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MIR19A Gene

RNA gene   GIFtS: 23
GCID: GC13P092081

MicroRNA 19a


(Previous symbol: MIRN19A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 10.4

Aliases
MicroRNA 19a1 2
MIRN19A1 2 5
hsa-mir-19a2
miR-19a2
miRNA19A2
mir-19a9

External Ids:    HGNC: 315741   Entrez Gene: 4069792   Ensembl: ENSG000002154177   OMIM: 6094185   
ORGUL members:    fRNAdb10:FR279683 FR360184 FR077146 FR262815 FR129211      
H-InvDB12: HIT000422028 HIT000484801 HIT000422027 HIT000422035 see all 8    
NCBI13:AB176708    
NONCODE14:n345746 n386735 n377774 n345232    
RNAdb15:EVF36612 EVF36611 RNZ10480 RNZ10479 LIT3364 see all 9    

Export aliases for MIR19A gene to outside databases

Previous GC identifers: GC13P090871 GC13P090879 GC13P092008 GC13P092017 GC13P092025 GC13P092033 GC13P092042 GC13P092052 GC13P092060 GC13P092070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR19A Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA belongs to a polycistronic
miRNA cluster that includes six consecutive mature miRNAs that are derived from a single primary transcript. The
mature miRNAs of this cluster are often overexpressed in solid cancers. (provided by RefSeq, May 2012)

GeneCards Summary for MIR19A Gene:
MIR19A (microRNA 19a) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MIR19A include hypoxia, and cervical cancer.



fRNAdb sequence ontologies for MIR19A - the ORGUL cluster for this gene includes several descriptions:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for MIR19A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR19A
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR19A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.3   Ensembl cytogenetic band:  13q31.3   HGNC cytogenetic band: 13q31.3

MIR19A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR19A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P092081:  view genomic region (via miRBase)     (about GC identifiers)

Start:
92,000,074 bp from pter      End:
92,006,833 bp from pter
Size:
6,760 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR19A

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MIR19A About    
See pathways by source

SuperPathContained pathways About
1miRNAs involved in DDR
miRNAs involved in DDR
2MicroRNAs in cancer
MicroRNAs in cancer

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MIR19A
    miRNAs involved in DDR


1 Kegg Pathway  (Kegg details for MIR19A):
    MicroRNAs in cancer


MIR19A for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR19A
Interactions:

    Search GeneGlobe Interaction Network for MIR19A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for MIR19A



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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5/7 fRNAdb Secondary structures (see all 7):


9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000582141(processed_transcript) ENST00000400282(processed_transcript) ENST00000581816(processed_transcript) ENST00000385012(processed_transcript) ENST00000362310(processed_transcript)
ENST00000384878(processed_transcript) ENST00000362279(processed_transcript) ENST00000384829(processed_transcript) ENST00000385233(processed_transcript)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR19A:RNAdb

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


MIR19A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical cord blood-derived endothelial progenitor cells
 
 Endothelium (Cardiovascular System)
         Umbilical cord blood-derived endothelial progenitor cells
MIR19A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MIR19A
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR19A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MIR19A (if available)
TreeFam Gene Tree for MIR19A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MIR19A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832679CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR19A
DNA2.0 Custom Variant and Variant Library Synthesis for MIR19A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609418OMIM information: 300037    
9 diseases for MIR19A:    
About MalaCards
hypoxia    cervical cancer    lymphoblastic leukemia    cervicitis
endotheliitis    leukemia    breast cancer    neuronitis
ovarian cancer


MIR19A for disorders           About GeneDecksing

Genetic Association Database (GAD): MIR19A
Human Genome Epidemiology (HuGE) Navigator: MIR19A (1 document)

Export disorders for MIR19A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR19A gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with MIR19A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PubMed id 20167074)1, 4 Shen J....Zhao H. (BMC Cancer 2010)
  2. MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. (PubMed id 23666757)1 Yu G....Tang J. (Mol. Cell. Biochem. 2013)
  3. miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. (PubMed id 23894411)1 Collins A.S....Stevenson N.J. (PLoS ONE 2013)
  4. Role of miR-19a targeting TNF-I+ in mediating ulcerative colitis. (PubMed id 23795660)1 Chen B....Liu F. (Scand. J. Gastroenterol. 2013)
  5. MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. (PubMed id 23603256)1 Wang F....Fan D. (Biochem. Biophys. Res. Commun. 2013)
  6. TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes. (PubMed id 22105995)1 Philippe L....Pfeffer S. (J. Immunol. 2012)
  7. Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approach. (PubMed id 22952885)1 Ouchida M....Shimizu K. (PLoS ONE 2012)
  8. MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. (PubMed id 22362744)1 Ye H....Guo A.Y. (Nucleic Acids Res. 2012)
  9. MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. (PubMed id 22561557)1 Xu X.M....Tang H. (Cancer Lett. 2012)
  10. Regulation of human lung alveolar multipotent cells by a novel p38I+ MAPK/miR-17-92 axis. (PubMed id 22828869)1 Oeztuerk-Winder F....Ventura J.J. (EMBO J. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 406979 HGNC: 31574 Ensembl:ENSG00000215417 miRBase: hsa-mir-19a euGenes: HUgn406979
ECgene: MIR19A Kegg: 406979 H-InvDB: MIR19A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR19A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR19A gene:
Search GeneIP for patents involving MIR19A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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