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Aliases for MIR194-2 Gene

Subcategory (RNA class) for MIR194-2 Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR194-2 Gene

  • MicroRNA 194-2 2 3 5
  • Hsa-Mir-194-2 3
  • Mir-194-2 3
  • MIRN194-2 3

External Ids for MIR194-2 Gene

Previous HGNC Symbols for MIR194-2 Gene

  • MIRN194-2

Previous GeneCards Identifiers for MIR194-2 Gene

  • GC11M064433
  • GC11M064436
  • GC11M064661
  • GC11M064665
  • GC11M064668
  • GC11M064671
  • GC11M064673
  • GC11M064675
  • GC11M064677
  • GC11M064682
  • GC11M064688
  • GC11M064693
  • GC11M064892
  • GC11M064893
  • GC11M064911

Summaries for MIR194-2 Gene

Entrez Gene Summary for MIR194-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-2 Gene

MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR194-2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR194-2

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR194-2 Gene

Genomics for MIR194-2 Gene

Genomic Location for MIR194-2 Gene

Chromosome:
11
Start:
64,891,355 bp from pter
End:
64,891,439 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-2 Gene

Genes around MIR194-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR194-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-2 Gene

ORGUL Member Location for MIR194-2 Gene

ORGUL Member Location for MIR194-2 gene

No data available for Regulatory Elements for MIR194-2 Gene

Proteins for MIR194-2 Gene

Post-translational modifications for MIR194-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-2 Gene

Domains & Families for MIR194-2 Gene

Gene Families for MIR194-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR194-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-2 Gene

Function for MIR194-2 Gene

Animal Model Products

miRNA for MIR194-2 Gene

miRTarBase miRNAs that target MIR194-2

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR194-2 Gene

Localization for MIR194-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR194-2 Gene

Pathways & Interactions for MIR194-2 Gene

SuperPathways for MIR194-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-2: view

Pathways by source for MIR194-2 Gene

1 KEGG pathway for MIR194-2 Gene

Interacting Proteins for MIR194-2 Gene

Gene Ontology (GO) - Biological Process for MIR194-2 Gene

None

No data available for SIGNOR curated interactions for MIR194-2 Gene

Transcripts for MIR194-2 Gene

fRNAdb Secondary structures for MIR194-2 Gene

  • FR030622

mRNA/cDNA for MIR194-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-2 Gene

No ASD Table

Relevant External Links for MIR194-2 Gene

GeneLoc Exon Structure for
MIR194-2
ECgene alternative splicing isoforms for
MIR194-2

Expression for MIR194-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR194-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR194-2 Gene

This gene is overexpressed in Colon - Transverse (x20.0) and Small Intestine - Terminal Ileum (x18.2).
genes like me logo Genes that share expression patterns with MIR194-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-2 Gene

Orthologs for MIR194-2 Gene

Evolution for MIR194-2 Gene

ENSEMBL:
Gene Tree for MIR194-2 (if available)
TreeFam:
Gene Tree for MIR194-2 (if available)

No data available for Orthologs for MIR194-2 Gene

Paralogs for MIR194-2 Gene

No data available for Paralogs for MIR194-2 Gene

Variants for MIR194-2 Gene

Sequence variations from dbSNP and Humsavar for MIR194-2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000588419 -- 64,891,594(+) GCCCC(A/G)TGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001108883 -- 64,891,132(+) GGTCC(C/T)GGTGG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002200033 -- 64,891,658(+) AAAGC(C/T)GGGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002302129 -- 64,891,698(+) TTTGC(C/T)CGCTC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002551245 -- 64,891,881(+) CCAGG(G/T)ACCTC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR194-2 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Relevant External Links for MIR194-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR194-2 Gene

Disorders for MIR194-2 Gene

Relevant External Links for MIR194-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR194-2

No disorders were found for MIR194-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-2 Gene

Publications for MIR194-2 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 3 64
  2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 1 3 64
  3. MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis. (PMID: 28040329) Yu X. … Su C. (Pathol. Res. Pract. 2017) 3 64
  4. MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway. (PMID: 25602366) Wang B. … Wang S. (Cell Cycle 2015) 3 64
  5. MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4. (PMID: 26722431) Zhao Y. … Zhao P. (Int J Clin Exp Pathol 2015) 3 64

Products for MIR194-2 Gene

Sources for MIR194-2 Gene

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