Aliases for MIR208A Gene
Subcategory (RNA class) for MIR208A Gene
miRNA
Quality Score for this RNA gene is
9
Aliases for MIR208A Gene
External Ids for MIR208A Gene
- HGNC: 31585
- Entrez Gene: 406990
- Ensembl: ENSG00000199157
- OMIM: 611116
- miRBase: hsa-mir-208a
ORGUL Members for MIR208A Gene
Previous HGNC Symbols for MIR208A Gene
- MIRN208
- MIRN208A
Previous GeneCards Identifiers for MIR208A Gene
- GC14M022931
- GC14M023858
- GC14M023860
- GC14M023863
Summaries for MIR208A Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR208A Gene
MIR208A (MicroRNA 208a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy.
fRNAdb sequence ontologies for MIR208A Gene
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR208A Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR208A Gene
Genomics for MIR208A Gene
GeneHancer (GH) Regulatory Elements for MIR208A Gene
Promoters and enhancers for MIR208A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR208A on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR208A Gene
Genomic Locations for MIR208A Gene
- chr14:23,388,596-23,388,666
- (GRCh38/hg38)
- Size:
- 71 bases
- Orientation:
- Minus strand
- chr14:23,857,799-23,857,881
- (GRCh37/hg19)
Genomic View for MIR208A Gene
Genes around MIR208A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
MIR208A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR208A Gene
ORGUL Member Location for MIR208A Gene
Proteins for MIR208A Gene
Post-translational modifications for MIR208A Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR208A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR208A
- Origene Custom Protein Services for MIR208A
- Search GeneTex for Proteins for MIR208A
No data available for DME Specific Peptides for MIR208A Gene
Domains & Families for MIR208A Gene
Gene Families for MIR208A Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR208A Gene
Function for MIR208A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 19726871 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR208A
-
- Search ViGene Biosciences for MIR208A
CRISPR Products
- Browse CRISPR knockouts for MIR208A
- Applied Biological Materials CRISPR for MIR208A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR208A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR208A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR208A
- VectorBuilder custom plasmid, inducible vectors for MIR208A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR208A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR208A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR208A Gene
Localization for MIR208A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | IDA | 28159509 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR208A Gene
Pathways & Interactions for MIR208A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cardiomyocyte hypertrophy | ||
Pathways by source for MIR208A Gene
1 BioSystems pathway for MIR208A Gene
Interacting Proteins for MIR208A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002155 | regulation of thyroid hormone mediated signaling pathway | ISS | -- |
| GO:0008284 | positive regulation of cell proliferation | IMP | 26169693 |
| GO:0010455 | positive regulation of cell fate commitment | ISS | -- |
| GO:0030335 | positive regulation of cell migration | IMP | 26169693 |
| GO:0030502 | negative regulation of bone mineralization | ISS | -- |
No data available for SIGNOR curated interactions for MIR208A Gene
Transcripts for MIR208A Gene
fRNAdb Secondary structures for MIR208A Gene
mRNA/cDNA for MIR208A Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR208A
- Applied Biological Materials CRISPR for MIR208A
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR208A
Inhibitory RNA Products
- Search ViGene Biosciences for MIR208A
Clone Products
- GenScript: Custom all cDNA clones Services for MIR208A
- VectorBuilder custom plasmid, inducible vectors for MIR208A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR208A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR208A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR208A Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR208A Gene:
MIR208APrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR208A Gene
Orthologs for MIR208A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | bta-mir-208a 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-208a 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mir208a 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | cfa-mir-208a 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-208a 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-208 34 |
|
OneToOne |
- Species where no ortholog for MIR208A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR208A Gene
No data available for Paralogs for MIR208A Gene
Variants for MIR208A Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1027186100 | likely-benign, Familial hypertrophic cardiomyopathy 14 | 23,390,449(-) | GGG/GG | upstream_transcript_variant | |
| rs1053714593 | likely-benign, Familial hypertrophic cardiomyopathy 14 | 23,390,155(-) | G/A | upstream_transcript_variant | |
| rs1060501426 | uncertain-significance, Familial hypertrophic cardiomyopathy 14 | 23,388,265(-) | C/G | downstream_transcript_variant | |
| rs111638554 | benign, likely-benign, not specified, Familial hypertrophic cardiomyopathy 14, Cardiovascular phenotype, Hypertrophic cardiomyopathy, Atrial septal defect, Dilated Cardiomyopathy, Dominant | 23,388,308(-) | G/A/C | downstream_transcript_variant | |
| rs115742584 | benign, not specified, Familial hypertrophic cardiomyopathy 14 | 23,389,444(-) | A/G | upstream_transcript_variant |
Additional Variant Information for MIR208A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR208A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR208A Gene
Disorders for MIR208A Gene
Additional Disease Information for MIR208A
No disorders were found for MIR208A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR208A Gene
Publications for MIR208A Gene
- New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 58
- Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 58
- Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. (PMID: 26754670) Tang Y … Zhang S (Journal of experimental & clinical cancer research : CR 2016) 3 58
- MicroRNA deep sequencing reveals chamber-specific miR-208 family expression patterns in the human heart. (PMID: 26974694) Kakimoto Y … Osawa M (International journal of cardiology 2016) 3 58
- miR-1, miR-133a/b, and miR-208a in human fetal hearts correlate to the apoptotic and proliferation markers. (PMID: 25125495) Boštjančič E … Zidar N (Experimental biology and medicine (Maywood, N.J.) 2015) 3 58
Products for MIR208A Gene
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- Browse R&D Systems for biochemical assays
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR208A
- VectorBuilder custom plasmid, inducible vectors for MIR208A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR208A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR208A
- Search GeneTex for Proteins for MIR208A
Sources for MIR208A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew