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Aliases for MIR208A Gene

Subcategory (RNA class) for MIR208A Gene

miRNA

Quality Score for this RNA gene is

11

Aliases for MIR208A Gene

  • MicroRNA 208a 2 3
  • MicroRNA 208 2 3
  • Hsa-Mir-208a 3
  • Hsa-Mir-208 3
  • MiRNA208 3
  • MIRN208A 3
  • MIRN208 3
  • MIR208 3

External Ids for MIR208A Gene

Previous HGNC Symbols for MIR208A Gene

  • MIRN208
  • MIRN208A

Previous GeneCards Identifiers for MIR208A Gene

  • GC14M022931
  • GC14M023858
  • GC14M023860
  • GC14M023863

Summaries for MIR208A Gene

Entrez Gene Summary for MIR208A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR208A Gene

MIR208A (MicroRNA 208a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR208A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR208A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR208A Gene

Genomics for MIR208A Gene

Genomic Location for MIR208A Gene

Chromosome:
14
Start:
23,388,590 bp from pter
End:
23,388,672 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR208A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR208A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR208A Gene

ORGUL Member Location for MIR208A Gene

ORGUL Member Location for MIR208A gene

No data available for Regulatory Elements for MIR208A Gene

Proteins for MIR208A Gene

Post-translational modifications for MIR208A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR208A Gene

Domains & Families for MIR208A Gene

Gene Families for MIR208A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR208A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208A Gene

Function for MIR208A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208A Gene

Localization for MIR208A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR208A Gene

Pathways & Interactions for MIR208A Gene

genes like me logo Genes that share pathways with MIR208A: view

Pathways by source for MIR208A Gene

1 BioSystems pathway for MIR208A Gene

Interacting Proteins for MIR208A Gene

Gene Ontology (GO) - Biological Process for MIR208A Gene

None

No data available for SIGNOR curated interactions for MIR208A Gene

Drugs & Compounds for MIR208A Gene

No Compound Related Data Available

Transcripts for MIR208A Gene

fRNAdb Secondary structures for MIR208A Gene

  • hsa-miR-208a-3p_MIMAT0000241_Homo_sapiens_miR-208a-3p_mature
  • hsa-miR-208a-5p_MIMAT0026474_Homo_sapiens_miR-208a-5p_mature

mRNA/cDNA for MIR208A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR208A Gene

No ASD Table

Relevant External Links for MIR208A Gene

GeneLoc Exon Structure for
MIR208A
ECgene alternative splicing isoforms for
MIR208A

Expression for MIR208A Gene

mRNA expression in normal human tissues for MIR208A Gene

genes like me logo Genes that share expression patterns with MIR208A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR208A Gene

Orthologs for MIR208A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR208A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-208a 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-208a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-208a 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir208a 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-208 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-208a 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR208A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR208A Gene

ENSEMBL:
Gene Tree for MIR208A (if available)
TreeFam:
Gene Tree for MIR208A (if available)

Paralogs for MIR208A Gene

No data available for Paralogs for MIR208A Gene

Variants for MIR208A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR208A Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for MIR208A Gene

HapMap Linkage Disequilibrium report
MIR208A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR208A Gene

Disorders for MIR208A Gene

Relevant External Links for MIR208A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR208A
genes like me logo Genes that share disorders with MIR208A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208A Gene

Publications for MIR208A Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 67
  2. miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers. (PMID: 25125495) BoA!tjanA8iA8 E. … Zidar N. (Exp. Biol. Med. (Maywood) 2015) 67
  3. miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion. (PMID: 24604208) Liu A. … Hu X. (Cell Biochem. Biophys. 2014) 67
  4. Identification of serum microRNAs for cardiovascular risk stratification in dyslipidemia subjects. (PMID: 24461990) Wu J. … Wang J. (Int. J. Cardiol. 2014) 67
  5. Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma. (PMID: 25023649) Li H. … Yang J. (J Transl Med 2014) 67

Products for MIR208A Gene

Sources for MIR208A Gene

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