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Aliases for MIR199A1 Gene

Subcategory (RNA class) for MIR199A1 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR199A1 Gene

  • MicroRNA 199a-1 2 3 5
  • Hsa-Mir-199a-1 3
  • MiR-199a-3p 3
  • Mir-199a-1 3
  • MIR-199-S 3
  • MIRN199A1 3

External Ids for MIR199A1 Gene

Previous HGNC Symbols for MIR199A1 Gene

  • MIRN199A1

Previous GeneCards Identifiers for MIR199A1 Gene

  • GC19M010928

Summaries for MIR199A1 Gene

Entrez Gene Summary for MIR199A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR199A1 Gene

MIR199A1 (MicroRNA 199a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR199A1 include Testicular Germ Cell Tumor. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and SRF and miRs in Smooth Muscle Differentiation and Proliferation.

fRNAdb sequence ontologies for MIR199A1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR199A1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR199A1 Gene

Genomics for MIR199A1 Gene

Regulatory Elements for MIR199A1 Gene

Enhancers for MIR199A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010779 1 Ensembl ENCODE 12.6 +37.0 37010 2.0 JUN KLF17 ZIC2 ZNF121 HIC1 POLR2A SCRT2 ZNF600 EGR2 SCRT1 MIR199A1 SLC44A2 SMARCA4 ILF3-AS1 MIR4748 GC19P010786
GH19F010776 0.5 Ensembl ENCODE 12.6 +40.3 40332 1.4 ZIC2 ZNF101 ZNF335 ZNF664 GLIS2 POLR2A PATZ1 ZNF433 ZNF202 ZNF639 ZNF627 YIPF2 TIMM29 FBXL12 MIR199A1 RAVER1 KRI1 SLC44A2 CDKN2D MIR1181
GH19F010746 1.4 FANTOM5 Ensembl ENCODE 12.3 +60.3 60283 20.8 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 NFYC TBX21 FBXL12 HNRNPA1P10 SLC44A2 CDKN2D ZNF627 RAVER1 DNM2 KRI1 MIR638 PRKCSH
GH19F010808 1.5 FANTOM5 Ensembl ENCODE 0.8 +3.0 3008 11.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 EIF3G FBXL12 KANK2 DOCK6 LOC105372273 C19orf38 S1PR2 CNN1 TIMM29 ILF3-AS1
GH19F010820 0.7 ENCODE 0.8 -3.6 -3607 0.7 HDAC1 TAL1 NR4A1 CEBPB REST ARID1B CCNT2 ZNF121 GATA3 POLR2A GC19M010822 MIR199A1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR199A1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR199A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343368 196 1001 HDAC1 ATF1 CREB3L1 SIN3A ZBTB40 ZEB1 ZNF366 SCRT2 SP3 ZBTB11

Genomic Location for MIR199A1 Gene

Chromosome:
19
Start:
10,817,426 bp from pter
End:
10,817,496 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR199A1 Gene

Genes around MIR199A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR199A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR199A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR199A1 Gene

ORGUL Member Location for MIR199A1 Gene

ORGUL Member Location for MIR199A1 gene

Proteins for MIR199A1 Gene

Post-translational modifications for MIR199A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR199A1 Gene

Domains & Families for MIR199A1 Gene

Gene Families for MIR199A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR199A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR199A1 Gene

Function for MIR199A1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR199A1 Gene

Localization for MIR199A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR199A1 Gene

Pathways & Interactions for MIR199A1 Gene

genes like me logo Genes that share pathways with MIR199A1: view

Pathways by source for MIR199A1 Gene

Interacting Proteins for MIR199A1 Gene

Gene Ontology (GO) - Biological Process for MIR199A1 Gene

None

No data available for SIGNOR curated interactions for MIR199A1 Gene

Transcripts for MIR199A1 Gene

fRNAdb Secondary structures for MIR199A1 Gene

  • FR299132
  • hsa-mir-199a-1_MI0000242_Homo_sapiens_miR-199a-1_stem-loop_hairpin
  • hsa-miR-199b-3p_MIMAT0004563_Homo_sapiens_miR-199b-3p_mature

mRNA/cDNA for MIR199A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR199A1 Gene

No ASD Table

Relevant External Links for MIR199A1 Gene

GeneLoc Exon Structure for
MIR199A1
ECgene alternative splicing isoforms for
MIR199A1

Expression for MIR199A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR199A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR199A1 Gene:

MIR199A1
genes like me logo Genes that share expression patterns with MIR199A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR199A1 Gene

Orthologs for MIR199A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR199A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-199a-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir199a-1 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-3604-1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-199-1 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-199b-3 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-199a-1 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-199-2 35
  • 63 (a)
ManyToMany
Species where no ortholog for MIR199A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR199A1 Gene

ENSEMBL:
Gene Tree for MIR199A1 (if available)
TreeFam:
Gene Tree for MIR199A1 (if available)

Paralogs for MIR199A1 Gene

No data available for Paralogs for MIR199A1 Gene

Variants for MIR199A1 Gene

Sequence variations from dbSNP and Humsavar for MIR199A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1005039 -- 10,817,405(+) CTCGA(C/T)GAGCC intron-variant, downstream-variant-500B
rs111448773 -- 10,817,827(+) CGCGC(-/GC)ACGCG intron-variant, upstream-variant-2KB
rs114385953 -- 10,817,837(+) CGTGC(A/G)TGCCG intron-variant, upstream-variant-2KB
rs114445673 -- 10,819,041(+) CCCCT(A/G)GCCGA intron-variant, upstream-variant-2KB
rs115513611 -- 10,818,904(+) GATCC(A/G)TGAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR199A1 Gene

Variant ID Type Subtype PubMed ID
nsv1160584 CNV deletion 26073780
nsv2416 CNV insertion 18451855
nsv833746 CNV loss 17160897
nsv833748 CNV loss 17160897

Relevant External Links for MIR199A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR199A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR199A1 Gene

Disorders for MIR199A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR199A1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
testicular germ cell tumor
  • male germ cell tumor, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR199A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR199A1
genes like me logo Genes that share disorders with MIR199A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR199A1 Gene

Publications for MIR199A1 Gene

  1. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H. … Zheng X. (FEBS Lett. 2005) 1 3 64
  2. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 3 64
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  4. IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. (PMID: 26655502) MatA R. … Belfiore A. (Oncotarget 2016) 3 64
  5. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. (PMID: 27453764) Triozzi P.L. … Singh A.D. (Clin Epigenetics 2016) 3 64

Products for MIR199A1 Gene

Sources for MIR199A1 Gene

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