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Aliases for MIR192 Gene

Subcategory (RNA class) for MIR192 Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR192 Gene

  • MicroRNA 192 2 3 5
  • Hsa-Mir-192 3
  • MiRNA192 3
  • MiR-192 3
  • MIRN192 3

External Ids for MIR192 Gene

Previous HGNC Symbols for MIR192 Gene

  • MIRN192

Previous GeneCards Identifiers for MIR192 Gene

  • GC11M064432
  • GC11M064435
  • GC11M064660
  • GC11M064664
  • GC11M064667
  • GC11M064669
  • GC11M064672
  • GC11M064674
  • GC11M064676
  • GC11M064687

Summaries for MIR192 Gene

Entrez Gene Summary for MIR192 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR192 Gene

MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR192 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR192

Additional gene information for MIR192 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR192 Gene

Genomics for MIR192 Gene

Regulatory Elements for MIR192 Gene

Enhancers for MIR192 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H064846 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +34.2 34193 20 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 EHD1 EHBP1L1 MAP4K2 MIR192 MEN1 MAJIN GPHA2 MAP3K11 CDC42EP2 CDC42BPG
GH11H064923 1.1 ENCODE 12 -33.2 -33235 2 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF207 ZNF143 MIR192 SSSCA1 SF1 SCYL1 ARL2 PPP2R5B GPHA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR192 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR192 Gene

Chromosome:
11
Start:
64,891,137 bp from pter
End:
64,891,246 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR192 Gene

Genes around MIR192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR192 Gene

ORGUL Member Location for MIR192 Gene

ORGUL Member Location for MIR192 gene

Proteins for MIR192 Gene

Post-translational modifications for MIR192 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR192 Gene

Domains & Families for MIR192 Gene

Gene Families for MIR192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR192: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR192 Gene

Function for MIR192 Gene

Animal Model Products

CRISPR Products

miRNA for MIR192 Gene

miRTarBase miRNAs that target MIR192

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR192
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR192 Gene

Localization for MIR192 Gene

Gene Ontology (GO) - Cellular Components for MIR192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIR192: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR192 Gene

Pathways & Interactions for MIR192 Gene

SuperPathways for MIR192 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR192: view

Pathways by source for MIR192 Gene

1 KEGG pathway for MIR192 Gene

Interacting Proteins for MIR192 Gene

Gene Ontology (GO) - Biological Process for MIR192 Gene

None

No data available for SIGNOR curated interactions for MIR192 Gene

Drugs & Compounds for MIR192 Gene

No Compound Related Data Available

Transcripts for MIR192 Gene

fRNAdb Secondary structures for MIR192 Gene

  • FR125149
  • hsa-miR-192-3p_MIMAT0004543_Homo_sapiens_miR-192-3p_mature

mRNA/cDNA for MIR192 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR192
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR192 Gene

No ASD Table

Relevant External Links for MIR192 Gene

GeneLoc Exon Structure for
MIR192
ECgene alternative splicing isoforms for
MIR192

Expression for MIR192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR192 Gene

mRNA differential expression in normal tissues according to GTEx for MIR192 Gene

This gene is overexpressed in Colon - Transverse (x22.9) and Small Intestine - Terminal Ileum (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR192 Gene:

MIR192
genes like me logo Genes that share expression patterns with MIR192: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR192 Gene

Orthologs for MIR192 Gene

Evolution for MIR192 Gene

ENSEMBL:
Gene Tree for MIR192 (if available)
TreeFam:
Gene Tree for MIR192 (if available)

No data available for Orthologs for MIR192 Gene

Paralogs for MIR192 Gene

No data available for Paralogs for MIR192 Gene

Variants for MIR192 Gene

Sequence variations from dbSNP and Humsavar for MIR192 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000588419 -- 64,891,594(+) GCCCC(A/G)TGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001108883 -- 64,891,132(+) GGTCC(C/T)GGTGG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002200033 -- 64,891,658(+) AAAGC(C/T)GGGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002302129 -- 64,891,698(+) TTTGC(C/T)CGCTC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002551245 -- 64,891,881(+) CCAGG(G/T)ACCTC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR192 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Relevant External Links for MIR192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR192 Gene

Disorders for MIR192 Gene

Relevant External Links for MIR192

Human Genome Epidemiology (HuGE) Navigator
MIR192
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR192

No disorders were found for MIR192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR192 Gene

Publications for MIR192 Gene

  1. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael MZ … James RJ (Molecular cancer research : MCR 2003) 1 3 60
  2. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M … Tuschl T (RNA (New York, N.Y.) 2003) 1 3 60
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 60
  4. Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction. (PMID: 28577875) Zununi Vahed S … Omidi Y (Archives of medical research 2017) 3 60
  5. Plasma microRNA192 in combination with serum CA19-9 as non-invasive prognostic biomarker in periampullary carcinoma. (PMID: 28351309) Murali Manohar K … Reddy DN (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60

Products for MIR192 Gene

Sources for MIR192 Gene

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