Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR196A1 Gene

Subcategory (RNA class) for MIR196A1 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR196A1 Gene

  • MicroRNA 196a-1 2 3 5
  • MicroRNA 196-1 2 3
  • MicroRNA 196a 2 3
  • MicroRNA MiR-196 3
  • Hsa-Mir-196a-1 3
  • Hsa-Mir-196-1 3
  • Mir-196a-1 3
  • MIRN196-1 3
  • MIRN196A1 3

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR196A1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196A1

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

Regulatory Elements for MIR196A1 Gene

Enhancers for MIR196A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048869 1.3 Ensembl ENCODE 9.9 -239.1 -239147 5.1 FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS ATP5G1 TTLL6 CALCOCO2 UBE2Z HOXB13 PRAC1 PRAC2 SUMO2P17 LOC105371811 ENSG00000238804
GH17G048471 1.3 Ensembl ENCODE dbSUPER 9.4 +159.9 159878 1.7 HDGF KLF17 FEZF1 SCRT2 FOS RELB IKZF2 GATAD2B TBX21 ZNF341 SKAP1 HOXB-AS2 HOXB3 HOXB4 MIR10A HOXB-AS1 HOXB2 HOXB1 MIR196A1 CDK5RAP3
GH17G048264 1.1 Ensembl ENCODE 10.6 +366.8 366819 2.7 ATF1 ZSCAN4 INSM2 KLF17 SIN3A ZBTB40 EGR1 ZNF366 SCRT2 FOS SKAP1 COPZ2 CDK5RAP3 EGID-105371807 MIR1203 MIR196A1 RNU6-1152P SNX11 CBX1 HOXB2
GH17G048139 1.1 FANTOM5 Ensembl 9.6 +492.4 492359 0.8 ESRRA ZBTB21 JUN ZNF384 ZEB1 FOSL1 HIC1 ZNF121 SCRT2 NR2F6 CDK5RAP3 SKAP1 CBX1 SNX11 NFE2L1 COPZ2 MIR152 HOXB-AS4 HOXB9 MIR196A1
GH17G048799 1 ENCODE 9.9 -168.4 -168353 3.6 ARID4B SIN3A ZNF48 YY1 SP5 MXD4 PPARG KAT8 SSRP1 MIER3 ATP5G1 TTLL6 PRAC1 PRAC2 LOC105371811 HOXB13 ENSG00000238804 ENSG00000230532 SNF8 RNU1-42P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR196A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR196A1 Gene

Chromosome:
17
Start:
48,632,490 bp from pter
End:
48,632,559 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR196A1 Gene

Genes around MIR196A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

ORGUL Member Location for MIR196A1 Gene

ORGUL Member Location for MIR196A1 gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains & Families for MIR196A1 Gene

Gene Families for MIR196A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways & Interactions for MIR196A1 Gene

SuperPathways for MIR196A1 Gene

No Data Available

Interacting Proteins for MIR196A1 Gene

Gene Ontology (GO) - Biological Process for MIR196A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196A1 Gene

Drugs & Compounds for MIR196A1 Gene

No Compound Related Data Available

Transcripts for MIR196A1 Gene

fRNAdb Secondary structures for MIR196A1 Gene

  • hsa-mir-196a-1_MI0000238_Homo_sapiens_miR-196a-1_stem-loop_hairpin

mRNA/cDNA for MIR196A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
MIR196A1
ECgene alternative splicing isoforms for
MIR196A1

Expression for MIR196A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196A1 Gene:

MIR196A1
genes like me logo Genes that share expression patterns with MIR196A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-1 35
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196a 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-1 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196c 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196b 35
  • 63 (a)
OneToOne
Species where no ortholog for MIR196A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

ENSEMBL:
Gene Tree for MIR196A1 (if available)
TreeFam:
Gene Tree for MIR196A1 (if available)

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

Sequence variations from dbSNP and Humsavar for MIR196A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000346929 -- 48,634,269(+) CACTG(A/C)AACCT upstream-variant-2KB
rs1000400864 -- 48,634,036(+) AGACC(C/G)TATGA upstream-variant-2KB
rs1002918694 -- 48,632,195(+) TAAGG(C/T)TGGAA downstream-variant-500B
rs1003245217 -- 48,633,948(+) TCTCT(C/T)GGAGG upstream-variant-2KB
rs1003666064 -- 48,633,717(+) AAATA(A/C)AATAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850
nsv833471 CNV gain 17160897

Relevant External Links for MIR196A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A1 Gene

Disorders for MIR196A1 Gene

Relevant External Links for MIR196A1

Genetic Association Database (GAD)
MIR196A1
Human Genome Epidemiology (HuGE) Navigator
MIR196A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196A1

No disorders were found for MIR196A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K. … Bai Y. (Biomarkers 2010) 3 46 64
  2. MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus. (PMID: 27816459) Motawi T.K. … Kortam M.A. (Chem. Biol. Interact. 2016) 3 64
  3. Serum microRNA-196 and microRNA-200 in pancreatic ductal adenocarcinoma of patients with diabetes mellitus. (PMID: 27267055) A krha P. … AndA9l M. (Pancreatology 2016) 3 64
  4. Downregulation of microRNA-196a enhances the sensitivity of non-small cell lung cancer cells to cisplatin treatment. (PMID: 26936095) Li Q. … Liu Y. (Int. J. Mol. Med. 2016) 3 64
  5. Inhibition of miR-196a affects esophageal cancer cell growth in vitro. (PMID: 27621035) Ma Y. … Bai M. (Biomed. Pharmacother. 2016) 3 64

Products for MIR196A1 Gene

Sources for MIR196A1 Gene

Content
Loading form....