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Aliases for MIR197 Gene

Subcategory (RNA class) for MIR197 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR197 Gene

  • MicroRNA 197 2 3
  • GNAI3 4 5
  • G Protein Subunit Alpha I3 5
  • G(I) Alpha-3 4
  • Hsa-Mir-197 3
  • MiRNA197 3
  • MiR-197 3
  • MIRN197 3

External Ids for MIR197 Gene

Previous HGNC Symbols for MIR197 Gene

  • MIRN197

Previous GeneCards Identifiers for MIR197 Gene

  • GC01P109943
  • GC01P110141
  • GC01P109598

Summaries for MIR197 Gene

Entrez Gene Summary for MIR197 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR197 Gene

MIR197 (MicroRNA 197) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR197 include Auriculocondylar Syndrome 1. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. An important paralog of this gene is GNAI1.

UniProtKB/Swiss-Prot for MIR197 Gene

  • Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR197 Gene

Genomics for MIR197 Gene

Regulatory Elements for MIR197 Gene

Enhancers for MIR197 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F109570 0.7 Ensembl ENCODE 13 +23.7 23691 4.6 ZBTB40 RAD21 SCRT2 RCOR1 EGR2 ZNF263 ZNF654 CEBPB REST ZEB2 GPR61 MIR197 ENSG00000225113 AMPD2 GNAT2 ENSG00000254942 ENSG00000228703 GNAI3 AMIGO1 GC01M109593
GH01F109567 0.5 Ensembl 12.1 +20.1 20090 2.2 SMARCA4 GLIS1 CEBPA PRDM10 ZNF600 PRDM1 ZNF18 MIR197 RNU6V AMPD2 GNAT2 ENSG00000225113 ENSG00000254942 GPR61 ENSG00000228703 GNAI3 CYB561D1
GH01F109643 0.6 Ensembl ENCODE 11.8 +95.1 95090 1.0 HDGF ARID4B ZNF2 RAD21 ZEB1 GLIS2 SCRT2 ZNF143 CREM DEK GSTM4 GNAT2 AMPD2 MIR197 GNAI3 ENSG00000225113 RNU6V GSTM3 GC01M109631 RPL7P8
GH01F109649 0.8 Ensembl ENCODE 10.9 +100.9 100926 0.9 CTCF ZNF654 IRF1 RAD21 ENSG00000254942 GPR61 GNAI3 MIR197 GNAT2 AMPD2 AHCYL1 EPS8L3 GSTM3 GSTM4
GH01F109776 0.7 Ensembl ENCODE 10.8 +228.7 228725 1.8 ELF3 HDGF ATF1 TBL1XR1 ARID4B ZNF48 DNMT3B ZNF2 RAD21 GLIS2 GSTM3 AHCYL1 ENSG00000228703 AMPD2 CSF1 MIR197 GNAI3 ENSG00000254942 GPR61 STRIP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR197 on UCSC Golden Path with GeneCards custom track

Promoters for MIR197 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000542387 89 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for MIR197 Gene

Chromosome:
1
Start:
109,548,611 bp from pter
End:
109,618,321 bp from pter
Size:
69,711 bases
Orientation:
Plus strand

Genomic View for MIR197 Gene

Genes around MIR197 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR197 Gene

Proteins for MIR197 Gene

  • Protein details for MIR197 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08754-GNAI3_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(k) subunit alpha
    Protein Accession:
    P08754
    Secondary Accessions:
    • P17539
    • Q5TZX1

    Protein attributes for MIR197 Gene

    Size:
    354 amino acids
    Molecular mass:
    40532 Da
    Quaternary structure:
    • Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha subunit contains the guanine nucleotide binding site. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. Interacts with GPSM1 (By similarity). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains) (PubMed:22952234). Does not interact with RGS2 (PubMed:19478087). Interacts with RGS8 and RGS10; this strongly enhances the intrinsic GTPase activity (PubMed:8774883, PubMed:18434541). Interacts with RGS16; this strongly enhances the intrinsic GTPase activity (PubMed:19478087). Interacts with RGS12 (By similarity). Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (By similarity).
    • Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha subunit contains the guanine nucleotide binding site. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins. Interacts with GPSM1 (By similarity). Interacts (GDP-bound form) with GPSM2 (via GoLoco domains) (PubMed:22952234). Does not interact with RGS2 (PubMed:19478087). Interacts with RGS8 and RGS10; this strongly enhances the intrinsic GTPase activity (PubMed:8774883, PubMed:18434541). Interacts with RGS16; this strongly enhances the intrinsic GTPase activity (PubMed:19478087). Interacts with RGS12 (By similarity). Interacts (via active GTP- or inactive GDP-bound form) with RGS14 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MIR197 Gene

neXtProt entry for MIR197 Gene

Post-translational modifications for MIR197 Gene

  • (Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
  • Ubiquitination at Lys 92, Lys 128, Lys 192, and Lys 349
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR197 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR197 Gene

Domains & Families for MIR197 Gene

Gene Families for MIR197 Gene

Graphical View of Domain Structure for InterPro Entry

P08754

UniProtKB/Swiss-Prot:

GNAI3_HUMAN :
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Family:
  • Belongs to the G-alpha family. G(i/o/t/z) subfamily.
genes like me logo Genes that share domains with MIR197: view

No data available for Suggested Antigen Peptide Sequences for MIR197 Gene

Function for MIR197 Gene

Molecular function for MIR197 Gene

UniProtKB/Swiss-Prot Function:
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).

Gene Ontology (GO) - Molecular Function for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0003924 GTPase activity IEA --
GO:0004871 signal transducer activity IBA --
GO:0005515 protein binding IPI --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MIR197: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR197 Gene

Localization for MIR197 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR197 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. {ECO:0000269 PubMed:17635935}.

Gene Ontology (GO) - Cellular Components for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA --
GO:0005794 Golgi apparatus IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with MIR197: view

No data available for Subcellular locations from COMPARTMENTS for MIR197 Gene

Pathways & Interactions for MIR197 Gene

genes like me logo Genes that share pathways with MIR197: view

Gene Ontology (GO) - Biological Process for MIR197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006810 transport NAS --
GO:0006906 vesicle fusion IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with MIR197: view

No data available for SIGNOR curated interactions for MIR197 Gene

Transcripts for MIR197 Gene

mRNA/cDNA for MIR197 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR197 Gene

No ASD Table

Relevant External Links for MIR197 Gene

GeneLoc Exon Structure for
MIR197
ECgene alternative splicing isoforms for
MIR197

Expression for MIR197 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR197 Gene:

MIR197
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR197 Gene

Orthologs for MIR197 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR197 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNAI3 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNAI3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNAI3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gnai3 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GNAI3 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNAI3 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves GNAI3 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GNAI3 35
  • 97 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii gnai3 35
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta G-ialpha65A 35
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10341 35
  • 82 (a)
OneToMany
Species where no ortholog for MIR197 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR197 Gene

ENSEMBL:
Gene Tree for MIR197 (if available)
TreeFam:
Gene Tree for MIR197 (if available)

Paralogs for MIR197 Gene

Paralogs for MIR197 Gene

genes like me logo Genes that share paralogs with MIR197: view

Variants for MIR197 Gene

Sequence variations from dbSNP and Humsavar for MIR197 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111351338 -- 109,599,060(+) CTGTT(C/T)TGGAC downstream-variant-500B
rs111978115 -- 109,599,168(+) CTTTT(A/G)TCCAT downstream-variant-500B
rs112644286 -- 109,597,511(+) CTTCA(A/G)TGCAC upstream-variant-2KB
rs113172998 -- 109,599,001(+) AAGTA(C/G/T)AGAGT downstream-variant-500B
rs116233808 -- 109,598,240(+) AAATC(A/G)CCTGT upstream-variant-2KB

Relevant External Links for MIR197 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR197

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR197 Gene

Disorders for MIR197 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR197 Gene - From: GeneCards

Disorder Aliases PubMed IDs
auriculocondylar syndrome 1
  • acs
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GNAI3_HUMAN
  • Auriculocondylar syndrome 1 (ARCND1) [MIM:602483]: An autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. {ECO:0000269 PubMed:22560091}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR197

Genetic Association Database (GAD)
MIR197
Human Genome Epidemiology (HuGE) Navigator
MIR197
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR197
genes like me logo Genes that share disorders with MIR197: view

No data available for Genatlas for MIR197 Gene

Publications for MIR197 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers. (PMID: 26199015) Remon J. … Lianes P. (Clin Transl Oncol 2016) 3 64
  3. Micro RNAs mir-106a, mir-122 and mir-197 are increased in severe acute viral hepatitis with coagulopathy. (PMID: 26352910) Weseslindtner L. … Odenthal M. (Liver Int. 2016) 3 64
  4. Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. (PMID: 26581983) Tang W.F. … Horng J.T. (J. Virol. 2016) 3 64
  5. STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells. (PMID: 25451482) Dubey R. … Saini N. (Biochim. Biophys. Acta 2015) 3 64

Products for MIR197 Gene

Sources for MIR197 Gene

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