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Aliases for MIR196A2 Gene

Subcategory (RNA class) for MIR196A2 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR196A2 Gene

  • MicroRNA 196a-2 2 3
  • MicroRNA 196-2 2 3
  • MIRN196A2 3 6
  • Hsa-Mir-196a-2 3
  • Hsa-Mir-196-2 3
  • MIRN196-2 3

External Ids for MIR196A2 Gene

ORGUL Members for MIR196A2 Gene

Previous HGNC Symbols for MIR196A2 Gene

  • MIRN196-2
  • MIRN196A2

Previous GeneCards Identifiers for MIR196A2 Gene

  • GC12P052675
  • GC12P054385

Summaries for MIR196A2 Gene

Entrez Gene Summary for MIR196A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A2 Gene

MIR196A2 (MicroRNA 196a-2) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR196A2 include keloids and pancreatic ductal adenocarcinoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR196A2 Gene

Genomics for MIR196A2 Gene

Genomic Location for MIR196A2 Gene

Start:
53,991,738 bp from pter
End:
53,991,847 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR196A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR196A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A2 Gene

No data available for Regulatory Elements for MIR196A2 Gene

Proteins for MIR196A2 Gene

Post-translational modifications for MIR196A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A2 Gene

Domains for MIR196A2 Gene

Gene Families for MIR196A2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A2 Gene

Function for MIR196A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR196A2 Gene

Localization for MIR196A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A2 Gene

Pathways for MIR196A2 Gene

SuperPathways for MIR196A2 Gene

No Data Available

Interacting Proteins for MIR196A2 Gene

Gene Ontology (GO) - Biological Process for MIR196A2 Gene

None

No data available for Pathways by source for MIR196A2 Gene

Transcripts for MIR196A2 Gene

mRNA/cDNA for MIR196A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR196A2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A2 Gene

No ASD Table

Relevant External Links for MIR196A2 Gene

GeneLoc Exon Structure for
MIR196A2
ECgene alternative splicing isoforms for
MIR196A2

Expression for MIR196A2 Gene

mRNA expression in normal human tissues for MIR196A2 Gene

genes like me logo Genes that share expressions with MIR196A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR196A2 Gene

Orthologs for MIR196A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-196a-2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-2 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196a-1 36
  • 78 (a)
OneToMany
mir196c 36
  • 75 (a)
OneToMany
mir196d 36
  • 74 (a)
OneToMany
Species with no ortholog for MIR196A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A2 Gene

ENSEMBL:
Gene Tree for MIR196A2 (if available)
TreeFam:
Gene Tree for MIR196A2 (if available)

Paralogs for MIR196A2 Gene

No data available for Paralogs for MIR196A2 Gene

Variants for MIR196A2 Gene

Sequence variations from dbSNP and Humsavar for MIR196A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11614913 -- 53,991,815(+) AACTG(C/T)CTGAG nc-transcript-variant
rs12304647 -- 53,991,163(+) TACAG(A/C)GGGTT upstream-variant-2KB
rs12318147 -- 53,991,092(+) GGTCT(C/T)CTCGA upstream-variant-2KB
rs12426535 -- 53,991,250(+) CCCTG(G/T)CTGTA upstream-variant-2KB
rs17105765 -- 53,992,208(+) GAAGA(C/G)GGTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR196A2 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Relevant External Links for MIR196A2 Gene

HapMap Linkage Disequilibrium report
MIR196A2
Human Gene Mutation Database (HGMD)
MIR196A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR196A2 Gene

Disorders for MIR196A2 Gene

Relevant External Links for MIR196A2

Genetic Association Database (GAD)
MIR196A2
Human Genome Epidemiology (HuGE) Navigator
MIR196A2
genes like me logo Genes that share disorders with MIR196A2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR196A2 Gene

Publications for MIR196A2 Gene

  1. Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population. (PMID: 21073609) Okubo M. … Hirata I. (Helicobacter 2010) 3 48
  2. A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. (PMID: 21080878) Li X.D. … Liu C.F. (Pathology 2010) 3 48
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  4. Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population. (PMID: 19514064) Xu J. … Chen Y. (Hum. Mutat. 2009) 3 48
  5. Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. (PMID: 19834808) Peng S. … Cheng Q. (Dig. Dis. Sci. 2010) 3 48

Products for MIR196A2 Gene

Sources for MIR196A2 Gene

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