Aliases for MIR196B Gene
Subcategory (RNA class) for MIR196B Gene
miRNA
Quality Score for this RNA gene is
10.2
External Ids for MIR196B Gene
- HGNC: 31790
- Entrez Gene: 442920
- Ensembl: ENSG00000283745
- OMIM: 609688
- miRBase: hsa-mir-196b
ORGUL Members for MIR196B Gene
Previous HGNC Symbols for MIR196B Gene
- MIRN196B
Previous GeneCards Identifiers for MIR196B Gene
- GC07M027177
- GC07M027209
- GC07M027178
- GC07M027179
- GC07M027184
- GC07M027165
Summaries for MIR196B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR196B Gene
MIR196B (MicroRNA 196b) is an RNA Gene, and is affiliated with the miRNA class.
fRNAdb sequence ontologies for MIR196B Gene - the ORGUL cluster for this gene includes several descriptions:
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
-
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.
Additional gene information for MIR196B Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196B Gene
Genomics for MIR196B Gene
GeneHancer (GH) Regulatory Elements for MIR196B Gene
Promoters and enhancers for MIR196B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07I027095 | Promoter/Enhancer | 3.4 | VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.3 | +31.4 | 31368 | 86.3 | MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 | HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR196B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR196B Gene
Genomic Locations for MIR196B Gene
- chr7:27,169,480-27,169,563
- (GRCh38/hg38)
- Size:
- 84 bases
- Orientation:
- Minus strand
- chr7:27,209,099-27,209,183
- (GRCh37/hg19)
Genomic View for MIR196B Gene
Genes around MIR196B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
MIR196B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR196B Gene
ORGUL Member Location for MIR196B Gene
Proteins for MIR196B Gene
Post-translational modifications for MIR196B Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR196B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR196B
- Origene Custom Protein Services for MIR196B
- Search GeneTex for Proteins for MIR196B
No data available for DME Specific Peptides for MIR196B Gene
Domains & Families for MIR196B Gene
Gene Families for MIR196B Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196B Gene
Function for MIR196B Gene
Phenotypes From GWAS Catalog for MIR196B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR196B
-
- Search ViGene Biosciences for MIR196B
CRISPR Products
- Browse CRISPR knockouts for MIR196B
- Applied Biological Materials CRISPR for MIR196B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR196B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR196B
- VectorBuilder custom plasmid, inducible vectors for MIR196B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR196B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR196B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196B Gene
Localization for MIR196B Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196B Gene
Transcripts for MIR196B Gene
fRNAdb Secondary structures for MIR196B Gene
mRNA/cDNA for MIR196B Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR196B
- Applied Biological Materials CRISPR for MIR196B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR196B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR196B
- VectorBuilder custom plasmid, inducible vectors for MIR196B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR196B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR196B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR196B Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR196B Gene:
MIR196BPrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196B Gene
Orthologs for MIR196B Gene
No data available for Orthologs for MIR196B Gene
Paralogs for MIR196B Gene
No data available for Paralogs for MIR196B Gene
Variants for MIR196B Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1002835168 | -- | 27,170,176(-) | C/G | upstream_transcript_variant | |
| rs1003298437 | -- | 27,170,006(-) | C/G | upstream_transcript_variant | |
| rs1003587495 | -- | 27,169,126(-) | G/A | downstream_transcript_variant | |
| rs1003980797 | -- | 27,170,972(-) | A/C | upstream_transcript_variant | |
| rs1005170518 | -- | 27,169,701(-) | G/C | upstream_transcript_variant |
Additional Variant Information for MIR196B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR196B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196B Gene
Disorders for MIR196B Gene
Additional Disease Information for MIR196B
No disorders were found for MIR196B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196B Gene
Publications for MIR196B Gene
- MicroRNA-directed cleavage of HOXB8 mRNA. (PMID: 15105502) Yekta S … Bartel DP (Science (New York, N.Y.) 2004) 1 3 58
- MicroRNA-196b Inhibits Cell Growth and Metastasis of Lung Cancer Cells by Targeting Runx2. (PMID: 28950255) Bai X … Hua S (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
- Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9. (PMID: 28387653) Chong GO … Cho YL (Cancer genomics & proteomics 2017) 3 58
- Over-expression of miR-196b-5p is significantly associated with the progression of myelodysplastic syndrome. (PMID: 28224273) Wen J … Liu Z (International journal of hematology 2017) 3 58
- MicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer. (PMID: 28186267) Kanno S … Nakase H (Carcinogenesis 2017) 3 58
Products for MIR196B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse cDNA Clones
- Browse Cell Culture Products
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR196B
- VectorBuilder custom plasmid, inducible vectors for MIR196B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR196B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR196B
- Search GeneTex for Proteins for MIR196B
Sources for MIR196B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew