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MIR196B Gene(RNA Gene)

MicroRNA 196b

GCID:
GC07M027166
GIFtS:
18
Genes Participants
UDN Logo

Aliases for MIR196B Gene

Subcategory (RNA class) for MIR196B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR196B Gene

  • MicroRNA 196b 2 3 5
  • Hsa-Mir-196b 3
  • MiRNA196B 3
  • MiR-196b 3
  • MIRN196B 3

External Ids for MIR196B Gene

ORGUL Members for MIR196B Gene

Previous HGNC Symbols for MIR196B Gene

  • MIRN196B

Previous GeneCards Identifiers for MIR196B Gene

  • GC07M027177
  • GC07M027209
  • GC07M027178
  • GC07M027179
  • GC07M027184
  • GC07M027165

Summaries for MIR196B Gene

Entrez Gene Summary for MIR196B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196B Gene

MIR196B (MicroRNA 196b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR196B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196B Gene

Genomics for MIR196B Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR196B Gene


Promoters for MIR196B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000325322 -237 801 KLF17 ZEB1 GLIS2 ZNF366 SCRT2 CEBPB OVOL3 ZEB2 ZNF398 ZFP69B
ENSR00000325323 463 201 ZNF473 ZSCAN4 ZNF76 GLI4 ZNF2 ZEB1 GLIS2 GATA2 ZNF366 ZNF391
ENSR00000325321 -1137 201 CTCF RNF2 SUZ12 CBX2 REST RAD21 ZNF335 CTBP1 CBX8 PRDM6

Genomic Location for MIR196B Gene

Chromosome:
7
Start:
27,169,480 bp from pter
End:
27,169,563 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR196B Gene

Genes around MIR196B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR196B Gene

ORGUL Member Location for MIR196B Gene

ORGUL Member Location for MIR196B gene

Proteins for MIR196B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR196B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196B Gene

Domains & Families for MIR196B Gene

Gene Families for MIR196B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196B Gene

Function for MIR196B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196B Gene

Localization for MIR196B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196B Gene

Pathways & Interactions for MIR196B Gene

SuperPathways for MIR196B Gene

PathCards logo More details on SuperPathways for MIR196B
No Data Available

Interacting Proteins for MIR196B Gene

Gene Ontology (GO) - Biological Process for MIR196B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196B Gene

Drugs & Compounds for MIR196B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR196B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR196B Gene

  • FR196588
  • FR186367
  • FR166337

mRNA/cDNA for MIR196B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196B Gene

No ASD Table

Relevant External Links for MIR196B Gene

GeneLoc Exon Structure for
MIR196B
ECgene alternative splicing isoforms for
MIR196B

Expression for MIR196B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196B Gene

mRNA expression in normal human tissues for MIR196B Gene
mRNA expression by BioGPS for MIR196B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196B Gene:

MIR196B
genes like me logo Genes that share expression patterns with MIR196B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196B Gene

Orthologs for MIR196B Gene

Evolution for MIR196B Gene

ENSEMBL:
Gene Tree for MIR196B (if available)
TreeFam:
Gene Tree for MIR196B (if available)

No data available for Orthologs for MIR196B Gene

Paralogs for MIR196B Gene

No data available for Paralogs for MIR196B Gene

Variants for MIR196B Gene

Sequence variations from dbSNP and Humsavar for MIR196B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001088460 -- 27,170,069(+) CCCCG(-/C)CCCCC intron-variant, upstream-variant-2KB
rs1002835168 -- 27,170,176(+) CGGGT(C/G)CACCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003298437 -- 27,170,006(+) TCCCC(C/G)TCTCC intron-variant, upstream-variant-2KB
rs1003587495 -- 27,169,126(+) TGTGT(A/G)TGTGT intron-variant, downstream-variant-500B
rs1003980797 -- 27,170,972(+) AAAAA(A/C)CTTTT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR196B Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Relevant External Links for MIR196B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196B Gene

Disorders for MIR196B Gene

Relevant External Links for MIR196B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196B

No disorders were found for MIR196B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196B Gene

Publications for MIR196B Gene

  1. MicroRNA-directed cleavage of HOXB8 mRNA. (PMID: 15105502) Yekta S. … Bartel D.P. (Science 2004) 1 3 64
  2. MicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer. (PMID: 28186267) Kanno S. … Nakase H. (Carcinogenesis 2017) 3 64
  3. Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9. (PMID: 28387653) Chong G.O. … Cho Y.L. (Cancer Genomics Proteomics 2017) 3 64
  4. Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. (PMID: 25485932) Lu Y.C. … Cheng A.J. (Clin. Biochem. 2015) 3 64
  5. MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells. (PMID: 25605245) Mo J.S. … Chae S.C. (Oncotarget 2015) 3 64

Products for MIR196B Gene

Sources for MIR196B Gene

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