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Aliases for MIR200B Gene

Subcategory (RNA class) for MIR200B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR200B Gene

  • MicroRNA 200b 2 3
  • MIRN200B 3 6
  • Hsa-Mir-200b 3

External Ids for MIR200B Gene

ORGUL Members for MIR200B Gene

Previous HGNC Symbols for MIR200B Gene

  • MIRN200B

Previous GeneCards Identifiers for MIR200B Gene

  • GC01P001100
  • GC01P001103
  • GC01P001106
  • GC01P001114
  • GC01P001127

Summaries for MIR200B Gene

Entrez Gene Summary for MIR200B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200B Gene

MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR200B include endometrial adenocarcinoma. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200B Gene

Genomics for MIR200B Gene

Genomic Location for MIR200B Gene

Start:
1,167,092 bp from pter
End:
1,167,202 bp from pter
Size:
111 bases
Orientation:
Plus strand

Genomic View for MIR200B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200B Gene

No data available for Regulatory Elements for MIR200B Gene

Proteins for MIR200B Gene

Post-translational modifications for MIR200B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200B Gene

Domains for MIR200B Gene

Gene Families for MIR200B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200B Gene

Function for MIR200B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR200B Gene

Localization for MIR200B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR200B Gene

Pathways for MIR200B Gene

SuperPathways for MIR200B Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR200B: view

Pathways by source for MIR200B Gene

1 KEGG pathway for MIR200B Gene

Interacting Proteins for MIR200B Gene

Gene Ontology (GO) - Biological Process for MIR200B Gene

None

Transcripts for MIR200B Gene

mRNA/cDNA for MIR200B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR200B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200B Gene

No ASD Table

Relevant External Links for MIR200B Gene

GeneLoc Exon Structure for
MIR200B
ECgene alternative splicing isoforms for
MIR200B

Expression for MIR200B Gene

mRNA expression in normal human tissues for MIR200B Gene

genes like me logo Genes that share expressions with MIR200B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR200B Gene

Orthologs for MIR200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-200b 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200b 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200b 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200b 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200b 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-200b 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-200b 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200b 36
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 36
  • 55 (a)
OneToMany
Species with no ortholog for MIR200B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200B Gene

ENSEMBL:
Gene Tree for MIR200B (if available)
TreeFam:
Gene Tree for MIR200B (if available)

Paralogs for MIR200B Gene

No data available for Paralogs for MIR200B Gene

Variants for MIR200B Gene

Sequence variations from dbSNP and Humsavar for MIR200B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7549819 -- 1,165,623(+) CCGTC(C/T)GCCGG upstream-variant-2KB
rs76791193 -- 1,165,477(+) CTCCC(A/G)GGTGA upstream-variant-2KB
rs79776491 -- 1,165,144(+) AGGTC(C/T)GTTTT upstream-variant-2KB
rs111627814 -- 1,165,253(+) AATCC(C/T)TGGTC upstream-variant-2KB
rs117646111 -- 1,165,319(+) GGGTC(A/G)GCCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR200B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294

Relevant External Links for MIR200B Gene

HapMap Linkage Disequilibrium report
MIR200B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR200B Gene

Disorders for MIR200B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MIR200B Gene including...

Search for MIR200B Gene in MalaCards »
genes like me logo Genes that share disorders with MIR200B: view

No data available for UniProtKB/Swiss-Prot for MIR200B Gene

Publications for MIR200B Gene

  1. Computational and experimental identification of C. elegans microRNAs. (PMID: 12769849) Grad Y. … Kim J. (Mol. Cell 2003) 3
  2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  3. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. miR-200b mediates post-transcriptional repression of ZFHX1B. (PMID: 17585049) Christoffersen N.R. … Lund A.H. (RNA 2007) 3

Products for MIR200B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR200B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR200B
    • Block miRNA regulation of MIR200B using miScript Target Protectors

    Sources for MIR200B Gene

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