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Aliases for MIR196A2 Gene

Subcategory (RNA class) for MIR196A2 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR196A2 Gene

  • MicroRNA 196a-2 2 3 5
  • MicroRNA 196-2 2 3
  • Hsa-Mir-196a-2 3
  • Hsa-Mir-196-2 3
  • Mir-196a-2 3
  • MIRN196-2 3
  • MIRN196A2 3

External Ids for MIR196A2 Gene

ORGUL Members for MIR196A2 Gene

Previous HGNC Symbols for MIR196A2 Gene

  • MIRN196-2
  • MIRN196A2

Previous GeneCards Identifiers for MIR196A2 Gene

  • GC12P052675
  • GC12P054385
  • GC12P053992
  • GC12P053997

Summaries for MIR196A2 Gene

Entrez Gene Summary for MIR196A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A2 Gene

MIR196A2 (MicroRNA 196a-2) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR196A2 Gene

Genomics for MIR196A2 Gene

Regulatory Elements for MIR196A2 Gene

Promoters for MIR196A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR196A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR196A2 Gene

Chromosome:
12
Start:
53,991,732 bp from pter
End:
53,991,852 bp from pter
Size:
121 bases
Orientation:
Plus strand

Genomic View for MIR196A2 Gene

Genes around MIR196A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A2 Gene

Proteins for MIR196A2 Gene

Post-translational modifications for MIR196A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A2 Gene

Domains & Families for MIR196A2 Gene

Gene Families for MIR196A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A2 Gene

Function for MIR196A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A2 Gene

Localization for MIR196A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A2 Gene

Pathways & Interactions for MIR196A2 Gene

SuperPathways for MIR196A2 Gene

No Data Available

Interacting Proteins for MIR196A2 Gene

Gene Ontology (GO) - Biological Process for MIR196A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196A2 Gene

Drugs & Compounds for MIR196A2 Gene

No Compound Related Data Available

Transcripts for MIR196A2 Gene

mRNA/cDNA for MIR196A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A2 Gene

No ASD Table

Relevant External Links for MIR196A2 Gene

GeneLoc Exon Structure for
MIR196A2
ECgene alternative splicing isoforms for
MIR196A2

Expression for MIR196A2 Gene

mRNA expression in normal human tissues for MIR196A2 Gene

genes like me logo Genes that share expression patterns with MIR196A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR196A2 Gene

Orthologs for MIR196A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196a 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-2 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196a-1 36
  • 78 (a)
OneToMany
mir196c 36
  • 75 (a)
OneToMany
mir196d 36
  • 74 (a)
OneToMany
Species with no ortholog for MIR196A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A2 Gene

ENSEMBL:
Gene Tree for MIR196A2 (if available)
TreeFam:
Gene Tree for MIR196A2 (if available)

Paralogs for MIR196A2 Gene

No data available for Paralogs for MIR196A2 Gene

Variants for MIR196A2 Gene

Sequence variations from dbSNP and Humsavar for MIR196A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34025887 -- 53,990,978(+) GGCAG(-/C)CGACT upstream-variant-2KB
rs61921775 -- 53,992,323(+) GAGCG(A/C)CAGCC downstream-variant-500B
rs73313174 -- 53,991,221(+) GCCTC(A/G)TCCAG upstream-variant-2KB
rs116581990 -- 53,991,923(+) AGTGG(G/T)TGCAG downstream-variant-500B
rs141350123 -- 53,991,939(+) GGAGG(A/G)CAAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR196A2 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Relevant External Links for MIR196A2 Gene

HapMap Linkage Disequilibrium report
MIR196A2
Human Gene Mutation Database (HGMD)
MIR196A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A2 Gene

Disorders for MIR196A2 Gene

Relevant External Links for MIR196A2

Genetic Association Database (GAD)
MIR196A2
Human Genome Epidemiology (HuGE) Navigator
MIR196A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196A2

No disorders were found for MIR196A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A2 Gene

Publications for MIR196A2 Gene

  1. A functional polymorphism in the pre-microRNA-196a2 and the risk of lung cancer in a Korean population. (PMID: 20466450) Kim M.J. … Park J.Y. (Lung Cancer 2010) 3 48 67
  2. Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population. (PMID: 26112096) NikoliA8 Z. … BrajuA!koviA8 G. (Exp. Mol. Pathol. 2015) 3
  3. The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose. (PMID: 25557604) Ghanbari M. … Dehghan A. (Obesity (Silver Spring) 2015) 3
  4. A functional polymorphism in microRNA-196a2 is associated with increased susceptibility to non-Hodgkin lymphoma. (PMID: 25501512) Li T. … Liu D. (Tumour Biol. 2015) 3
  5. MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of II_BI+ both in vitro and in vivo. (PMID: 24463357) Yang G. … Zhao S. (Neuro-oncology 2014) 3

Products for MIR196A2 Gene

Sources for MIR196A2 Gene

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