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Aliases for MIR200B Gene

Subcategory (RNA class) for MIR200B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR200B Gene

  • MicroRNA 200b 2 3 5
  • Hsa-Mir-200b 3
  • Mir-200b 3
  • MIRN200B 3

External Ids for MIR200B Gene

ORGUL Members for MIR200B Gene

Previous HGNC Symbols for MIR200B Gene

  • MIRN200B

Previous GeneCards Identifiers for MIR200B Gene

  • GC01P001100
  • GC01P001103
  • GC01P001106
  • GC01P001114
  • GC01P001127

Summaries for MIR200B Gene

Entrez Gene Summary for MIR200B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200B Gene

MIR200B (MicroRNA 200b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200B Gene

Genomics for MIR200B Gene

Regulatory Elements for MIR200B Gene

Enhancers for MIR200B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001189 0.6 FANTOM5 13.6 +22.3 22288 0.3 MLX ZFP64 ARID4B DMAP1 RAD21 THRB YY1 RARA GATA4 THAP11 SDF4 B3GALT6 MIR200A MIR200B MIR429 LINC01786 UBE2J2 FAM132A SLC35E2 TNFRSF18
GH01F001109 0.5 ENCODE 11.6 -57.2 -57246 1.1 HDAC1 PKNOX1 CBX3 ATF1 NFRKB ZBTB40 YY1 ZEB1 GATA2 CREM LINC01786 UBE2J2 MIR200A MIR200B MIR429 PERM1 PLEKHN1 ENSG00000239906 C1orf159 GC01M001107
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR200B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR200B Gene

Chromosome:
1
Start:
1,167,104 bp from pter
End:
1,167,198 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR200B Gene

Genes around MIR200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200B Gene

Proteins for MIR200B Gene

Post-translational modifications for MIR200B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200B Gene

Domains & Families for MIR200B Gene

Gene Families for MIR200B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR200B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR200B Gene

Function for MIR200B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR200B Gene

Localization for MIR200B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR200B Gene

Pathways & Interactions for MIR200B Gene

SuperPathways for MIR200B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR200B: view

Pathways by source for MIR200B Gene

1 KEGG pathway for MIR200B Gene

Interacting Proteins for MIR200B Gene

Gene Ontology (GO) - Biological Process for MIR200B Gene

None

No data available for SIGNOR curated interactions for MIR200B Gene

Transcripts for MIR200B Gene

mRNA/cDNA for MIR200B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200B Gene

No ASD Table

Relevant External Links for MIR200B Gene

GeneLoc Exon Structure for
MIR200B
ECgene alternative splicing isoforms for
MIR200B

Expression for MIR200B Gene

mRNA expression in normal human tissues for MIR200B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR200B Gene:

MIR200B
genes like me logo Genes that share expression patterns with MIR200B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR200B Gene

Orthologs for MIR200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-200b 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200b 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200b 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200b 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-200b 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-200b 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-200b 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-200b 35
  • 72 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 35
  • 55 (a)
OneToMany
Species where no ortholog for MIR200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR200B Gene

ENSEMBL:
Gene Tree for MIR200B (if available)
TreeFam:
Gene Tree for MIR200B (if available)

Paralogs for MIR200B Gene

No data available for Paralogs for MIR200B Gene

Variants for MIR200B Gene

Sequence variations from dbSNP and Humsavar for MIR200B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111233725 -- 1,166,160(+) CCAGT(G/T)GGCAC upstream-variant-2KB
rs111627814 -- 1,165,253(+) AATCC(C/T)TGGTC upstream-variant-2KB
rs11260534 -- 1,166,992(+) CACCC(A/G)GGCCC upstream-variant-2KB
rs112823253 -- 1,166,860(+) CAGAG(A/G)GCCCG upstream-variant-2KB
rs113882248 -- 1,166,916(+) CTTCG(A/G)CCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR200B Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509257 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544954 CNV loss 21841781
nsv950452 CNV deletion 24416366

Relevant External Links for MIR200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR200B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR200B Gene

Disorders for MIR200B Gene

Relevant External Links for MIR200B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR200B

No disorders were found for MIR200B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR200B Gene

Publications for MIR200B Gene

  1. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. (PMID: 25798833) Kundu S.T. … Gibbons D.L. (Oncogene 2016) 3 64
  2. GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. (PMID: 26887977) Chung V.Y. … Huang R.Y. (Sci Rep 2016) 3 64
  3. miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells. (PMID: 26783187) Nishijima N. … Gemma A. (Int. J. Oncol. 2016) 3 64
  4. MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2. (PMID: 26648487) Li J. … Liu J. (Int. J. Oncol. 2016) 3 64
  5. Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-I^1/ZEB/miR-200 signaling network. (PMID: 25422078) Shen A. … Peng J. (Int. J. Oncol. 2015) 3 64

Products for MIR200B Gene

Sources for MIR200B Gene

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