Subcategory (RNA class) for MIR206 Gene
Quality Score for this RNA gene is
External Ids for MIR206 Gene
Previous HGNC Symbols for MIR206 Gene
Previous GeneCards Identifiers for MIR206 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Disruption of the encoded miRNA has been implicated in multiple skeletal muscle disorders, including amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD), as well as in several cancers. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Aug 2017]
GeneCards Summary for MIR206 Gene
MIR206 (MicroRNA 206) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR206 include Duchenne Muscular Dystrophy and Muscle Disorders. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cancer.