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Aliases for MIR195 Gene

Subcategory (RNA class) for MIR195 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR195 Gene

  • MicroRNA 195 2 3
  • MIRN195 3 6
  • Hsa-Mir-195 3
  • MiRNA195 3

External Ids for MIR195 Gene

Previous HGNC Symbols for MIR195 Gene

  • MIRN195

Previous GeneCards Identifiers for MIR195 Gene

  • GC17M006866
  • GC17M006920

Summaries for MIR195 Gene

Entrez Gene Summary for MIR195 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR195 Gene

MIR195 (MicroRNA 195) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR195 include tongue squamous cell carcinoma and primary peritoneal carcinoma. Among its related pathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy.

fRNAdb sequence ontologies for MIR195 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR195

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR195 Gene

Genomics for MIR195 Gene

Genomic Location for MIR195 Gene

Start:
7,017,615 bp from pter
End:
7,017,701 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR195 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR195 Gene

ORGUL Member Location for MIR195 Gene

ORGUL Member Location for MIR195 gene

No data available for Regulatory Elements for MIR195 Gene

Proteins for MIR195 Gene

Post-translational modifications for MIR195 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR195 Gene

Domains for MIR195 Gene

Gene Families for MIR195 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR195: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR195 Gene

Function for MIR195 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR195 Gene

Localization for MIR195 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR195 Gene

Pathways for MIR195 Gene

genes like me logo Genes that share pathways with MIR195: view

Pathways by source for MIR195 Gene

2 BioSystems pathways for MIR195 Gene
1 KEGG pathway for MIR195 Gene

Interacting Proteins for MIR195 Gene

Gene Ontology (GO) - Biological Process for MIR195 Gene

None

Transcripts for MIR195 Gene

fRNAdb Secondary structures for MIR195 Gene

  • hsa-miR-195-5p_MIMAT0000461_Homo_sapiens_miR-195-5p_mature
  • FR228819

mRNA/cDNA for MIR195 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR195

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR195 Gene

No ASD Table

Relevant External Links for MIR195 Gene

GeneLoc Exon Structure for
MIR195
ECgene alternative splicing isoforms for
MIR195

Expression for MIR195 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR195 Gene

Orthologs for MIR195 Gene

Evolution for MIR195 Gene

ENSEMBL:
Gene Tree for MIR195 (if available)
TreeFam:
Gene Tree for MIR195 (if available)

No data available for Orthologs for MIR195 Gene

Paralogs for MIR195 Gene

No data available for Paralogs for MIR195 Gene

Variants for MIR195 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR195 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990

Relevant External Links for MIR195 Gene

HapMap Linkage Disequilibrium report
MIR195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR195 Gene

Disorders for MIR195 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MIR195 Gene including...

Search for MIR195 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR195: view

No data available for UniProtKB/Swiss-Prot for MIR195 Gene

Publications for MIR195 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. (PMID: 17108080) van Rooij E. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma. (PMID: 18677302) Flavin R.J. … O'Leary J.J. (Mod. Pathol. 2009) 3

Products for MIR195 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR195
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR195
    • Block miRNA regulation of MIR195 using miScript Target Protectors

    Sources for MIR195 Gene

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