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Aliases for MIR192 Gene

Subcategory (RNA class) for MIR192 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR192 Gene

  • MicroRNA 192 2 3
  • MIR194-2 Host Gene 5
  • Hsa-Mir-192 3
  • MIR194-2HG 5
  • MiRNA192 3
  • MiR-192 3
  • MIRN192 3

External Ids for MIR192 Gene

Previous HGNC Symbols for MIR192 Gene

  • MIRN192

Previous GeneCards Identifiers for MIR192 Gene

  • GC11M064432
  • GC11M064435
  • GC11M064660
  • GC11M064664
  • GC11M064667
  • GC11M064669
  • GC11M064672
  • GC11M064674
  • GC11M064676
  • GC11M064687

Summaries for MIR192 Gene

Entrez Gene Summary for MIR192 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR192 Gene

MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR192 Gene

Genomics for MIR192 Gene

Regulatory Elements for MIR192 Gene

Enhancers for MIR192 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064846 1.9 FANTOM5 Ensembl ENCODE 12.4 +33.2 33178 27.0 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 EHD1 NEAT1 KAT5 MAP4K2 SNX15 MIR192 MEN1 SSSCA1-AS1 EHBP1L1 FAU
GH11F064923 1.1 ENCODE 12 -31.0 -31032 2.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YY1 ZNF207 ZNF143 FOS MIR192 NEAT1 KAT5 SSSCA1-AS1 FAU SNX15 ENSG00000269038 MRPL49 ARL2 PPP2R5B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR192 on UCSC Golden Path with GeneCards custom track

Promoters for MIR192 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769236 749 1401 HDGF ATF1 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1
ENSR00001769235 1949 201 NR2F1 RAD21 NR2F2 RARA YY1 ATF3 HNF4G NR2F6 ZBTB33

Genomic Location for MIR192 Gene

Chromosome:
11
Start:
64,889,560 bp from pter
End:
64,893,449 bp from pter
Size:
3,890 bases
Orientation:
Minus strand

Genomic View for MIR192 Gene

Genes around MIR192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR192 Gene

Proteins for MIR192 Gene

Post-translational modifications for MIR192 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR192 Gene

Domains & Families for MIR192 Gene

Gene Families for MIR192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR192: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR192 Gene

Function for MIR192 Gene

Animal Model Products

miRNA for MIR192 Gene

miRTarBase miRNAs that target MIR192

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR192 Gene

Localization for MIR192 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR192 Gene

Pathways & Interactions for MIR192 Gene

SuperPathways for MIR192 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR192: view

Pathways by source for MIR192 Gene

1 KEGG pathway for MIR192 Gene

Interacting Proteins for MIR192 Gene

Gene Ontology (GO) - Biological Process for MIR192 Gene

None

No data available for SIGNOR curated interactions for MIR192 Gene

Transcripts for MIR192 Gene

mRNA/cDNA for MIR192 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR192 Gene

No ASD Table

Relevant External Links for MIR192 Gene

GeneLoc Exon Structure for
MIR192
ECgene alternative splicing isoforms for
MIR192

Expression for MIR192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR192 Gene

mRNA differential expression in normal tissues according to GTEx for MIR192 Gene

This gene is overexpressed in Colon - Transverse (x22.9) and Small Intestine - Terminal Ileum (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR192 Gene:

MIR192
genes like me logo Genes that share expression patterns with MIR192: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR192 Gene

Orthologs for MIR192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-194-2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir194-2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-194-2 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-194-2 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-194a 35
  • 65 (a)
OneToMany
CU138503.6 35
  • 60 (a)
OneToMany
dre-mir-194b 35
  • 60 (a)
OneToMany
Species where no ortholog for MIR192 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR192 Gene

ENSEMBL:
Gene Tree for MIR192 (if available)
TreeFam:
Gene Tree for MIR192 (if available)

Paralogs for MIR192 Gene

No data available for Paralogs for MIR192 Gene

Variants for MIR192 Gene

Sequence variations from dbSNP and Humsavar for MIR192 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111974253 -- 64,891,284(+) ATCTG(A/G)CCTGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs112241987 -- 64,892,607(+) CACGC(C/T)GGGCT nc-transcript-variant, upstream-variant-2KB
rs11231898 -- 64,891,364(+) CCCTC(A/G)CCCCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs11231899 -- 64,891,528(+) TCTTC(A/G)TGGCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs112590834 -- 64,892,993(+) TCAGG(A/G)TGCAG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR192 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Relevant External Links for MIR192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR192 Gene

Disorders for MIR192 Gene

Relevant External Links for MIR192

Human Genome Epidemiology (HuGE) Navigator
MIR192
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR192

No disorders were found for MIR192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR192 Gene

Publications for MIR192 Gene

  1. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. (PMID: 26684241) Lian J. … He X. (Oncotarget 2016) 3 64
  2. The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio. (PMID: 26881255) Ma X. … Wang Q. (J Diabetes Res 2016) 3 64
  3. miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy. (PMID: 26942205) Jia Y. … Xue Y. (J Diabetes Res 2016) 3 64
  4. MicroRNA-192* impairs adipocyte triglyceride storage. (PMID: 26747651) Mysore R. … Olkkonen V.M. (Biochim. Biophys. Acta 2016) 3 64
  5. MiR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein. (PMID: 26743688) Sun J. … Huo Q. (Int. J. Mol. Med. 2016) 3 64

Products for MIR192 Gene

Sources for MIR192 Gene

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