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Aliases for MIR200B Gene

Subcategory (RNA class) for MIR200B Gene


Quality Score for this RNA gene is


Aliases for MIR200B Gene

  • MicroRNA 200b 2 3 5
  • Hsa-Mir-200b 3
  • Mir-200b 3
  • MIRN200B 3

External Ids for MIR200B Gene

ORGUL Members for MIR200B Gene

Previous HGNC Symbols for MIR200B Gene

  • MIRN200B

Previous GeneCards Identifiers for MIR200B Gene

  • GC01P001100
  • GC01P001103
  • GC01P001106
  • GC01P001114
  • GC01P001127

Summaries for MIR200B Gene

Entrez Gene Summary for MIR200B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200B Gene

MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200B Gene

Genomics for MIR200B Gene

Genomic Location for MIR200B Gene

1,167,092 bp from pter
1,167,202 bp from pter
111 bases
Plus strand

Genomic View for MIR200B Gene

Genes around MIR200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200B Gene

No data available for Regulatory Elements for MIR200B Gene

Proteins for MIR200B Gene

Post-translational modifications for MIR200B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200B Gene

Domains & Families for MIR200B Gene

Gene Families for MIR200B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200B Gene

Function for MIR200B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200B Gene

Localization for MIR200B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR200B Gene

Pathways & Interactions for MIR200B Gene

SuperPathways for MIR200B Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR200B: view

Pathways by source for MIR200B Gene

1 KEGG pathway for MIR200B Gene

Interacting Proteins for MIR200B Gene

Gene Ontology (GO) - Biological Process for MIR200B Gene


No data available for SIGNOR curated interactions for MIR200B Gene

Drugs & Compounds for MIR200B Gene

No Compound Related Data Available

Transcripts for MIR200B Gene

mRNA/cDNA for MIR200B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200B Gene

No ASD Table

Relevant External Links for MIR200B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR200B Gene

mRNA expression in normal human tissues for MIR200B Gene

genes like me logo Genes that share expression patterns with MIR200B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR200B Gene

Orthologs for MIR200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-200b 36
  • 97 (a)
(Canis familiaris)
Mammalia cfa-mir-200b 36
  • 85 (a)
(Monodelphis domestica)
Mammalia mdo-mir-200b 36
  • 84 (a)
(Mus musculus)
Mammalia Mir200b 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-200b 36
  • 62 (a)
(Gallus gallus)
Aves gga-mir-200b 36
  • 67 (a)
(Anolis carolinensis)
Reptilia aca-mir-200b 36
  • 70 (a)
(Danio rerio)
Actinopterygii dre-mir-200b 36
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 36
  • 55 (a)
Species with no ortholog for MIR200B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200B Gene

Gene Tree for MIR200B (if available)
Gene Tree for MIR200B (if available)

Paralogs for MIR200B Gene

No data available for Paralogs for MIR200B Gene

Variants for MIR200B Gene

Sequence variations from dbSNP and Humsavar for MIR200B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7549819 -- 1,165,623(+) CCGTC(C/T)GCCGG upstream-variant-2KB
rs76791193 -- 1,165,477(+) CTCCC(A/G)GGTGA upstream-variant-2KB
rs79776491 -- 1,165,144(+) AGGTC(C/T)GTTTT upstream-variant-2KB
rs111627814 -- 1,165,253(+) AATCC(C/T)TGGTC upstream-variant-2KB
rs117646111 -- 1,165,319(+) GGGTC(A/G)GCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR200B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR200B Gene

Disorders for MIR200B Gene

Relevant External Links for MIR200B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR200B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR200B Gene

Publications for MIR200B Gene

  1. 53BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer. (PMID: 26011542) Kong X. … Yang Q. (Cancer Sci. 2015) 3 67
  2. Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer. (PMID: 25411357) Kurashige J. … Mimori K. (Carcinogenesis 2015) 3
  3. Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-I^1/ZEB/miR-200 signaling network. (PMID: 25422078) Shen A. … Peng J. (Int. J. Oncol. 2015) 3
  4. Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia. (PMID: 25563880) Pereira-Terra P. … Keijzer R. (Ann. Surg. 2015) 3
  5. MiR-200b expression in breast cancer: a prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. (PMID: 25639535) Yao Y. … Yue L. (J. Cell. Mol. Med. 2015) 3

Products for MIR200B Gene

Sources for MIR200B Gene