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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR208A Gene

RNA gene   GIFtS: 23
GCID: GC14M023860

MicroRNA 208a

(Previous name: microRNA 208)
(Previous symbols: MIRN208, MIRN208A)
  3 related diseases
at
MalaCards
 

Aliases
for MIR208A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Subcategory (RNA class): miRNA

Quality score for this RNA gene is 19

Aliases
MicroRNA 208a1 2     MicroRNA 2081
MIRN2081 2 5     hsa-mir-208a2
MIRN208A1 2 5     miRNA2082
MIR2082 5     mir-208a9

External Ids:    HGNC: 315851   Entrez Gene: 4069902   Ensembl: ENSG000001991577   OMIM: 6111165   
ORGUL members:    fRNAdb10:FR389734 FR389734 FR201550      
miRBase:MI0000251 MIMAT0000520 MIMAT0000880 MIMAT0000241 MIMAT0026474    
NCBI13:AJ560749    
NONCODE14:u3269      

Export aliases for MIR208A gene to outside databases

Previous GC identifers: GC14M022931 GC14M023858


Summaries
for MIR208A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR208A Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed
by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an
approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer
ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated
into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq
represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR208A Gene: 
MIR208A (microRNA 208a) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR208A include dilated cardiomyopathy, and acute myocardial infarction.



fRNAdb sequence ontology for MIR208A:
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR208A

Genomic Views
for MIR208A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR208A
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR208A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

MIR208A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR208A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023860:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 23,857,799 bp from pter      End:
 23,857,881 bp from pter
Size:
 83 bases      Orientation:
 minus strand

Proteins
for MIR208A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR208A gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

Function
for MIR208A gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Animal Models:
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miRNA
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Pathways & Interactions
for MIR208A gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MIR208A About                                                                                                See pathways by source

SuperPathContained pathways About
1MicroRNAs in cardiomyocyte hypertrophy
MicroRNAs in cardiomyocyte hypertrophy


1 BioSystems Pathway for MIR208A
    MicroRNAs in cardiomyocyte hypertrophy


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR208A

Drugs & Compounds
for MIR208A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MIR208A

Search CenterWatch for drugs/clinical trials and news about MIR208A

Transcripts
for MIR208A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 2 fRNAdb Secondary structures:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362287(miRNA)
miRNA
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GeneLoc Exon Structure


Expression
for MIR208A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR208A:miRBase

MIR208A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR208A Expression
About this image

    SABiosciences Custom PCR Arrays for MIR208A
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In Situ
Assay Products: 
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Orthologs
for MIR208A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for MIR208A (if available)
TreeFam Gene Tree for MIR208A (if available)

Paralogs
for MIR208A gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for MIR208A gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MIR208A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv901493CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for MIR208A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MIR208A for disorders           About GeneDecksing

OMIM gene information: 611116OMIM information: 160710    
3 diseases for MIR208A:    About MalaCards
dilated cardiomyopathy    acute myocardial infarction    myocardial infarction


Export disorders for MIR208A gene to outside databases

Publications
for MIR208A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR208A gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR208A)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The emerging role of miR-208a in the heart. (PubMed id 23121236)1 Oliveira-Carvalho V....Bocchi E.A. (2013)
  2. Circulating microRNAs as novel and sensitive biomarker s of acute myocardial Infarction. (PubMed id 22713968)1 Li C....Zeng C. (2012)
  3. Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy. (PubMed id 20447577)1 Satoh M....Nakamura M. (2010)
  4. MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are d ysregulated in human myocardial infarction. (PubMed id 20029200)1 Bostjancic E....Glavac D. (2010)
  5. Control of stress-dependent cardiac growth and gene e xpression by a microRNA. (PubMed id 17379774)1 van Rooij E....Olson E.N. (2007)
  6. miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)
  7. New microRNAs from mouse and human. (PubMed id 12554859)1 Lagos-Quintana M....Tuschl T. (2003)
  8. (PubMed id 12624257)10 
  9. (PubMed id 11081491)10 
  10. (PubMed id 15608158)10 

External Searches for MIR208A gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR208A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 406990 HGNC: 31585 Ensembl:ENSG00000199157 miRBase: hsa-mir-208a euGenes: HUgn406990
ECgene: MIR208A H-InvDB: MIR208A

Other Databases showing MIR208A gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR208A gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR208A Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR208A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR208A gene:
Search GeneIP for patents involving MIR208A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR208A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

 
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