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Aliases for MIR196A1 Gene

Subcategory (RNA class) for MIR196A1 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR196A1 Gene

  • MicroRNA 196a-1 2 3 5
  • MicroRNA 196-1 2 3
  • MicroRNA 196a 2 3
  • MicroRNA MiR-196 3
  • Hsa-Mir-196a-1 3
  • Hsa-Mir-196-1 3
  • Mir-196a-1 3
  • MIRN196-1 3
  • MIRN196A1 3

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR196A1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196A1

Additional gene information for MIR196A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

GeneHancer (GH) Regulatory Elements for MIR196A1 Gene

Promoters and enhancers for MIR196A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I048631 Enhancer 1.1 ENCODE dbSUPER 550.8 +1.3 1345 0.2 PKNOX1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 NCOA1 GTF2B MIR196A1 UBE2Z SP2 CDK5RAP3 HOXB-AS4 HOXB7
GH17I048869 Enhancer 1.2 Ensembl ENCODE 9.9 -239.1 -239147 5.1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 SP5 NFYC MXD4 ATP5MC1 TTLL6 CALCOCO2 UBE2Z ENSG00000230532 HOXB13 PRAC1 PRAC2 SUMO2P17 LOC105371811
GH17I048264 Enhancer 1.1 Ensembl ENCODE 10.6 +366.8 366818 2.7 ATF1 ZSCAN4 INSM2 KLF17 SIN3A ZBTB40 POLR2B EGR1 ZNF366 SCRT2 SKAP1 COPZ2 CDK5RAP3 EGID-105371807 MIR1203 MIR196A1 RNU6-1152P SNX11 CBX1 HOXB2
GH17I048471 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.4 +159.9 159877 1.7 HDGF KLF17 FEZF1 SCRT2 FOS IKZF2 ZBTB11 SP1 IKZF1 ZNF341 SKAP1 HOXB-AS2 HOXB3 MIR10A HOXB4 HOXB2 HOXB-AS1 HOXB1 MIR196A1 CDK5RAP3
GH17I048470 Enhancer 0.9 ENCODE dbSUPER 9.4 +161.8 161785 1 CTCF ZNF189 ZBTB8A FOSL1 ZSCAN21 JUND ZNF366 IKZF1 ZSCAN5C FOS SKAP1 HOXB-AS2 HOXB3 MIR10A HOXB4 HOXB2 HOXB-AS1 HOXB1 MIR196A1 GC17P048482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR196A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR196A1 Gene

Genomic Locations for MIR196A1 Gene
chr17:48,632,490-48,632,559
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chr17:46,709,852-46,709,921
(GRCh37/hg19)

Genomic View for MIR196A1 Gene

Genes around MIR196A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

ORGUL Member Location for MIR196A1 Gene

ORGUL Member Location for MIR196A1 gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains & Families for MIR196A1 Gene

Gene Families for MIR196A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

Gene Ontology (GO) - Molecular Function for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways & Interactions for MIR196A1 Gene

SuperPathways for MIR196A1 Gene

No Data Available

Interacting Proteins for MIR196A1 Gene

Gene Ontology (GO) - Biological Process for MIR196A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010593 negative regulation of lamellipodium assembly IDA 22773844
GO:0035195 gene silencing by miRNA IDA 22773844
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA 22773844
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22773844
genes like me logo Genes that share ontologies with MIR196A1: view

No data available for Pathways by source and SIGNOR curated interactions for MIR196A1 Gene

Drugs & Compounds for MIR196A1 Gene

No Compound Related Data Available

Transcripts for MIR196A1 Gene

fRNAdb Secondary structures for MIR196A1 Gene

  • hsa-mir-196a-1_MI0000238_Homo_sapiens_miR-196a-1_stem-loop_hairpin

mRNA/cDNA for MIR196A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
MIR196A1
ECgene alternative splicing isoforms for
MIR196A1

Expression for MIR196A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR196A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR196A1 Gene:

MIR196A1
genes like me logo Genes that share expression patterns with MIR196A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-1 34
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-196a-1 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196a 34
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-1 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-1 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196c 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196b 34
  • 63 (a)
OneToOne
Species where no ortholog for MIR196A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

ENSEMBL:
Gene Tree for MIR196A1 (if available)
TreeFam:
Gene Tree for MIR196A1 (if available)

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

Sequence variations from dbSNP and Humsavar for MIR196A1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000346929 -- 48,634,269(-) C/A upstream_transcript_variant
rs1000400864 -- 48,634,036(-) C/G upstream_transcript_variant
rs1002918694 -- 48,632,195(-) C/T downstream_transcript_variant
rs1003245217 -- 48,633,948(-) C/T upstream_transcript_variant
rs1003666064 -- 48,633,717(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850
nsv833471 CNV gain 17160897

Additional Variant Information for MIR196A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR196A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A1 Gene

Disorders for MIR196A1 Gene

Additional Disease Information for MIR196A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR196A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K … Bai Y (Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010) 3 44 58
  2. Negative regulation of lncRNA GAS5 by miR-196a inhibits esophageal squamous cell carcinoma growth. (PMID: 29170131) Wang K … Bai Y (Biochemical and biophysical research communications 2018) 3 58
  3. Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells. (PMID: 27880728) Guerriero I … Viglietto G (Oncotarget 2017) 3 58
  4. GAS5 suppresses malignancy of human glioma stem cells via a miR-196a-5p/FOXO1 feedback loop. (PMID: 28666797) Zhao X … Xue Y (Biochimica et biophysica acta 2017) 3 58
  5. LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. (PMID: 28671039) Yang W … Jiang L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for MIR196A1 Gene

Sources for MIR196A1 Gene

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