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Aliases for MIR196A1 Gene

Subcategory (RNA class) for MIR196A1 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR196A1 Gene

  • MicroRNA 196a-1 2 3 5
  • MicroRNA 196-1 2 3
  • MicroRNA 196a 2 3
  • MicroRNA MiR-196 3
  • Hsa-Mir-196a-1 3
  • Hsa-Mir-196-1 3
  • Mir-196a-1 3
  • MIRN196-1 3
  • MIRN196A1 3

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR196A1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196A1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

Regulatory Elements for MIR196A1 Gene

Enhancers for MIR196A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR196A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR196A1 Gene

Chromosome:
17
Start:
48,632,490 bp from pter
End:
48,632,559 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR196A1 Gene

Genes around MIR196A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR196A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

ORGUL Member Location for MIR196A1 Gene

ORGUL Member Location for MIR196A1 gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains & Families for MIR196A1 Gene

Gene Families for MIR196A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways & Interactions for MIR196A1 Gene

SuperPathways for MIR196A1 Gene

No Data Available

Interacting Proteins for MIR196A1 Gene

Gene Ontology (GO) - Biological Process for MIR196A1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR196A1 Gene

Drugs & Compounds for MIR196A1 Gene

No Compound Related Data Available

Transcripts for MIR196A1 Gene

fRNAdb Secondary structures for MIR196A1 Gene

  • hsa-mir-196a-1_MI0000238_Homo_sapiens_miR-196a-1_stem-loop_hairpin

mRNA/cDNA for MIR196A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
MIR196A1
ECgene alternative splicing isoforms for
MIR196A1

Expression for MIR196A1 Gene

mRNA expression in normal human tissues for MIR196A1 Gene

genes like me logo Genes that share expression patterns with MIR196A1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-196a-1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-196a-1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-196a 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir196a-1 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-196a-1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-196-1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-196c 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mir196b 36
  • 63 (a)
OneToOne
Species with no ortholog for MIR196A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

ENSEMBL:
Gene Tree for MIR196A1 (if available)
TreeFam:
Gene Tree for MIR196A1 (if available)

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

Sequence variations from dbSNP and Humsavar for MIR196A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs718079 -- 48,632,473(+) TAAGC(A/G)AGGAG downstream-variant-500B
rs2303488 -- 48,633,618(+) GGGTC(C/T)GAGTG upstream-variant-2KB
rs5820722 -- 48,632,827(+) CACAG(-/G)CACAA upstream-variant-2KB
rs12940554 -- 48,633,684(+) CTCCC(C/G)CTCCC upstream-variant-2KB
rs41280122 -- 48,632,594(+) AGAGC(G/T)CACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
nsv833471 CNV Gain 17160897

Relevant External Links for MIR196A1 Gene

HapMap Linkage Disequilibrium report
MIR196A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR196A1 Gene

Disorders for MIR196A1 Gene

Relevant External Links for MIR196A1

Genetic Association Database (GAD)
MIR196A1
Human Genome Epidemiology (HuGE) Navigator
MIR196A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR196A1

No disorders were found for MIR196A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K. … Bai Y. (Biomarkers 2010) 3 48 67
  2. Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. (PMID: 25485932) Lu Y.C. … Cheng A.J. (Clin. Biochem. 2015) 3
  3. The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma. (PMID: 25860510) Darda L. … Hunter K.D. (PLoS ONE 2015) 3
  4. MicroRNA-196a overexpression promotes cell proliferation and inhibits cell apoptosis through PTEN/Akt/FOXO1 pathway. (PMID: 26045752) Shang Y. … Shi T.L. (Int J Clin Exp Pathol 2015) 3
  5. The effect and mechanism of miR196a in HepG2 cell. (PMID: 26054667) Hao Y. … Zhao L. (Biomed. Pharmacother. 2015) 3

Products for MIR196A1 Gene

Sources for MIR196A1 Gene

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