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Aliases for MIR206 Gene

Subcategory (RNA class) for MIR206 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR206 Gene

  • MicroRNA 206 2 3 5
  • Hsa-Mir-206 3
  • MiRNA206 3
  • Mir-206 3
  • MIRN206 3

External Ids for MIR206 Gene

ORGUL Members for MIR206 Gene

Previous HGNC Symbols for MIR206 Gene

  • MIRN206

Previous GeneCards Identifiers for MIR206 Gene

  • GC06P052120
  • GC06P052009

Summaries for MIR206 Gene

Entrez Gene Summary for MIR206 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR206 Gene

MIR206 (MicroRNA 206) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR206 include Myotonic Disease. Among its related pathways are miRs in Muscle Cell Differentiation and Glial Cell Differentiation.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR206 Gene

Genomics for MIR206 Gene

Regulatory Elements for MIR206 Gene

Enhancers for MIR206 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G052101 0.8 ENCODE dbSUPER 10.9 -41.3 -41275 3.8 MAFF KLF1 ZNF316 CREB1 MAFG EMSY MAFK LINCMD1 MIR133B MIR206 IL17A IL17F SLC25A20P1 PKHD1 GC06P052124
GH06G052179 0.8 dbSUPER 10.3 +41.0 40979 11.9 CTCF TBL1XR1 CEBPG RAD21 ARID3A SMC3 NFE2 MAFK NFE2L2 ZNF263 IL17F SLC25A20P1 LINCMD1 MIR133B MIR206 PKHD1 IL17A GC06P052177
GH06G052263 0.8 ENCODE 10.1 +119.6 119569 0.2 CTCF ZNF48 RAD21 RFX5 ZNF143 SMC3 NR2F6 THAP11 ZNF654 MAZ LINCMD1 MIR133B PKHD1 MIR206 IL17A SLC25A20P1 PIR36045
GH06G052116 0.7 ENCODE dbSUPER 11 -27.8 -27831 0.9 ZNF766 GLIS1 FEZF1 LINCMD1 MIR133B PKHD1 MIR206 GC06P052124
GH06G052271 0.7 ENCODE 9.3 +127.6 127607 1.4 ELF3 STAT1 FOXA2 FOXA3 JUN KAT8 JUND ZGPAT GATA2 POLR2A IL17F SLC25A20P1 EFHC1 PAQR8 LINCMD1 MIR133B MIR206 PIR36045
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR206 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR206 Gene

Chromosome:
6
Start:
52,144,349 bp from pter
End:
52,144,434 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR206 Gene

Genes around MIR206 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR206 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR206 Gene

Proteins for MIR206 Gene

Post-translational modifications for MIR206 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR206 Gene

Domains & Families for MIR206 Gene

Gene Families for MIR206 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR206: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR206 Gene

Function for MIR206 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR206 Gene

Localization for MIR206 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR206 Gene

Pathways & Interactions for MIR206 Gene

genes like me logo Genes that share pathways with MIR206: view

Pathways by source for MIR206 Gene

2 BioSystems pathways for MIR206 Gene
1 KEGG pathway for MIR206 Gene

Interacting Proteins for MIR206 Gene

Gene Ontology (GO) - Biological Process for MIR206 Gene

None

No data available for SIGNOR curated interactions for MIR206 Gene

Drugs & Compounds for MIR206 Gene

No Compound Related Data Available

Transcripts for MIR206 Gene

mRNA/cDNA for MIR206 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR206 Gene

No ASD Table

Relevant External Links for MIR206 Gene

GeneLoc Exon Structure for
MIR206
ECgene alternative splicing isoforms for
MIR206

Expression for MIR206 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR206 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR206 Gene:

MIR206
genes like me logo Genes that share expression patterns with MIR206: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR206 Gene

Orthologs for MIR206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR206 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-206 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-206 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-206 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-206 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir206 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-206 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-206 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-206 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-206-1 35
  • 63 (a)
OneToMany
dre-mir-206-2 35
  • 60 (a)
OneToMany
Species where no ortholog for MIR206 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR206 Gene

ENSEMBL:
Gene Tree for MIR206 (if available)
TreeFam:
Gene Tree for MIR206 (if available)

Paralogs for MIR206 Gene

No data available for Paralogs for MIR206 Gene

Variants for MIR206 Gene

Sequence variations from dbSNP and Humsavar for MIR206 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000320950 -- 52,142,350(+) TTCAA(A/G)CTCTC upstream-variant-2KB
rs1001297727 -- 52,143,564(+) CCACC(C/G)CAGCC upstream-variant-2KB
rs1002298903 -- 52,144,806(+) GAATC(A/G)TAATC downstream-variant-500B
rs1004344881 -- 52,144,595(+) GAGGC(A/G)TCCTC downstream-variant-500B
rs1005193881 -- 52,143,167(+) CAGTA(C/T)GGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR206 Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Relevant External Links for MIR206 Gene

Human Gene Mutation Database (HGMD)
MIR206
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR206

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR206 Gene

Disorders for MIR206 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR206 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myotonic disease
  • myotonic disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR206

Genetic Association Database (GAD)
MIR206
Human Genome Epidemiology (HuGE) Navigator
MIR206
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR206
genes like me logo Genes that share disorders with MIR206: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR206 Gene

Publications for MIR206 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  2. Dual-receptor (EGFR and c-MET) inhibition by tumor-suppressive miR-1 and miR-206 in head and neck squamous cell carcinoma. (PMID: 27169691) Koshizuka K. … Seki N. (J. Hum. Genet. 2017) 3 64
  3. Regulation of nucleolin expression by miR-194, miR-206, and HuR. (PMID: 27221739) Bose S. … Spicer E.K. (Mol. Cell. Biochem. 2016) 3 64
  4. MiR-206 Suppresses the Progression of Coronary Artery Disease by Modulating Vascular Endothelial Growth Factor (VEGF) Expression. (PMID: 27994218) Wang M. … Ding W. (Med. Sci. Monit. 2016) 3 64
  5. miR-206 inhibits renal cell cancer growth by targeting GAK. (PMID: 27924503) Wei C. … Chen Z.Q. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2016) 3 64

Products for MIR206 Gene

Sources for MIR206 Gene

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