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Aliases for MIR194-1 Gene

Subcategory (RNA class) for MIR194-1 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR194-1 Gene

  • MicroRNA 194-1 2 3
  • MIRN194-1 3 6
  • Hsa-Mir-194-1 3

External Ids for MIR194-1 Gene

Previous Symbols for MIR194-1 Gene

  • MIRN194-1

Summaries for MIR194-1 Gene

Entrez Gene Summary for MIR194-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-1 Gene

MIR194-1 (MicroRNA 194-1) is an RNA Gene, and belongs to the miRNA class. Diseases associated with MIR194-1 include multiple myeloma. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR194-1 Gene

Genomics for MIR194-1 Gene

Genomic Location for MIR194-1 Gene

Start:
220,118,157 bp from pter
End:
220,118,241 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR194-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-1 Gene

ORGUL Member Location for MIR194-1 Gene

ORGUL Member Location for MIR194-1 gene

No data available for Regulatory Elements for MIR194-1 Gene

Proteins for MIR194-1 Gene

Post-translational modifications for MIR194-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-1 Gene

Domains for MIR194-1 Gene

Gene Families for MIR194-1 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR194-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-1 Gene

Function for MIR194-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR194-1 Gene

Localization for MIR194-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR194-1 Gene

Pathways for MIR194-1 Gene

SuperPathways for MIR194-1 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-1: view

Pathways by source for MIR194-1 Gene

1 KEGG pathway for MIR194-1 Gene

Interacting Proteins for MIR194-1 Gene

Gene Ontology (GO) - Biological Process for MIR194-1 Gene

None

Transcripts for MIR194-1 Gene

mRNA/cDNA for MIR194-1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-1 Gene

No ASD Table

Relevant External Links for MIR194-1 Gene

GeneLoc Exon Structure for
MIR194-1
ECgene alternative splicing isoforms for
MIR194-1

Expression for MIR194-1 Gene

mRNA expression in normal human tissues for MIR194-1 Gene

genes like me logo Genes that share expressions with MIR194-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR194-1 Gene

Orthologs for MIR194-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR194-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-194 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-194-1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-194 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir194-1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-194-1 36
  • 69 (a)
OneToMany
oan-mir-194-1 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-194 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-194-1 36
  • 65 (a)
OneToOne
Species with no ortholog for MIR194-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR194-1 Gene

ENSEMBL:
Gene Tree for MIR194-1 (if available)
TreeFam:
Gene Tree for MIR194-1 (if available)

Paralogs for MIR194-1 Gene

No data available for Paralogs for MIR194-1 Gene

Variants for MIR194-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR194-1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897

Relevant External Links for MIR194-1 Gene

HapMap Linkage Disequilibrium report
MIR194-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR194-1 Gene

Disorders for MIR194-1 Gene

(1) MalaCards Diseases for MIR194-1 Gene

Search for MIR194-1 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR194-1: view

No data available for UniProtKB/Swiss-Prot for MIR194-1 Gene

Publications for MIR194-1 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 3
  2. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. (PMID: 20951946) Pichiorri F. … Croce C.M. (Cancer Cell 2010) 3

Products for MIR194-1 Gene

Sources for MIR194-1 Gene

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