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Aliases for MIR192 Gene

Subcategory (RNA class) for MIR192 Gene

miRNA

Quality Score for this RNA gene is

20.2

Aliases for MIR192 Gene

  • MicroRNA 192 2 3 5
  • Hsa-Mir-192 3
  • MiRNA192 3
  • MiR-192 3
  • MIRN192 3

External Ids for MIR192 Gene

Previous HGNC Symbols for MIR192 Gene

  • MIRN192

Previous GeneCards Identifiers for MIR192 Gene

  • GC11M064432
  • GC11M064435
  • GC11M064660
  • GC11M064664
  • GC11M064667
  • GC11M064669
  • GC11M064672
  • GC11M064674
  • GC11M064676
  • GC11M064687

Summaries for MIR192 Gene

Entrez Gene Summary for MIR192 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR192 Gene

MIR192 (MicroRNA 192) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR192 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR192

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR192 Gene

Genomics for MIR192 Gene

Regulatory Elements for MIR192 Gene

Enhancers for MIR192 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064846 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +34.2 34193 20.6 CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 GLIS1 EHD1 MAP4K2 SNX15 MIR192 MEN1 KAT5 SSSCA1-AS1 MAJIN GPHA2 ENSG00000269038
GH11G064923 1.1 ENCODE 12 -33.2 -33235 2.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF207 MIR192 KAT5 SSSCA1-AS1 SNX15 ENSG00000269038 ARL2 PPP2R5B GPHA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR192 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR192 Gene

Chromosome:
11
Start:
64,891,137 bp from pter
End:
64,891,246 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR192 Gene

Genes around MIR192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR192 Gene

ORGUL Member Location for MIR192 Gene

ORGUL Member Location for MIR192 gene

Proteins for MIR192 Gene

Post-translational modifications for MIR192 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR192 Gene

Domains & Families for MIR192 Gene

Gene Families for MIR192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR192: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR192 Gene

Function for MIR192 Gene

Animal Model Products

miRNA for MIR192 Gene

miRTarBase miRNAs that target MIR192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR192 Gene

Localization for MIR192 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR192 Gene

Pathways & Interactions for MIR192 Gene

SuperPathways for MIR192 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR192: view

Pathways by source for MIR192 Gene

1 KEGG pathway for MIR192 Gene

Interacting Proteins for MIR192 Gene

Gene Ontology (GO) - Biological Process for MIR192 Gene

None

No data available for SIGNOR curated interactions for MIR192 Gene

Drugs & Compounds for MIR192 Gene

No Compound Related Data Available

Transcripts for MIR192 Gene

fRNAdb Secondary structures for MIR192 Gene

  • FR125149
  • hsa-miR-192-3p_MIMAT0004543_Homo_sapiens_miR-192-3p_mature

mRNA/cDNA for MIR192 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR192 Gene

No ASD Table

Relevant External Links for MIR192 Gene

GeneLoc Exon Structure for
MIR192
ECgene alternative splicing isoforms for
MIR192

Expression for MIR192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR192 Gene

mRNA differential expression in normal tissues according to GTEx for MIR192 Gene

This gene is overexpressed in Colon - Transverse (x22.9) and Small Intestine - Terminal Ileum (x17.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR192 Gene:

MIR192
genes like me logo Genes that share expression patterns with MIR192: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR192 Gene

Orthologs for MIR192 Gene

Evolution for MIR192 Gene

ENSEMBL:
Gene Tree for MIR192 (if available)
TreeFam:
Gene Tree for MIR192 (if available)

No data available for Orthologs for MIR192 Gene

Paralogs for MIR192 Gene

No data available for Paralogs for MIR192 Gene

Variants for MIR192 Gene

Sequence variations from dbSNP and Humsavar for MIR192 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000588419 -- 64,891,594(+) GCCCC(A/G)TGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001108883 -- 64,891,132(+) GGTCC(C/T)GGTGG intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002200033 -- 64,891,658(+) AAAGC(C/T)GGGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002302129 -- 64,891,698(+) TTTGC(C/T)CGCTC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1002551245 -- 64,891,881(+) CCAGG(G/T)ACCTC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR192 Gene

Variant ID Type Subtype PubMed ID
nsv360 CNV deletion 18451855
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv951014 CNV deletion 24416366

Relevant External Links for MIR192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR192 Gene

Disorders for MIR192 Gene

Relevant External Links for MIR192

Human Genome Epidemiology (HuGE) Navigator
MIR192
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR192

No disorders were found for MIR192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR192 Gene

Publications for MIR192 Gene

  1. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 3 64
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 1 3 64
  4. Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. (PMID: 28039611) Kim R. … Chang W. (Mol. Cell. Biochem. 2017) 3 64
  5. Plasma microRNA192 in combination with serum CA19-9 as non-invasive prognostic biomarker in periampullary carcinoma. (PMID: 28351309) Murali Manohar K. … Reddy D.N. (Tumour Biol. 2017) 3 64

Products for MIR192 Gene

Sources for MIR192 Gene

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