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Aliases for MIR199B Gene

Subcategory (RNA class) for MIR199B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR199B Gene

  • MicroRNA 199b 2 3 5
  • Hsa-Mir-199b 3
  • Mir-199b 3
  • MIRN199B 3

External Ids for MIR199B Gene

Previous HGNC Symbols for MIR199B Gene

  • MIRN199B

Previous GeneCards Identifiers for MIR199B Gene

  • GC09M130047
  • GC09M131007

Summaries for MIR199B Gene

Entrez Gene Summary for MIR199B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199B Gene

MIR199B (MicroRNA 199b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR199B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR199B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199B Gene

Genomics for MIR199B Gene

Regulatory Elements for MIR199B Gene

Enhancers for MIR199B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G128222 0.5 dbSUPER 12.4 +22.2 22249 1.1 ZNF121 RUNX1 ZMYM3 KDM1A MIR199B C9orf16 LCN2 CIZ1 GC09M128212
GH09G128241 1.6 FANTOM5 Ensembl ENCODE 0.7 +0.5 504 5.7 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF121 GLIS2 SP3 MIER2 REST URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6 CERCAM CIZ1 ST6GALNAC4 PIP5KL1 FPGS
GH09G128232 0.7 ENCODE 0.4 +12.7 12724 0.2 SMARCA5 ZNF263 L3MBTL2 BHLHE40 USF2 MNT ZIC2 FOSL1 RAD51 CBX1 GC09M128212 MIR199B
GH09G128230 0.6 FANTOM5 0.4 +14.5 14503 0.1 KDM1A ZNF623 ZIC2 DNM1 CIZ1 C9orf16 LCN2 SLC25A25 SH2D3C ST6GALNAC6 SPTAN1 GC09M128212 MIR199B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR199B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR199B Gene

Chromosome:
9
Start:
128,244,721 bp from pter
End:
128,244,830 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR199B Gene

Genes around MIR199B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199B Gene

ORGUL Member Location for MIR199B Gene

ORGUL Member Location for MIR199B gene

Proteins for MIR199B Gene

Post-translational modifications for MIR199B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199B Gene

Domains & Families for MIR199B Gene

Gene Families for MIR199B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199B Gene

Function for MIR199B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199B Gene

Localization for MIR199B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR199B Gene

Pathways & Interactions for MIR199B Gene

genes like me logo Genes that share pathways with MIR199B: view

Pathways by source for MIR199B Gene

1 BioSystems pathway for MIR199B Gene
1 KEGG pathway for MIR199B Gene

Interacting Proteins for MIR199B Gene

Gene Ontology (GO) - Biological Process for MIR199B Gene

None

No data available for SIGNOR curated interactions for MIR199B Gene

Drugs & Compounds for MIR199B Gene

No Compound Related Data Available

Transcripts for MIR199B Gene

fRNAdb Secondary structures for MIR199B Gene

  • hsa-miR-199a-3p_MIMAT0000232_Homo_sapiens_miR-199a-3p_mature
  • hsa-miR-199b-3p_MIMAT0004563_Homo_sapiens_miR-199b-3p_mature

mRNA/cDNA for MIR199B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199B Gene

No ASD Table

Relevant External Links for MIR199B Gene

GeneLoc Exon Structure for
MIR199B
ECgene alternative splicing isoforms for
MIR199B

Expression for MIR199B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR199B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR199B Gene:

MIR199B
genes like me logo Genes that share expression patterns with MIR199B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199B Gene

Orthologs for MIR199B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-199-3 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-199b 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199b 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-1 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-199-1 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199b 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-3 35
  • 74 (a)
OneToOne
Species where no ortholog for MIR199B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199B Gene

ENSEMBL:
Gene Tree for MIR199B (if available)
TreeFam:
Gene Tree for MIR199B (if available)

Paralogs for MIR199B Gene

No data available for Paralogs for MIR199B Gene

Variants for MIR199B Gene

Sequence variations from dbSNP and Humsavar for MIR199B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001157151 -- 128,246,086(+) CTGCC(A/T)GAGGC intron-variant, upstream-variant-2KB
rs1005136838 -- 128,246,744(+) CCTTC(C/T)ATCCT intron-variant, upstream-variant-2KB
rs1006059034 -- 128,245,291(+) CGGGA(C/T)GACGC intron-variant, upstream-variant-2KB
rs1006141033 -- 128,245,475(+) CCTCC(C/G)TAGAT intron-variant, upstream-variant-2KB
rs1007121262 -- 128,244,473(+) TTGGG(A/G)TGAGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR199B Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897
nsv951772 CNV deletion 24416366

Relevant External Links for MIR199B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR199B Gene

Disorders for MIR199B Gene

Relevant External Links for MIR199B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR199B

No disorders were found for MIR199B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199B Gene

Publications for MIR199B Gene

  1. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 1 3 64
  3. Increased Expression of microRNA-199b-5p Associates with Poor Prognosis Through Promoting Cell Proliferation, Invasion and Migration Abilities of Human Osteosarcoma. (PMID: 26183062) Zeng H. … Jin Z. (Pathol. Oncol. Res. 2016) 3 64
  4. Down-regulation of miR-199b-5p is correlated with poor prognosis for breast cancer patients. (PMID: 27788476) Fang C. … Zeng X.T. (Biomed. Pharmacother. 2016) 3 64
  5. Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy. (PMID: 26813039) Kang W.L. … Xu G.S. (Sci Rep 2016) 3 64

Products for MIR199B Gene

Sources for MIR199B Gene

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