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Aliases for MIR21 Gene

Subcategory (RNA class) for MIR21 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR21 Gene

  • MicroRNA 21 2 3
  • VMP1 4 5
  • Vacuole Membrane Protein 1 5
  • Transmembrane Protein 49 4
  • Hsa-Mir-21 3
  • MiRNA21 3
  • MiR-21 3
  • MIRN21 3
  • TMEM49 4
  • TDC1 4

External Ids for MIR21 Gene

Previous HGNC Symbols for MIR21 Gene

  • MIRN21

Previous GeneCards Identifiers for MIR21 Gene

  • GC17P055276
  • GC17P057918
  • GC17P059841

Summaries for MIR21 Gene

Entrez Gene Summary for MIR21 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR21 Gene

MIR21 (MicroRNA 21) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR21 include Chromosome 17P Deletion. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer.

UniProtKB/Swiss-Prot for MIR21 Gene

  • Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.

Gene Wiki entry for MIR21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR21 Gene

Genomics for MIR21 Gene

Regulatory Elements for MIR21 Gene

Enhancers for MIR21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F059824 2.2 VISTA FANTOM5 Ensembl ENCODE 10.9 +135.7 135694 36.2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPM1D RPS6KB1 NDUFB8P2 SMG8 LOC101927755 DHX40 TUBD1 VMP1 PTRH2 MIR21
GH17F059781 1.8 VISTA FANTOM5 ENCODE 12.7 +79.3 79298 9.5 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 LOC101927755 SKA2 RPS6KB1 LOC100996660 RNU6-450P MIR21 PPM1D TRIM37 VMP1 DHX40
GH17F059751 1.7 FANTOM5 Ensembl ENCODE 12.6 +54.3 54293 20.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 RPS6KB1 NDUFB8P2 LOC101927755 MIR21 RNU6-450P TUBD1 PPM1D SMG8 CA4 DHX40
GH17F059667 1.1 Ensembl ENCODE 11.7 -37.9 -37946 3.6 CTCF JUN SIN3A FEZF1 ZIC2 RAD21 ZNF664 CTBP1 GATA3 ZBTB48 MIR21 VMP1 PTRH2 RPS6KB1 TUBD1 HEATR6 PRR11 GC17M059649 ENSG00000273702
GH17F059521 1.2 Ensembl ENCODE 9.9 -185.5 -185537 1.2 WRNIP1 ARID4B ZNF48 ZNF2 YY1 ZNF143 ZNF263 MXD4 REST PPARG DHX40 YPEL2 MIR21 PTRH2 VMP1 LINC01476 LOC105371845
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR21 on UCSC Golden Path with GeneCards custom track

Promoters for MIR21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350173 408 3601 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for MIR21 Gene

Chromosome:
17
Start:
59,707,192 bp from pter
End:
59,842,255 bp from pter
Size:
135,064 bases
Orientation:
Plus strand

Genomic View for MIR21 Gene

Genes around MIR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR21 Gene

Proteins for MIR21 Gene

  • Protein details for MIR21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GC9-VMP1_HUMAN
    Recommended name:
    Vacuole membrane protein 1
    Protein Accession:
    Q96GC9
    Secondary Accessions:
    • B4DVV9
    • Q9H0P4
    • Q9P089

    Protein attributes for MIR21 Gene

    Size:
    406 amino acids
    Molecular mass:
    46238 Da
    Quaternary structure:
    • Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2.
    • Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2.

    Alternative splice isoforms for MIR21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR21 Gene

Post-translational modifications for MIR21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR21 Gene

Domains & Families for MIR21 Gene

Gene Families for MIR21 Gene

Protein Domains for MIR21 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96GC9

UniProtKB/Swiss-Prot:

VMP1_HUMAN :
  • Belongs to the VMP1 family.
Family:
  • Belongs to the VMP1 family.
genes like me logo Genes that share domains with MIR21: view

No data available for Suggested Antigen Peptide Sequences for MIR21 Gene

Function for MIR21 Gene

Molecular function for MIR21 Gene

UniProtKB/Swiss-Prot Function:
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.

Gene Ontology (GO) - Molecular Function for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR21: view

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR21

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR21 Gene

Localization for MIR21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR21 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005730 nucleolus IDA --
GO:0005773 vacuole IEA --
GO:0005774 vacuolar membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with MIR21: view

No data available for Subcellular locations from COMPARTMENTS for MIR21 Gene

Pathways & Interactions for MIR21 Gene

genes like me logo Genes that share pathways with MIR21: view

Pathways by source for MIR21 Gene

1 BioSystems pathway for MIR21 Gene
2 KEGG pathways for MIR21 Gene

Gene Ontology (GO) - Biological Process for MIR21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0006914 autophagy IEA --
GO:0007029 endoplasmic reticulum organization IBA --
GO:0007030 Golgi organization IBA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MIR21: view

No data available for SIGNOR curated interactions for MIR21 Gene

Transcripts for MIR21 Gene

mRNA/cDNA for MIR21 Gene

(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR21 Gene

No ASD Table

Relevant External Links for MIR21 Gene

GeneLoc Exon Structure for
MIR21
ECgene alternative splicing isoforms for
MIR21

Expression for MIR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR21 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR21 Gene:

MIR21
genes like me logo Genes that share expression patterns with MIR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR21 Gene

Orthologs for MIR21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VMP1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VMP1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VMP1 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vmp1 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves VMP1 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VMP1 35
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii vmp1 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32087 35
  • 43 (a)
OneToMany
Tango5 35
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea epg-3 35
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6481 35
  • 58 (a)
OneToOne
Species where no ortholog for MIR21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR21 Gene

ENSEMBL:
Gene Tree for MIR21 (if available)
TreeFam:
Gene Tree for MIR21 (if available)

Paralogs for MIR21 Gene

Pseudogenes.org Pseudogenes for MIR21 Gene

genes like me logo Genes that share paralogs with MIR21: view

No data available for Paralogs for MIR21 Gene

Variants for MIR21 Gene

Sequence variations from dbSNP and Humsavar for MIR21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111262775 -- 59,839,806(+) TTGGT(C/T)GTTGT upstream-variant-2KB, reference, synonymous-codon
rs111890520 -- 59,841,172(+) TTTTT(C/T)TGGTT upstream-variant-2KB, utr-variant-3-prime
rs111935573 -- 59,839,289(+) CCCGG(C/G)CAGAG intron-variant, upstream-variant-2KB
rs112275511 -- 59,840,012(+) CTGTA(C/T)CAATT upstream-variant-2KB, utr-variant-3-prime
rs112373467 -- 59,840,891(+) AAAAC(-/C)ACACT upstream-variant-2KB, utr-variant-3-prime

Relevant External Links for MIR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR21 Gene

Disorders for MIR21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR21 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chromosome 17p deletion
  • 17p deletion
- elite association - COSMIC cancer census association via MalaCards
Search MIR21 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MIR21

Genetic Association Database (GAD)
MIR21
Human Genome Epidemiology (HuGE) Navigator
MIR21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR21
genes like me logo Genes that share disorders with MIR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR21 Gene

Publications for MIR21 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  3. Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: a systematic review and meta-analysis. (PMID: 25516467) Li S. … Zhang D. (Clin. Exp. Med. 2016) 3 64
  4. A microRNA code for prostate cancer metastasis. (PMID: 26073083) Bonci D. … De Maria R. (Oncogene 2016) 3 64
  5. Targeting microRNAs in heart failure. (PMID: 26119078) Duygu B. … da Costa Martins P.A. (Trends Cardiovasc. Med. 2016) 3 64

Products for MIR21 Gene

Sources for MIR21 Gene

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