Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR20B Gene

Subcategory (RNA class) for MIR20B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR20B Gene

  • MicroRNA 20b 2 3
  • MicroRNA 19b-2 5
  • Hsa-Mir-20b 3
  • MIR19B2 5
  • Mir-20b 3
  • MIRN20B 3

External Ids for MIR20B Gene

Previous HGNC Symbols for MIR20B Gene

  • MIRN20B

Previous GeneCards Identifiers for MIR20B Gene

  • GC0XM133153
  • GC0XM133160
  • GC0XM133307
  • GC0XM133312
  • GC0XM133316
  • GC0XM133320
  • GC0XM133325
  • GC0XM133329
  • GC0XM133333
  • GC0XM133337
  • GC0XM133340
  • GC0XM133351
  • GC0XM133375
  • GC0XM134173
  • GC0XM134178

Summaries for MIR20B Gene

Entrez Gene Summary for MIR20B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR20B Gene

MIR20B (MicroRNA 20b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR20B Gene

Genomics for MIR20B Gene

Regulatory Elements for MIR20B Gene

Enhancers for MIR20B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF134171 1.3 FANTOM5 Ensembl ENCODE 0.8 +0.5 455 4.8 MAX ZNF76 ZIC2 ZNF664 ZFHX2 GLIS2 POLR2A PATZ1 ZNF143 PRDM10 CCDC160 GPC3 PHF6 GC0XM134196 GC0XM134201 MIR92A2 MIR106A MIR18B MIR19B2 MIR20B
GH0XF134179 0.2 ENCODE 0.4 -6.9 -6879 2.4 ZNF133 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134187 0.2 Ensembl 0.4 -13.2 -13212 0.2 CBX8 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134186 0.4 ENCODE 0.4 -12.9 -12857 0.2 CBX8 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134188 0.2 Ensembl 0.4 -12.4 -12412 0.2 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR20B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR20B Gene

Chromosome:
X
Start:
134,168,911 bp from pter
End:
134,174,089 bp from pter
Size:
5,179 bases
Orientation:
Minus strand

Genomic View for MIR20B Gene

Genes around MIR20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR20B Gene

Proteins for MIR20B Gene

Post-translational modifications for MIR20B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR20B Gene

Domains & Families for MIR20B Gene

Gene Families for MIR20B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR20B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR20B Gene

Function for MIR20B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR20B Gene

Localization for MIR20B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR20B Gene

Pathways & Interactions for MIR20B Gene

SuperPathways for MIR20B Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR20B: view

Pathways by source for MIR20B Gene

1 BioSystems pathway for MIR20B Gene

Interacting Proteins for MIR20B Gene

Gene Ontology (GO) - Biological Process for MIR20B Gene

None

No data available for SIGNOR curated interactions for MIR20B Gene

Transcripts for MIR20B Gene

mRNA/cDNA for MIR20B Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR20B Gene

No ASD Table

Relevant External Links for MIR20B Gene

GeneLoc Exon Structure for
MIR20B
ECgene alternative splicing isoforms for
MIR20B

Expression for MIR20B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR20B Gene:

MIR20B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR20B Gene

Orthologs for MIR20B Gene

Evolution for MIR20B Gene

ENSEMBL:
Gene Tree for MIR20B (if available)
TreeFam:
Gene Tree for MIR20B (if available)

No data available for Orthologs for MIR20B Gene

Paralogs for MIR20B Gene

No data available for Paralogs for MIR20B Gene

Variants for MIR20B Gene

Sequence variations from dbSNP and Humsavar for MIR20B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs113658998 -- 134,170,166(+) CACAA(A/G)CTACA downstream-variant-500B, upstream-variant-2KB
rs137881717 -- 134,171,170(+) TAAAC(A/G)AGTGA upstream-variant-2KB
rs142112727 -- 134,171,521(+) TCTGG(C/T)ATCCC upstream-variant-2KB
rs146939378 -- 134,170,567(+) TATGT(A/C)TAAGC upstream-variant-2KB
rs180944931 -- 134,170,957(+) AAGTA(A/G)GCAGA upstream-variant-2KB

Relevant External Links for MIR20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR20B Gene

Disorders for MIR20B Gene

Relevant External Links for MIR20B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR20B

No disorders were found for MIR20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR20B Gene

Publications for MIR20B Gene

  1. MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells. (PMID: 26829385) Li S. … Chen B. (Life Sci. 2016) 3 64
  2. MicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis. (PMID: 26708577) Li Y. … Lai Y. (Mol Med Rep 2016) 3 64
  3. MicroRNA-20b inhibits the proliferation, migration and invasion of bladder cancer EJA cells via the targeting of cellA cycle regulation and Sp-1-mediated MMP-2 expression. (PMID: 26166554) Park S.L. … Moon S.K. (Oncol. Rep. 2015) 3 64
  4. Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1I+ and VEGF Effect on Cell Biological Behaviour. (PMID: 26612965) Xue T.M. … Zhang P.J. (Dis. Markers 2015) 3 64
  5. Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients. (PMID: 26845056) Chunjie N. … Xiaojian Z. (Eur. Cytokine Netw. 2015) 3 64

Products for MIR20B Gene

Sources for MIR20B Gene

Content
Loading form....