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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIR193A Gene

RNA gene GIFtS: 20
GCID: GC17P029887

MicroRNA 193a

(Previous name: microRNA 193)
(Previous symbols: MIRN193, MIRN193A)

7 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 193a¹ ²
MIRN193¹ ²
MIRN193A¹ ²
MicroRNA 193¹
mir-193a⁹

External Ids:	HGNC: 31563¹	Entrez Gene: 406968²	Ensembl: ENSG00000207614⁷	OMIM: 614733⁵

ORGUL members:	fRNAdb¹⁰:FR259839

Export aliases for MIR193A gene to outside databases

Previous GC identifer: GC17P026914

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR193A Gene:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of

gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are

transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can

be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme

to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the

cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The

mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through

imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of

the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR193A Gene:

MIR193A (microRNA 193a) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR193A include acute myeloid leukemia, and cervical cancer.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIR193A
Other transcription factors

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Epigenetics:

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Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

MIR193A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR193A gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P029887: view genomic region (via miRBase) (about GC identifiers)

Start:	29,887,015 bp from pter	End:	29,887,102 bp from pter
Size:	88 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

MIR: ncRNAs / Micro RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIR193A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000384882(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR193A:none

MIR193A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MIR193A gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	aca-mir-193⁶	aca-mir-193	81(a)	1 ↔ 1	GL343198.1(1030746-1030819) ENSACAG00000018152
zebrafish (Danio rerio)	Actinopterygii	mir193a-1⁶	microRNA 193a-1	56(a)	1 ↔ 1	3(44210575-44210673) ENSDARG00000083334

Species with no ortholog for MIR193A

ENSEMBL Gene Tree for MIR193A (if available)
TreeFam Gene Tree for MIR193A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71697208^1,2	C	--	29885056(+)	`GCTAA-/TT/TT TT/TTTTTTTTTT`	1	--	us2k¹		0	--	--	--	--
rs140838846^1,2		--	29885107(+)	`TTCCCA/GGGCTG`	1	--	us2k¹		0	--	--	--	--
rs144786886^1,2		--	29885191(+)	`TGCCCA/GGCCTC`	1	--	us2k¹		0	--	--	--	--
rs56161228^1,2	C,F	--	29885217(+)	`GGCATG/AATCTG`	1	--	us2k¹		5		WA CSA NA EA	362
rs73991206^1,2	C	--	29885273(+)	`TATGTC/TGGGAC`	1	--	us2k¹		4		WA NA EA	360
rs151302260^1,2		--	29885383(+)	`ACCCAC/TGGTGC`	1	--	us2k¹		0	--	--	--	--
rs114327507^1,2	C	--	29885431(+)	`AGAGGC/TCTGGT`	1	--	us2k¹		0	--	--	--	--
rs148866329^1,2	C	--	29885590(+)	`TCTGT-/CCCACT`	1	--	us2k¹		0	--	--	--	--
rs150494825^1,2		--	29885648(+)	`GCCAGA/GAAGAG`	1	--	us2k¹		0	--	--	--	--
rs188441282^1,2		--	29885741(+)	`CTTGGC/TACTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MIR193A (29887015 - 29887102 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for MIR193A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 614733 OMIM disorders: --

7 diseases for MIR193A: About MalaCards

acute myeloid leukemia cervical cancer myeloid leukemia cervicitis

leukemia lung cancer breast cancer

MIR193A for disorders About GeneDecksing

Export disorders for MIR193A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIR193A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MIR193A)

Utopia: connect your pdf to the dynamic
world of online information

A novel miR-193a-5p-YY1-APC regulatory axis in human e ndometrioid endometrial adenocarcinoma. (PubMed id 22907428)¹ Yang Y....Wang H. (2013)
Epigenetic silencing of microRNA-193a contributes to l eukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K sign al pathway. (PubMed id 23223432)¹ Li Y....Yu L. (2013)
Global microRNA level regulation of EGFR-driven cell-c ycle protein network in breast cancer. (PubMed id 22333974)¹ Uhlmann S....Sahin O. (2012)
MicroRNA-193 pro-proliferation effects for bone mesenc hymal stem cells after low-level laser irradiation treatment through inhibitor o f growth family, member 5. (PubMed id 22384930)¹ Wang J....Zhang H. (2012)
Micro-RNA profiling as biomarkers in flap ischemia-rep erfusion injury. (PubMed id 23097335)¹ Chang K.P. and Lai C.S. (2012)
MicroRNA-193a represses c-kit expression and function s as a methylation-silenced tumor suppressor in acute myeloid leukemia. (PubMed id 21399664)¹ Gao X.N....Yu L. (2011)
Inhibition of miR-193a expression by Max and RXRI+ act ivates K-Ras and PLAU to mediate distinct aspects of cellular transformation. (PubMed id 21670079)¹ Iliopoulos D....Struhl K. (2011)
[Epithelial-mesenchymal transition (EMT) and its effec t on microRNA expression in lung cancer]. (PubMed id 22325218)¹ Wang H.B....Chen X.F. (2011)
Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)¹ Lui W.O....Fire A. (2007)
A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 406968	HGNC: 31563	Ensembl:ENSG00000207614	miRBase: hsa-mir-193a	euGenes: HUgn406968
ECgene: MIR193A	H-InvDB: MIR193A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIR193A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR193A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MIR193A gene:
Search GeneIP for patents involving MIR193A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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