Aliases
for MIR192 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
|---|
| MicroRNA 1921 2 | | MIRN1921 2 5 | | Hsa-Mir-1921 | | MiR-1921 | | MiRNA1921 | | Mir-1921 |
| External Ids: | HGNC: 315621 | Entrez Gene: 4069672 | Ensembl: ENSG000002076487 | OMIM: 6109395 |
Export aliases for MIR192 gene to outside databasesPrevious GC identifers: GC11M064432 GC11M064435 GC11M064660 GC11M064664 GC11M064667 GC11M064669 GC11M064672 GC11M064674
|---|
Summaries
for MIR192 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR192:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
|
Genomic Views
for MIR192 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR192
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR192
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR192 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1MIR192 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064676: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
64,658,609 bp from pter |
End:
|
64,658,718 bp from pter |
Size:
|
110 bases |
Orientation:
|
minus strand |
|
Proteins
for MIR192 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for MIR192 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR192 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
miRNA
Products: | | miRTarBase genes targeted by MIR192:
LOXL2(MIRT004135), HRH1(MIRT004851), CADM1(MIRT004167), E2F5(MIRT004134), ATP10D(MIRT004152), SETD4(MIRT004168), MAP3K1(MIRT004142), CDC7(MIRT004845), MSN(MIRT004153), ALCAM(MIRT004163), B3GALNT1(MIRT004161), ERLIN2(MIRT004154), CD164(MIRT004165), WDR44(MIRT004133), CDKN1B(MIRT005064), STX7(MIRT004164), GRIA1(MIRT004156), CUL3(MIRT004141), TFG(MIRT004131), WNK1(MIRT005582), MCM10(MIRT004854), DTL(MIRT004848), LMNB2(MIRT004852), RRM1(MIRT004159), TRAPPC2P1(MIRT004862), HSP90B1(MIRT004158), PTP4A3(MIRT004166), ABCA8(MIRT004151), PRPF38A(MIRT004858), KIDINS220(MIRT004136), BCL2(MIRT004844), SPARC(MIRT004126), ATXN7(MIRT004157), ODC1(MIRT004127), MAD2L1(MIRT004853), DLG5(MIRT004847), SEMA4D(MIRT004149), GOLGA6A(MIRT004173), PANX1(MIRT004125), HOXA10(MIRT004850), KIF20B(MIRT004856), MFSD10(MIRT004147), CLIC1(MIRT004124), ERCC3(MIRT004849), DDOST(MIRT004128), PERP(MIRT004143), ABCC3(MIRT004155), BRD3(MIRT004162), RABGAP1(MIRT004150), CUL5(MIRT004846), PIK3R4(MIRT004145), AKAP9(MIRT004170), RAB2A(MIRT004140), XPA(MIRT004137), ENTPD3(MIRT004160), PIM1(MIRT004857), RACGAP1(MIRT004859), EGR1(MIRT004130), ENOSF1(MIRT004171), ABCG2(MIRT004129), MIS12(MIRT004855), BARD1(MIRT004138), RBL2(MIRT004139), RANBP3(MIRT004172), SEPT10(MIRT004860), PDE2A(MIRT004169), SMARCB1(MIRT004861), C1D(MIRT004148), DDX3X(MIRT004132) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR192 | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR192 | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR192 | |  | Search LifeMap BioReagents cell lines for MIR192 |
Pathways & Interactions
for MIR192 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR192
|
Drugs & Compounds
for MIR192 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR192
Search CenterWatch for drugs/clinical trials and news about MIR192 
|
Transcripts
for MIR192 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000384915(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR192 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR192:none
MIR192 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR192
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR192 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR192 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR192 |
Orthologs
for MIR192 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MIR192 (if available)
TreeFam Gene Tree for MIR192 (if available) |
Paralogs
for MIR192 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR192 gene
- MIR2152
MIR192 for paralogs About GeneDecksing
|
Genomic Variants
for MIR192 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MIR192 (64658609 - 64658718 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR192: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MIR192 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIR192 for disorders About GeneDecksing
OMIM gene information: 610939
OMIM disorders: --
8  diseases for MIR192: About MalaCardssystemic lupus erythematosus lupus erythematosus multiple myeloma myeloma
retinoblastoma nephropathy lung cancer neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR192 (1 document)
Export disorders for MIR192 gene to outside databases
|
Publications
for MIR192 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIR192 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with MIR192) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Transforming growth factor b1 represses proximal tubul ar cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. (PubMed id 22264233)1 Jenkins R.H....Fraser D.J. (2012)
- Expression levels of microRNA-192 and -215 in gastric carcinoma. (PubMed id 22205577)1 Chiang Y....Xu H. (2012)
- Differentially expressed microRNAs in pancreatic cance r stem cells. (PubMed id 21785383)1 Jung D.E....Song S.Y. (2011)
- MicroRNA-192 and -215 are upregulated in human gastri c cancer in vivo and suppress ALCAM expression in vitro. (PubMed id 21119604)1 Jin Z....Meltzer S.J. (2011)
- [HBx gene down-regulates miR-192 expression and inhibi ts apoptosis of human hepatoma cell line HepG2]. (PubMed id 22433310)1 Xie Q.H....Lin J.S. (2011)
- Serum and urinary free microRNA level in patients wit h systemic lupus erythematosus. (PubMed id 21372198)1 Wang G....Szeto C.C. (2011)
- MiR-192 inhibits nucleotide excision repair by target ing ERCC3 and ERCC4 in HepG2.2.15 cells. (PubMed id 21672525)1 Xie Q.H....Lin J.S. (2011)
- MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. (PubMed id 21511813)1 Feng S....Zhang B. (2011)
- miR-192/miR-215 influence 5-fluorouracil resistance t hrough cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. (PubMed id 20647341)1 Boni V....Bandres E. (2010)
- Loss of MicroRNA-192 promotes fibrogenesis in diabeti c nephropathy. (PubMed id 20056746)1 Krupa A....Fraser D. (2010)
|
External Searches for MIR192 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIR192 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIR192 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR192 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR192 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MIR192 gene:
Search GeneIP for patents involving MIR192
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR192 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR192 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR192 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR192 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR192 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR192 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR192 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MIR192 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MIR192 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR192 |
| |  | |
|
|
|
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 106 solr: 1.4
|
