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Aliases for MIR195 Gene

Subcategory (RNA class) for MIR195 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR195 Gene

  • MicroRNA 195 2 3
  • Mir-497-195 Cluster Host Gene 5
  • Hsa-Mir-195 3
  • MiRNA195 3
  • MIR497HG 5
  • Mir-195 3
  • MIRN195 3

External Ids for MIR195 Gene

Previous HGNC Symbols for MIR195 Gene

  • MIRN195

Previous GeneCards Identifiers for MIR195 Gene

  • GC17M006866
  • GC17M006920

Summaries for MIR195 Gene

Entrez Gene Summary for MIR195 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR195 Gene

MIR195 (MicroRNA 195) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR195 include Primary Peritoneal Carcinoma. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR195 Gene

Genomics for MIR195 Gene

Regulatory Elements for MIR195 Gene

Enhancers for MIR195 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F006913 1 Ensembl ENCODE 11.4 +105.6 105558 1.0 CTCF MAZ STAT1 ZNF740 TRIM22 REST ZBTB7A RAD21 ZNF664 POLR2A ALOX12 RNASEK RNASEK-C17orf49 ALOX12-AS1 BCL6B MIR195 SLC16A11 ENSG00000256806 MED31 SLC13A5
GH17F006887 0.3 FANTOM5 10.1 +132.2 132217 0.2 ZNF512 MIR195 DLG4 SLC16A11 GC17P006901 GC17M006868
GH17F006919 0.4 FANTOM5 10 +99.9 99906 0.4 TFAP4 PKNOX1 ZNF175 GABPA POLR2H ZNF589 SMARCA4 IKZF1 NR2F6 FOS ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 BCL6B SLC13A5 MIR195 SLC16A11 GC17M006933 GC17P006901
GH17F006666 0.5 ENCODE 9.9 +353.4 353383 0.4 GTF2F1 ELF3 CTCF SAP130 ARID4B CEBPG ZIC2 RAD21 RFX5 TEAD3 ENSG00000261996 KIAA0753 TXNDC17 SLC13A5 MIR195 PITPNM3 BCL6B ALOX15P1 GC17P006673 PIR54331
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR195 on UCSC Golden Path with GeneCards custom track

Promoters for MIR195 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001804747 259 2001 HDGF BRD4 NFRKB YY1 ZFHX2 ZNF366 PATZ1 PRDM10 ZNF263 ZBTB10

Genomic Location for MIR195 Gene

Chromosome:
17
Start:
7,015,818 bp from pter
End:
7,019,659 bp from pter
Size:
3,842 bases
Orientation:
Minus strand

Genomic View for MIR195 Gene

Genes around MIR195 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR195 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR195 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR195 Gene

Proteins for MIR195 Gene

Post-translational modifications for MIR195 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR195 Gene

Domains & Families for MIR195 Gene

Gene Families for MIR195 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR195: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR195 Gene

Function for MIR195 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR195 Gene

Localization for MIR195 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR195 Gene

Pathways & Interactions for MIR195 Gene

genes like me logo Genes that share pathways with MIR195: view

Pathways by source for MIR195 Gene

1 BioSystems pathway for MIR195 Gene
1 KEGG pathway for MIR195 Gene

Interacting Proteins for MIR195 Gene

Gene Ontology (GO) - Biological Process for MIR195 Gene

None

No data available for SIGNOR curated interactions for MIR195 Gene

Transcripts for MIR195 Gene

mRNA/cDNA for MIR195 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR195 Gene

No ASD Table

Relevant External Links for MIR195 Gene

GeneLoc Exon Structure for
MIR195
ECgene alternative splicing isoforms for
MIR195

Expression for MIR195 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR195 Gene:

MIR195
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR195 Gene

Orthologs for MIR195 Gene

Evolution for MIR195 Gene

ENSEMBL:
Gene Tree for MIR195 (if available)
TreeFam:
Gene Tree for MIR195 (if available)

No data available for Orthologs for MIR195 Gene

Paralogs for MIR195 Gene

No data available for Paralogs for MIR195 Gene

Variants for MIR195 Gene

Sequence variations from dbSNP and Humsavar for MIR195 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111731181 -- 7,017,431(+) ACCTC(A/G)CTATT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs113990702 -- 7,019,189(+) GGGGG(A/G)CTCTC intron-variant, upstream-variant-2KB
rs11548333 -- 7,017,283(-) CATGA(A/G)AAGGC nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs12450517 -- 7,018,644(+) GACCC(A/G)AGCCG intron-variant, upstream-variant-2KB
rs142120415 -- 7,019,115(+) CAGCT(C/T)CTACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR195 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1121929 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Relevant External Links for MIR195 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR195 Gene

Disorders for MIR195 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR195 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary peritoneal carcinoma
  • serous surface papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR195

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR195
genes like me logo Genes that share disorders with MIR195: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR195 Gene

Publications for MIR195 Gene

  1. Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells. (PMID: 27179445) Zhao N. … Zhuang S.M. (Biochim. Biophys. Acta 2016) 3 64
  2. Expression level of microRNA-195 in the serum of patients with gastric cancer and its relationship with the clinicopathological staging of the cancer. (PMID: 27097947) Shen Y.H. … Huang S.R. (Eur Rev Med Pharmacol Sci 2016) 3 64
  3. miR-195 in human primary mesenchymal stromal/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis. (PMID: 26683705) Almeida M.I. … Barbosa M.A. (Oncotarget 2016) 3 64
  4. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. (PMID: 25304377) Wang J. … Sen S. (Cancer Lett. 2015) 3 64
  5. MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma. (PMID: 25607636) Zheng C. … Cao K. (Oncol. Rep. 2015) 3 64

Products for MIR195 Gene

Sources for MIR195 Gene

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