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Aliases for MIR195 Gene

Subcategory (RNA class) for MIR195 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR195 Gene

  • MicroRNA 195 2 3 5
  • Hsa-Mir-195 3
  • MiRNA195 3
  • Mir-195 3
  • MIRN195 3

External Ids for MIR195 Gene

Previous HGNC Symbols for MIR195 Gene

  • MIRN195

Previous GeneCards Identifiers for MIR195 Gene

  • GC17M006866
  • GC17M006920

Summaries for MIR195 Gene

Entrez Gene Summary for MIR195 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR195 Gene

MIR195 (MicroRNA 195) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR195 include Primary Peritoneal Carcinoma. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR195 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR195

Additional gene information for MIR195 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR195 Gene

Genomics for MIR195 Gene

Regulatory Elements for MIR195 Gene

Enhancers for MIR195 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H006853 1.2 Ensembl ENCODE 10.3 +163.0 163040 2 ELF3 ARID4B SIN3A DMAP1 THRB ZBTB40 RAD21 ZBTB7B YY1 ETS1 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 ALOX12P2 GC17M006868
GH17H006913 1 Ensembl ENCODE 11.4 +103.6 103560 0 CTCF RB1 RAD21 CC2D1A POLR2A ZNF143 SMC3 CREM MAZ ZNF740 ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 MIR195 BCL6B SLC16A11 C17orf100 MED31 SLC13A5
GH17H006666 0.8 ENCODE 9.9 +351.4 351425 0 GTF2F1 ELF3 CTCF SAP130 ARID4B RAD21 RFX5 TEAD3 POLR2A SMC3 ENSG00000261996 KIAA0753 TXNDC17 SLC13A5 MIR195 PITPNM3 BCL6B ALOX15P1 PIR54331 GC17P006673
GH17H006919 0.7 FANTOM5 10 +97.9 97948 0 HDAC1 PKNOX1 ZNF175 CEBPG GABPA ZNF589 CTBP1 SMARCA4 TARDBP IKZF1 ALOX12 RNASEK RNASEK-C17orf49 ALOX12-AS1 BCL6B SLC13A5 MIR195 SLC16A11 GC17M006933 GC17P006901
GH17H006887 0.4 FANTOM5 10.1 +130.3 130259 0 ZNF512 MIR195 DLG4 SLC16A11 GC17P006901 GC17M006868
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR195 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR195 Gene

Chromosome:
17
Start:
7,017,615 bp from pter
End:
7,017,701 bp from pter
Size:
87 bases
Orientation:
Minus strand

Genomic View for MIR195 Gene

Genes around MIR195 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR195 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR195 Gene

ORGUL Member Location for MIR195 Gene

ORGUL Member Location for MIR195 gene

Proteins for MIR195 Gene

Post-translational modifications for MIR195 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR195 Gene

Domains & Families for MIR195 Gene

Gene Families for MIR195 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR195: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR195 Gene

Function for MIR195 Gene

Phenotypes From GWAS Catalog for MIR195 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR195
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR195 Gene

Localization for MIR195 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR195 Gene

Pathways & Interactions for MIR195 Gene

genes like me logo Genes that share pathways with MIR195: view

Pathways by source for MIR195 Gene

1 BioSystems pathway for MIR195 Gene
1 KEGG pathway for MIR195 Gene

Interacting Proteins for MIR195 Gene

Gene Ontology (GO) - Biological Process for MIR195 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis ISS --
GO:0003300 cardiac muscle hypertrophy ISS --
GO:0010666 positive regulation of cardiac muscle cell apoptotic process ISS --
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle ISS --
GO:0045930 negative regulation of mitotic cell cycle ISS --
genes like me logo Genes that share ontologies with MIR195: view

No data available for SIGNOR curated interactions for MIR195 Gene

Drugs & Compounds for MIR195 Gene

No Compound Related Data Available

Transcripts for MIR195 Gene

fRNAdb Secondary structures for MIR195 Gene

  • hsa-miR-195-5p_MIMAT0000461_Homo_sapiens_miR-195-5p_mature
  • FR228819

mRNA/cDNA for MIR195 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR195
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR195 Gene

No ASD Table

Relevant External Links for MIR195 Gene

GeneLoc Exon Structure for
MIR195
ECgene alternative splicing isoforms for
MIR195

Expression for MIR195 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR195 Gene:

MIR195
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR195 Gene

Orthologs for MIR195 Gene

Evolution for MIR195 Gene

ENSEMBL:
Gene Tree for MIR195 (if available)
TreeFam:
Gene Tree for MIR195 (if available)

No data available for Orthologs for MIR195 Gene

Paralogs for MIR195 Gene

No data available for Paralogs for MIR195 Gene

Variants for MIR195 Gene

Sequence variations from dbSNP and Humsavar for MIR195 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001337651 -- 7,017,410(+) TGAAA(A/G)GCTGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1001397642 -- 7,017,139(+) GCTCT(C/T)ATACA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1001872040 -- 7,017,629(+) GCCTG(C/G)AGCAG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1003037341 -- 7,019,600(+) GGACA(A/C)CCCCC nc-transcript-variant, upstream-variant-2KB
rs1003412908 -- 7,018,673(+) ATCAG(C/T)CCATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR195 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1121929 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Relevant External Links for MIR195 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR195 Gene

Disorders for MIR195 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR195 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR195

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR195
genes like me logo Genes that share disorders with MIR195: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR195 Gene

Publications for MIR195 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 60
  2. MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway. (PMID: 28639885) Xu Z … Xu J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer. (PMID: 28345460) Zhang M … Fei Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration. (PMID: 28315863) Ren C … Yu J (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  5. Identification of miR‑195‑3p as an oncogene in RCC. (PMID: 28260025) Jin L … Lai Y (Molecular medicine reports 2017) 3 60

Products for MIR195 Gene

Sources for MIR195 Gene

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