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Aliases for MIR199A1 Gene

Subcategory (RNA class) for MIR199A1 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR199A1 Gene

  • MicroRNA 199a-1 2 3 5
  • Hsa-Mir-199a-1 3
  • MiR-199a-3p 3
  • Mir-199a-1 3
  • MIR-199-S 3
  • MIRN199A1 3

External Ids for MIR199A1 Gene

Previous HGNC Symbols for MIR199A1 Gene

  • MIRN199A1

Previous GeneCards Identifiers for MIR199A1 Gene

  • GC19M010928

Summaries for MIR199A1 Gene

Entrez Gene Summary for MIR199A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A1 Gene

MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR199A1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR199A1

Additional gene information for MIR199A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A1 Gene

Genomics for MIR199A1 Gene

Regulatory Elements for MIR199A1 Gene

Enhancers for MIR199A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010757 1.6 Ensembl ENCODE dbSUPER 12.4 +54.8 54788 9 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF207 MIR199A1 SLC44A2 DNM2 MIR638 KRI1 CDKN2D SMARCA4 MIR4748 PIR47140
GH19H010776 1.2 Ensembl ENCODE dbSUPER 12.6 +40.3 40332 1 ZBTB21 ZNF664 ZNF433 ZNF639 ZNF202 ZNF680 ZNF654 NR2F1 OVOL3 ZNF404 KRI1 ZNF627 ILF3 DNMT1 YIPF2 TIMM29 PPAN FBXL12 MIR199A1 ZNF846
GH19H010779 1 Ensembl ENCODE dbSUPER 12.6 +37.0 37010 1 ZNF362 JUND JUN MIR199A1 SLC44A2 SMARCA4 ILF3-AS1 MIR4748 GC19P010786
GH19H010782 0.5 dbSUPER 12.6 +34.6 34577 0 ZNF121 POLR2A MAX MIR199A1 SLC44A2 GC19P010786 MIR4748
GH19H010808 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +3.0 3008 11 HDGF PKNOX1 ATF1 TCF12 ZNF121 ZNF766 GATA2 FOS ATF7 REST KRI1 ILF3 TIMM29 ZNF441 PPAN ZNF627 C19orf38 FBXL12 EIF3G ILF3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR199A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR199A1 Gene

Chromosome:
19
Start:
10,817,426 bp from pter
End:
10,817,496 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR199A1 Gene

Genes around MIR199A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A1 Gene

ORGUL Member Location for MIR199A1 Gene

ORGUL Member Location for MIR199A1 gene

Proteins for MIR199A1 Gene

Post-translational modifications for MIR199A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A1 Gene

Domains & Families for MIR199A1 Gene

Gene Families for MIR199A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199A1 Gene

Function for MIR199A1 Gene

Gene Ontology (GO) - Molecular Function for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24011070
genes like me logo Genes that share ontologies with MIR199A1: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR199A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A1 Gene

Localization for MIR199A1 Gene

Gene Ontology (GO) - Cellular Components for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MIR199A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR199A1 Gene

Pathways & Interactions for MIR199A1 Gene

genes like me logo Genes that share pathways with MIR199A1: view

Pathways by source for MIR199A1 Gene

Interacting Proteins for MIR199A1 Gene

Gene Ontology (GO) - Biological Process for MIR199A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle ISS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP 27038547
GO:0010507 negative regulation of autophagy ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0032008 positive regulation of TOR signaling ISS --
genes like me logo Genes that share ontologies with MIR199A1: view

No data available for SIGNOR curated interactions for MIR199A1 Gene

Drugs & Compounds for MIR199A1 Gene

No Compound Related Data Available

Transcripts for MIR199A1 Gene

fRNAdb Secondary structures for MIR199A1 Gene

  • FR299132
  • hsa-mir-199a-1_MI0000242_Homo_sapiens_miR-199a-1_stem-loop_hairpin
  • hsa-miR-199b-3p_MIMAT0004563_Homo_sapiens_miR-199b-3p_mature

mRNA/cDNA for MIR199A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR199A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A1 Gene

No ASD Table

Relevant External Links for MIR199A1 Gene

GeneLoc Exon Structure for
MIR199A1
ECgene alternative splicing isoforms for
MIR199A1

Expression for MIR199A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR199A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR199A1 Gene:

MIR199A1
genes like me logo Genes that share expression patterns with MIR199A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR199A1 Gene

Orthologs for MIR199A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-1 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199a-1 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-3604-1 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-199-1 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-3 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-1 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-2 34
  • 63 (a)
ManyToMany
Species where no ortholog for MIR199A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199A1 Gene

ENSEMBL:
Gene Tree for MIR199A1 (if available)
TreeFam:
Gene Tree for MIR199A1 (if available)

Paralogs for MIR199A1 Gene

No data available for Paralogs for MIR199A1 Gene

Variants for MIR199A1 Gene

Sequence variations from dbSNP and Humsavar for MIR199A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001392772 -- 10,818,235(+) CCTCC(A/G)TGGCC intron-variant, upstream-variant-2KB
rs1001990474 -- 10,819,481(+) AGGCG(A/T)GGGGC intron-variant, upstream-variant-2KB
rs1004803427 -- 10,818,399(+) CTCTG(C/T)AGTGG intron-variant, upstream-variant-2KB
rs1005039 -- 10,817,405(+) CTCGA(C/T)GAGCC intron-variant, downstream-variant-500B
rs1005246716 -- 10,817,882(+) GGAAT(C/T)GCACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR199A1 Gene

Variant ID Type Subtype PubMed ID
nsv1160584 CNV deletion 26073780
nsv2416 CNV insertion 18451855
nsv833746 CNV loss 17160897
nsv833748 CNV loss 17160897

Relevant External Links for MIR199A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR199A1 Gene

Disorders for MIR199A1 Gene

Relevant External Links for MIR199A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR199A1

No disorders were found for MIR199A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR199A1 Gene

Publications for MIR199A1 Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H … Zheng X (FEBS letters 2005) 1 3 60
  2. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 60
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 60
  4. MiR-199a-5p suppresses tumorigenesis by targeting clathrin heavy chain in hepatocellular carcinoma. (PMID: 28261837) Huang GH … Pang PF (Cell biochemistry and function 2017) 3 60
  5. miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. (PMID: 26160071) Li Z … Yang X (Cell death and differentiation 2017) 3 60

Products for MIR199A1 Gene

Sources for MIR199A1 Gene

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