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MicroRNA 196b
(Previous symbol: MIRN196B)
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Aliases
for MIR196B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
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| MicroRNA 196b1 2 | | MIRN196B1 2 5 | | miR-196b2 | | miRNA196B2 | | mir-196b9 |
Export aliases for MIR196B gene to outside databasesPrevious GC identifer: GC07M027177 |
Summaries
for MIR196B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for MIR196B Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
GeneCards Summary for MIR196B Gene: 
MIR196B (microRNA 196b) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR196B include acute lymphoblastic leukemia, and acute myeloid leukemia.
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Genomic Views
for MIR196B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR196B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR196B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR196B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15.2 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2MIR196B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M027209: view genomic region (via miRBase)
(about GC identifiers)
Start:
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27,209,099 bp from pter |
End:
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27,209,183 bp from pter |
Size:
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85 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 27,260,284-27,260,367 |
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Proteins
for MIR196B gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR196B gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
MIR: ncRNAs / Micro RNAs
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Function
for MIR196B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR196B | |  | Search LifeMap BioReagents cell lines for MIR196B | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR196B |
Pathways & Interactions
for MIR196B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR196B
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Drugs & Compounds
for MIR196B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR196B
Search CenterWatch for drugs/clinical trials and news about MIR196B
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Transcripts
for MIR196B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000384852(miRNA)
GeneLoc Exon Structure
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Expression
for MIR196B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR196B:none
MIR196B expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR196B
Primer
Products: |  | Browse OriGene qPCR
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR196B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR196B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR196B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR196B |
Orthologs
for MIR196B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for MIR196B gene from 1/7 species (see all 7) About this table
Species with no ortholog for MIR196B
ENSEMBL Gene Tree for MIR196B (if available)
TreeFam Gene Tree for MIR196B (if available) |
Paralogs
for MIR196B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MIR196B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for MIR196B (see all 11): About this table 
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR196B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR196B for disorders About GeneDecksing
OMIM gene information: 609688
OMIM disorders: --
11  diseases for MIR196B: About MalaCardsacute lymphoblastic leukemia acute myeloid leukemia nasopharyngitis lymphoblastic leukemia
cervical cancer myeloid leukemia cervicitis leukemia
hepatitis c neuronitis hepatitis
Export disorders for MIR196B gene to outside databases
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Publications
for MIR196B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR196B gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MIR196B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MicroRNAs regulate tumor angiogenesis modulated by end othelial progenitor cells. (PubMed id 22836757)1 Plummer P.N....Mellick A.S. (2013)
- miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells. (PubMed id 23293219)1 Abe W....Narahara H. (2013)
- Transcriptional regulation of miR-196b by ETS2 in gast ric cancer cells. (PubMed id 22298639)1 Liao Y.L....Lin W.C. (2012)
- Differential miRNA expression in childhood acute lymph oblastic leukemia and association with clinical and biological features. (PubMed id 22099053)1 de Oliveira J.C....Tone L.G. (2012)
- miR-196b directly targets both HOXA9/MEIS1 oncogenes a nd FAS tumour suppressor in MLL-rearranged leukaemia. (PubMed id 22353710)1 Li Z....Chen J. (2012)
- Upregulation of miR-196b confers a poor prognosis in g lioblastoma patients via inducing a proliferative phenotype. (PubMed id 22723849)1 Ma R....Kang X. (2012)
- Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma. (PubMed id 22976466)1 Shen J....Santella R.M. (2012)
- Significance of miR-196b in tumor-related epilepsy of patients with gliomas. (PubMed id 23049982)1 You G....Jiang T. (2012)
- The role of microRNA-196a and microRNA-196b as ERG re gulators in acute myeloid leukemia and acute T-lymphoblastic leukemia. (PubMed id 20570349)1 Coskun E....Baldus C.D. (2011)
- Coordinated increase of miRNA-155 and miRNA-196b expre ssion correlates with the detection of the antigenomic strand of hepatitis C vir us in peripheral blood mononuclear cells. (PubMed id 21750860)1 Grek M....Sidorkiewicz M. (2011)
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External Searches for MIR196B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR196B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIR196B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR196B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR196B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR196B gene:
Search GeneIP for patents involving MIR196B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR196B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR196B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR196B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR196B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR196B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR196B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR196B |
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| | | | Search Tocris compounds for MIR196B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR196B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MIR196B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR196B |
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