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Aliases for MIR193B Gene

Subcategory (RNA class) for MIR193B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR193B Gene

  • MicroRNA 193b 2 3 5
  • Hsa-Mir-193b 3
  • Mir-193b 3
  • MIRN193B 3

External Ids for MIR193B Gene

ORGUL Members for MIR193B Gene

Previous HGNC Symbols for MIR193B Gene

  • MIRN193B

Previous GeneCards Identifiers for MIR193B Gene

  • GC16P014306
  • GC16P014397

Summaries for MIR193B Gene

Entrez Gene Summary for MIR193B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR193B Gene

MIR193B (MicroRNA 193b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR193B Gene

Genomics for MIR193B Gene

Regulatory Elements for MIR193B Gene

Enhancers for MIR193B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G014508 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +206.8 206767 4.0 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 TCF12 SLC30A9 SP5 MIR193B LOC100505915 LOC105371094 RN7SL274P
GH16G014500 1.6 Ensembl ENCODE dbSUPER 11.7 +198.4 198351 3.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS ZNF263 BFAR MIR193B RPS26P52 ERCC4 LOC100505915 LOC105371094 RN7SL274P
GH16G014337 1.5 Ensembl ENCODE dbSUPER 12.1 +33.9 33897 1.0 FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 ZNF48 YY1 YY2 MXD4 ENSG00000183458 NPIPA3 NPIPA2 ENSG00000261819 LOC100505915 MIR193B ENSG00000262732 NOMO1 GC16M014339 GC16P014313
GH16G014504 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +201.9 201893 2.1 CTCF FOXA2 SAP130 SIN3A RAD21 GATA3 SMC3 FOS MAFK TEAD1 MIR193B LOC105371094 RN7SL274P
GH16G014485 1.6 Ensembl ENCODE dbSUPER 10.8 +183.3 183275 2.8 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 RRN3 BFAR MIR193B C16orf45 NPIPA2 LOC105371094 RN7SL274P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR193B on UCSC Golden Path with GeneCards custom track

Promoters for MIR193B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083669 -967 2801 FOXA2 ZFP64 WRNIP1 ARID4B SIN3A ZNF48 TCF12 GLIS2 FOS ZNF263

Genomic Location for MIR193B Gene

Chromosome:
16
Start:
14,303,967 bp from pter
End:
14,304,049 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR193B Gene

Genes around MIR193B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR193B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR193B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR193B Gene

Proteins for MIR193B Gene

Post-translational modifications for MIR193B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR193B Gene

Domains & Families for MIR193B Gene

Gene Families for MIR193B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR193B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR193B Gene

Function for MIR193B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR193B Gene

Localization for MIR193B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR193B Gene

Pathways & Interactions for MIR193B Gene

SuperPathways for MIR193B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR193B: view

Pathways by source for MIR193B Gene

1 KEGG pathway for MIR193B Gene

Interacting Proteins for MIR193B Gene

Gene Ontology (GO) - Biological Process for MIR193B Gene

None

No data available for SIGNOR curated interactions for MIR193B Gene

Drugs & Compounds for MIR193B Gene

No Compound Related Data Available

Transcripts for MIR193B Gene

mRNA/cDNA for MIR193B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR193B Gene

No ASD Table

Relevant External Links for MIR193B Gene

GeneLoc Exon Structure for
MIR193B
ECgene alternative splicing isoforms for
MIR193B

Expression for MIR193B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR193B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR193B Gene:

MIR193B
genes like me logo Genes that share expression patterns with MIR193B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR193B Gene

Orthologs for MIR193B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR193B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-193b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-193b 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-193b 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir193b 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-193b 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-193 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-193b 35
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-193b 35
  • 74 (a)
OneToOne
Species where no ortholog for MIR193B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR193B Gene

ENSEMBL:
Gene Tree for MIR193B (if available)
TreeFam:
Gene Tree for MIR193B (if available)

Paralogs for MIR193B Gene

No data available for Paralogs for MIR193B Gene

Variants for MIR193B Gene

Sequence variations from dbSNP and Humsavar for MIR193B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001545400 -- 14,304,546(+) GTTCT(C/T)TTTGT intron-variant, downstream-variant-500B
rs1001731864 -- 14,303,560(+) GGACA(C/G)AAATA intron-variant, upstream-variant-2KB
rs1001789284 -- 14,303,757(+) CCTCT(G/T)GCCCT intron-variant, upstream-variant-2KB
rs1002548814 -- 14,302,934(+) CTCGC(C/T)GCGTG intron-variant, upstream-variant-2KB
rs1002950707 -- 14,303,180(+) AAAAA(A/G)ACTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR193B Gene

Variant ID Type Subtype PubMed ID
nsv1070750 CNV deletion 25765185

Relevant External Links for MIR193B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR193B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR193B Gene

Disorders for MIR193B Gene

Relevant External Links for MIR193B

Human Genome Epidemiology (HuGE) Navigator
MIR193B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR193B

No disorders were found for MIR193B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR193B Gene

Publications for MIR193B Gene

  1. Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression. (PMID: 25384965) Iwamoto N. … Distler O. (Ann. Rheum. Dis. 2016) 3 64
  2. Aberrant methylation of microRNA-193b in human Barrett's esophagus and esophageal adenocarcinoma. (PMID: 27176876) LA1 L. … Mei Z. (Mol Med Rep 2016) 3 64
  3. MicroRNA-193b inhibits the proliferation, migration and invasion of gastric cancer cells via targeting cyclin D1. (PMID: 27071318) Wang L. … Sun G. (Acta Histochem. 2016) 3 64
  4. MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells. (PMID: 26878873) Nyhan M.J. … McKenna S.L. (BMC Cancer 2016) 3 64
  5. The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-I^ signaling. (PMID: 26822621) Zhou X. … Zhao X. (Sci Rep 2016) 3 64

Products for MIR193B Gene

Sources for MIR193B Gene

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