Subcategory (RNA class) for MIR199A1 Gene
Quality Score for this RNA gene is
Aliases for MIR199A1 Gene
External Ids for MIR199A1 Gene
ORGUL Members for MIR199A1 Gene
Previous HGNC Symbols for MIR199A1 Gene
Previous GeneCards Identifiers for MIR199A1 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR199A1 Gene
MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A1 include Testicular Germ Cell Tumor. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and SRF and miRs in Smooth Muscle Differentiation and Proliferation.
fRNAdb sequence ontologies for MIR199A1 Gene - the ORGUL cluster for this gene includes several descriptions:
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.