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microRNA 20a(Previous name: microRNA 20 )
(Previous symbols: MIRN20, MIRN20A)
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Aliases
for MIR20A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 20a1 2 | | MicroRNA 201 | | MIRN20A1 2 5 | | MIR202 | | MIRN201 2 | | MiR-201 | | Hsa-Mir-201 | | MiRNA20A1 | | Hsa-Mir-20a1 | | Mir-20a1 |
| External Ids: | HGNC: 315771 | Entrez Gene: 4069822 | Ensembl: ENSG000001991497 | OMIM: 6094205 |
Export aliases for MIR20A gene to outside databasesPrevious GC identifers: GC13P090872 GC13P090880 GC13P092016 GC13P092024 GC13P092031 GC13P092039 GC13P092048 GC13P092058 GC13P092067 GC13P092077
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Summaries
for MIR20A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for MIR20A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. This miRNA belongs to a polycistronic miRNA cluster that includes sixconsecutive mature miRNAs that are derived from a single primary transcript. The mature miRNAs of this cluster areoften overexpressed in solid cancers. (provided by RefSeq, May 2012)
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Genomic Views
for MIR20A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR20A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR20A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR20A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q31.3 Ensembl cytogenetic band: 13q31.3 HGNC cytogenetic band: 13q31.3MIR20A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P092086: view genomic region (via miRBase)
(about GC identifiers)
Start:
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92,003,319 bp from pter |
End:
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92,003,389 bp from pter |
Size:
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71 bases |
Orientation:
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plus strand |
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Proteins
for MIR20A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR20A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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Function
for MIR20A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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miRNA
Products: | | miRTarBase genes targeted by MIR20A:
RB1(MIRT005857), BMPR2(MIRT000181), MAPK9(MIRT005856), RBL1(MIRT005858), NRAS(MIRT003903), PTEN(MIRT003369), WEE1(MIRT005860), TGFBR2(MIRT001785), E2F3(MIRT005855), BNIP2(MIRT005481), HIF1A(MIRT000002), SMAD4(MIRT005631), RUNX1(MIRT003742), VEGFA(MIRT004450), MUC17(MIRT004711), BCL2(MIRT003011), MEF2D(MIRT003012), E2F1(MIRT000180), MAP3K12(MIRT003010), APP(MIRT003382), CCND1(MIRT000179), THBS1(MIRT005627), MYC(MIRT005289), RBL2(MIRT005859), CCND2(MIRT005854), CDKN1A(MIRT000597) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR20A | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR20A | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
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Pathways & Interactions
for MIR20A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR20A
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Drugs & Compounds
for MIR20A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR20A
Search CenterWatch for drugs/clinical trials and news about MIR20A 
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Transcripts
for MIR20A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000362279(miRNA)
GeneLoc Exon Structure
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Expression
for MIR20A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR20A:none
MIR20A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR20A
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR20A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR20A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR20A |
Orthologs
for MIR20A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR20A (if available)
TreeFam Gene Tree for MIR20A (if available) |
Paralogs
for MIR20A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR20A gene
- MIR18B2 MIR20B2 MIR106B2 MIR106A2 MIR18A2 MIR932 MIR172
MIR20A for paralogs About GeneDecksing
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Genomic Variants
for MIR20A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR20A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR20A for disorders About GeneDecksing
OMIM gene information: 609420
OMIM disorders: --
14  diseases for MIR20A: About MalaCardsmantle cell lymphoma familial breast cancer breast cancer cervical cancer
cervicitis pancreatic carcinoma retinoblastoma prostate cancer
pancreatitis hypoxia prostatitis adenocarcinoma
carcinoma neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR20A (2 documents)
Export disorders for MIR20A gene to outside databases
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Publications
for MIR20A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR20A gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with MIR20A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells. (PubMed id 22449978)1 Kang H.W....Tang H. (2012)
- Suppression of CX43 expression by miR-20a in the progr ession of human prostate cancer. (PubMed id 22785209)1 Li X....Su Y.P. (2012)
- Differential distribution of miR-20a and miR-20b may u nderly metastatic heterogeneity of breast cancers. (PubMed id 22901144)1 Li J.Y....Zhu X.Y. (2012)
- Preeclampsia up-regulates angiogenesis-associated micr oRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human pla centa. (PubMed id 22438230)1 Wang W....Chen D.B. (2012)
- miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. (PubMed id 22186140)1 Huang G....Kleinerman E.S. (2012)
- STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. (PubMed id 22751500)1 Chen A.J....Depinho R.A. (2012)
- Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. (PubMed id 22648654)1 Lin S.C....Tsai S.J. (2012)
- The structure of human argonaute-2 in complex with miR -20a. (PubMed id 22682761)1 Elkayam E....Joshua-Tor L. (2012)
- MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concer t to modulate E2F activity on cell cycle arrest during neuronal lineage differe ntiation of USSC. (PubMed id 21283765)1 Trompeter H.I....Wernet P. (2011)
- miR-17~92 cooperates with RB pathway mutations to pro mote retinoblastoma. (PubMed id 21816922)1 Conkrite K....MacPherson D. (2011)
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External Searches for MIR20A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR20A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIR20A gene
(According to HUGE)
About This Section
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Specialized Databases showing MIR20A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR20A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR20A gene:
Search GeneIP for patents involving MIR20A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR20A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR20A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR20A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR20A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR20A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR20A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR20A |
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| | | | Search Tocris compounds for MIR20A |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR20A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR20A |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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