Subcategory (RNA class) for MIR20A Gene
Quality Score for this RNA gene is
Aliases for MIR20A Gene
Previous HGNC Symbols for MIR20A Gene
Previous GeneCards Identifiers for MIR20A Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA belongs to a polycistronic miRNA cluster that includes six consecutive mature miRNAs that are derived from a single primary transcript. The mature miRNAs of this cluster are often overexpressed in solid cancers. [provided by RefSeq, May 2012]
GeneCards Summary for MIR20A Gene
MIR20A (MicroRNA 20a) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR20A include colorectal adenocarcinoma and mantle cell lymphoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.