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Aliases for MIR197 Gene

Subcategory (RNA class) for MIR197 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR197 Gene

  • MicroRNA 197 2 3 5
  • Hsa-Mir-197 3
  • MiRNA197 3
  • MiR-197 3
  • MIRN197 3

External Ids for MIR197 Gene

Previous HGNC Symbols for MIR197 Gene

  • MIRN197

Previous GeneCards Identifiers for MIR197 Gene

  • GC01P109943
  • GC01P110141
  • GC01P109598

Summaries for MIR197 Gene

Entrez Gene Summary for MIR197 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR197 Gene

MIR197 (MicroRNA 197) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DAG and IP3 signaling and Response to elevated platelet cytosolic Ca2+.

Additional gene information for MIR197 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR197 Gene

Genomics for MIR197 Gene

GeneHancer (GH) Regulatory Elements for MIR197 Gene

Promoters and enhancers for MIR197 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I109600 Enhancer 0.2 FANTOM5 550.8 +1.4 1387 0.3 MIR197 GNAT2 PSRC1 GC01P109607 GNAI3
GH01I109761 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.2 +165.9 165936 5.9 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF766 FOS ATF7 EPS8L3 GSTM3 AHCYL1 ENSG00000228703 AMPD2 ENSG00000254942 GPR61 GNAT2 ENSG00000258634 GNAI3
GH01I109643 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.7 +44.7 44681 0.7 HDGF RB1 ARID4B ZNF2 RAD21 ZEB1 ZNF335 GLIS2 ZNF213 ARID2 GSTM4 GNAT2 AMPD2 GNAI3 MIR197 ENSG00000225113 RNU6V GSTM3 GC01M109631 RPL7P8
GH01I109776 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +178.4 178443 1.8 HDGF ATF1 FOXA2 ARID4B ZNF2 IRF4 ZNF48 GLIS2 ARID2 ZNF143 GSTM3 AHCYL1 ENSG00000228703 AMPD2 CSF1 GNAI3 ENSG00000254942 GPR61 MIR197 ENSG00000235005
GH01I109773 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +174.9 174908 0.4 HDGF CLOCK ATF1 ARNT ARID4B SIN3A IRF4 ZNF213 E2F8 ARID2 AHCYL1 ENSG00000228703 AMPD2 GSTM3 CSF1 GNAI3 ENSG00000254942 GPR61 MIR197 UBL4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR197 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR197 Gene

Genomic Locations for MIR197 Gene
chr1:109,598,893-109,598,967
(GRCh38/hg38)
Size:
75 bases
Orientation:
Plus strand
chr1:110,141,515-110,141,589
(GRCh37/hg19)

Genomic View for MIR197 Gene

Genes around MIR197 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR197 Gene

Proteins for MIR197 Gene

Post-translational modifications for MIR197 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR197 Gene

Domains & Families for MIR197 Gene

Gene Families for MIR197 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR197: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR197 Gene

Function for MIR197 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR197 Gene

Localization for MIR197 Gene

Gene Ontology (GO) - Cellular Components for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR197: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR197 Gene

Pathways & Interactions for MIR197 Gene

genes like me logo Genes that share pathways with MIR197: view

Interacting Proteins for MIR197 Gene

Gene Ontology (GO) - Biological Process for MIR197 Gene

None

No data available for SIGNOR curated interactions for MIR197 Gene

Drugs & Compounds for MIR197 Gene

No Compound Related Data Available

Transcripts for MIR197 Gene

mRNA/cDNA for MIR197 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR197 Gene

No ASD Table

Relevant External Links for MIR197 Gene

GeneLoc Exon Structure for
MIR197
ECgene alternative splicing isoforms for
MIR197

Expression for MIR197 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR197 Gene:

MIR197
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR197 Gene

Orthologs for MIR197 Gene

Evolution for MIR197 Gene

ENSEMBL:
Gene Tree for MIR197 (if available)
TreeFam:
Gene Tree for MIR197 (if available)

No data available for Orthologs for MIR197 Gene

Paralogs for MIR197 Gene

No data available for Paralogs for MIR197 Gene

Variants for MIR197 Gene

Sequence variations from dbSNP and Humsavar for MIR197 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000805828 -- 109,597,357(+) G/A upstream_transcript_variant
rs1001122869 -- 109,597,586(+) AAA/AAAA upstream_transcript_variant
rs1003082552 -- 109,598,785(+) C/A upstream_transcript_variant
rs1003997269 -- 109,598,984(+) C/G/T downstream_transcript_variant
rs1004646962 -- 109,597,570(+) C/T upstream_transcript_variant

Additional Variant Information for MIR197 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR197

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR197 Gene

Disorders for MIR197 Gene

Additional Disease Information for MIR197

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR197 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR197 Gene

Publications for MIR197 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. EBV‑BART‑6‑3p and cellular microRNA‑197 compromise the immune defense of host cells in EBV‑positive Burkitt lymphoma. (PMID: 28259992) Zhang YM … Zhao HP (Molecular medicine reports 2017) 3 58
  3. Micro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy. (PMID: 26352910) Weseslindtner L … Odenthal M (Liver international : official journal of the International Association for the Study of the Liver 2016) 3 58
  4. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  5. MicroRNA-197 Mediates the Overgrowth and Anti-Apoptotic Effects by Downregulating Insulin-Like Growth Factor-Binding Protein-3 During Nephroblastoma Tumorigenesis. (PMID: 27223680) Hu J … Xia H (Fetal and pediatric pathology 2016) 3 58

Products for MIR197 Gene

Sources for MIR197 Gene

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