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Aliases for MIR203A Gene

Subcategory (RNA class) for MIR203A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR203A Gene

  • MicroRNA 203a 2 3 5
  • MicroRNA 203 2 3
  • Hsa-Mir-203a 3
  • Hsa-Mir-203 3
  • MiRNA203 3
  • Mir-203a 3
  • MiR-203 3
  • MIRN203 3
  • MIR203 3

External Ids for MIR203A Gene

ORGUL Members for MIR203A Gene

Previous HGNC Symbols for MIR203A Gene

  • MIRN203
  • MIR203

Previous GeneCards Identifiers for MIR203A Gene

  • GC14P104585

Summaries for MIR203A Gene

Entrez Gene Summary for MIR203A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR203A Gene

MIR203A (MicroRNA 203a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and DNA damage response.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR203A Gene

Genomics for MIR203A Gene

Regulatory Elements for MIR203A Gene


Promoters for MIR203A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001792749 -605 801 SIN3A ZNF766 GATA2 ELK1 FOS ZBTB11 USF2 REST NR2F2 MEF2D

Genomic Location for MIR203A Gene

Chromosome:
14
Start:
104,117,405 bp from pter
End:
104,117,514 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR203A Gene

Genes around MIR203A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR203A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR203A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR203A Gene

Proteins for MIR203A Gene

Post-translational modifications for MIR203A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR203A Gene

Domains & Families for MIR203A Gene

Gene Families for MIR203A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR203A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR203A Gene

Function for MIR203A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR203A Gene

Localization for MIR203A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR203A Gene

Pathways & Interactions for MIR203A Gene

genes like me logo Genes that share pathways with MIR203A: view

Pathways by source for MIR203A Gene

2 BioSystems pathways for MIR203A Gene
1 KEGG pathway for MIR203A Gene

Interacting Proteins for MIR203A Gene

Gene Ontology (GO) - Biological Process for MIR203A Gene

None

No data available for SIGNOR curated interactions for MIR203A Gene

Transcripts for MIR203A Gene

mRNA/cDNA for MIR203A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR203A Gene

No ASD Table

Relevant External Links for MIR203A Gene

GeneLoc Exon Structure for
MIR203A
ECgene alternative splicing isoforms for
MIR203A

Expression for MIR203A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR203A Gene

mRNA differential expression in normal tissues according to GTEx for MIR203A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x17.6), Skin - Not Sun Exposed (Suprapubic) (x17.1), and Esophagus - Mucosa (x11.8).

NURSA nuclear receptor signaling pathways regulating expression of MIR203A Gene:

MIR203A
genes like me logo Genes that share expression patterns with MIR203A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR203A Gene

Orthologs for MIR203A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR203A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-203 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-203 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir203 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-203 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-203 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-203 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-203b 35
  • 72 (a)
OneToMany
dre-mir-203a 35
  • 71 (a)
OneToMany
Species where no ortholog for MIR203A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR203A Gene

ENSEMBL:
Gene Tree for MIR203A (if available)
TreeFam:
Gene Tree for MIR203A (if available)

Paralogs for MIR203A Gene

No data available for Paralogs for MIR203A Gene

Variants for MIR203A Gene

Sequence variations from dbSNP and Humsavar for MIR203A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs139042166 -- 104,117,992(+) TCCCC(A/G)GAGCG downstream-variant-500B, upstream-variant-2KB
rs141491119 -- 104,115,806(+) CAAGC(C/T)CCTGT upstream-variant-2KB
rs146176986 -- 104,117,975(+) TGGTT(C/T)CCGCT downstream-variant-500B, upstream-variant-2KB
rs182049888 -- 104,117,585(+) GGGAG(C/G)CCACG downstream-variant-500B, upstream-variant-2KB
rs183789316 -- 104,116,282(+) GAAGG(A/G)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR203A Gene

Variant ID Type Subtype PubMed ID
esv3635614 CNV gain 21293372
nsv1050479 CNV gain 25217958
nsv1054574 CNV loss 25217958
nsv470674 CNV loss 18288195
nsv519605 CNV loss 19592680
nsv566029 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv827072 CNV gain 20364138
nsv952262 CNV deletion 24416366

Relevant External Links for MIR203A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR203A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR203A Gene

Disorders for MIR203A Gene

Relevant External Links for MIR203A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR203A

No disorders were found for MIR203A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR203A Gene

Publications for MIR203A Gene

  1. miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. (PMID: 26179263) Wan D. … Peng B. (Anticancer Agents Med Chem 2016) 3 64
  2. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia. (PMID: 26383628) Deppe J. … Ries C. (Toxicol. Lett. 2016) 3 64
  3. Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion. (PMID: 26567912) Fite K. … Gomez-Cambronero J. (J. Biol. Chem. 2016) 3 64
  4. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer. (PMID: 26882562) Obayashi M. … Takata T. (Oncotarget 2016) 3 64
  5. MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. (PMID: 26980572) Chu S.J. … Zhu J.S. (J. Exp. Clin. Cancer Res. 2016) 3 64

Products for MIR203A Gene

Sources for MIR203A Gene

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