Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR200C Gene

Subcategory (RNA class) for MIR200C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR200C Gene

  • MicroRNA 200c 2 3 5
  • Hsa-Mir-200c 3
  • Mir-200c 3
  • MIRN200C 3

External Ids for MIR200C Gene

ORGUL Members for MIR200C Gene

Previous HGNC Symbols for MIR200C Gene

  • MIRN200C

Previous GeneCards Identifiers for MIR200C Gene

  • GC12P006971
  • GC12P006974
  • GC12P007072
  • GC12P007027
  • GC12P007176
  • GC12P007219
  • GC12P007270
  • GC12P007325
  • GC12P007369

Summaries for MIR200C Gene

Entrez Gene Summary for MIR200C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200C Gene

MIR200C (MicroRNA 200c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Additional gene information for MIR200C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200C Gene

Genomics for MIR200C Gene

Regulatory Elements for MIR200C Gene

Enhancers for MIR200C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006923 1.7 FANTOM5 ENCODE dbSUPER 11.8 -36.5 -36549 6 HDGF ARID4B SIN3A ZNF2 YY1 ZNF143 FOS DEK PAF1 SP3 ZNF384 CHD4 ENSG00000219410 LRRC23 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5 NCAPD2
GH12H006930 0.2 dbSUPER 11.8 -32.6 -32642 0 MIR200C MIR200CHG MIR141 SCARNA12 PHB2 EMG1 SPSB2 LRRC23 RPL13P5 TPI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR200C on UCSC Golden Path with GeneCards custom track

Promoters for MIR200C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048377 -199 1001 GTF2F1 NFIB SIN3A RELA HIC1 POLR2A MAZ ZNF740 NFIA NRF1

Genomic Location for MIR200C Gene

Chromosome:
12
Start:
6,963,699 bp from pter
End:
6,963,766 bp from pter
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR200C Gene

Genes around MIR200C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200C Gene

Proteins for MIR200C Gene

Post-translational modifications for MIR200C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200C Gene

Domains & Families for MIR200C Gene

Gene Families for MIR200C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200C Gene

Function for MIR200C Gene

Gene Ontology (GO) - Molecular Function for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23765923
genes like me logo Genes that share ontologies with MIR200C: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR200C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200C Gene

Localization for MIR200C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR200C Gene

Pathways & Interactions for MIR200C Gene

genes like me logo Genes that share pathways with MIR200C: view

Pathways by source for MIR200C Gene

1 BioSystems pathway for MIR200C Gene
1 KEGG pathway for MIR200C Gene

Interacting Proteins for MIR200C Gene

Gene Ontology (GO) - Biological Process for MIR200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23765923
GO:0045603 positive regulation of endothelial cell differentiation IDA 23765923
GO:1905562 NOT regulation of vascular endothelial cell proliferation IDA 23765923
GO:1905772 positive regulation of mesodermal cell differentiation IDA 23765923
genes like me logo Genes that share ontologies with MIR200C: view

No data available for SIGNOR curated interactions for MIR200C Gene

Drugs & Compounds for MIR200C Gene

No Compound Related Data Available

Transcripts for MIR200C Gene

mRNA/cDNA for MIR200C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR200C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200C Gene

No ASD Table

Relevant External Links for MIR200C Gene

GeneLoc Exon Structure for
MIR200C
ECgene alternative splicing isoforms for
MIR200C

Expression for MIR200C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR200C Gene:

MIR200C
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR200C Gene

Orthologs for MIR200C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-200c 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200c 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200c 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-200c 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200c 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200c 34
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 34
  • 44 (a)
OneToMany
Species where no ortholog for MIR200C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200C Gene

ENSEMBL:
Gene Tree for MIR200C (if available)
TreeFam:
Gene Tree for MIR200C (if available)

Paralogs for MIR200C Gene

No data available for Paralogs for MIR200C Gene

Variants for MIR200C Gene

Sequence variations from dbSNP and Humsavar for MIR200C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001110105 -- 6,963,829(+) GCAGC(A/C)CCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001273984 -- 6,964,080(+) AGCGC(A/G)CACCG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001417130 -- 6,963,487(+) GCCGA(C/T)GGTCG intron-variant, upstream-variant-2KB
rs1005625574 -- 6,963,031(+) CTAGG(C/T)AGGTT nc-transcript-variant, upstream-variant-2KB
rs1005677858 -- 6,963,176(+) TGTGC(G/T)CAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR200C Gene

Variant ID Type Subtype PubMed ID
nsv1035811 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv509453 CNV insertion 20534489

Relevant External Links for MIR200C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200C Gene

Disorders for MIR200C Gene

Relevant External Links for MIR200C

Genetic Association Database (GAD)
MIR200C
Human Genome Epidemiology (HuGE) Navigator
MIR200C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR200C

No disorders were found for MIR200C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR200C Gene

Publications for MIR200C Gene

  1. Epigenetic silencing of miR-200c in breast cancer is associated with aggressiveness and is modulated by ZEB1. (PMID: 27717206) Damiano V … Santarosa M (Genes, chromosomes & cancer 2017) 3 60
  2. MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN. (PMID: 28459373) Zhang ZZ … Zhang W (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. (PMID: 26400206) Huang CC … Lee WH (Biotechnology and applied biochemistry 2017) 3 60
  4. Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). (PMID: 28163188) Pan Q … Wang R (Cancer letters 2017) 3 60
  5. MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells. (PMID: 28113080) Zhang H … Jiang H (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 60

Products for MIR200C Gene

Sources for MIR200C Gene

Content
Loading form....