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Aliases for MIR1915 Gene

Subcategory (RNA class) for MIR1915 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR1915 Gene

  • MicroRNA 1915 2 3 5
  • Hsa-Mir-1915 3
  • MIRN1915 3

External Ids for MIR1915 Gene

Previous HGNC Symbols for MIR1915 Gene

  • MIRN1915

Previous GeneCards Identifiers for MIR1915 Gene

  • GC00U923043
  • GC10M021826
  • GC10M021785

Summaries for MIR1915 Gene

Entrez Gene Summary for MIR1915 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1915 Gene

MIR1915 (MicroRNA 1915) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1915 Gene

Genomics for MIR1915 Gene

Regulatory Elements for MIR1915 Gene

Enhancers for MIR1915 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G021515 2.7 FANTOM5 ENCODE dbSUPER 12.1 -21.6 -21597 6.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 CASC10 MIR1915 MLLT10 SKIDA1 GC10P021497
GH10G021522 1.7 FANTOM5 ENCODE dbSUPER 11.4 -29.7 -29734 7.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D MIR1915 CASC10 SKIDA1 MLLT10
GH10G021278 1.5 Ensembl ENCODE dbSUPER 11.2 +213.7 213690 9.3 HDGF PKNOX1 FOXA2 MLX ZNF133 ARID4B ZNF2 ZNF48 ETS1 TCF12 RNU6-15P ENSG00000199222 CASC10 MIR1915 NEBL GC10P021323 LUZP4P1
GH10G021726 1.3 Ensembl ENCODE 12.4 -231.1 -231064 2.1 ATF1 PKNOX1 ARNT FEZF1 TCF12 ZNF766 GATA2 ZNF302 NCOA1 TSHZ1 CASC10 MIR1915 MLLT10 GC10P021711 RN7SKP219
GH10G021723 1.3 Ensembl ENCODE 12.4 -228.0 -227961 2.3 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 SP3 ZNF610 SMARCA4 MIR1915 CASC10 MLLT10 RNU6-1141P BMI1 GC10P021711 RN7SKP219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1915 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1915 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025393 641 3600 HNRNPUL1 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MIR1915 Gene

Chromosome:
10
Start:
21,496,562 bp from pter
End:
21,496,641 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR1915 Gene

Genes around MIR1915 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1915 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1915 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1915 Gene

ORGUL Member Location for MIR1915 Gene

ORGUL Member Location for MIR1915 gene

Proteins for MIR1915 Gene

Post-translational modifications for MIR1915 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1915 Gene

Domains & Families for MIR1915 Gene

Gene Families for MIR1915 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1915: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1915 Gene

Function for MIR1915 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1915 Gene

Localization for MIR1915 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1915 Gene

Pathways & Interactions for MIR1915 Gene

SuperPathways for MIR1915 Gene

No Data Available

Interacting Proteins for MIR1915 Gene

Gene Ontology (GO) - Biological Process for MIR1915 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1915 Gene

Transcripts for MIR1915 Gene

mRNA/cDNA for MIR1915 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1915 Gene

No ASD Table

Relevant External Links for MIR1915 Gene

GeneLoc Exon Structure for
MIR1915
ECgene alternative splicing isoforms for
MIR1915

Expression for MIR1915 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR1915 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1915 Gene:

MIR1915
genes like me logo Genes that share expression patterns with MIR1915: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR1915 Gene

Orthologs for MIR1915 Gene

Evolution for MIR1915 Gene

ENSEMBL:
Gene Tree for MIR1915 (if available)
TreeFam:
Gene Tree for MIR1915 (if available)

No data available for Orthologs for MIR1915 Gene

Paralogs for MIR1915 Gene

No data available for Paralogs for MIR1915 Gene

Variants for MIR1915 Gene

Sequence variations from dbSNP and Humsavar for MIR1915 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001054791 -- 21,496,694(+) CCGCG(C/G)CCTGG intron-variant, upstream-variant-2KB
rs1002004225 -- 21,498,150(+) TCTTA(C/T)GACTC upstream-variant-2KB
rs1002033129 -- 21,498,545(+) GTTAA(A/G)AATAG upstream-variant-2KB
rs1004432640 -- 21,497,220(+) TGCCT(A/G)GAGCC upstream-variant-2KB, utr-variant-5-prime
rs1004568511 -- 21,496,224(+) CCGCT(C/T)GGAGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR1915 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
esv3622584 CNV loss 21293372
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv825289 CNV loss 20364138

Relevant External Links for MIR1915 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1915

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1915 Gene

Disorders for MIR1915 Gene

Relevant External Links for MIR1915

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1915

No disorders were found for MIR1915 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1915 Gene

Publications for MIR1915 Gene

  1. The Plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-regulating NFIX. (PMID: 26695693) Hu J. … Cai S. (Curr. Mol. Med. 2016) 3 64
  2. MicroRNAa891915a893p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2. (PMID: 26572100) Xu C. … Lu C. (Mol Med Rep 2016) 3 64
  3. Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. (PMID: 24814047) Nakazawa K. … Yoshida K. (FEBS J. 2014) 3 64
  4. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. (PMID: 23861881) Sallustio F. … Schena F.P. (PLoS ONE 2013) 3 64
  5. miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. (PMID: 22121083) Xu K. … Liu J. (Mol. Carcinog. 2013) 3 64

Products for MIR1915 Gene

Sources for MIR1915 Gene

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