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Aliases for MIR192 Gene

Subcategory (RNA class) for MIR192 Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR192 Gene

  • MicroRNA 192 2 3
  • MIRN192 3 6
  • Hsa-Mir-192 3
  • MiRNA192 3
  • MiR-192 3

External Ids for MIR192 Gene

Previous HGNC Symbols for MIR192 Gene

  • MIRN192

Previous GeneCards Identifiers for MIR192 Gene

  • GC11M064432
  • GC11M064435
  • GC11M064660
  • GC11M064664
  • GC11M064667
  • GC11M064669
  • GC11M064672
  • GC11M064674
  • GC11M064676
  • GC11M064687

Summaries for MIR192 Gene

Entrez Gene Summary for MIR192 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR192 Gene

MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR192 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR192

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR192 Gene

Genomics for MIR192 Gene

Genomic Location for MIR192 Gene

Start:
64,891,132 bp from pter
End:
64,891,246 bp from pter
Size:
115 bases
Orientation:
Minus strand

Genomic View for MIR192 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR192 Gene

ORGUL Member Location for MIR192 Gene

ORGUL Member Location for MIR192 gene

No data available for Regulatory Elements for MIR192 Gene

Proteins for MIR192 Gene

Post-translational modifications for MIR192 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR192 Gene

Domains for MIR192 Gene

Gene Families for MIR192 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR192: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR192 Gene

Function for MIR192 Gene

miRNA for MIR192 Gene

miRTarBase miRNAs that target MIR192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MIR192 Gene

Localization for MIR192 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR192 Gene

Pathways for MIR192 Gene

SuperPathways for MIR192 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR192: view

Pathways by source for MIR192 Gene

1 KEGG pathway for MIR192 Gene

Interacting Proteins for MIR192 Gene

Gene Ontology (GO) - Biological Process for MIR192 Gene

None

Transcripts for MIR192 Gene

fRNAdb Secondary structures for MIR192 Gene

  • FR125149
  • hsa-miR-192-3p_MIMAT0004543_Homo_sapiens_miR-192-3p_mature

mRNA/cDNA for MIR192 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR192

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR192 Gene

No ASD Table

Relevant External Links for MIR192 Gene

GeneLoc Exon Structure for
MIR192
ECgene alternative splicing isoforms for
MIR192

Expression for MIR192 Gene

mRNA expression in normal human tissues for MIR192 Gene

mRNA differential expression in normal tissues according to GTEx for MIR192 Gene

This gene is overexpressed in Colon - Transverse (22.9) and Small Intestine - Terminal Ileum (17.6).
genes like me logo Genes that share expressions with MIR192: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MIR192 Gene

Orthologs for MIR192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-192 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-192 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-192 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir192 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-192 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-192 36
  • 68 (a)
OneToMany
Species with no ortholog for MIR192:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR192 Gene

ENSEMBL:
Gene Tree for MIR192 (if available)
TreeFam:
Gene Tree for MIR192 (if available)

Paralogs for MIR192 Gene

No data available for Paralogs for MIR192 Gene

Variants for MIR192 Gene

Sequence variations from dbSNP and Humsavar for MIR192 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs17199860 -- 64,890,712(+) GGGCA(C/T)GCGCC downstream-variant-500B
rs78113980 -- 64,890,665(+) TCAGG(A/G)TGCAA downstream-variant-500B
rs376646184 -- 64,890,805(+) TCTGC(A/G)GCAGC downstream-variant-500B
rs531024954 -- 64,890,754(+) AGGAG(C/T)GAGAC downstream-variant-500B
rs564028048 -- 64,890,849(+) GCTTC(A/C)ATAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR192 Gene

Variant ID Type Subtype PubMed ID
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
dgv1173n71 CNV Loss 21882294
nsv360 CNV Loss 18451855
nsv526181 CNV Gain 19592680

Relevant External Links for MIR192 Gene

HapMap Linkage Disequilibrium report
MIR192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR192 Gene

Disorders for MIR192 Gene

Relevant External Links for MIR192

Human Genome Epidemiology (HuGE) Navigator
MIR192
genes like me logo Genes that share disorders with MIR192: view

No data available for UniProtKB/Swiss-Prot for MIR192 Gene

Publications for MIR192 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 3
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  4. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR192 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR192
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR192
    • Block miRNA regulation of MIR192 using miScript Target Protectors

    Sources for MIR192 Gene

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