17q23.1 HGNC cytogenetic band: 17q23.1

MIR21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR21 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P057918: view genomic region (via miRBase) (about GC identifiers)

Start:	57,918,627 bp from pter	End:	57,918,698 bp from pter
Size:	72 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		miRTarBase genes targeted by MIR21: DERL1(MIRT000172), PDCD4(MIRT003054), TM9SF3(MIRT000166), MSH6(MIRT005430), WFS1(MIRT000164), WIBG(MIRT000163), TP53BP2(MIRT005328), ISCU(MIRT005717), TGFBI(MIRT001208), PTEN(MIRT001190), PCBP1(MIRT004814), EIF4A2(MIRT005772), TOPORS(MIRT005324), BCL2(MIRT000159), RTN4(MIRT000167), RPS7(MIRT000168), JAG1(MIRT000176), ICAM1(MIRT005952), CDC25A(MIRT000157), SOX5(MIRT000960), PPIF(MIRT005331), ERBB2(MIRT004318), HNRNPK(MIRT005325), APAF1(MIRT002410), MEF2C(MIRT005737), MYC(MIRT004307), ANKRD46(MIRT005773), MTAP(MIRT000961), E2F1(MIRT001191), NCOA3(MIRT004306), PDHA2(MIRT000170), TIAM1(MIRT005565), E2F2(MIRT001121), MSH2(MIRT005429), REST(MIRT000177), JMY(MIRT005323), TNFAIP3(MIRT005955), PLOD3(MIRT000169), FMOD(MIRT001188), TP63(MIRT005329), TPM1(MIRT001980), RECK(MIRT000969), EIF2S1(MIRT004813), SPRY2(MIRT000672), TIMP3(MIRT000954), TGFBR3(MIRT005330), PTX3(MIRT005954), SERPINB5(MIRT003567), BMPR2(MIRT003837), IL1B(MIRT005951), TGIF1(MIRT004287), BTG2(MIRT002416), LRRFIP1(MIRT001220), SPATS2L(MIRT004812), PLAT(MIRT005953), CDK2AP1(MIRT005974), RASGRP1(MIRT000019), TGFBR2(MIRT001189), BASP1(MIRT000173), RHOB(MIRT003317), CCR1(MIRT005956), EGFR(MIRT005807), NCAPG(MIRT000171), MARCKS(MIRT001221), DAXX(MIRT005327)

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MIR21

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about MIR21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000362134(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR21:none

MIR21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MIR21 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for MIR21

SABiosciences Custom PCR Arrays for MIR21

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for MIR21 (if available)
TreeFam Gene Tree for MIR21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138847109^1,2		--	57918468(+)	`TATGAA/GCATTA`	1	--	us2k¹		0	--	--	--	--
rs188041455^1,2		--	57918497(+)	`TTGGGA/GTTCGA`	1	--	us2k¹		0	--	--	--	--
rs149373146^1,2		--	57918509(+)	`CTTAAC/TAGGCC`	1	--	us2k¹		0	--	--	--	--
rs79800958^1,2	F,	--	57918582(+)	`TGTCTG/CCTTGT`	1	--	us2k¹		1		EA	120
rs193062491^1,2		--	57918601(+)	`CCATCA/GTGACA`	1	--	us2k¹		0	--	--	--	--
rs1292037^1,2	C,F,O,A,H,	--	57918908(-)	`CCACAA/GTGCAG`	1	--	ds500¹		15		MN NS EA NA	2056
rs138230604^1,2		--	57918965(+)	`ACTTTG/TCTAGC`	1	--	ds500¹		0	--	--	--	--
rs13137^1,2	C,F,A,H,	--	57919031(-)	`GTTAAT/ACTATC`	1	--	ds500¹		8		MN NS EA NA	792
rs77524042^1,2	C,	--	57919066(+)	`ATCGAA/GTCAGC`	1	--	ds500¹		0	--	--	--	--
rs117526670^1,2	F,	--	57919097(+)	`CTAGTC/TGTGGT`	1	--	ds500¹		1		NA	120

HapMap Linkage Disequilibrium report for MIR21 (57918627 - 57918698 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR21: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MIR21 for disorders           About GeneDecksing

OMIM gene information: 611020    OMIM disorders: --

20/59 diseases for MIR21 (see all 59):    About MalaCards

arteriosclerosis obliterans squamous cell carcinoma oral squamous cell carcinoma esophageal squamous cell carcinoma

allergic rhinitis pancreatic ductal adenocarcinoma arteriosclerosis papillary thyroid carcinoma

epithelial ovarian cancer kaposi's sarcoma rhinitis familial breast cancer

renal cell carcinoma carcinoma cholesteatoma thyroid carcinoma

myelodysplastic syndrome laryngitis leiomyosarcoma laryngeal carcinoma

Human Genome Epidemiology (HuGE) Navigator: MIR21 (3 documents)

Export disorders for MIR21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIR21 gene, integrated from 9 sources (see all 244):
(articles sorted by number of sources associating them with MIR21)

Utopia: connect your pdf to the dynamic
world of online information

Micro-RNA expression in the urinary sediment of patien ts with chronic kidney diseases. (PubMed id 22960330)¹ Szeto C.C....Kam-Tao L.P. (2012)
TGFb-stimulated microRNA-21 utilizes PTEN to orchestra te AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. (PubMed id 22879939)¹ Dey N....Choudhury G.G. (2012)
Differential expression of microRNAs miR-21, miR-31, m iR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinom a of the head and neck. (PubMed id 22690848)¹ Odar K....Zidar N. (2012)
MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pa ncreatic ductal adenocarcinoma. (PubMed id 22114136)¹ Jamieson N.B....Oien K.A. (2012)
Homo sapiens systemic RNA interference-defective-1 tra nsmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. (PubMed id 22174421)¹ Elhassan M.O....Duxbury M.S. (2012)
Association of microRNA-21 expression with its targets , PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma. (PubMed id 21983937)¹ Nagao Y....Hashimoto H. (2012)
Circulating microRNA-21 as a novel biomarker for hepat ocellular carcinoma. (PubMed id 21749846)¹ Tomimaru Y....Mori M. (2012)
Circulating miRNA is a novel marker for head and neck squamous cell carcinoma. (PubMed id 22811001)¹ Hsu C.M....Yang M.Y. (2012)
Role of miR-21 in the pathogenesis of atrial fibrosis. (PubMed id 22760500)¹ Adam O....Laufs U. (2012)
MicroRNA-21: a ubiquitously expressed pro-survival fac tor in cancer and other diseases. (PubMed id 21909994)¹ Li S....Zou F. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 406991	HGNC: 31586	Ensembl:ENSG00000199004	miRBase: hsa-mir-21	euGenes: HUgn406991
ECgene: MIR21	H-InvDB: MIR21

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIR21	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MIR21 gene:
Search GeneIP for patents involving MIR21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MIR21 Gene

microRNA 21

Aliasesfor MIR21 gene

Summariesfor MIR21 gene

Genomic Viewsfor MIR21 gene

Proteinsfor MIR21 gene

Protein Domains /Familiesfor MIR21 gene

Functionfor MIR21 gene

Pathways & Interactionsfor MIR21 gene

Drugs & Compoundsfor MIR21 gene

Transcriptsfor MIR21 gene

Expression for MIR21 gene

Orthologsfor MIR21 gene

Paralogsfor MIR21 gene

Genomic Variantsfor MIR21 gene

Disorders / Diseasesfor MIR21 gene

Publicationsfor MIR21 gene

External Searches for MIR21 gene

Genome Databases showing MIR21 gene

Other Databases showing MIR21 gene

Specialized Databases showing MIR21 gene

Intellectual Propertyfor MIR21 gene

Productsfor MIR21 gene

View Random Gene

Aliases
for MIR21 gene

Summaries
for MIR21 gene

Genomic Views
for MIR21 gene

Proteins
for MIR21 gene

Protein Domains /
Families
for MIR21 gene

Function
for MIR21 gene

Pathways & Interactions
for MIR21 gene

Drugs & Compounds
for MIR21 gene

Transcripts
for MIR21 gene

Expression
for MIR21 gene

Orthologs
for MIR21 gene

Paralogs
for MIR21 gene

Genomic Variants
for MIR21 gene

Disorders / Diseases
for MIR21 gene

Publications
for MIR21 gene

Intellectual Property
for MIR21 gene

Products
for MIR21 gene