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Aliases for MIR199A2 Gene

Subcategory (RNA class) for MIR199A2 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR199A2 Gene

  • MicroRNA 199a-2 2 3 5
  • Hsa-Mir-199a-2 3
  • MiR-199a-3p 3
  • Mir-199a-2 3
  • MIR-199-S 3
  • MIRN199A2 3

External Ids for MIR199A2 Gene

Previous HGNC Symbols for MIR199A2 Gene

  • MIRN199A2

Previous GeneCards Identifiers for MIR199A2 Gene

  • GC01M170381
  • GC01M172181
  • GC01M172184
  • GC01M172190
  • GC01M172194
  • GC01M172199

Summaries for MIR199A2 Gene

Entrez Gene Summary for MIR199A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A2 Gene

MIR199A2 (MicroRNA 199a-2) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR199A2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A2 Gene

Genomics for MIR199A2 Gene

Regulatory Elements for MIR199A2 Gene

Enhancers for MIR199A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F172179 1.4 FANTOM5 Ensembl ENCODE 11.7 -39.0 -39044 8.0 TBP TBL1XR1 SIN3A ASH2L BMI1 EBF1 RAD21 GATA3 POLR2A CBX5 DNM3OS MIR199A2 MIR214 RNU6-157P GC01P172160 GC01P172209
GH01F172487 1 Ensembl 12.9 -342.9 -342857 0.6 HDGF PKNOX1 ATF1 ZNF766 GATA2 CREB3 MEF2D MBD2 SMARCA4 MYNN MIR199A2 PIGC C1orf105 PFN1P1 LOC102724528 SUCO
GH01F172455 0.9 ENCODE 12.9 -311.1 -311092 1.2 ATF1 TBL1XR1 PTRF GATA2 SMARCA5 ZBTB2 ZBTB11 CREB3 MEF2D ZNF589 MIR199A2 C1orf105 SUCO PFN1P1 DNM3 PIGC LOC102724528
GH01F172630 0.8 Ensembl 12.8 -486.0 -485957 1.2 HINFP DDX20 PTRF BACH1 CHAMP1 RELA IRF9 ZNF316 DIDO1 NFE2 MIR199A2 FASLG SUCO PFN1P1 RNU6-693P
GH01F172210 0.7 ENCODE 10.6 -66.8 -66751 2.7 SIN3A RAD21 ZBTB40 GATA3 CREM MTA2 CBFB TRIM22 JUNB KLF4 DNM3OS MIR199A2 MIR214 GC01P172209 GC01P172216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR199A2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR199A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001526005 1843 6000 ZNF680 JUN SIN3A RAD21 NR2F2 ZFHX2 JUND ZNF366 POLR2A GLIS1

Genomic Location for MIR199A2 Gene

Chromosome:
1
Start:
172,144,535 bp from pter
End:
172,144,644 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR199A2 Gene

Genes around MIR199A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A2 Gene

ORGUL Member Location for MIR199A2 Gene

ORGUL Member Location for MIR199A2 gene

Proteins for MIR199A2 Gene

Post-translational modifications for MIR199A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A2 Gene

Domains & Families for MIR199A2 Gene

Gene Families for MIR199A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199A2 Gene

Function for MIR199A2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A2 Gene

Localization for MIR199A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR199A2 Gene

Pathways & Interactions for MIR199A2 Gene

genes like me logo Genes that share pathways with MIR199A2: view

Pathways by source for MIR199A2 Gene

1 BioSystems pathway for MIR199A2 Gene
1 KEGG pathway for MIR199A2 Gene

Interacting Proteins for MIR199A2 Gene

Gene Ontology (GO) - Biological Process for MIR199A2 Gene

None

No data available for SIGNOR curated interactions for MIR199A2 Gene

Transcripts for MIR199A2 Gene

mRNA/cDNA for MIR199A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A2 Gene

No ASD Table

Relevant External Links for MIR199A2 Gene

GeneLoc Exon Structure for
MIR199A2
ECgene alternative splicing isoforms for
MIR199A2

Expression for MIR199A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR199A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR199A2 Gene

This gene is overexpressed in Ovary (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of MIR199A2 Gene:

MIR199A2
genes like me logo Genes that share expression patterns with MIR199A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR199A2 Gene

Orthologs for MIR199A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-199a-1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-199-2 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199a-2 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-199 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-199-2 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-2 35
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-1 35
  • 90 (a)
OneToOne
Species where no ortholog for MIR199A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199A2 Gene

ENSEMBL:
Gene Tree for MIR199A2 (if available)
TreeFam:
Gene Tree for MIR199A2 (if available)

Paralogs for MIR199A2 Gene

No data available for Paralogs for MIR199A2 Gene

Variants for MIR199A2 Gene

Sequence variations from dbSNP and Humsavar for MIR199A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113038350 -- 172,145,328(+) TGTCT(C/G)TCTCT intron-variant, upstream-variant-2KB
rs113199612 -- 172,145,324(+) TGTCT(C/G)TCTCT intron-variant, upstream-variant-2KB
rs114361567 -- 172,145,428(+) TCTCT(A/C)TCCCT intron-variant, upstream-variant-2KB
rs116184441 -- 172,146,055(+) AGATC(A/G)AAATG intron-variant, upstream-variant-2KB
rs116753258 -- 172,145,357(+) CTTCC(C/T)CTCTC intron-variant, upstream-variant-2KB

Relevant External Links for MIR199A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR199A2 Gene

Disorders for MIR199A2 Gene

Relevant External Links for MIR199A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR199A2

No disorders were found for MIR199A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199A2 Gene

Publications for MIR199A2 Gene

  1. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. (PMID: 27453764) Triozzi P.L. … Singh A.D. (Clin Epigenetics 2016) 3 64
  2. CCL5 promotes vascular endothelial growth factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells. (PMID: 25444917) Liu G.T. … Tang C.H. (Cancer Lett. 2015) 3 64
  3. Inhibition of MiR-199a-5p reduced cell proliferation in autosomal dominant polycystic kidney disease through targeting CDKN1C. (PMID: 25588980) Sun L. … Mei C. (Med. Sci. Monit. 2015) 3 64
  4. The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma. (PMID: 25839163) Kinose Y. … Kimura T. (Oncotarget 2015) 3 64
  5. A critical role of mir-199a in the cell biological behaviors of colorectal cancer. (PMID: 26065676) Ye H. … Zheng X. (Diagn Pathol 2015) 3 64

Products for MIR199A2 Gene

Sources for MIR199A2 Gene

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