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Aliases for MIR206 Gene

Subcategory (RNA class) for MIR206 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR206 Gene

  • MicroRNA 206 2 3
  • MIRN206 3 6
  • Hsa-Mir-206 3
  • MiRNA206 3

External Ids for MIR206 Gene

ORGUL Members for MIR206 Gene

Previous HGNC Symbols for MIR206 Gene

  • MIRN206

Previous GeneCards Identifiers for MIR206 Gene

  • GC06P052120
  • GC06P052009

Summaries for MIR206 Gene

Entrez Gene Summary for MIR206 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR206 Gene

MIR206 (MicroRNA 206) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR206 include alzheimer disease. Among its related pathways are MicroRNAs in cancer and Glial Cell Differentiation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR206 Gene

Genomics for MIR206 Gene

Genomic Location for MIR206 Gene

Start:
52,144,331 bp from pter
End:
52,144,442 bp from pter
Size:
112 bases
Orientation:
Plus strand

Genomic View for MIR206 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR206 Gene

No data available for Regulatory Elements for MIR206 Gene

Proteins for MIR206 Gene

Post-translational modifications for MIR206 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR206 Gene

Domains for MIR206 Gene

Gene Families for MIR206 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR206: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR206 Gene

Function for MIR206 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR206 Gene

Localization for MIR206 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR206 Gene

Pathways for MIR206 Gene

genes like me logo Genes that share pathways with MIR206: view

Pathways by source for MIR206 Gene

2 BioSystems pathways for MIR206 Gene
1 KEGG pathway for MIR206 Gene

Interacting Proteins for MIR206 Gene

Gene Ontology (GO) - Biological Process for MIR206 Gene

None

Transcripts for MIR206 Gene

mRNA/cDNA for MIR206 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR206 Gene

No ASD Table

Relevant External Links for MIR206 Gene

GeneLoc Exon Structure for
MIR206
ECgene alternative splicing isoforms for
MIR206

Expression for MIR206 Gene

mRNA expression in normal human tissues for MIR206 Gene

genes like me logo Genes that share expressions with MIR206: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR206 Gene

Orthologs for MIR206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR206 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-206 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-206 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-206 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir206 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-206 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-206 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-206 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-206 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-206-1 36
  • 63 (a)
OneToMany
dre-mir-206-2 36
  • 60 (a)
OneToMany
Species with no ortholog for MIR206:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR206 Gene

ENSEMBL:
Gene Tree for MIR206 (if available)
TreeFam:
Gene Tree for MIR206 (if available)

Paralogs for MIR206 Gene

No data available for Paralogs for MIR206 Gene

Variants for MIR206 Gene

Sequence variations from dbSNP and Humsavar for MIR206 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs945210 -- 52,143,936(-) GAGCC(A/C)CTCAT upstream-variant-2KB
rs1537670 -- 52,144,802(-) ATGAT(C/T)CAGTT downstream-variant-500B
rs2397080 -- 52,143,088(+) AGCCA(C/T)TGGAT upstream-variant-2KB
rs4266495 -- 52,143,173(+) GGTTT(C/T)TAAGC upstream-variant-2KB
rs6920648 -- 52,143,818(+) TTCCC(A/G)CAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR206 Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897
nsv522645 CNV Gain 19592680

Relevant External Links for MIR206 Gene

HapMap Linkage Disequilibrium report
MIR206
Human Gene Mutation Database (HGMD)
MIR206

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR206 Gene

Disorders for MIR206 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR206 Gene in MalaCards »

(1) Diseases for MIR206 Gene including...

Relevant External Links for MIR206

Genetic Association Database (GAD)
MIR206
Human Genome Epidemiology (HuGE) Navigator
MIR206
genes like me logo Genes that share disorders with MIR206: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR206 Gene

Publications for MIR206 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 48
  2. Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. (PMID: 20487562) Gambardella S. … Botta A. (J Transl Med 2010) 3
  3. microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. (PMID: 20519629) Roccaro A.M. … Ghobrial I.M. (Blood 2010) 3
  4. Circulating muscle-specific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcoma. (PMID: 20696132) Miyachi M. … Hosoi H. (Biochem. Biophys. Res. Commun. 2010) 3
  5. MicroRNA-206 is associated with invasion and metastasis of lung cancer. (PMID: 21157919) Wang X. … Zhao J. (Anat Rec (Hoboken) 2011) 3

Products for MIR206 Gene

Sources for MIR206 Gene

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