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Aliases for MIR208B Gene

Subcategory (RNA class) for MIR208B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR208B Gene

  • MicroRNA 208b 2 3 5
  • Hsa-Mir-208b 3
  • Mir-208b 3
  • MIRN208B 3

External Ids for MIR208B Gene

Previous HGNC Symbols for MIR208B Gene

  • MIRN208B

Previous GeneCards Identifiers for MIR208B Gene

  • GC14M022959
  • GC14M023887

Summaries for MIR208B Gene

Entrez Gene Summary for MIR208B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR208B Gene

MIR208B (MicroRNA 208b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR208B Gene

Genomics for MIR208B Gene

Regulatory Elements for MIR208B Gene

Enhancers for MIR208B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G023442 1.5 VISTA FANTOM5 ENCODE dbSUPER 11.3 -25.2 -25190 1.9 ZNF341 IKZF1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14G023284 1.4 ENCODE dbSUPER 10 +132.3 132313 3.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 HOMEZ RNA5SP383 LOC102724814 BCL2L2-PABPN1 PABPN1 THTPA CMTM5 ACIN1 MIR208B ZFHX2-AS1
GH14G023378 1.2 VISTA ENCODE 11 +38.0 38024 3.2 ELF3 RB1 NFIB ARID4B ZNF76 KLF17 ZNF2 ZNF48 ZSCAN9 RAD21 MYH6 SLC22A17 MIR208B PPP1R3E HOMEZ BCL2L2 DHRS4-AS1 CMTM5 MIR208A
GH14G023445 1.1 ENCODE dbSUPER 11.2 -29.0 -29008 3.1 ZFP64 ZNF121 ZNF202 ZNF680 ZBTB11 ZNF426 REST ZNF623 ZNF781 ZNF518A NYNRIN KHNYN NFATC4 RNA5SP383 MMP14 MIR208B HOMEZ MYH6 THTPA SLC22A17
GH14G023279 1.2 ENCODE dbSUPER 10 +137.5 137477 2.1 HDGF PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 CBX5 GATA2 FOS PABPN1 CMTM5 MIR208B ACIN1 ZFHX2-AS1 ZFHX2 HOMEZ PIR53909 HMGN2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR208B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR208B Gene

Chromosome:
14
Start:
23,417,987 bp from pter
End:
23,418,063 bp from pter
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR208B Gene

Genes around MIR208B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR208B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR208B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR208B Gene

ORGUL Member Location for MIR208B Gene

ORGUL Member Location for MIR208B gene

Proteins for MIR208B Gene

Post-translational modifications for MIR208B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR208B Gene

Domains & Families for MIR208B Gene

Gene Families for MIR208B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR208B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208B Gene

Function for MIR208B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208B Gene

Localization for MIR208B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR208B Gene

Pathways & Interactions for MIR208B Gene

SuperPathways for MIR208B Gene

No Data Available

Interacting Proteins for MIR208B Gene

Gene Ontology (GO) - Biological Process for MIR208B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR208B Gene

Drugs & Compounds for MIR208B Gene

No Compound Related Data Available

Transcripts for MIR208B Gene

mRNA/cDNA for MIR208B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR208B Gene

No ASD Table

Relevant External Links for MIR208B Gene

GeneLoc Exon Structure for
MIR208B
ECgene alternative splicing isoforms for
MIR208B

Expression for MIR208B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR208B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR208B Gene:

MIR208B
genes like me logo Genes that share expression patterns with MIR208B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR208B Gene

Orthologs for MIR208B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR208B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-208b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-208b 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir208b 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-208b 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-208b 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-736 35
  • 70 (a)
OneToOne
Species where no ortholog for MIR208B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR208B Gene

ENSEMBL:
Gene Tree for MIR208B (if available)
TreeFam:
Gene Tree for MIR208B (if available)

Paralogs for MIR208B Gene

No data available for Paralogs for MIR208B Gene

Variants for MIR208B Gene

Sequence variations from dbSNP and Humsavar for MIR208B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs397516187 Pathogenic 23,419,993(-) CCTGC(A/G)CAAGA upstream-variant-2KB, reference, missense
rs397516201 Pathogenic 23,418,249(-) TGAGA(C/T)GGACG upstream-variant-2KB, reference, missense
rs540263945 Pathogenic 23,419,587(+) AGGTC(C/G/T)GGCAC upstream-variant-2KB, reference, missense
rs730880780 Pathogenic 23,419,951(-) GCAGA(A/T)CGACA upstream-variant-2KB, reference, missense
rs730880910 Pathogenic 23,418,235(-) TTCAG(A/C/T)GGACT upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR208B Gene

Variant ID Type Subtype PubMed ID
esv2748480 CNV deletion 23290073
esv3584149 CNV gain 25503493
nsv456166 CNV gain 19166990
nsv470623 CNV gain 18288195
nsv564041 CNV gain 21841781

Relevant External Links for MIR208B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR208B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR208B Gene

Disorders for MIR208B Gene

Relevant External Links for MIR208B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR208B

No disorders were found for MIR208B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208B Gene

Publications for MIR208B Gene

  1. Circulation of miR-26a, miR-191, and miR-208b in plasma of patients with acute myocardial infarction. (PMID: 26712201) Bilal M. … Khan M.A. (J Pak Med Assoc 2016) 3 64
  2. microRNAs: Modulators of the underlying pathophysiology of sarcopenia? (PMID: 26342566) Brown D.M. … Goljanek-Whysall K. (Ageing Res. Rev. 2015) 3 64
  3. MicroRNA Stability in Postmortem FFPE Tissues: Quantitative Analysis Using Autoptic Samples from Acute Myocardial Infarction Patients. (PMID: 26046358) Kakimoto Y. … Osawa M. (PLoS ONE 2015) 3 64
  4. The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. (PMID: 24241692) McFarland A.P. … Savan R. (Nat. Immunol. 2014) 3 64
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64

Products for MIR208B Gene

Sources for MIR208B Gene

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