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Aliases for MIR196A1 Gene

Subcategory (RNA class) for MIR196A1 Gene


Quality Score for this RNA gene is


Aliases for MIR196A1 Gene

  • MicroRNA 196a-1 2 3
  • MicroRNA 196-1 2 3
  • MicroRNA 196a 2 3
  • MIRN196A1 3 6
  • MicroRNA MiR-196 3
  • Hsa-Mir-196a-1 3
  • Hsa-Mir-196-1 3
  • MIRN196-1 3

External Ids for MIR196A1 Gene

Previous HGNC Symbols for MIR196A1 Gene

  • MIRN196-1
  • MIRN196A1

Previous GeneCards Identifiers for MIR196A1 Gene

  • GC17M044069
  • GC17M046709

Summaries for MIR196A1 Gene

Entrez Gene Summary for MIR196A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR196A1 Gene

MIR196A1 (MicroRNA 196a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR196A1 include pancreatic ductal adenocarcinoma and keloids.

fRNAdb sequence ontologies for MIR196A1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR196A1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR196A1 Gene

Genomics for MIR196A1 Gene

Genomic Location for MIR196A1 Gene

48,632,490 bp from pter
48,632,559 bp from pter
70 bases
Minus strand

Genomic View for MIR196A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR196A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR196A1 Gene

ORGUL Member Location for MIR196A1 Gene

ORGUL Member Location for MIR196A1 gene

No data available for Regulatory Elements for MIR196A1 Gene

Proteins for MIR196A1 Gene

Post-translational modifications for MIR196A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR196A1 Gene

Domains for MIR196A1 Gene

Gene Families for MIR196A1 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR196A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR196A1 Gene

Function for MIR196A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR196A1 Gene

Localization for MIR196A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR196A1 Gene

Pathways for MIR196A1 Gene

SuperPathways for MIR196A1 Gene

No Data Available

Interacting Proteins for MIR196A1 Gene

Gene Ontology (GO) - Biological Process for MIR196A1 Gene


No data available for Pathways by source for MIR196A1 Gene

Transcripts for MIR196A1 Gene

fRNAdb Secondary structures for MIR196A1 Gene

  • hsa-mir-196a-1_MI0000238_Homo_sapiens_miR-196a-1_stem-loop_hairpin

mRNA/cDNA for MIR196A1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR196A1 Gene

No ASD Table

Relevant External Links for MIR196A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR196A1 Gene

mRNA expression in normal human tissues for MIR196A1 Gene

genes like me logo Genes that share expressions with MIR196A1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR196A1 Gene

Orthologs for MIR196A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR196A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-196a-1 36
  • 66 (a)
(Canis familiaris)
Mammalia cfa-mir-196a-1 36
  • 75 (a)
(Monodelphis domestica)
Mammalia mdo-mir-196a 36
  • 64 (a)
(Mus musculus)
Mammalia Mir196a-1 36
  • 63 (a)
(Pan troglodytes)
Mammalia ptr-mir-196a-1 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-196-1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia aca-mir-196c 36
  • 59 (a)
(Danio rerio)
Actinopterygii mir196b 36
  • 63 (a)
Species with no ortholog for MIR196A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR196A1 Gene

Gene Tree for MIR196A1 (if available)
Gene Tree for MIR196A1 (if available)

Paralogs for MIR196A1 Gene

No data available for Paralogs for MIR196A1 Gene

Variants for MIR196A1 Gene

Sequence variations from dbSNP and Humsavar for MIR196A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs718079 -- 48,632,473(+) TAAGC(A/G)AGGAG downstream-variant-500B
rs2303488 -- 48,633,618(+) GGGTC(C/T)GAGTG upstream-variant-2KB
rs4793960 -- 48,633,586(+) CCAGG(C/T)TCCCT upstream-variant-2KB
rs5820722 -- 48,632,827(+) CACAG(-/G)CACAA upstream-variant-2KB
rs12940554 -- 48,633,684(+) CTCCC(C/G)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR196A1 Gene

Variant ID Type Subtype PubMed ID
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
nsv833471 CNV Gain 17160897

Relevant External Links for MIR196A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR196A1 Gene

Disorders for MIR196A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR196A1 Gene in MalaCards »

(3) Diseases for MIR196A1 Gene including...

Relevant External Links for MIR196A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR196A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR196A1 Gene

Publications for MIR196A1 Gene

  1. A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. (PMID: 20722507) Wang K. … Bai Y. (Biomarkers 2010) 3 48
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. (PMID: 21077158) Mueller D.W. … Bosserhoff A.K. (Int. J. Cancer 2011) 3
  4. Clinical potential of microRNAs in pancreatic ductal adenocarcinoma. (PMID: 22001830) Steele C.W. … Jamieson N.B. (Pancreas 2011) 3
  5. Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis. (PMID: 22139073) Palmieri D. … Fusco A. (Oncogene 2012) 3

Products for MIR196A1 Gene

Sources for MIR196A1 Gene

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