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Aliases for MIR198 Gene

Subcategory (RNA class) for MIR198 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR198 Gene

  • MicroRNA 198 2 3 5
  • Hsa-Mir-198 3
  • MiR-198 3
  • MIRN198 3

External Ids for MIR198 Gene

Previous HGNC Symbols for MIR198 Gene

  • MIRN198

Previous GeneCards Identifiers for MIR198 Gene

  • GC03M121599
  • GC03M120112

Summaries for MIR198 Gene

Entrez Gene Summary for MIR198 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR198 Gene

MIR198 (MicroRNA 198) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by BMP and Signaling by GPCR.

Additional gene information for MIR198 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR198 Gene

Genomics for MIR198 Gene

Regulatory Elements for MIR198 Gene

Enhancers for MIR198 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H120416 1.5 Ensembl ENCODE dbSUPER 0.3 -23.6 -23647 6 PKNOX1 ATF1 FOXA2 ARID4B SIN3A GATA2 ZNF143 FOS ATF7 DEK GPR156 FSTL1 RPL10P7 LOC100130701 LRRC58 MIR198
GH03H120431 1.1 Ensembl ENCODE dbSUPER 0.3 -40.5 -40464 9 JUN REST JUND GATA3 POLR2A ZNF239 FOXP2 FOS SP7 FSTL1 MIR198
GH03H120422 1 Ensembl ENCODE dbSUPER 0.3 -29.9 -29927 5 JUND POLR2A HNF4A RCOR1 FSTL1 GPR156 LOC100130701 LRRC58 GSK3B ADPRH MIR198
GH03H120446 1.2 ENCODE dbSUPER 0.2 -53.9 -53904 5 KLF17 SIN3A FEZF1 GLIS2 POLR3A ZNF366 KLF7 EGR2 SP3 CEBPB FSTL1 RPL34P9 MIR198
GH03H120409 0.6 ENCODE dbSUPER 0.4 -14.7 -14683 2 REST GPR156 MIR198 FSTL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR198 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR198 Gene

Chromosome:
3
Start:
120,395,668 bp from pter
End:
120,395,729 bp from pter
Size:
62 bases
Orientation:
Minus strand

Genomic View for MIR198 Gene

Genes around MIR198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR198 Gene

Proteins for MIR198 Gene

Post-translational modifications for MIR198 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR198 Gene

Domains & Families for MIR198 Gene

Gene Families for MIR198 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR198: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR198 Gene

Function for MIR198 Gene

Phenotypes for MIR198 Gene

GenomeRNAi human phenotypes for MIR198:
genes like me logo Genes that share phenotypes with MIR198: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR198
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR198 Gene

Localization for MIR198 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR198 Gene

Pathways & Interactions for MIR198 Gene

SuperPathways for MIR198 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 Signaling by BMP
genes like me logo Genes that share pathways with MIR198: view

Pathways by source for MIR198 Gene

2 Reactome pathways for MIR198 Gene

Interacting Proteins for MIR198 Gene

Gene Ontology (GO) - Biological Process for MIR198 Gene

None

No data available for SIGNOR curated interactions for MIR198 Gene

Drugs & Compounds for MIR198 Gene

No Compound Related Data Available

Transcripts for MIR198 Gene

mRNA/cDNA for MIR198 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR198
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR198 Gene

No ASD Table

Relevant External Links for MIR198 Gene

GeneLoc Exon Structure for
MIR198
ECgene alternative splicing isoforms for
MIR198

Expression for MIR198 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR198 Gene:

MIR198
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR198 Gene

Orthologs for MIR198 Gene

Evolution for MIR198 Gene

ENSEMBL:
Gene Tree for MIR198 (if available)
TreeFam:
Gene Tree for MIR198 (if available)

No data available for Orthologs for MIR198 Gene

Paralogs for MIR198 Gene

No data available for Paralogs for MIR198 Gene

Variants for MIR198 Gene

Sequence variations from dbSNP and Humsavar for MIR198 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000141661 -- 120,395,526(+) AGTGG(G/T)GTGGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000334811 -- 120,396,732(+) TTACA(A/G)TTTCT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000873660 -- 120,397,148(+) AACAA(A/T)TTGAG intron-variant, upstream-variant-2KB
rs1003393005 -- 120,397,202(+) GTTTA(C/T)TGAAT intron-variant, upstream-variant-2KB
rs1004494370 -- 120,396,381(+) TCATT(G/T)GGGTG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR198 Gene

Variant ID Type Subtype PubMed ID
nsv829698 CNV gain 17160897

Relevant External Links for MIR198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR198

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR198 Gene

Disorders for MIR198 Gene

Relevant External Links for MIR198

Genetic Association Database (GAD)
MIR198
Human Genome Epidemiology (HuGE) Navigator
MIR198
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR198

No disorders were found for MIR198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR198 Gene

Publications for MIR198 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 45 60
  3. miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma. (PMID: 26553359) Wu S … Zhao G (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  4. miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. (PMID: 27063186) Gigante M … Ranieri E (Journal of translational medicine 2016) 3 60
  5. Decreased miR-198 expression and its prognostic significance in human gastric cancer. (PMID: 26852230) Cui Z … Kong D (World journal of surgical oncology 2016) 3 60

Products for MIR198 Gene

Sources for MIR198 Gene

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