Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR196A2 Gene

Subcategory (RNA class) for MIR196A2 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR196A2 Gene

  • MicroRNA 196a-2 2 3 5
  • MicroRNA 196-2 2 3
  • Hsa-Mir-196a-2 3
  • Hsa-Mir-196-2 3
  • Mir-196a-2 3
  • MIRN196-2 3
  • MIRN196A2 3

External Ids for MIR196A2 Gene

ORGUL Members for MIR196A2 Gene

Previous HGNC Symbols for MIR196A2 Gene

  • MIRN196-2
  • MIRN196A2

Previous GeneCards Identifiers for MIR196A2 Gene

  • GC12P052675
  • GC12P054385
  • GC12P053992
  • GC12P053997
  • GC12P054012
  • GC12P054041
  • GC12P054052

Summaries for MIR196A2 Gene

Entrez Gene Summary for MIR196A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A2 Gene

MIR196A2 (MicroRNA 196a-2) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR196A2 Gene

Genomics for MIR196A2 Gene

Regulatory Elements for MIR196A2 Gene

Enhancers for MIR196A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G054195 1.5 FANTOM5 Ensembl ENCODE 11.8 +204.9 204938 3.1 HDGF PKNOX1 KLF17 ZNF121 GLIS2 ZNF366 SMARCC2 FOS KLF7 KDM4B MAP3K12 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR196A2 MIR615 HOXC4 HOXC5
GH12G053962 1.4 ENCODE dbSUPER 12.6 -25.1 -25060 7.5 CREB3L1 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 HOXC8 HOXC9 MAP3K12 HOXC5 HOTAIR HOXC6 HOXC4 SP1 SPRYD3 ENSG00000258086
GH12G054191 1.2 Ensembl ENCODE 11.3 +200.0 200000 0.9 ATF1 WRNIP1 ARID4B SIN3A ZNF2 ZNF143 KLF7 DEK SP3 YY2 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR615 HOXC5 HOXC4 MAP3K12 LOC102724030
GH12G054130 1.2 ENCODE dbSUPER 10.9 +143.0 143026 8.3 FOXA2 ZSCAN4 KLF17 FEZF1 RAD21 RARA ZNF121 MIXL1 DEK EGR2 FLJ12825 TARBP2 SMUG1 MIR615 HOXC4 HOXC5 HOXC6 ENSG00000260470 HOXC8 HOXC-AS1
GH12G054051 1.1 ENCODE 11.2 +61.8 61780 4.8 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 ZNF143 ZNF263 SP3 CBX5 HOTAIR SP1 ENSG00000258344 HOXC4 HOXC5 HOXC6 MIR196A2 HOXC-AS3 HOXC10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR196A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR196A2 Gene

Chromosome:
12
Start:
53,991,738 bp from pter
End:
53,991,847 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR196A2 Gene

Genes around MIR196A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A2 Gene

Proteins for MIR196A2 Gene

Post-translational modifications for MIR196A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A2 Gene

Domains & Families for MIR196A2 Gene

Gene Families for MIR196A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A2 Gene

Function for MIR196A2 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A2 Gene

Localization for MIR196A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A2 Gene

Pathways & Interactions for MIR196A2 Gene

SuperPathways for MIR196A2 Gene

No Data Available

Interacting Proteins for MIR196A2 Gene

Gene Ontology (GO) - Biological Process for MIR196A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196A2 Gene

Drugs & Compounds for MIR196A2 Gene

No Compound Related Data Available

Transcripts for MIR196A2 Gene

mRNA/cDNA for MIR196A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A2 Gene

No ASD Table

Relevant External Links for MIR196A2 Gene

GeneLoc Exon Structure for
MIR196A2
ECgene alternative splicing isoforms for
MIR196A2

Expression for MIR196A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196A2 Gene:

MIR196A2
genes like me logo Genes that share expression patterns with MIR196A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A2 Gene

Orthologs for MIR196A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-196a-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-196a 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-3 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196a-2 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196a-1 35
  • 78 (a)
OneToMany
mir196c 35
  • 75 (a)
OneToMany
mir196d 35
  • 74 (a)
OneToMany
Species where no ortholog for MIR196A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A2 Gene

ENSEMBL:
Gene Tree for MIR196A2 (if available)
TreeFam:
Gene Tree for MIR196A2 (if available)

Paralogs for MIR196A2 Gene

No data available for Paralogs for MIR196A2 Gene

Variants for MIR196A2 Gene

Sequence variations from dbSNP and Humsavar for MIR196A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000637790 -- 53,990,067(+) CATCT(A/G)GTAAC upstream-variant-2KB, utr-variant-3-prime
rs1001220548 -- 53,991,023(+) CCATG(A/G)GGGTT upstream-variant-2KB
rs1003794287 -- 53,991,718(+) AGATG(C/T)AAAGC upstream-variant-2KB
rs1005665014 -- 53,990,247(+) AAAAA(A/T)CCTAA upstream-variant-2KB, utr-variant-3-prime
rs1006362729 -- 53,990,485(+) AGTAA(C/T)GTCAG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR196A2 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Relevant External Links for MIR196A2 Gene

Human Gene Mutation Database (HGMD)
MIR196A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A2 Gene

Disorders for MIR196A2 Gene

Relevant External Links for MIR196A2

Genetic Association Database (GAD)
MIR196A2
Human Genome Epidemiology (HuGE) Navigator
MIR196A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196A2

No disorders were found for MIR196A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A2 Gene

Publications for MIR196A2 Gene

  1. Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. (PMID: 19834808) Peng S. … Cheng Q. (Dig. Dis. Sci. 2010) 3 46 64
  2. Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. (PMID: 19847796) Catucci I. … Peterlongo P. (Hum. Mutat. 2010) 3 46 64
  3. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 46 64
  4. Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. (PMID: 19881472) Wang M. … Ni C. (J. Hum. Genet. 2010) 3 46 64
  5. Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. (PMID: 20188135) Qi P. … Gao C.F. (Hum. Immunol. 2010) 3 46 64

Products for MIR196A2 Gene

Sources for MIR196A2 Gene

Content
Loading form....