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Aliases for MIR196B Gene

Subcategory (RNA class) for MIR196B Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR196B Gene

  • MicroRNA 196b 2 3 5
  • Hsa-Mir-196b 3
  • MiRNA196B 3
  • MiR-196b 3
  • MIRN196B 3

External Ids for MIR196B Gene

Previous HGNC Symbols for MIR196B Gene

  • MIRN196B

Previous GeneCards Identifiers for MIR196B Gene

  • GC07M027177
  • GC07M027209
  • GC07M027178
  • GC07M027179

Summaries for MIR196B Gene

Entrez Gene Summary for MIR196B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196B Gene

MIR196B (MicroRNA 196b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR196B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196B Gene

Genomics for MIR196B Gene

Regulatory Elements for MIR196B Gene

Promoters for MIR196B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR196B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR196B Gene

Chromosome:
7
Start:
27,169,480 bp from pter
End:
27,169,564 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR196B Gene

Genes around MIR196B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196B Gene

ORGUL Member Location for MIR196B Gene

ORGUL Member Location for MIR196B gene

Proteins for MIR196B Gene

Post-translational modifications for MIR196B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196B Gene

Domains & Families for MIR196B Gene

Gene Families for MIR196B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196B Gene

Function for MIR196B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196B Gene

Localization for MIR196B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196B Gene

Pathways & Interactions for MIR196B Gene

SuperPathways for MIR196B Gene

No Data Available

Interacting Proteins for MIR196B Gene

Gene Ontology (GO) - Biological Process for MIR196B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196B Gene

Drugs & Compounds for MIR196B Gene

No Compound Related Data Available

Transcripts for MIR196B Gene

fRNAdb Secondary structures for MIR196B Gene

  • FR196588
  • FR186367
  • FR166337

mRNA/cDNA for MIR196B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196B Gene

No ASD Table

Relevant External Links for MIR196B Gene

GeneLoc Exon Structure for
MIR196B
ECgene alternative splicing isoforms for
MIR196B

Expression for MIR196B Gene

mRNA expression in normal human tissues for MIR196B Gene

genes like me logo Genes that share expression patterns with MIR196B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR196B Gene

Orthologs for MIR196B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-196b 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196b 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196b 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196b 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-2 36
  • 76 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-1 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196a-2 36
  • 63 (a)
ManyToMany
Species with no ortholog for MIR196B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196B Gene

ENSEMBL:
Gene Tree for MIR196B (if available)
TreeFam:
Gene Tree for MIR196B (if available)

Paralogs for MIR196B Gene

No data available for Paralogs for MIR196B Gene

Variants for MIR196B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR196B Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294
dgv7237n71 CNV Loss 21882294
dgv7238n71 CNV Loss 21882294
dgv7239n71 CNV Loss 21882294

Relevant External Links for MIR196B Gene

HapMap Linkage Disequilibrium report
MIR196B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR196B Gene

Disorders for MIR196B Gene

Relevant External Links for MIR196B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196B

No disorders were found for MIR196B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196B Gene

Publications for MIR196B Gene

  1. Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. (PMID: 25485932) Lu Y.C. … Cheng A.J. (Clin. Biochem. 2015) 3 67
  2. MicroRNA-directed cleavage of HOXB8 mRNA. (PMID: 15105502) Yekta S. … Bartel D.P. (Science 2004) 1 3
  3. MicroRNA-196b promotes cell proliferation and suppress cell differentiation in vitro. (PMID: 25475721) Cao D. … Zhong L. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. (PMID: 24334453) Velu C.S. … Grimes H.L. (J. Clin. Invest. 2014) 3
  5. MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection? (PMID: 24591085) KaA8uA1na E.M. (Rev. Med. Virol. 2014) 3

Products for MIR196B Gene

Sources for MIR196B Gene

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