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MIR193A Gene

RNA gene   GIFtS: 19
GCID: GC17P029887

MicroRNA 193a

(Previous name: microRNA 193)
(Previous symbols: MIRN193, MIRN193A)
  See MIR193A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 193a1 2
MIRN1931 2
MIRN193A1 2
MicroRNA 1931
mir-193a9

External Ids:    HGNC: 315631   Entrez Gene: 4069682   Ensembl: ENSG000002076147   OMIM: 6147335   
ORGUL members:    fRNAdb10:FR259839      

Export aliases for MIR193A gene to outside databases

Previous GC identifer: GC17P026914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR193A Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR193A Gene:
MIR193A (microRNA 193a) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR193A include endometrial adenocarcinoma, and acute myeloid leukemia.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR193A
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR193A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

MIR193A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR193A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P029887:  view genomic region (via miRBase)     (about GC identifiers)

Start:
29,887,015 bp from pter      End:
29,887,102 bp from pter
Size:
88 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MIR193A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR193A
Interactions:

    Search GeneGlobe Interaction Network for MIR193A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000384882(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR193A:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MIR193A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIR193A gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia aca-mir-1936
aca-mir-193
77(a)
1 ↔ 1
GL343198.1(1030746-1030819)
zebrafish
(Danio rerio)
Actinopterygii dre-mir-193a-16
dre-mir-193a-1
58(a)
1 ↔ 1
3(44210575-44210673) ENSDARG00000083334
        Species with no ortholog for MIR193A

ENSEMBL Gene Tree for MIR193A (if available)
TreeFam Gene Tree for MIR193A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIR193A (see all 58)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs716972081,2
C--29885056(+) GCTAA-/TT/TT 
TT
/TTTTT
TTTTT
1 -- us2k10--------
rs1408388461,2
--29885107(+) TTCCCA/GGGCTG 1 -- us2k10--------
rs1447868861,2
--29885191(+) TGCCCA/GGCCTC 1 -- us2k10--------
rs561612281,2
C,F--29885217(+) GGCATG/AATCTG 1 -- us2k15Minor allele frequency- A:0.26WA CSA NA EA 362
rs739912061,2
C--29885273(+) TATGTC/TGGGAC 1 -- us2k14Minor allele frequency- T:0.12WA NA EA 360
rs1513022601,2
--29885383(+) ACCCAC/TGGTGC 1 -- us2k10--------
rs1143275071,2
C--29885431(+) AGAGGC/TCTGGT 1 -- us2k10--------
rs1488663291,2
C--29885590(+) TCTGT-/CCCACT 1 -- us2k10--------
rs1504948251,2
--29885648(+) GCCAGA/GAAGAG 1 -- us2k10--------
rs1884412821,2
--29885741(+) CTTGGC/TACTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MIR193A (29887015 - 29887102 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MIR193A: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR193A
DNA2.0 Custom Variant and Variant Library Synthesis for MIR193A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614733    OMIM disorders: --

2 diseases for MIR193A:    
About MalaCards
endometrial adenocarcinoma    acute myeloid leukemia


Find genes that share disorders with MIR193A           About GenesLikeMe


Export disorders for MIR193A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR193A gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with MIR193A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. (PubMed id 22907428)1 Yang Y....Wang H. (Oncogene 2013)
  2. Gain-of-function microRNA screens identify miR-193a regulating proliferation and apoptosis in epithelial ovarian cancer cells. (PubMed id 23588298)1 Nakano H....Yoshida T. (Int. J. Oncol. 2013)
  3. Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway. (PubMed id 23223432)1 Li Y....Yu L. (Blood 2013)
  4. Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression. (PubMed id 22986534)1 Hu Q....Huang S. (Oncogene 2013)
  5. Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. (PubMed id 23758639)1 Yong F.L....Wang C.W. (BMC Cancer 2013)
  6. Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1. (PubMed id 23546867)1 Kwon J.E....Han Y.H. (Apoptosis 2013)
  7. MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5. (PubMed id 22384930)1 Wang J....Zhang H. (Stem Cells Dev. 2012)
  8. Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. (PubMed id 22333974)1 Uhlmann S....Sahin O. (Mol. Syst. Biol. 2012)
  9. Micro-RNA profiling as biomarkers in flap ischemia-reperfusion injury. (PubMed id 23097335)1 Chang K.P. and Lai C.S. (Microsurgery 2012)
  10. MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. (PubMed id 21399664)1 Gao X.N....Yu L. (Oncogene 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 406968 HGNC: 31563 Ensembl:ENSG00000207614 miRBase: hsa-mir-193a euGenes: HUgn406968
ECgene: MIR193A H-InvDB: MIR193A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR193A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR193A gene:
Search GeneIP for patents involving MIR193A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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