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Aliases for MIR200A Gene

Subcategory (RNA class) for MIR200A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR200A Gene

  • MicroRNA 200a 2 3
  • MIRN200A 3 6
  • Hsa-Mir-200a 3

External Ids for MIR200A Gene

ORGUL Members for MIR200A Gene

Previous Symbols for MIR200A Gene

  • MIRN200A

Summaries for MIR200A Gene

Entrez Gene Summary for MIR200A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR200A Gene

MIR200A (MicroRNA 200a) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR200A include gastric adenocarcinoma and renal cell carcinoma. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR200A Gene

Genomics for MIR200A Gene

Genomic Location for MIR200A Gene

Start:
1,167,846 bp from pter
End:
1,167,956 bp from pter
Size:
111 bases
Orientation:
Plus strand

Genomic View for MIR200A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR200A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR200A Gene

No data available for Regulatory Elements for MIR200A Gene

Proteins for MIR200A Gene

Post-translational modifications for MIR200A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR200A Gene

Domains for MIR200A Gene

Gene Families for MIR200A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR200A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR200A Gene

Function for MIR200A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR200A Gene

Localization for MIR200A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR200A Gene

Pathways for MIR200A Gene

SuperPathways for MIR200A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR200A: view

Pathways by source for MIR200A Gene

1 KEGG pathway for MIR200A Gene

Interacting Proteins for MIR200A Gene

Gene Ontology (GO) - Biological Process for MIR200A Gene

None

Transcripts for MIR200A Gene

mRNA/cDNA for MIR200A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR200A Gene

No ASD Table

Relevant External Links for MIR200A Gene

GeneLoc Exon Structure for
MIR200A
ECgene alternative splicing isoforms for
MIR200A

Expression for MIR200A Gene

mRNA expression in normal human tissues for MIR200A Gene

genes like me logo Genes that share expressions with MIR200A: view

Orthologs for MIR200A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR200A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-200a 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-200a 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-200a 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir200a 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-200a 37
  • 79 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-141 37
  • 56 (a)
OneToMany
Species with no ortholog for MIR200A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR200A Gene

ENSEMBL:
Gene Tree for MIR200A (if available)
TreeFam:
Gene Tree for MIR200A (if available)

Paralogs for MIR200A Gene

No data available for Paralogs for MIR200A Gene

Variants for MIR200A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR200A Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
dgv18n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
nsv509257 CNV Insertion 20534489
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
nsv871079 CNV Loss 21882294
dgv22n71 CNV Loss 21882294
esv2744807 CNV Deletion 23290073

Relevant External Links for MIR200A Gene

HapMap Linkage Disequilibrium report
MIR200A

No data available for Sequence variations from dbSNP and Humsavar for MIR200A Gene

Disorders for MIR200A Gene

Relevant External Links for MIR200A

Genetic Association Database (GAD)
MIR200A
Human Genome Epidemiology (HuGE) Navigator
MIR200A
genes like me logo Genes that share disorders with MIR200A: view

No data available for UniProtKB/Swiss-Prot for MIR200A Gene

Publications for MIR200A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. (PMID: 20473948) Wiklund E.D. … Clark S.J. (Int. J. Cancer 2011) 3
  3. miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. (PMID: 20514023) Uhlmann S. … Sahin O. (Oncogene 2010) 3
  4. Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. (PMID: 20551052) Li A. … Goggins M. (Cancer Res. 2010) 3
  5. miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling. (PMID: 20826811) Xia H. … Lin M.C. (J. Biol. Chem. 2010) 3

Products for MIR200A Gene

Sources for MIR200A Gene

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