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Aliases for MIR194-1 Gene

Subcategory (RNA class) for MIR194-1 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR194-1 Gene

  • MicroRNA 194-1 2 3 5
  • Hsa-Mir-194-1 3
  • Mir-194-1 3
  • MIRN194-1 3

External Ids for MIR194-1 Gene

Previous HGNC Symbols for MIR194-1 Gene

  • MIRN194-1

Previous GeneCards Identifiers for MIR194-1 Gene

  • GC01M218360
  • GC01M220292
  • GC01M220293
  • GC01M220295

Summaries for MIR194-1 Gene

Entrez Gene Summary for MIR194-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR194-1 Gene

MIR194-1 (MicroRNA 194-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR194-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR194-1 Gene

Genomics for MIR194-1 Gene

Regulatory Elements for MIR194-1 Gene

Enhancers for MIR194-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H220158 0.4 ENCODE 12.4 -41.3 -41314 1 CEBPG IARS2 MIR194-1 MIR215 EPRS RAB3GAP2 GC01P220165 RPS15AP12
GH01H220114 1.3 ENCODE dbSUPER 0.7 -2.1 -2056 11 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF302 SP3 REST SMARCB1 MEF2D EPRS RPS15AP12 ZC3H11B RIMKLBP2 RAB3GAP2 ENSG00000272823 MIR194-1
GH01H220136 0.5 ENCODE dbSUPER 0.4 -19.2 -19183 1 RPS15AP12 MIR194-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR194-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR194-1 Gene

Chromosome:
1
Start:
220,118,157 bp from pter
End:
220,118,241 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR194-1 Gene

Genes around MIR194-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR194-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR194-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR194-1 Gene

ORGUL Member Location for MIR194-1 Gene

ORGUL Member Location for MIR194-1 gene

Proteins for MIR194-1 Gene

Post-translational modifications for MIR194-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR194-1 Gene

Domains & Families for MIR194-1 Gene

Gene Families for MIR194-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR194-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR194-1 Gene

Function for MIR194-1 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR194-1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR194-1 Gene

Localization for MIR194-1 Gene

Gene Ontology (GO) - Cellular Components for MIR194-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25203061
genes like me logo Genes that share ontologies with MIR194-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR194-1 Gene

Pathways & Interactions for MIR194-1 Gene

SuperPathways for MIR194-1 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR194-1: view

Pathways by source for MIR194-1 Gene

1 KEGG pathway for MIR194-1 Gene

Interacting Proteins for MIR194-1 Gene

Gene Ontology (GO) - Biological Process for MIR194-1 Gene

None

No data available for SIGNOR curated interactions for MIR194-1 Gene

Drugs & Compounds for MIR194-1 Gene

No Compound Related Data Available

Transcripts for MIR194-1 Gene

mRNA/cDNA for MIR194-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR194-1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR194-1 Gene

No ASD Table

Relevant External Links for MIR194-1 Gene

GeneLoc Exon Structure for
MIR194-1
ECgene alternative splicing isoforms for
MIR194-1

Expression for MIR194-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR194-1 Gene

genes like me logo Genes that share expression patterns with MIR194-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR194-1 Gene

Orthologs for MIR194-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR194-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-194 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-194 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir194-1 34
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-194-1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-194-1 34 34
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-194 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-194-1 34
  • 65 (a)
OneToOne
Species where no ortholog for MIR194-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR194-1 Gene

ENSEMBL:
Gene Tree for MIR194-1 (if available)
TreeFam:
Gene Tree for MIR194-1 (if available)

Paralogs for MIR194-1 Gene

No data available for Paralogs for MIR194-1 Gene

Variants for MIR194-1 Gene

Sequence variations from dbSNP and Humsavar for MIR194-1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000510918 -- 220,119,793(+) AAAAT(A/G)TCAGC intron-variant, upstream-variant-2KB
rs1003012789 -- 220,119,271(+) ATAAG(G/T)CCTTT intron-variant, upstream-variant-2KB
rs1004985583 -- 220,118,074(+) AAATC(-/T)TTTTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1010346154 -- 220,118,858(+) CTTCA(A/G)AATGG intron-variant, upstream-variant-2KB
rs1010439904 -- 220,119,156(+) CATTC(C/T)GGTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR194-1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV loss 17160897
nsv947468 CNV deletion 23825009

Relevant External Links for MIR194-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR194-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR194-1 Gene

Disorders for MIR194-1 Gene

Relevant External Links for MIR194-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR194-1

No disorders were found for MIR194-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR194-1 Gene

Publications for MIR194-1 Gene

  1. Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells. (PMID: 28618953) Gong B … Zhou X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. (PMID: 28358423) Bai M … Zhao R (Oncology reports 2017) 3 60
  3. MicroRNA-194 represses glioma cell epithelial‑to‑mesenchymal transition by targeting Bmi1. (PMID: 28098896) Zhang X … Qu J (Oncology reports 2017) 3 60
  4. MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein. (PMID: 27959429) Kong Q … Xu P (Oncology reports 2017) 3 60
  5. Original Research: miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells. (PMID: 27480251) Cui G … Zhao S (Experimental biology and medicine (Maywood, N.J.) 2017) 3 60

Products for MIR194-1 Gene

Sources for MIR194-1 Gene

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