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Aliases for MIR203B Gene

Subcategory (RNA class) for MIR203B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR203B Gene

  • MicroRNA 203b 2 3 5
  • MicroRNA 3545 2 3
  • Hsa-Mir-203b 3
  • Hsa-Mir-3545 3
  • MIR3545 3

External Ids for MIR203B Gene

Previous HGNC Symbols for MIR203B Gene

  • MIR3545

Previous GeneCards Identifiers for MIR203B Gene

  • GC14M104588

Summaries for MIR203B Gene

Entrez Gene Summary for MIR203B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR203B Gene

MIR203B (MicroRNA 203b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR203B Gene

Genomics for MIR203B Gene

Regulatory Elements for MIR203B Gene

Enhancers for MIR203B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G104134 0.8 ENCODE 0.4 -17.8 -17757 1.2 CTCF ZNF777 SUZ12 ZIC2 RAD21 ZFHX2 GLIS2 POLR2A RBAK ZBTB48 ENSG00000258748 MIR203B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR203B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR203B Gene

Chromosome:
14
Start:
104,117,418 bp from pter
End:
104,117,503 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR203B Gene

Genes around MIR203B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR203B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR203B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR203B Gene

ORGUL Member Location for MIR203B Gene

ORGUL Member Location for MIR203B gene

Proteins for MIR203B Gene

Post-translational modifications for MIR203B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR203B Gene

Domains & Families for MIR203B Gene

Gene Families for MIR203B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR203B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR203B Gene

Function for MIR203B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203B Gene

Localization for MIR203B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR203B Gene

Pathways & Interactions for MIR203B Gene

SuperPathways for MIR203B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR203B: view

Pathways by source for MIR203B Gene

1 KEGG pathway for MIR203B Gene

Interacting Proteins for MIR203B Gene

Gene Ontology (GO) - Biological Process for MIR203B Gene

None

No data available for SIGNOR curated interactions for MIR203B Gene

Drugs & Compounds for MIR203B Gene

No Compound Related Data Available

Transcripts for MIR203B Gene

mRNA/cDNA for MIR203B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR203B Gene

No ASD Table

Relevant External Links for MIR203B Gene

GeneLoc Exon Structure for
MIR203B
ECgene alternative splicing isoforms for
MIR203B

Expression for MIR203B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR203B Gene:

MIR203B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR203B Gene

Orthologs for MIR203B Gene

Evolution for MIR203B Gene

ENSEMBL:
Gene Tree for MIR203B (if available)
TreeFam:
Gene Tree for MIR203B (if available)

No data available for Orthologs for MIR203B Gene

Paralogs for MIR203B Gene

No data available for Paralogs for MIR203B Gene

Variants for MIR203B Gene

Sequence variations from dbSNP and Humsavar for MIR203B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000547842 -- 104,117,991(+) CTCCC(C/T)GGAGC downstream-variant-500B, upstream-variant-2KB
rs1001562153 -- 104,118,212(+) GCGCG(A/T)CAATC upstream-variant-2KB
rs1006192963 -- 104,117,572(+) GCGAC(C/T)AATCC downstream-variant-500B, upstream-variant-2KB
rs1006225359 -- 104,117,872(+) GGAAC(C/T)GGCGG downstream-variant-500B, upstream-variant-2KB
rs1006355502 -- 104,118,404(+) CTGGG(A/G)GATGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR203B Gene

Variant ID Type Subtype PubMed ID
esv3635614 CNV gain 21293372
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv827072 CNV gain 20364138
nsv952262 CNV deletion 24416366

Relevant External Links for MIR203B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR203B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR203B Gene

Disorders for MIR203B Gene

Relevant External Links for MIR203B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR203B

No disorders were found for MIR203B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR203B Gene

Publications for MIR203B Gene

  1. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J. … Ries C. (Toxicol. Lett. 2016) 3 64
  2. Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. (PMID: 27791400) Liu W. … Guo W. (Cancer Invest. 2016) 3 64
  3. miR-203 inhibition of renal cancer cell proliferation, migration and invasion by targeting of FGF2. (PMID: 25890121) Xu M. … Da J. (Diagn Pathol 2015) 3 64
  4. Ectopic expressed miR-203 contributes to chronic obstructive pulmonary disease via targeting TAK1 and PIK3CA. (PMID: 26617776) Shi L. … Ma Z. (Int J Clin Exp Pathol 2015) 3 64
  5. Potential roles of EZH2, Bmi-1 and miR-203 in cell proliferation and invasion in hepatocellular carcinoma cell line Hep3B. (PMID: 26715809) Yang F. … Jiang Y. (World J. Gastroenterol. 2015) 3 64

Products for MIR203B Gene

Sources for MIR203B Gene

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