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Aliases for MIR197 Gene

Subcategory (RNA class) for MIR197 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR197 Gene

  • MicroRNA 197 2 3
  • Hsa-Mir-197 3
  • MiRNA197 3
  • MiR-197 3
  • MIRN197 3

External Ids for MIR197 Gene

Previous Symbols for MIR197 Gene

  • MIRN197

Summaries for MIR197 Gene

Entrez Gene Summary for MIR197 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR197 Gene

MIR197 (MicroRNA 197) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR197 Gene

Genomics for MIR197 Gene

Genomic Location for MIR197 Gene

Start:
109,598,893 bp from pter
End:
109,598,967 bp from pter
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR197 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR197 Gene

No data available for Regulatory Elements for MIR197 Gene

Proteins for MIR197 Gene

Post-translational modifications for MIR197 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR197 Gene

Domains for MIR197 Gene

Gene Families for MIR197 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR197: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR197 Gene

Function for MIR197 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR197 Gene

Localization for MIR197 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR197 Gene

Pathways for MIR197 Gene

SuperPathways for MIR197 Gene

No Data Available

Interacting Proteins for MIR197 Gene

Gene Ontology (GO) - Biological Process for MIR197 Gene

None

No data available for Pathways by source for MIR197 Gene

Transcripts for MIR197 Gene

mRNA/cDNA for MIR197 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR197 Gene

No ASD Table

Relevant External Links for MIR197 Gene

GeneLoc Exon Structure for
MIR197
ECgene alternative splicing isoforms for
MIR197

Expression for MIR197 Gene

genes like me logo Genes that share expressions with MIR197: view

Orthologs for MIR197 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR197 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-197 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-197 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-197 37
  • 100 (a)
OneToOne
Species with no ortholog for MIR197:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR197 Gene

ENSEMBL:
Gene Tree for MIR197 (if available)
TreeFam:
Gene Tree for MIR197 (if available)

Paralogs for MIR197 Gene

No data available for Paralogs for MIR197 Gene

Variants for MIR197 Gene

Sequence variations from dbSNP and Humsavar for MIR197 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs505303 -- 109,598,355(+) CCAAC(C/T)AGCTA upstream-variant-2KB
rs1889470 -- 109,598,799(-) ATGAA(A/C/G/T)ACATT upstream-variant-2KB
rs17024132 -- 109,597,477(+) TTTTA(A/T)AGTCA upstream-variant-2KB
rs17648684 -- 109,598,565(+) TTCAA(C/T)GTAGT upstream-variant-2KB
rs34028288 -- 109,599,459(+) GACTA(-/T)TTTTA downstream-variant-500B

Relevant External Links for MIR197 Gene

HapMap Linkage Disequilibrium report
MIR197

No data available for Structural Variations from Database of Genomic Variants (DGV) for MIR197 Gene

Disorders for MIR197 Gene

Relevant External Links for MIR197

Genetic Association Database (GAD)
MIR197
Human Genome Epidemiology (HuGE) Navigator
MIR197
genes like me logo Genes that share disorders with MIR197: view

No data available for UniProtKB/Swiss-Prot for MIR197 Gene

Publications for MIR197 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. (PMID: 21435175) Sana J. … Slaby O. (J. Cell. Mol. Med. 2011) 3
  4. A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration. (PMID: 22351693) Keutgen X.M. … Fahey T.J. (Clin. Cancer Res. 2012) 3
  5. miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. (PMID: 23139153) Hamada S. … Shimosegawa T. (J. Cell. Physiol. 2013) 3

Products for MIR197 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR197
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR197
    • Block miRNA regulation of MIR197 using miScript Target Protectors

    Sources for MIR197 Gene

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