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Aliases for MIR204 Gene

Subcategory (RNA class) for MIR204 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR204 Gene

  • MicroRNA 204 2 3 5
  • Hsa-Mir-204 3
  • MiRNA204 3
  • Mir-204 3
  • MIRN204 3
  • RDICC 3

External Ids for MIR204 Gene

Previous HGNC Symbols for MIR204 Gene

  • MIRN204

Previous GeneCards Identifiers for MIR204 Gene

  • GC09M072615
  • GC09M073424

Summaries for MIR204 Gene

Entrez Gene Summary for MIR204 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR204 Gene

MIR204 (MicroRNA 204) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR204 include Retinal Dystrophy And Iris Coloboma With Or Without Cataract.

fRNAdb sequence ontologies for MIR204 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR204

Additional gene information for MIR204 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR204 Gene

Genomics for MIR204 Gene

Regulatory Elements for MIR204 Gene

Enhancers for MIR204 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H070868 0.6 ENCODE 10.9 -59.0 -59019 0 SCRT1 CBX8 JUND ZNF341 SCRT2 TRIM28 MIR204 PIGUP1
GH09H070789 0.3 FANTOM5 12.1 +20.5 20536 0 MIR204 TRPM3 PIR55506 ENSG00000223966
GH09H070901 0.8 Ensembl ENCODE 0.2 -92.6 -92580 2 JUND POLR2A JUN FOS FOXP2 TRPM3 PIGUP1 MIR204
GH09H070822 0.3 FANTOM5 0.4 -13.0 -12950 0 TRPM3 MIR204 PIGUP1
GH09H070902 0.4 ENCODE 0.2 -91.1 -91146 0 KLF1 PIGUP1 MIR204
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR204 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR204 Gene

Chromosome:
9
Start:
70,809,975 bp from pter
End:
70,810,084 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR204 Gene

Genes around MIR204 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR204 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR204 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR204 Gene

ORGUL Member Location for MIR204 Gene

ORGUL Member Location for MIR204 gene

Proteins for MIR204 Gene

Post-translational modifications for MIR204 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR204 Gene

Domains & Families for MIR204 Gene

Gene Families for MIR204 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR204: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR204 Gene

Function for MIR204 Gene

Gene Ontology (GO) - Molecular Function for MIR204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22982025
genes like me logo Genes that share ontologies with MIR204: view

Human Phenotype Ontology for MIR204 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR204
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR204 Gene

Localization for MIR204 Gene

Gene Ontology (GO) - Cellular Components for MIR204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR204: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR204 Gene

Pathways & Interactions for MIR204 Gene

SuperPathways for MIR204 Gene

No Data Available

Interacting Proteins for MIR204 Gene

Gene Ontology (GO) - Biological Process for MIR204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 22982025
GO:0060045 positive regulation of cardiac muscle cell proliferation ISS --
GO:2000727 positive regulation of cardiac muscle cell differentiation IMP 22982025
genes like me logo Genes that share ontologies with MIR204: view

No data available for Pathways by source and SIGNOR curated interactions for MIR204 Gene

Drugs & Compounds for MIR204 Gene

No Compound Related Data Available

Transcripts for MIR204 Gene

fRNAdb Secondary structures for MIR204 Gene

  • FR370744

mRNA/cDNA for MIR204 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR204
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR204 Gene

No ASD Table

Relevant External Links for MIR204 Gene

GeneLoc Exon Structure for
MIR204
ECgene alternative splicing isoforms for
MIR204

Expression for MIR204 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR204 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR204 Gene:

MIR204
genes like me logo Genes that share expression patterns with MIR204: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR204 Gene

Orthologs for MIR204 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR204 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-204 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir204 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-204 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-204 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-204-1 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-204a-2 34
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-204-1 34
  • 80 (a)
OneToOne
Species where no ortholog for MIR204 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR204 Gene

ENSEMBL:
Gene Tree for MIR204 (if available)
TreeFam:
Gene Tree for MIR204 (if available)

Paralogs for MIR204 Gene

No data available for Paralogs for MIR204 Gene

Variants for MIR204 Gene

Sequence variations from dbSNP and Humsavar for MIR204 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs767146880 Pathogenic 70,810,048(+) ACAAA(A/C/G)GGAAG intron-variant, nc-transcript-variant
rs1002227900 -- 70,811,819(+) TAAAA(G/T)AGGAA intron-variant, upstream-variant-2KB
rs1002580332 -- 70,811,490(+) TTATT(C/T)TCTTC intron-variant, upstream-variant-2KB
rs1003254442 -- 70,809,508(+) TTACC(A/G)TCGTG intron-variant, downstream-variant-500B
rs1004541112 -- 70,810,465(+) CCACG(C/T)TCCTC intron-variant, upstream-variant-2KB

Relevant External Links for MIR204 Gene

Human Gene Mutation Database (HGMD)
MIR204
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR204

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR204 Gene

Disorders for MIR204 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR204 Gene - From: OMIM, ClinVar, and GeneTests

Disorder Aliases PubMed IDs
retinal dystrophy and iris coloboma with or without cataract
  • retinal dystrophy and iris coloboma with or without congenital cataract
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR204

Human Genome Epidemiology (HuGE) Navigator
MIR204
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR204
genes like me logo Genes that share disorders with MIR204: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR204 Gene

Publications for MIR204 Gene

  1. MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer. (PMID: 28675122) Wang Y … Zhang Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma. (PMID: 28746200) Luo YH … Cao J (Medicine 2017) 3 60
  3. The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1. (PMID: 28720061) Hou Z … Liu S (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. (PMID: 28133610) Yuan X … Xu AM (BioMed research international 2017) 3 60
  5. Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer. (PMID: 28050800) Todorova K … Hayrabedyan S (Hormones & cancer 2017) 3 60

Products for MIR204 Gene

Sources for MIR204 Gene

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