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Aliases for MIR198 Gene

Subcategory (RNA class) for MIR198 Gene


Quality Score for this RNA gene is


Aliases for MIR198 Gene

  • MicroRNA 198 2 3
  • FSTL1 4 5
  • Follistatin-Like Protein 1 4
  • Follistatin Like 1 5
  • Hsa-Mir-198 3
  • MiR-198 3
  • MIRN198 3
  • FRP 4

External Ids for MIR198 Gene

Previous HGNC Symbols for MIR198 Gene

  • MIRN198

Previous GeneCards Identifiers for MIR198 Gene

  • GC03M121599
  • GC03M120112

Summaries for MIR198 Gene

Entrez Gene Summary for MIR198 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR198 Gene

MIR198 (MicroRNA 198) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Signaling by GPCR and Signaling by BMP. An important paralog of this gene is FSTL4.

UniProtKB/Swiss-Prot for MIR198 Gene

  • May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR198 Gene

Genomics for MIR198 Gene

Regulatory Elements for MIR198 Gene

Enhancers for MIR198 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F120741 1.1 ENCODE 17.3 -291.5 -291539 3.1 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 MIR198 RPL7AP11 GTF2E1 RABL3
GH03F119778 1.1 ENCODE 17.3 +672.1 672140 1.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 CEBPZ MIR198 TMEM39A NR1I2 PIR58327
GH03F119468 1.1 ENCODE 17.3 +982.1 982128 2.2 HDGF ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 ETS1 YY1 POGLUT1 MIR198 TMEM39A CD80 TIMMDC1 ENSG00000272662
GH03F119462 1.1 ENCODE 17.3 +987.8 987816 2.8 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POGLUT1 MIR198 TIMMDC1 TMEM39A GC03P119428
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR198 on UCSC Golden Path with GeneCards custom track

Promoters for MIR198 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001482793 653 2801 KLF17 SIN3A FEZF1 ZNF335 GLIS2 POLR3A ZNF366 KLF7 FOS EGR2

Genomic Location for MIR198 Gene

120,392,293 bp from pter
120,451,253 bp from pter
58,961 bases
Minus strand

Genomic View for MIR198 Gene

Genes around MIR198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR198 Gene

Proteins for MIR198 Gene

  • Protein details for MIR198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follistatin-related protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K523
    • B4DTT5
    • D3DN90
    • Q549Z0

    Protein attributes for MIR198 Gene

    308 amino acids
    Molecular mass:
    34986 Da
    Quaternary structure:
    • Interacts with SCN10A.
    • Interacts with SCN10A.

    Alternative splice isoforms for MIR198 Gene


neXtProt entry for MIR198 Gene

Post-translational modifications for MIR198 Gene

  • Glycosylation at Asn 144, Asn 175, and Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR198 Gene

No data available for DME Specific Peptides for MIR198 Gene

Domains & Families for MIR198 Gene

Gene Families for MIR198 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
  • Contains 1 follistatin-like domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 VWFC domain.
genes like me logo Genes that share domains with MIR198: view

No data available for Suggested Antigen Peptide Sequences for MIR198 Gene

Function for MIR198 Gene

Molecular function for MIR198 Gene

UniProtKB/Swiss-Prot Function:
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).

Gene Ontology (GO) - Molecular Function for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0008201 heparin binding TAS --
genes like me logo Genes that share ontologies with MIR198: view

Phenotypes for MIR198 Gene

GenomeRNAi human phenotypes for MIR198:
genes like me logo Genes that share phenotypes with MIR198: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR198 Gene

Localization for MIR198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR198 Gene

Gene Ontology (GO) - Cellular Components for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR198: view

No data available for Subcellular locations from COMPARTMENTS for MIR198 Gene

Pathways & Interactions for MIR198 Gene

SuperPathways for MIR198 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 Signaling by BMP
genes like me logo Genes that share pathways with MIR198: view

Pathways by source for MIR198 Gene

2 Reactome pathways for MIR198 Gene

Gene Ontology (GO) - Biological Process for MIR198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030509 BMP signaling pathway TAS --
GO:0042594 response to starvation IEA --
genes like me logo Genes that share ontologies with MIR198: view

No data available for SIGNOR curated interactions for MIR198 Gene

Transcripts for MIR198 Gene

mRNA/cDNA for MIR198 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR198 Gene

No ASD Table

Relevant External Links for MIR198 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR198 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR198 Gene:


mRNA Expression by UniProt/SwissProt for MIR198 Gene:

Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR198 Gene

Orthologs for MIR198 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR198 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-198 35
  • 100 (a)
(Bos Taurus)
Mammalia FSTL1 35
  • 97 (a)
(Canis familiaris)
Mammalia FSTL1 35
  • 93 (a)
(Mus musculus)
Mammalia Fstl1 35
  • 92 (a)
(Monodelphis domestica)
Mammalia FSTL1 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia FSTL1 35
  • 71 (a)
(Gallus gallus)
Aves FSTL1 35
  • 84 (a)
(Anolis carolinensis)
Reptilia FSTL1 35
  • 80 (a)
(Danio rerio)
Actinopterygii fstl1b 35
  • 70 (a)
fstl1a 35
  • 65 (a)
FSTL1 (3 of 3) 35
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 7 (a)
Species where no ortholog for MIR198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR198 Gene

Gene Tree for MIR198 (if available)
Gene Tree for MIR198 (if available)

Paralogs for MIR198 Gene

Paralogs for MIR198 Gene

genes like me logo Genes that share paralogs with MIR198: view

Variants for MIR198 Gene

Sequence variations from dbSNP and Humsavar for MIR198 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1056928 -- 120,396,067(-) TTGGC(C/T)CCCCT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111272417 -- 120,395,933(+) TGCCT(C/T)AACTT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111972816 -- 120,395,309(+) GCATC(C/T)GAAAC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs112472213 -- 120,395,608(-) TTGAT(C/G)TCAGC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs114109084 -- 120,397,017(+) GAAAA(C/G/T)AGGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR198 Gene

Variant ID Type Subtype PubMed ID
nsv829698 CNV gain 17160897

Relevant External Links for MIR198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR198 Gene

Disorders for MIR198 Gene

Relevant External Links for MIR198

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR198 Gene

Publications for MIR198 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  3. miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. (PMID: 27063186) Gigante M. … Ranieri E. (J Transl Med 2016) 3 64
  4. Decreased miR-198 expression and its prognostic significance in human gastric cancer. (PMID: 26852230) Cui Z. … Kong D. (World J Surg Oncol 2016) 3 64
  5. MicroRNA-198 inhibited tumorous behaviors of human osteosarcoma through directly targeting ROCK1. (PMID: 26970302) Zhang S. … Wang L. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for MIR198 Gene

Sources for MIR198 Gene

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