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Aliases for MIR199A2 Gene

Subcategory (RNA class) for MIR199A2 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR199A2 Gene

  • MicroRNA 199a-2 2 3 5
  • Hsa-Mir-199a-2 3
  • MiR-199a-3p 3
  • Mir-199a-2 3
  • MIR-199-S 3
  • MIRN199A2 3

External Ids for MIR199A2 Gene

Previous HGNC Symbols for MIR199A2 Gene

  • MIRN199A2

Previous GeneCards Identifiers for MIR199A2 Gene

  • GC01M170381
  • GC01M172181
  • GC01M172184
  • GC01M172190
  • GC01M172194
  • GC01M172199
  • GC01M172200

Summaries for MIR199A2 Gene

Entrez Gene Summary for MIR199A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A2 Gene

MIR199A2 (MicroRNA 199a-2) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR199A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A2 Gene

Genomics for MIR199A2 Gene

Regulatory Elements for MIR199A2 Gene

Enhancers for MIR199A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G172179 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -39.0 -39044 8.0 TBP TBL1XR1 SIN3A BMI1 RAD21 CBX5 FOS RELB IKZF2 CREM MIR199A2 DNM3OS RNU6-157P GC01P172160 GC01P172209
GH01G172455 1.2 ENCODE dbSUPER 12.9 -311.1 -311092 1.2 HDGF ATF1 TBL1XR1 ARNT TCF12 GATA2 SMARCA5 CAVIN1 ZBTB2 ZBTB11 MIR199A2 C1orf105 SUCO PFN1P1 DNM3 PIGC LOC102724528
GH01G172486 1 dbSUPER 12.9 -343.2 -343181 2.5 HDGF PKNOX1 ATF1 TCF12 ZNF766 GATA2 CAVIN1 ZNF592 MEF2D CREB3 MIR199A2 PIGC C1orf105 PFN1P1 LOC102724528 SUCO
GH01G172456 1 dbSUPER 12.9 -311.9 -311851 0.1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 CAVIN1 NCOA1 ZNF592 MIR199A2 C1orf105 PFN1P1 LOC102724528 SUCO
GH01G172210 0.8 ENCODE 10.6 -66.8 -66751 2.7 SIN3A RAD21 ZBTB40 GATA3 ARID3A RELB CREM IKZF2 MTA2 CBFB DNM3OS MIR199A2 GC01P172209 GC01P172216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR199A2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR199A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015759 1443 4400 TAF1 JUN SIN3A RAD21 ZFHX2 ZNF366 POLR2A EGR2 ZNF680 ZNF398

Genomic Location for MIR199A2 Gene

Chromosome:
1
Start:
172,144,535 bp from pter
End:
172,144,644 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR199A2 Gene

Genes around MIR199A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A2 Gene

ORGUL Member Location for MIR199A2 Gene

ORGUL Member Location for MIR199A2 gene

Proteins for MIR199A2 Gene

Post-translational modifications for MIR199A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A2 Gene

Domains & Families for MIR199A2 Gene

Gene Families for MIR199A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199A2 Gene

Function for MIR199A2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A2 Gene

Localization for MIR199A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR199A2 Gene

Pathways & Interactions for MIR199A2 Gene

genes like me logo Genes that share pathways with MIR199A2: view

Pathways by source for MIR199A2 Gene

1 KEGG pathway for MIR199A2 Gene

Interacting Proteins for MIR199A2 Gene

Gene Ontology (GO) - Biological Process for MIR199A2 Gene

None

No data available for SIGNOR curated interactions for MIR199A2 Gene

Drugs & Compounds for MIR199A2 Gene

No Compound Related Data Available

Transcripts for MIR199A2 Gene

mRNA/cDNA for MIR199A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A2 Gene

No ASD Table

Relevant External Links for MIR199A2 Gene

GeneLoc Exon Structure for
MIR199A2
ECgene alternative splicing isoforms for
MIR199A2

Expression for MIR199A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR199A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR199A2 Gene

This gene is overexpressed in Ovary (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of MIR199A2 Gene:

MIR199A2
genes like me logo Genes that share expression patterns with MIR199A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A2 Gene

Orthologs for MIR199A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-199a-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-199-2 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199a-2 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-199 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-199-2 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-2 35
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-1 35
  • 90 (a)
OneToOne
Species where no ortholog for MIR199A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199A2 Gene

ENSEMBL:
Gene Tree for MIR199A2 (if available)
TreeFam:
Gene Tree for MIR199A2 (if available)

Paralogs for MIR199A2 Gene

No data available for Paralogs for MIR199A2 Gene

Variants for MIR199A2 Gene

Sequence variations from dbSNP and Humsavar for MIR199A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001559396 -- 172,144,480(+) GAGCA(A/T)ACAAA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1001614686 -- 172,144,088(+) AGCCT(C/T)ATTAA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1001675405 -- 172,144,899(+) GTATG(A/C)GCTGT intron-variant, upstream-variant-2KB
rs1001948632 -- 172,145,487(+) CTTGA(A/G)CAGTA intron-variant, upstream-variant-2KB
rs1005226542 -- 172,146,042(+) ATTGC(C/T)CTTCT intron-variant, upstream-variant-2KB

Relevant External Links for MIR199A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR199A2 Gene

Disorders for MIR199A2 Gene

Relevant External Links for MIR199A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR199A2

No disorders were found for MIR199A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199A2 Gene

Publications for MIR199A2 Gene

  1. MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM). (PMID: 28126676) Fan X. … Huang T. (Biomed. Pharmacother. 2017) 3 64
  2. MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells. (PMID: 26781989) Gui R. … Nie X.M. (Oncol. Rep. 2016) 3 64
  3. The conglomeration of diagnostic, prognostic and therapeutic potential of serum miR-199a and its association with clinicopathological features in epithelial ovarian cancer. (PMID: 26951510) Zuberi M. … Saxena A. (Tumour Biol. 2016) 3 64
  4. Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. (PMID: 26952538) Yamac A.H. … Kilic U. (Cardiovasc. Pathol. 2016) 3 64
  5. miR-199a-5p regulates I^1 integrin through Ets-1 to suppress invasion in breast cancer. (PMID: 27094578) Li W. … Zhao C. (Cancer Sci. 2016) 3 64

Products for MIR199A2 Gene

Sources for MIR199A2 Gene

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