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Aliases for MIR1973 Gene

Subcategory (RNA class) for MIR1973 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1973 Gene

  • MicroRNA 1973 2 3
  • MTRNR2L13 4 5
  • MT-RNR2-Like Protein 13 4
  • MT-RNR2-Like 13 5
  • Hsa-Mir-1973 3
  • Mir-1973 3
  • HN13 4

External Ids for MIR1973 Gene

Previous GeneCards Identifiers for MIR1973 Gene

  • GC00U923182
  • GC04P117220

Summaries for MIR1973 Gene

Entrez Gene Summary for MIR1973 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1973 Gene

MIR1973 (MicroRNA 1973) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is MTRNR2L10.

UniProtKB/Swiss-Prot for MIR1973 Gene

  • Plays a role as a neuroprotective and antiapoptotic factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1973 Gene

Genomics for MIR1973 Gene

Genomic Location for MIR1973 Gene

Chromosome:
4
Start:
116,298,876 bp from pter
End:
116,300,320 bp from pter
Size:
1,445 bases
Orientation:
Plus strand

Genomic View for MIR1973 Gene

Genes around MIR1973 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1973 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1973 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1973 Gene

No data available for Regulatory Elements for MIR1973 Gene

Proteins for MIR1973 Gene

  • Protein details for MIR1973 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    S4R3P1-HMN13_HUMAN
    Recommended name:
    Humanin-like 13
    Protein Accession:
    S4R3P1

    Protein attributes for MIR1973 Gene

    Size:
    24 amino acids
    Molecular mass:
    2751 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR1973 Gene

Post-translational modifications for MIR1973 Gene

No Post-translational modifications

Other Protein References for MIR1973 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR1973 Gene

Domains & Families for MIR1973 Gene

Gene Families for MIR1973 Gene

Protein Domains for MIR1973 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

S4R3P1

UniProtKB/Swiss-Prot:

HMN13_HUMAN :
  • Belongs to the humanin family.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MIR1973: view

No data available for Suggested Antigen Peptide Sequences for MIR1973 Gene

Function for MIR1973 Gene

Molecular function for MIR1973 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective and antiapoptotic factor.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1973 Gene

Localization for MIR1973 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1973 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MIR1973 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR1973: view

No data available for Subcellular locations from COMPARTMENTS for MIR1973 Gene

Pathways & Interactions for MIR1973 Gene

SuperPathways for MIR1973 Gene

No Data Available

Interacting Proteins for MIR1973 Gene

Gene Ontology (GO) - Biological Process for MIR1973 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1973 Gene

Drugs & Compounds for MIR1973 Gene

No Compound Related Data Available

Transcripts for MIR1973 Gene

mRNA/cDNA for MIR1973 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1973 Gene

No ASD Table

Relevant External Links for MIR1973 Gene

GeneLoc Exon Structure for
MIR1973
ECgene alternative splicing isoforms for
MIR1973

Expression for MIR1973 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1973 Gene:

MIR1973
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1973 Gene

Orthologs for MIR1973 Gene

Evolution for MIR1973 Gene

ENSEMBL:
Gene Tree for MIR1973 (if available)
TreeFam:
Gene Tree for MIR1973 (if available)

No data available for Orthologs for MIR1973 Gene

Paralogs for MIR1973 Gene

Paralogs for MIR1973 Gene

genes like me logo Genes that share paralogs with MIR1973: view

Variants for MIR1973 Gene

Sequence variations from dbSNP and Humsavar for MIR1973 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2007759 -- 116,300,127(+) GTTTA(C/T)AACCT downstream-variant-500B
rs9685647 -- 116,299,955(+) CTGGC(C/T)TACTA downstream-variant-500B
rs10025558 -- 116,299,359(+) CCAAA(A/C/T)GCAGC upstream-variant-2KB
rs79610426 -- 116,299,314(+) ACGAC(A/G)TTCCT upstream-variant-2KB
rs75309287 -- 116,300,047(+) CTAAG(C/T)GAGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR1973 Gene

Variant ID Type Subtype PubMed ID
dgv5370n100 CNV gain 25217958
esv3575769 CNV gain 25503493
esv3601878 CNV gain 21293372
nsv1008744 CNV loss 25217958
nsv595232 CNV loss 21841781
nsv980249 CNV duplication 23825009

Relevant External Links for MIR1973 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1973

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1973 Gene

Disorders for MIR1973 Gene

Relevant External Links for MIR1973

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1973

No disorders were found for MIR1973 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1973 Gene

Publications for MIR1973 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  2. Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. (PMID: 18923441) Schotte D. … den Boer M.L. (Leukemia 2009) 3 65
  3. Evidence for potential functionality of nuclearly-encoded humanin isoforms. (PMID: 19477263) Bodzioch M. … Dembinska-Kiec A. (Genomics 2009) 4 65
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 65

Products for MIR1973 Gene

Sources for MIR1973 Gene

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