Aliases
for MIR19A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
|---|
| MicroRNA 19a1 2 | | MIRN19A1 2 5 | | Hsa-Mir-19a1 | | MiR-19a1 | | MiRNA19A1 | | Mir-19a1 |
| External Ids: | HGNC: 315741 | Entrez Gene: 4069792 | Ensembl: ENSG000002076107 | OMIM: 6094185 |
Export aliases for MIR19A gene to outside databasesPrevious GC identifers: GC13P090871 GC13P090879 GC13P092008 GC13P092017 GC13P092025 GC13P092033 GC13P092042 GC13P092052 GC13P092060 GC13P092070
|---|
Summaries
for MIR19A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR19A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. This miRNA belongs to a polycistronic miRNA cluster that includes sixconsecutive mature miRNAs that are derived from a single primary transcript. The mature miRNAs of this cluster areoften overexpressed in solid cancers. (provided by RefSeq, May 2012)
|
Genomic Views
for MIR19A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR19A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR19A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR19A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q31.3 Ensembl cytogenetic band: 13q31.3 HGNC cytogenetic band: 13q31.3MIR19A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P092081: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
92,003,145 bp from pter |
End:
|
92,003,226 bp from pter |
Size:
|
82 bases |
Orientation:
|
plus strand |
|
Proteins
for MIR19A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for MIR19A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR19A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
miRNA
Products: | | miRTarBase genes targeted by MIR19A:
SOCS1(MIRT004337), BMPR2(MIRT004934), PTEN(MIRT002958), ATXN1(MIRT003781), MECP2(MIRT001795), TGFBR2(MIRT004593), HOXA5(MIRT001794), ARIH2(MIRT005396), ESR1(MIRT003214), NR4A2(MIRT003536), KAT2B(MIRT004334), BCL2L11(MIRT004452), PRMT5(MIRT004350), ERBB4(MIRT003533), SMAD4(MIRT005630), CCND1(MIRT003426) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR19A | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR19A | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR19A | |  | Search LifeMap BioReagents cell lines for MIR19A |
Pathways & Interactions
for MIR19A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR19A
|
Drugs & Compounds
for MIR19A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR19A
Search CenterWatch for drugs/clinical trials and news about MIR19A 
|
Transcripts
for MIR19A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000384878(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR19A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR19A:none
MIR19A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR19A
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR19A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR19A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR19A |
Orthologs
for MIR19A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MIR19A (if available)
TreeFam Gene Tree for MIR19A (if available) |
Paralogs
for MIR19A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR19A gene
- MIR19B22 MIR19B12
MIR19A for paralogs About GeneDecksing
|
Genomic Variants
for MIR19A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MIR19A (92003145 - 92003226 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR19A: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MIR19A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIR19A for disorders About GeneDecksing
OMIM gene information: 609418
OMIM disorders: --
5  diseases for MIR19A: About MalaCardscervical cancer cervicitis breast cancer hypoxia
neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR19A (1 document)
Export disorders for MIR19A gene to outside databases
|
Publications
for MIR19A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIR19A gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MIR19A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TLR2 expression is regulated by microRNA miR-19 in rh eumatoid fibroblast-like synoviocytes. (PubMed id 22105995)1 Philippe L....Pfeffer S. (2012)
- Novel direct targets of miR-19a identified in breast c ancer cells by a quantitative proteomic approach. (PubMed id 22952885)1 Ouchida M....Shimizu K. (2012)
- MicroRNA and transcription factor co-regulatory networ k analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. (PubMed id 22362744)1 Ye H....Guo A.Y. (2012)
- MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. (PubMed id 22561557)1 Xu X.M....Tang H. (2012)
- Regulation of human lung alveolar multipotent cells by a novel p38a MAPK/miR-17-92 axis. (PubMed id 22828869)1 Oeztuerk-Winder F....Ventura J.J. (2012)
- MicroRNA-19 (miR-19) regulates tissue factor expressi on in breast cancer cells. (PubMed id 21059650)1 Zhang X....Ding W.Q. (2011)
- TNF-I+ is a novel target of miR-19a. (PubMed id 21271217)1 Liu M....Xu N. (2011)
- MicroRNA-dependent regulation of PTEN after arsenic t rioxide treatment in bladder cancer cell line T24. (PubMed id 20857258)1 Cao Y....An R.H. (2011)
- MicroRNA-19a mediates the suppressive effect of lamin ar flow on cyclin D1 expression in human umbilical vein endothelial cells. (PubMed id 20133739)1 Qin X....Wang N. (2010)
- Novel genetic variants in miR-191 gene and familial o varian cancer. (PubMed id 20167074)1 Shen J....Zhao H. (2010)
|
External Searches for MIR19A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIR19A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIR19A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR19A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR19A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MIR19A gene:
Search GeneIP for patents involving MIR19A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR19A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR19A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR19A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR19A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR19A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR19A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR19A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MIR19A |
| |  |  |  |  | | | | |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MIR19A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR19A |
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