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Aliases for MIR208A Gene

Subcategory (RNA class) for MIR208A Gene

miRNA

Quality Score for this RNA gene is

9

Aliases for MIR208A Gene

  • MicroRNA 208a 2 3 5
  • MicroRNA 208 2 3
  • Hsa-Mir-208a 3
  • Hsa-Mir-208 3
  • MiRNA208 3
  • MIRN208A 3
  • MIRN208 3
  • MIR208 3

External Ids for MIR208A Gene

Previous HGNC Symbols for MIR208A Gene

  • MIRN208
  • MIRN208A

Previous GeneCards Identifiers for MIR208A Gene

  • GC14M022931
  • GC14M023858
  • GC14M023860
  • GC14M023863

Summaries for MIR208A Gene

Entrez Gene Summary for MIR208A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR208A Gene

MIR208A (MicroRNA 208a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR208A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR208A

Additional gene information for MIR208A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR208A Gene

Genomics for MIR208A Gene

GeneHancer (GH) Regulatory Elements for MIR208A Gene

Promoters and enhancers for MIR208A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023442 Enhancer 1.3 VISTA FANTOM5 ENCODE dbSUPER 10.5 -54.6 -54587 1.9 ZNF341 IKZF1 PHB2 E4F1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14I023453 Enhancer 0.9 ENCODE 10.5 -65.7 -65720 1.8 FOXA2 MLX ARNT ARID4B BRCA1 SLC30A9 TCF12 ZNF766 NCOA1 MIER2 MYH6 MIR208B SLC22A17 MIR208A ZFHX2-AS1 ZFHX2 BCL2L2 CMTM5 IL25 HOMEZ
GH14I023328 Enhancer 0.8 ENCODE 10.9 +60.5 60459 0.2 ELF3 ARNT ZSCAN9 RAD21 RFX5 ARID2 SCRT2 ZNF143 THAP11 MIXL1 SLC22A17 EFS CMTM5 BCL2L2 HOMEZ PPP1R3E MIR208A IL25 MYH6 MIR208B
GH14I023445 Enhancer 0.7 ENCODE dbSUPER 10.5 -58.4 -58404 3.1 GATAD2A NBN MNT ZNF644 MIR208B MYH6 SLC22A17 MIR208A ZFHX2-AS1 ZFHX2 CMTM5 NGDN MYH7
GH14I023404 Promoter/Enhancer 1.5 VISTA EPDnew dbSUPER 0.4 -18.3 -18340 4.9 SCRT1 PKNOX1 YBX1 EBF1 TSHZ1 ZIC2 FOXA1 ZNF585B SCRT2 IKZF1 MYH6 PABPN1 MDP1 CDH24 NFATC4 PRMT5-AS1 DHRS4-AS1 MIR208A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR208A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR208A Gene

Genomic Locations for MIR208A Gene
chr14:23,388,596-23,388,666
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand
chr14:23,857,799-23,857,881
(GRCh37/hg19)

Genomic View for MIR208A Gene

Genes around MIR208A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR208A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR208A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR208A Gene

ORGUL Member Location for MIR208A Gene

ORGUL Member Location for MIR208A gene

Proteins for MIR208A Gene

Post-translational modifications for MIR208A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR208A Gene

Domains & Families for MIR208A Gene

Gene Families for MIR208A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR208A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208A Gene

Function for MIR208A Gene

Gene Ontology (GO) - Molecular Function for MIR208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19726871
genes like me logo Genes that share ontologies with MIR208A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208A Gene

Localization for MIR208A Gene

Gene Ontology (GO) - Cellular Components for MIR208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR208A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR208A Gene

Pathways & Interactions for MIR208A Gene

genes like me logo Genes that share pathways with MIR208A: view

Pathways by source for MIR208A Gene

1 BioSystems pathway for MIR208A Gene

Interacting Proteins for MIR208A Gene

Gene Ontology (GO) - Biological Process for MIR208A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002155 regulation of thyroid hormone mediated signaling pathway ISS --
GO:0008284 positive regulation of cell proliferation IMP 26169693
GO:0010455 positive regulation of cell fate commitment ISS --
GO:0030335 positive regulation of cell migration IMP 26169693
GO:0030502 negative regulation of bone mineralization ISS --
genes like me logo Genes that share ontologies with MIR208A: view

No data available for SIGNOR curated interactions for MIR208A Gene

Drugs & Compounds for MIR208A Gene

No Compound Related Data Available

Transcripts for MIR208A Gene

fRNAdb Secondary structures for MIR208A Gene

  • hsa-miR-208a-3p_MIMAT0000241_Homo_sapiens_miR-208a-3p_mature
  • hsa-miR-208a-5p_MIMAT0026474_Homo_sapiens_miR-208a-5p_mature

mRNA/cDNA for MIR208A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR208A Gene

No ASD Table

Relevant External Links for MIR208A Gene

GeneLoc Exon Structure for
MIR208A
ECgene alternative splicing isoforms for
MIR208A

Expression for MIR208A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR208A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR208A Gene:

MIR208A
genes like me logo Genes that share expression patterns with MIR208A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR208A Gene

Orthologs for MIR208A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR208A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-208a 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-208a 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir208a 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-208a 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-208a 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-208 34
  • 67 (a)
OneToOne
Species where no ortholog for MIR208A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR208A Gene

ENSEMBL:
Gene Tree for MIR208A (if available)
TreeFam:
Gene Tree for MIR208A (if available)

Paralogs for MIR208A Gene

No data available for Paralogs for MIR208A Gene

Variants for MIR208A Gene

Sequence variations from dbSNP and Humsavar for MIR208A Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1027186100 likely-benign, Familial hypertrophic cardiomyopathy 14 23,390,449(-) GGG/GG upstream_transcript_variant
rs1053714593 likely-benign, Familial hypertrophic cardiomyopathy 14 23,390,155(-) G/A upstream_transcript_variant
rs1060501426 uncertain-significance, Familial hypertrophic cardiomyopathy 14 23,388,265(-) C/G downstream_transcript_variant
rs111638554 benign, likely-benign, not specified, Familial hypertrophic cardiomyopathy 14, Cardiovascular phenotype, Hypertrophic cardiomyopathy, Atrial septal defect, Dilated Cardiomyopathy, Dominant 23,388,308(-) G/A/C downstream_transcript_variant
rs115742584 benign, not specified, Familial hypertrophic cardiomyopathy 14 23,389,444(-) A/G upstream_transcript_variant

Additional Variant Information for MIR208A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR208A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR208A Gene

Disorders for MIR208A Gene

Additional Disease Information for MIR208A

No disorders were found for MIR208A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208A Gene

Publications for MIR208A Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 58
  2. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
  3. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. (PMID: 26754670) Tang Y … Zhang S (Journal of experimental & clinical cancer research : CR 2016) 3 58
  4. MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart. (PMID: 26974694) Kakimoto Y … Osawa M (International journal of cardiology 2016) 3 58
  5. miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers. (PMID: 25125495) Boštjančič E … Zidar N (Experimental biology and medicine (Maywood, N.J.) 2015) 3 58

Products for MIR208A Gene

Sources for MIR208A Gene

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