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Aliases for MIR1976 Gene

Subcategory (RNA class) for MIR1976 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1976 Gene

  • MicroRNA 1976 2 3 5
  • Hsa-Mir-1976 3

External Ids for MIR1976 Gene

Previous GeneCards Identifiers for MIR1976 Gene

  • GC00U923176
  • GC01P026883

Summaries for MIR1976 Gene

Entrez Gene Summary for MIR1976 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1976 Gene

MIR1976 (MicroRNA 1976) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1976 Gene

Genomics for MIR1976 Gene

Regulatory Elements for MIR1976 Gene

Enhancers for MIR1976 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G026499 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -53.4 -53362 2.8 MLX CREB3L1 AGO1 ZFP64 DMAP1 ZNF143 ZNF263 SP3 ZNF610 GLIS1 LOC101928324 HMGN2 ACTG1P20 DHDDS RPS6KA1 GPATCH3 WASF2 RPL17P9 MIR1976 NPM1P39
GH01G026618 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +65.9 65854 4.0 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 HMGN2 ACTG1P20 ZNF593 AHDC1 LOC101928324 WASF2 NPM1P39 RPL17P9 ARID1A PIGV
GH01G026580 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 +26.6 26646 0.7 FOXA2 FOS MXD4 JUNB SREBF1 MIER3 SMARCA4 NBN HNF4A KDM1A MIR1976 RPS6KA1 ENSG00000226698 GPATCH3 NUDC UBXN11 PIGV SH3BGRL3 RN7SL679P
GH01G026581 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 +28.4 28410 2.1 HNRNPUL1 ARID4B ZNF48 YY1 FOS PAF1 MXD4 JUNB MIER2 TBX21 MIR1976 RPS6KA1 SFN ENSG00000226698 UBXN11 GPATCH3 NUDC PIGV SH3BGRL3 RN7SL679P
GH01G026782 1.7 FANTOM5 ENCODE dbSUPER 10.7 +232.6 232605 9.2 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ACTG1P20 HMGN2 RPS6KA1 PIGV ZDHHC18 ENSG00000226698 SFN MIR1976 GPATCH3 NUDC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1976 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR1976 Gene

Chromosome:
1
Start:
26,554,542 bp from pter
End:
26,554,593 bp from pter
Size:
52 bases
Orientation:
Plus strand

Genomic View for MIR1976 Gene

Genes around MIR1976 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1976 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1976 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1976 Gene

Proteins for MIR1976 Gene

Post-translational modifications for MIR1976 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1976 Gene

Domains & Families for MIR1976 Gene

Gene Families for MIR1976 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1976: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1976 Gene

Function for MIR1976 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1976 Gene

Localization for MIR1976 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1976 Gene

Pathways & Interactions for MIR1976 Gene

SuperPathways for MIR1976 Gene

No Data Available

Interacting Proteins for MIR1976 Gene

Gene Ontology (GO) - Biological Process for MIR1976 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1976 Gene

Drugs & Compounds for MIR1976 Gene

No Compound Related Data Available

Transcripts for MIR1976 Gene

mRNA/cDNA for MIR1976 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1976 Gene

No ASD Table

Relevant External Links for MIR1976 Gene

GeneLoc Exon Structure for
MIR1976
ECgene alternative splicing isoforms for
MIR1976

Expression for MIR1976 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1976 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1976 Gene:

MIR1976
genes like me logo Genes that share expression patterns with MIR1976: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1976 Gene

Orthologs for MIR1976 Gene

Evolution for MIR1976 Gene

ENSEMBL:
Gene Tree for MIR1976 (if available)
TreeFam:
Gene Tree for MIR1976 (if available)

No data available for Orthologs for MIR1976 Gene

Paralogs for MIR1976 Gene

No data available for Paralogs for MIR1976 Gene

Variants for MIR1976 Gene

Sequence variations from dbSNP and Humsavar for MIR1976 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002538241 -- 26,553,167(+) TAGGC(C/T)TGTTT intron-variant, upstream-variant-2KB
rs1003764429 -- 26,553,443(+) TCTGG(G/T)CCTGG upstream-variant-2KB, reference, missense
rs1004429322 -- 26,553,065(+) TCCAT(C/G)TCAGA intron-variant, upstream-variant-2KB
rs1007052188 -- 26,553,635(+) AGTGG(A/G)GTGGG intron-variant, upstream-variant-2KB
rs1011623714 -- 26,554,830(+) TAGGG(C/T)TCTCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR1976 Gene

Variant ID Type Subtype PubMed ID
nsv526179 CNV gain 19592680
nsv545908 CNV loss 21841781

Relevant External Links for MIR1976 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1976

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1976 Gene

Disorders for MIR1976 Gene

Relevant External Links for MIR1976

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1976

No disorders were found for MIR1976 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1976 Gene

Publications for MIR1976 Gene

  1. MicroRNA-1976 functions as a tumor suppressor and serves as a prognostic indicator in non-small cell lung cancer by directly targeting PLCE1. (PMID: 27063799) Chen G. … Chen M. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. (PMID: 18923441) Schotte D. … den Boer M.L. (Leukemia 2009) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR1976 Gene

Sources for MIR1976 Gene

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