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Aliases for MIR205 Gene

Subcategory (RNA class) for MIR205 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR205 Gene

  • MicroRNA 205 2 3
  • MIR205 Host Gene 5
  • Hsa-Mir-205 3
  • MIR205HG 5
  • Mir-205 3
  • MIRN205 3

External Ids for MIR205 Gene

Previous HGNC Symbols for MIR205 Gene

  • MIRN205

Previous GeneCards Identifiers for MIR205 Gene

  • GC01P207673
  • GC01P209605

Summaries for MIR205 Gene

Entrez Gene Summary for MIR205 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR205 Gene

MIR205 (MicroRNA 205) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR205 include Mir184 and Hereditary Hemorrhagic Telangiectasia. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR205 Gene

Genomics for MIR205 Gene

Regulatory Elements for MIR205 Gene

Enhancers for MIR205 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F209403 1.5 FANTOM5 Ensembl ENCODE 12 -23.7 -23721 3.7 CTCF BMI1 ZIC2 RAD21 ZNF366 SCRT2 PATZ1 SMC3 PRDM10 CREM MIR205 MIR205HG LAMB3 ENSG00000224260 IRF6 TFDP1P HSD11B1 LINC01698
GH01F209396 1.4 FANTOM5 Ensembl ENCODE 11.9 -30.2 -30177 4.0 MAX ZIC2 RFX5 YY1 ZNF316 ELK1 NFE2 MAFK TCF7L2 NFE2L2 MIR205 MIR205HG TFDP1P LAMB3 LINC01698
GH01F209382 1.3 FANTOM5 Ensembl ENCODE 11.7 -42.0 -42010 8.8 JUN BHLHE40 MCM5 CEBPB SIN3A ZNF704 EP300 GATA3 JUND SMARCA4 LAMB3 SERTAD4-AS1 MIR205 MIR205HG IRF6 TFDP1P LINC01698
GH01F209354 1 FANTOM5 Ensembl ENCODE 11.7 -73.0 -73034 3.5 CTCF TFAP4 WRNIP1 ZNF384 YBX1 PLRG1 RAD21 RFX5 ZNF316 GATA3 MIR205 MIR205HG TFDP1P ENSG00000224260 IRF6 LAMB3 LINC01698 LINC01696
GH01F209366 1.3 FANTOM5 Ensembl ENCODE 11.1 -59.8 -59776 5.1 SOX5 SOX13 ZNF316 JUND SIN3A FOS MAFK LAMB3 MIR205 MIR205HG ENSG00000224260 IRF6 LINC01698 HSD11B1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR205 on UCSC Golden Path with GeneCards custom track

Promoters for MIR205 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000552123 980 1601 CTCF ZNF654 ZBED1 SMC3 TRIM22 REST RAD21 MAFK

Genomic Location for MIR205 Gene

Chromosome:
1
Start:
209,428,820 bp from pter
End:
209,432,838 bp from pter
Size:
4,019 bases
Orientation:
Plus strand

Genomic View for MIR205 Gene

Genes around MIR205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR205 Gene

Proteins for MIR205 Gene

Post-translational modifications for MIR205 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR205 Gene

Domains & Families for MIR205 Gene

Gene Families for MIR205 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR205: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR205 Gene

Function for MIR205 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR205 Gene

Localization for MIR205 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR205 Gene

Pathways & Interactions for MIR205 Gene

SuperPathways for MIR205 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR205: view

Pathways by source for MIR205 Gene

1 KEGG pathway for MIR205 Gene

Interacting Proteins for MIR205 Gene

Gene Ontology (GO) - Biological Process for MIR205 Gene

None

No data available for SIGNOR curated interactions for MIR205 Gene

Transcripts for MIR205 Gene

mRNA/cDNA for MIR205 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR205 Gene

No ASD Table

Relevant External Links for MIR205 Gene

GeneLoc Exon Structure for
MIR205
ECgene alternative splicing isoforms for
MIR205

Expression for MIR205 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR205 Gene:

MIR205
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR205 Gene

Orthologs for MIR205 Gene

Evolution for MIR205 Gene

ENSEMBL:
Gene Tree for MIR205 (if available)
TreeFam:
Gene Tree for MIR205 (if available)

No data available for Orthologs for MIR205 Gene

Paralogs for MIR205 Gene

No data available for Paralogs for MIR205 Gene

Variants for MIR205 Gene

Sequence variations from dbSNP and Humsavar for MIR205 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1045735 -- 209,432,448(-) TGCGG(G/T)GCTTT downstream-variant-500B, utr-variant-3-prime
rs111433249 -- 209,432,277(+) ACCGC(C/T)GCCGC downstream-variant-500B, reference, synonymous-codon
rs111563613 -- 209,431,120(+) AGGTG(C/T)ATCTG intron-variant, upstream-variant-2KB
rs111792969 -- 209,432,693(+) GGCTG(A/G)GACAC downstream-variant-500B
rs112301138 -- 209,432,290(+) CCACC(A/C/G)TAGCA downstream-variant-500B, reference, missense

Relevant External Links for MIR205 Gene

Human Gene Mutation Database (HGMD)
MIR205
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR205 Gene

Disorders for MIR205 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR205 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mir184
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR205

Genetic Association Database (GAD)
MIR205
Human Genome Epidemiology (HuGE) Navigator
MIR205
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR205
genes like me logo Genes that share disorders with MIR205: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR205 Gene

Publications for MIR205 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. (PMID: 26230475) Yue X. … Wang J. (J. Neurosurg. 2016) 3 64
  3. MiR-205 functions as a tumor suppressor via targeting TGF-I+ in osteosarcoma. (PMID: 26708425) Yang G. … Wang G. (Exp. Mol. Pathol. 2016) 3 64
  4. MiR-205 suppresses autophagy and enhances radiosensitivity of prostate cancer cells by targeting TP53INP1. (PMID: 26813458) Wang W. … Wu Q. (Eur Rev Med Pharmacol Sci 2016) 3 64
  5. MiR-205 promotes proliferation, migration and invasion of nasopharyngeal carcinoma cells by activation of AKT signalling. (PMID: 26880795) Mao Y. … Deng Q. (J. Int. Med. Res. 2016) 3 64

Products for MIR205 Gene

Sources for MIR205 Gene

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