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Aliases for MIR196B Gene

Subcategory (RNA class) for MIR196B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR196B Gene

  • MicroRNA 196b 2 3
  • HOXA9 4 5
  • Homeobox Protein Hox-1G 4
  • Hsa-Mir-196b 3
  • Homeobox A9 5
  • MiRNA196B 3
  • MiR-196b 3
  • MIRN196B 3
  • HOX1G 4

External Ids for MIR196B Gene

Previous HGNC Symbols for MIR196B Gene

  • MIRN196B

Previous GeneCards Identifiers for MIR196B Gene

  • GC07M027177
  • GC07M027209
  • GC07M027178
  • GC07M027179
  • GC07M027184
  • GC07M027165

Summaries for MIR196B Gene

Entrez Gene Summary for MIR196B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196B Gene

MIR196B (MicroRNA 196b) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is HOXD9.

UniProtKB/Swiss-Prot for MIR196B Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR196B Gene

Genomics for MIR196B Gene

Regulatory Elements for MIR196B Gene

Enhancers for MIR196B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F026372 1.5 ENCODE 12 +800.2 800188 5.5 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF302 ZNF143 ZNF548 SP3 REST RPL23P7 TPM3P4 HMGB3P20 ENSG00000227386 HOXA10-AS HOXA9 MIR196B CBX3 HNRNPA2B1 KIAA0087
GH07F027095 2.8 VISTA FANTOM5 Ensembl ENCODE 11.7 +37.0 36985 86.3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA-AS2 HOXA10-AS HOXA2 HOXA9 TPM3P4 HMGB3P20 PSMC1P2 RPL23P7 HOXA11-AS
GH07F027210 0.8 VISTA ENCODE 11.7 -35.7 -35659 1.2 CTCF RNF2 SUZ12 CBX2 RAD21 YY1 ZFHX2 POLR2A SMARCA4 SMC3 ENSG00000253308 EVX1 EVX1-AS HOXA11 HOXA11-AS HOXA10 HOXA9 MIR196B HOXA1 HOTAIRM1
GH07F027213 1.1 FANTOM5 11.7 -38.6 -38551 0.1 CBX8 RNF2 CBX2 EZH2 ENSG00000253308 EVX1 EVX1-AS HOXA11 HOXA11-AS HOXA10 HOXA9 MIR196B HOTAIRM1 HOXA1
GH07F026862 1.1 ENCODE 10.7 +311.1 311066 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 HOTAIRM1 HMGB3P20 TPM3P4 PSMC1P2 RPL23P7 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR196B on UCSC Golden Path with GeneCards custom track

Promoters for MIR196B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001890139 -920 201 CBX8 RNF2 ZNF366 BCL11A CBX2 GLI4 PRDM1 BCL11B

Genomic Location for MIR196B Gene

Chromosome:
7
Start:
27,162,435 bp from pter
End:
27,175,180 bp from pter
Size:
12,746 bases
Orientation:
Minus strand

Genomic View for MIR196B Gene

Genes around MIR196B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196B Gene

Proteins for MIR196B Gene

  • Protein details for MIR196B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31269-HXA9_HUMAN
    Recommended name:
    Homeobox protein Hox-A9
    Protein Accession:
    P31269
    Secondary Accessions:
    • O43369
    • O43429
    • Q99820

    Protein attributes for MIR196B Gene

    Size:
    272 amino acids
    Molecular mass:
    30172 Da
    Quaternary structure:
    • Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
    • Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
    SequenceCaution:
    • Sequence=AAC50364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MIR196B Gene

Post-translational modifications for MIR196B Gene

  • Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR196B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR196B Gene

Domains & Families for MIR196B Gene

Gene Families for MIR196B Gene

Graphical View of Domain Structure for InterPro Entry

P31269

UniProtKB/Swiss-Prot:

HXA9_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with MIR196B: view

No data available for Suggested Antigen Peptide Sequences for MIR196B Gene

Function for MIR196B Gene

Molecular function for MIR196B Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Ontology (GO) - Molecular Function for MIR196B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MIR196B: view

Animal Model Products

Transcription Factor Targets for MIR196B Gene

Selected GeneGlobe predicted Target genes for MIR196B

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for MIR196B Gene

Localization for MIR196B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR196B Gene

Gene Ontology (GO) - Cellular Components for MIR196B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR196B: view

No data available for Subcellular locations from COMPARTMENTS for MIR196B Gene

Pathways & Interactions for MIR196B Gene

SuperPathways for MIR196B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR196B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development TAS --
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with MIR196B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR196B Gene

Transcripts for MIR196B Gene

mRNA/cDNA for MIR196B Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196B Gene

No ASD Table

Relevant External Links for MIR196B Gene

GeneLoc Exon Structure for
MIR196B
ECgene alternative splicing isoforms for
MIR196B

Expression for MIR196B Gene

mRNA expression in normal human tissues for MIR196B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196B Gene:

MIR196B
genes like me logo Genes that share expression patterns with MIR196B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR196B Gene

Orthologs for MIR196B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hoxa9 35
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HOXA9 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HOXA9 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 89 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 95 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hoxa9b 35
  • 48 (a)
ManyToMany
hoxa9a 35 35
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for MIR196B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196B Gene

ENSEMBL:
Gene Tree for MIR196B (if available)
TreeFam:
Gene Tree for MIR196B (if available)

Paralogs for MIR196B Gene

genes like me logo Genes that share paralogs with MIR196B: view

Variants for MIR196B Gene

Sequence variations from dbSNP and Humsavar for MIR196B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1064032 -- 27,169,583(-) GCAGC(C/G)CTTCG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1064033 -- 27,169,439(-) GGCCG(C/G)GCGGG intron-variant, nc-transcript-variant, downstream-variant-500B
rs111242660 -- 27,169,781(+) AGGGA(C/G)AGGGA intron-variant, upstream-variant-2KB
rs116681061 -- 27,171,113(+) ATTAT(C/T)TATCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs117827196 -- 27,169,566(+) AGTTC(A/T)GGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR196B Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Relevant External Links for MIR196B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196B Gene

Disorders for MIR196B Gene

UniProtKB/Swiss-Prot

HXA9_HUMAN
  • Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.
  • Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

Relevant External Links for MIR196B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196B

No disorders were found for MIR196B Gene.

No data available for MalaCards and Genatlas for MIR196B Gene

Publications for MIR196B Gene

  1. MicroRNA-196b promotes cell proliferation and suppress cell differentiation in vitro. (PMID: 25475721) Cao D. … Zhong L. (Biochem. Biophys. Res. Commun. 2015) 3 64
  2. Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. (PMID: 25485932) Lu Y.C. … Cheng A.J. (Clin. Biochem. 2015) 3 64
  3. Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency. (PMID: 26469550) Wang P. … Zhu H. (Virology 2015) 3 64
  4. Specific microRNAs as novel biomarkers for combination chemotherapy resistance detection of colon adenocarcinoma. (PMID: 26626874) Hu J. … Cai S. (Eur. J. Med. Res. 2015) 3 64
  5. MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells. (PMID: 25605245) Mo J.S. … Chae S.C. (Oncotarget 2015) 3 64

Products for MIR196B Gene

Sources for MIR196B Gene

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