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Aliases for MIR194-2 Gene

Subcategory (RNA class) for MIR194-2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR194-2 Gene

  • MicroRNA 194-2 2 3
  • MIR194-2 Host Gene 5
  • Hsa-Mir-194-2 3
  • MIR194-2HG 5
  • Mir-194-2 3
  • MIRN194-2 3

External Ids for MIR194-2 Gene

Previous HGNC Symbols for MIR194-2 Gene

  • MIRN194-2

Previous GeneCards Identifiers for MIR194-2 Gene

  • GC11M064433
  • GC11M064436
  • GC11M064661
  • GC11M064665
  • GC11M064668
  • GC11M064671
  • GC11M064673
  • GC11M064675
  • GC11M064677
  • GC11M064682
  • GC11M064688
  • GC11M064693
  • GC11M064892
  • GC11M064893

Summaries for MIR194-2 Gene

Entrez Gene Summary for MIR194-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-2 Gene

MIR194-2 (MicroRNA 194-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR194-2 Gene

Genomics for MIR194-2 Gene

Regulatory Elements for MIR194-2 Gene


Promoters for MIR194-2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769236 749 1401 HDGF ATF1 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1
ENSR00001769235 1949 201 NR2F1 RAD21 NR2F2 RARA YY1 ATF3 HNF4G NR2F6 ZBTB33

Genomic Location for MIR194-2 Gene

Chromosome:
11
Start:
64,889,560 bp from pter
End:
64,893,449 bp from pter
Size:
3,890 bases
Orientation:
Minus strand

Genomic View for MIR194-2 Gene

Genes around MIR194-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR194-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-2 Gene

Proteins for MIR194-2 Gene

Post-translational modifications for MIR194-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-2 Gene

Domains & Families for MIR194-2 Gene

Gene Families for MIR194-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR194-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-2 Gene

Function for MIR194-2 Gene

Animal Model Products

miRNA for MIR194-2 Gene

miRTarBase miRNAs that target MIR194-2

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR194-2 Gene

Localization for MIR194-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR194-2 Gene

Pathways & Interactions for MIR194-2 Gene

SuperPathways for MIR194-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-2: view

Pathways by source for MIR194-2 Gene

1 KEGG pathway for MIR194-2 Gene

Interacting Proteins for MIR194-2 Gene

Gene Ontology (GO) - Biological Process for MIR194-2 Gene

None

No data available for SIGNOR curated interactions for MIR194-2 Gene

Transcripts for MIR194-2 Gene

mRNA/cDNA for MIR194-2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-2 Gene

No ASD Table

Relevant External Links for MIR194-2 Gene

GeneLoc Exon Structure for
MIR194-2
ECgene alternative splicing isoforms for
MIR194-2

Expression for MIR194-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR194-2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR194-2 Gene

This gene is overexpressed in Colon - Transverse (x20.0) and Small Intestine - Terminal Ileum (x18.2).
genes like me logo Genes that share expression patterns with MIR194-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR194-2 Gene

Orthologs for MIR194-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR194-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-194-2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir194-2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-194-2 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-194-2 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-194a 35
  • 65 (a)
OneToMany
CU138503.6 35
  • 60 (a)
OneToMany
dre-mir-194b 35
  • 60 (a)
OneToMany
Species where no ortholog for MIR194-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR194-2 Gene

ENSEMBL:
Gene Tree for MIR194-2 (if available)
TreeFam:
Gene Tree for MIR194-2 (if available)

Paralogs for MIR194-2 Gene

No data available for Paralogs for MIR194-2 Gene

Variants for MIR194-2 Gene

Sequence variations from dbSNP and Humsavar for MIR194-2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111974253 -- 64,891,284(+) ATCTG(A/G)CCTGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs112241987 -- 64,892,607(+) CACGC(C/T)GGGCT nc-transcript-variant, upstream-variant-2KB
rs11231898 -- 64,891,364(+) CCCTC(A/G)CCCCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs11231899 -- 64,891,528(+) TCTTC(A/G)TGGCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs112590834 -- 64,892,993(+) TCAGG(A/G)TGCAG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR194-2 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Relevant External Links for MIR194-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR194-2 Gene

Disorders for MIR194-2 Gene

Relevant External Links for MIR194-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR194-2

No disorders were found for MIR194-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-2 Gene

Publications for MIR194-2 Gene

  1. MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c-Jun/MDM2 signaling pathway. (PMID: 25602366) Wang B. … Wang S. (Cell Cycle 2015) 3 64
  2. MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4. (PMID: 26722431) Zhao Y. … Zhao P. (Int J Clin Exp Pathol 2015) 3 64
  3. microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R. (PMID: 25096247) Han K. … Ma B. (Int. J. Oncol. 2014) 3 64
  4. Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas. (PMID: 23639576) Guo L. … Piedrahita J.A. (Placenta 2013) 3 64
  5. miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma. (PMID: 23715501) Khella H.W. … Yousef G.M. (Carcinogenesis 2013) 3 64

Products for MIR194-2 Gene

Sources for MIR194-2 Gene

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