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Aliases for MIR19B1 Gene

Subcategory (RNA class) for MIR19B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR19B1 Gene

  • MicroRNA 19b-1 2 3 5
  • Putative MicroRNA 17 Host Gene Protein 3
  • Putative MicroRNA Host Gene 1 Protein 3
  • Hsa-Mir-19b-1 3
  • MicroRNA-19b 3
  • MiR-19b-1 3
  • MiRNA19B1 3
  • C13orf25 3
  • MIRN19B1 3
  • MIR17HG 3
  • MiR-19b 3
  • MIRHG1 3
  • MIR19B 3
  • MIRH1 3

External Ids for MIR19B1 Gene

Previous HGNC Symbols for MIR19B1 Gene

  • MIRN19B1

Previous GeneCards Identifiers for MIR19B1 Gene

  • GC13P090873
  • GC13P090881
  • GC13P092011
  • GC13P092020
  • GC13P092027
  • GC13P092035
  • GC13P092044
  • GC13P092054
  • GC13P092063
  • GC13P092073
  • GC13P092082
  • GC13P091354
  • GC13P091359
  • GC13P091365
  • GC13P091376

Summaries for MIR19B1 Gene

Entrez Gene Summary for MIR19B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR19B1 Gene

MIR19B1 (MicroRNA 19b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and DNA Damage Response.

Additional gene information for MIR19B1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR19B1 Gene

Genomics for MIR19B1 Gene

Genomic Location for MIR19B1 Gene

Chromosome:
13
Start:
91,351,192 bp from pter
End:
91,351,278 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR19B1 Gene

Genes around MIR19B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR19B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR19B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR19B1 Gene

No data available for Regulatory Elements for MIR19B1 Gene

Proteins for MIR19B1 Gene

Post-translational modifications for MIR19B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR19B1 Gene

Domains & Families for MIR19B1 Gene

Gene Families for MIR19B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR19B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR19B1 Gene

Function for MIR19B1 Gene

Gene Ontology (GO) - Molecular Function for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18728182
genes like me logo Genes that share ontologies with MIR19B1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR19B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR19B1 Gene

Localization for MIR19B1 Gene

Gene Ontology (GO) - Cellular Components for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
GO:0072562 blood microparticle IDA 24998411
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR19B1 Gene

Pathways & Interactions for MIR19B1 Gene

genes like me logo Genes that share pathways with MIR19B1: view

Pathways by source for MIR19B1 Gene

1 KEGG pathway for MIR19B1 Gene

Interacting Proteins for MIR19B1 Gene

Gene Ontology (GO) - Biological Process for MIR19B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation ISS --
GO:0010629 negative regulation of gene expression IDA 25765596
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0035195 gene silencing by miRNA IDA 18728182
GO:0035278 miRNA mediated inhibition of translation IDA 21796614
genes like me logo Genes that share ontologies with MIR19B1: view

No data available for SIGNOR curated interactions for MIR19B1 Gene

Drugs & Compounds for MIR19B1 Gene

No Compound Related Data Available

Transcripts for MIR19B1 Gene

mRNA/cDNA for MIR19B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR19B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR19B1 Gene

No ASD Table

Relevant External Links for MIR19B1 Gene

GeneLoc Exon Structure for
MIR19B1
ECgene alternative splicing isoforms for
MIR19B1

Expression for MIR19B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR19B1 Gene:

MIR19B1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR19B1 Gene

Orthologs for MIR19B1 Gene

Evolution for MIR19B1 Gene

ENSEMBL:
Gene Tree for MIR19B1 (if available)
TreeFam:
Gene Tree for MIR19B1 (if available)

No data available for Orthologs for MIR19B1 Gene

Paralogs for MIR19B1 Gene

No data available for Paralogs for MIR19B1 Gene

Variants for MIR19B1 Gene

Sequence variations from dbSNP and Humsavar for MIR19B1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1001980789 -- 91,351,489(+) AAAAT(A/G)TGTAA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002349918 -- 91,351,188(+) GTTAC(G/T)GAACA intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1002944928 -- 91,349,535(+) TATTG(A/G)GCTTT intron-variant, upstream-variant-2KB
rs1003385207 -- 91,349,835(+) GTTGA(A/G)TAAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1004434983 -- 91,349,440(+) ATCAT(A/T)ATCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR19B1 Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Relevant External Links for MIR19B1 Gene

Human Gene Mutation Database (HGMD)
MIR19B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR19B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR19B1 Gene

Disorders for MIR19B1 Gene

Relevant External Links for MIR19B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR19B1

No disorders were found for MIR19B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR19B1 Gene

Publications for MIR19B1 Gene

  1. Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. (PMID: 28364280) Gu Y … Chen X (Protein & cell 2017) 3 60
  2. Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. (PMID: 28091918) Osip'yants AI … Alekseev BY (Bulletin of experimental biology and medicine 2017) 3 60
  3. MicroRNA-19b Expression in Human Biliary Atresia Specimens and Its Role in BA-Related Fibrosis. (PMID: 28083843) Zhao D … Xia Q (Digestive diseases and sciences 2017) 3 60
  4. MicroRNA-19b Mediates Lung Epithelial-Mesenchymal Transition via Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase in Response to Mechanical Stretch. (PMID: 27508324) Mao P … Li Y (American journal of respiratory cell and molecular biology 2017) 3 60
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60

Products for MIR19B1 Gene

Sources for MIR19B1 Gene

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