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MIR208A Gene(RNA Gene)

MicroRNA 208a

GCID:
GC14M023388
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR208A Gene

Subcategory (RNA class) for MIR208A Gene

miRNA

Quality Score for this RNA gene is

9

Aliases for MIR208A Gene

  • MicroRNA 208a 2 3 5
  • MicroRNA 208 2 3
  • Hsa-Mir-208a 3
  • Hsa-Mir-208 3
  • MiRNA208 3
  • MIRN208A 3
  • MIRN208 3
  • MIR208 3

External Ids for MIR208A Gene

ORGUL Members for MIR208A Gene

Previous HGNC Symbols for MIR208A Gene

  • MIRN208
  • MIRN208A

Previous GeneCards Identifiers for MIR208A Gene

  • GC14M022931
  • GC14M023858
  • GC14M023860
  • GC14M023863

Summaries for MIR208A Gene

Entrez Gene Summary for MIR208A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR208A Gene

MIR208A (MicroRNA 208a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR208A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR208A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR208A Gene

Genomics for MIR208A Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR208A Gene

Enhancers for MIR208A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023442 1.2 VISTA FANTOM5 ENCODE 10.5 -54.6 -54587 1.9 ZNF341 IKZF1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14F023453 0.9 ENCODE 10.5 -65.7 -65721 1.8 ELF3 ARNT MLX ARID4B ZSCAN9 SLC30A9 MIXL1 HMG20B NCOA1 ZEB2 MYH6 MIR208B SLC22A17 MIR208A ENSG00000157306 ZFHX2 BCL2L2 CMTM5 IL25 HOMEZ
GH14F023328 0.8 ENCODE 10.9 +60.5 60460 0.2 ELF3 CTCF ZSCAN9 RAD21 RFX5 FOXK2 POLR2A SCRT2 ZNF143 SMC3 SLC22A17 EFS CMTM5 PPP1R3E BCL2L2 HOMEZ MIR208A IL25 MYH6 MIR208B
GH14F023445 0.8 ENCODE 10.4 -58.4 -58405 3.1 CTCF ZFP64 ZNF140 ZNF266 ZNF644 ZNF101 ZNF121 ZNF791 ZNF433 GATAD2A NYNRIN KHNYN RNA5SP383 NFATC4 LOC102724814 HOMEZ MMP14 ENSG00000259321 PABPN1 ABHD4
GH14F023378 1.2 VISTA ENCODE 0.4 +8.6 8627 3.2 ELF3 ZNF76 KLF17 ARID4B ZNF48 ZSCAN9 ZNF2 RAD21 RARA SLC30A9 MYH6 SLC22A17 MIR208B PPP1R3E HOMEZ BCL2L2 DHRS4-AS1 CMTM5 MIR208A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR208A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR208A Gene

Chromosome:
14
Start:
23,388,596 bp from pter
End:
23,388,666 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR208A Gene

Genes around MIR208A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR208A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR208A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR208A Gene

ORGUL Member Location for MIR208A Gene

ORGUL Member Location for MIR208A gene

Proteins for MIR208A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR208A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR208A Gene

Domains & Families for MIR208A Gene

Gene Families for MIR208A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR208A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208A Gene

Function for MIR208A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208A Gene

Localization for MIR208A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR208A Gene

Pathways & Interactions for MIR208A Gene

genes like me logo Genes that share pathways with MIR208A: view

Pathways by source for MIR208A Gene

1 BioSystems pathway for MIR208A Gene

Interacting Proteins for MIR208A Gene

Gene Ontology (GO) - Biological Process for MIR208A Gene

None

No data available for SIGNOR curated interactions for MIR208A Gene

Drugs & Compounds for MIR208A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR208A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

fRNAdb Secondary structures for MIR208A Gene

  • hsa-miR-208a-3p_MIMAT0000241_Homo_sapiens_miR-208a-3p_mature
  • hsa-miR-208a-5p_MIMAT0026474_Homo_sapiens_miR-208a-5p_mature

mRNA/cDNA for MIR208A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR208A Gene

No ASD Table

Relevant External Links for MIR208A Gene

GeneLoc Exon Structure for
MIR208A
ECgene alternative splicing isoforms for
MIR208A

Expression for MIR208A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR208A Gene

mRNA expression in normal human tissues for MIR208A Gene
mRNA expression by GTEx for MIR208A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR208A Gene:

MIR208A
genes like me logo Genes that share expression patterns with MIR208A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR208A Gene

Orthologs for MIR208A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR208A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia bta-mir-208a 35
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-208a 35
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir208a 35
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-208a 35
  • 94 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-208a 35
  • 87 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-208 35
  • 67 (a)
 OneToOne
Species where no ortholog for MIR208A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR208A Gene

ENSEMBL:
Gene Tree for MIR208A (if available)
TreeFam:
Gene Tree for MIR208A (if available)

Paralogs for MIR208A Gene

No data available for Paralogs for MIR208A Gene

Variants for MIR208A Gene

Sequence variations from dbSNP and Humsavar for MIR208A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193922652 Likely benign 23,389,063(-) CCCCC(-/C)TCCCC intron-variant, upstream-variant-2KB
rs201016285 Likely benign 23,388,221(+) TCCAC(C/T)ATCAA downstream-variant-500B, reference, missense
rs201804323 Likely benign 23,389,468(+) AGCTG(C/G/T)GAGAT upstream-variant-2KB, reference, synonymous-codon
rs34935550 Likely benign 23,389,488(-) TAGAG(C/G)AAAAG upstream-variant-2KB, reference, missense
rs367866050 Likely benign 23,389,385(+) CACTG(A/G)GCCTC intron-variant, upstream-variant-2KB

Relevant External Links for MIR208A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR208A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR208A Gene

Disorders for MIR208A Gene

Relevant External Links for MIR208A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR208A

No disorders were found for MIR208A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208A Gene

Publications for MIR208A Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 3 64
  2. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. (PMID: 26754670) Tang Y. … Zhang S. (J. Exp. Clin. Cancer Res. 2016) 3 64
  3. miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers. (PMID: 25125495) BoA!tjanA8iA8 E. … Zidar N. (Exp. Biol. Med. (Maywood) 2015) 3 64
  4. MicroRNA208 family in cardiovascular diseases: therapeutic implication and potential biomarker. (PMID: 25840809) Huang Y. … Li J. (J. Physiol. Biochem. 2015) 3 64
  5. Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation. (PMID: 26032092) Guo H. … Fu Q. (Tumour Biol. 2015) 3 64

Products for MIR208A Gene

Sources for MIR208A Gene

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