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Aliases for MIR1915 Gene

Subcategory (RNA class) for MIR1915 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR1915 Gene

  • MicroRNA 1915 2 3 5
  • Hsa-Mir-1915 3
  • MIRN1915 3

External Ids for MIR1915 Gene

Previous HGNC Symbols for MIR1915 Gene

  • MIRN1915

Previous GeneCards Identifiers for MIR1915 Gene

  • GC00U923043
  • GC10M021826
  • GC10M021785

Summaries for MIR1915 Gene

Entrez Gene Summary for MIR1915 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1915 Gene

MIR1915 (MicroRNA 1915) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1915 Gene

Genomics for MIR1915 Gene

Regulatory Elements for MIR1915 Gene

Enhancers for MIR1915 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F021515 2.4 FANTOM5 ENCODE 12.1 -21.6 -21597 6.3 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 CASC10 MIR1915 MLLT10 SKIDA1 GC10P021497
GH10F021723 1.3 Ensembl ENCODE 12.4 -228.0 -227974 2.4 ATF1 ARID4B SIN3A FEZF1 ZNF2 ZNF202 SP3 TSHZ1 ZNF518A ZNF610 MIR1915 CASC10 MLLT10 RNU6-1141P GC10P021711 RN7SKP219
GH10F021726 1.3 Ensembl ENCODE 12.4 -231.1 -231064 2.1 ATF1 PKNOX1 ARNT FEZF1 ZNF766 ZNF302 GATA2 NCOA1 TSHZ1 PPARG MIR1915 CASC10 MLLT10 GC10P021711 RN7SKP219
GH10F021522 1.4 FANTOM5 ENCODE 11.4 -29.7 -29734 7.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MIR1915 CASC10 MLLT10 SKIDA1
GH10F022433 1.6 FANTOM5 Ensembl ENCODE 9.5 -939.7 -939660 5.8 PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 FOS ZNF202 ZNF263 BMI1 COMMD3 CASC10 MIR1915 HNRNPRP1 DNAJC1 LOC100499489 GC10P022433
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1915 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1915 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000351770 741 3801 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5

Genomic Location for MIR1915 Gene

Chromosome:
10
Start:
21,496,562 bp from pter
End:
21,496,641 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR1915 Gene

Genes around MIR1915 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1915 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1915 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1915 Gene

ORGUL Member Location for MIR1915 Gene

ORGUL Member Location for MIR1915 gene

Proteins for MIR1915 Gene

Post-translational modifications for MIR1915 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR1915 Gene

Domains & Families for MIR1915 Gene

Gene Families for MIR1915 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR1915: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR1915 Gene

Function for MIR1915 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1915 Gene

Localization for MIR1915 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR1915 Gene

Pathways & Interactions for MIR1915 Gene

SuperPathways for MIR1915 Gene

No Data Available

Interacting Proteins for MIR1915 Gene

Gene Ontology (GO) - Biological Process for MIR1915 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR1915 Gene

Transcripts for MIR1915 Gene

mRNA/cDNA for MIR1915 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1915 Gene

No ASD Table

Relevant External Links for MIR1915 Gene

GeneLoc Exon Structure for
MIR1915
ECgene alternative splicing isoforms for
MIR1915

Expression for MIR1915 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1915 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1915 Gene:

MIR1915
genes like me logo Genes that share expression patterns with MIR1915: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR1915 Gene

Orthologs for MIR1915 Gene

Evolution for MIR1915 Gene

ENSEMBL:
Gene Tree for MIR1915 (if available)
TreeFam:
Gene Tree for MIR1915 (if available)

No data available for Orthologs for MIR1915 Gene

Paralogs for MIR1915 Gene

No data available for Paralogs for MIR1915 Gene

Variants for MIR1915 Gene

Sequence variations from dbSNP and Humsavar for MIR1915 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs112329944 -- 21,496,084(+) GCGCC(C/T)TCCCC intron-variant, downstream-variant-500B
rs115989849 -- 21,497,634(+) AAAAA(A/G)GACTT upstream-variant-2KB
rs138673157 -- 21,496,779(+) CTCTC(C/T)GCCGT upstream-variant-2KB, reference, synonymous-codon
rs138941395 -- 21,496,947(+) TGGGA(A/G)ACTTG upstream-variant-2KB, utr-variant-5-prime
rs141300809 -- 21,497,372(+) CAGGC(A/C/G)GGCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1915 Gene

Variant ID Type Subtype PubMed ID
nsv825289 CNV loss 20364138
nsv550200 CNV loss 21841781
nsv527055 CNV loss 19592680
nsv517469 CNV loss 19592680
esv3622584 CNV loss 21293372
dgv135n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv133n67 CNV gain 20364138

Relevant External Links for MIR1915 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1915

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1915 Gene

Disorders for MIR1915 Gene

Relevant External Links for MIR1915

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1915

No disorders were found for MIR1915 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1915 Gene

Publications for MIR1915 Gene

  1. MicroRNAa891915a893p prevents the apoptosis of lung cancer cells by downregulating DRG2 and PBX2. (PMID: 26572100) Xu C. … Lu C. (Mol Med Rep 2016) 3 64
  2. The Plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-regulating NFIX. (PMID: 26695693) Hu J. … Cai S. (Curr. Mol. Med. 2016) 3 64
  3. Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. (PMID: 24814047) Nakazawa K. … Yoshida K. (FEBS J. 2014) 3 64
  4. miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. (PMID: 22121083) Xu K. … Liu J. (Mol. Carcinog. 2013) 3 64
  5. miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells. (PMID: 23861881) Sallustio F. … Schena F.P. (PLoS ONE 2013) 3 64

Products for MIR1915 Gene

Sources for MIR1915 Gene

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