Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR19B1 Gene

Subcategory (RNA class) for MIR19B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR19B1 Gene

  • MicroRNA 19b-1 2 3
  • MiR-17-92a-1 Cluster Host Gene 5
  • Hsa-Mir-19b-1 3
  • MicroRNA-19b 3
  • MiR-19b-1 3
  • MiRNA19B1 3
  • MIRN19B1 3
  • MIR17HG 5
  • MiR-19b 3
  • MIR19B 3

External Ids for MIR19B1 Gene

Previous HGNC Symbols for MIR19B1 Gene

  • MIRN19B1

Previous GeneCards Identifiers for MIR19B1 Gene

  • GC13P090873
  • GC13P090881
  • GC13P092011
  • GC13P092020
  • GC13P092027
  • GC13P092035
  • GC13P092044
  • GC13P092054
  • GC13P092063
  • GC13P092073
  • GC13P092082
  • GC13P091354
  • GC13P091359

Summaries for MIR19B1 Gene

Entrez Gene Summary for MIR19B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19B1 Gene

MIR19B1 (MicroRNA 19b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR19B1 Gene

Genomics for MIR19B1 Gene

Regulatory Elements for MIR19B1 Gene

Enhancers for MIR19B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F091346 1 ENCODE 0.8 +1.2 1213 4.8 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5 GPC5 GC13P091376 MIR92A1 MIR17 MIR17HG MIR18A MIR19A MIR19B1 MIR20A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR19B1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR19B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000667089 780 3601 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5

Genomic Location for MIR19B1 Gene

Chromosome:
13
Start:
91,347,820 bp from pter
End:
91,354,579 bp from pter
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR19B1 Gene

Genes around MIR19B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR19B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19B1 Gene

Proteins for MIR19B1 Gene

Post-translational modifications for MIR19B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19B1 Gene

Domains & Families for MIR19B1 Gene

Gene Families for MIR19B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR19B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR19B1 Gene

Function for MIR19B1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR19B1 Gene

Localization for MIR19B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR19B1 Gene

Pathways & Interactions for MIR19B1 Gene

genes like me logo Genes that share pathways with MIR19B1: view

Pathways by source for MIR19B1 Gene

1 KEGG pathway for MIR19B1 Gene

Interacting Proteins for MIR19B1 Gene

Gene Ontology (GO) - Biological Process for MIR19B1 Gene

None

No data available for SIGNOR curated interactions for MIR19B1 Gene

Transcripts for MIR19B1 Gene

mRNA/cDNA for MIR19B1 Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19B1 Gene

No ASD Table

Relevant External Links for MIR19B1 Gene

GeneLoc Exon Structure for
MIR19B1
ECgene alternative splicing isoforms for
MIR19B1

Expression for MIR19B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR19B1 Gene:

MIR19B1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR19B1 Gene

Orthologs for MIR19B1 Gene

Evolution for MIR19B1 Gene

ENSEMBL:
Gene Tree for MIR19B1 (if available)
TreeFam:
Gene Tree for MIR19B1 (if available)

No data available for Orthologs for MIR19B1 Gene

Paralogs for MIR19B1 Gene

No data available for Paralogs for MIR19B1 Gene

Variants for MIR19B1 Gene

Sequence variations from dbSNP and Humsavar for MIR19B1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112107109 -- 91,350,002(+) GTTTA(C/T)GAAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs113832160 -- 91,350,575(+) AGAAC(A/C)TCACC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs12865889 -- 91,350,726(+) GTGCA(G/T)GGCCT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs138661876 -- 91,349,698(+) TCCAG(A/C/T)CATAC nc-transcript-variant, upstream-variant-2KB
rs139418718 -- 91,351,555(+) GGTTG(C/T)GTGTC intron-variant, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR19B1 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Relevant External Links for MIR19B1 Gene

Human Gene Mutation Database (HGMD)
MIR19B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR19B1 Gene

Disorders for MIR19B1 Gene

Relevant External Links for MIR19B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR19B1

No disorders were found for MIR19B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR19B1 Gene

Publications for MIR19B1 Gene

  1. Angiomirs expression profiling in diffuse large B-Cell lymphoma. (PMID: 26683099) Borges N.M. … Colleoni G.W. (Oncotarget 2016) 3 64
  2. Circulating MiR-19b-3p, MiR-134-5p and MiR-186-5p are Promising Novel Biomarkers for Early Diagnosis of Acute Myocardial Infarction. (PMID: 26939053) Wang K.J. … Chen Z.J. (Cell. Physiol. Biochem. 2016) 3 64
  3. miR-19, a component of the oncogenic miR-17a8192 cluster, targets the DNA-end resection factor CtIP. (PMID: 25308476) HA1hn D. … Sartori A.A. (Oncogene 2015) 3 64
  4. miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells. (PMID: 25643913) Ohira T. … Kugoh H. (Sci Rep 2015) 3 64
  5. MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder. (PMID: 25675938) FernA!ndez-Santiago R. … Ezquerra M. (Ann. Neurol. 2015) 3 64

Products for MIR19B1 Gene

Sources for MIR19B1 Gene

Content
Loading form....