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Aliases for MIR1914 Gene

Subcategory (RNA class) for MIR1914 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1914 Gene

  • MicroRNA 1914 2 3
  • EC 2.7.1.48 4 61
  • UCKL1 4 5
  • Uridine-Cytidine Kinase 1 Like 1 5
  • Hsa-Mir-1914 3
  • MIRN1914 3
  • URKL1 4

External Ids for MIR1914 Gene

Previous HGNC Symbols for MIR1914 Gene

  • MIRN1914

Previous GeneCards Identifiers for MIR1914 Gene

  • GC00U923143
  • GC20M062046
  • GC20M062572

Summaries for MIR1914 Gene

Entrez Gene Summary for MIR1914 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1914 Gene

MIR1914 (MicroRNA 1914) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is MIR3658.

UniProtKB/Swiss-Prot for MIR1914 Gene

  • May contribute to UTP accumulation needed for blast transformation and proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1914 Gene

Genomics for MIR1914 Gene

Regulatory Elements for MIR1914 Gene

Enhancers for MIR1914 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F063893 1.7 FANTOM5 Ensembl ENCODE 14.5 +58.5 58524 7.8 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 MIR647 MIR1914 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181 FNDC11
GH20F063657 1.2 ENCODE 20.1 +298.0 297981 2.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 LINC00029 MIR647 RTEL1 LOC105372725 GMEB2 ENSG00000237371 MIR1914 LINC01056 PRPF6 SLC2A4RG
GH20F063452 1.7 FANTOM5 Ensembl ENCODE 11.8 +501.6 501583 5.5 HDGF PKNOX1 CREB3L1 ZNF207 FOS ZNF263 SP3 JUNB ZHX2 REST MIR647 RTEL1 ENSG00000226390 EEF1A2 ZNF512B KCNQ2 ARFGAP1 TNFRSF6B LOC105372725 MIR1914
GH20F063947 1.4 Ensembl ENCODE 14.2 +6.3 6338 5.9 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 PRPF6 CICP4 MIR647 MIR1914 GMEB2 RTEL1 ENSG00000237371 UCKL1 LINC00176 UCKL1-AS1
GH20F063260 0.8 ENCODE 24.8 +694.9 694920 1.7 SAP130 ZNF133 KLF17 NFXL1 YBX1 ZIC2 ZBTB40 ZKSCAN1 FOSL1 ZNF791 BIRC7 MIR647 MIR1914 MIR4758 NKAIN4 ENSG00000237371 COL20A1 RNU6-994P ENSG00000226332 PRPF6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1914 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1914 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000650086 215 2401 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MIR1914 Gene

Chromosome:
20
Start:
63,939,829 bp from pter
End:
63,956,415 bp from pter
Size:
16,587 bases
Orientation:
Minus strand

Genomic View for MIR1914 Gene

Genes around MIR1914 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1914 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1914 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1914 Gene

Proteins for MIR1914 Gene

  • Protein details for MIR1914 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWZ5-UCKL1_HUMAN
    Recommended name:
    Uridine-cytidine kinase-like 1
    Protein Accession:
    Q9NWZ5
    Secondary Accessions:
    • B7Z8N2
    • Q5JWV0
    • Q70AQ5
    • Q8N524
    • Q9H3Z2

    Protein attributes for MIR1914 Gene

    Size:
    548 amino acids
    Molecular mass:
    61141 Da
    Quaternary structure:
    • Interacts with RNF19B and EBV EBNA3.
    • Interacts with RNF19B and EBV EBNA3.

    Alternative splice isoforms for MIR1914 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1914 Gene

Selected DME Specific Peptides for MIR1914 Gene

Q9NWZ5:
  • DHPDAFD
  • NTVAIDL

Post-translational modifications for MIR1914 Gene

  • Ubiquitinated by RNF19B; which induces proteasomal degradation.
  • Ubiquitination at Lys 111, Lys 387, and Lys 392
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR1914 Gene

Domains & Families for MIR1914 Gene

Gene Families for MIR1914 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWZ5

UniProtKB/Swiss-Prot:

UCKL1_HUMAN :
  • Belongs to the uridine kinase family.
Family:
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with MIR1914: view

No data available for Suggested Antigen Peptide Sequences for MIR1914 Gene

Function for MIR1914 Gene

Molecular function for MIR1914 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP.
UniProtKB/Swiss-Prot Function:
May contribute to UTP accumulation needed for blast transformation and proliferation.

Enzyme Numbers (IUBMB) for MIR1914 Gene

Gene Ontology (GO) - Molecular Function for MIR1914 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MIR1914: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1914 Gene

Localization for MIR1914 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1914 Gene

Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Gene Ontology (GO) - Cellular Components for MIR1914 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with MIR1914: view

No data available for Subcellular locations from COMPARTMENTS for MIR1914 Gene

Pathways & Interactions for MIR1914 Gene

SuperPathways for MIR1914 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NWZ5-UCKL1_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Gene Ontology (GO) - Biological Process for MIR1914 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0006222 UMP biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0009116 nucleoside metabolic process IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with MIR1914: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1914 Gene

Transcripts for MIR1914 Gene

mRNA/cDNA for MIR1914 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1914 Gene

No ASD Table

Relevant External Links for MIR1914 Gene

GeneLoc Exon Structure for
MIR1914
ECgene alternative splicing isoforms for
MIR1914

Expression for MIR1914 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1914 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1914 Gene:

MIR1914

mRNA Expression by UniProt/SwissProt for MIR1914 Gene:

Q9NWZ5-UCKL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MIR1914: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1914 Gene

Orthologs for MIR1914 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1914 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCKL1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uckl1 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCKL1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UCKL1 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCKL1 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF512B 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 93 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii uckl1b 35
  • 81 (a)
OneToMany
uckl1a 35
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(2)k01209 35
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F19B6.1 35
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 37 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
Species where no ortholog for MIR1914 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1914 Gene

ENSEMBL:
Gene Tree for MIR1914 (if available)
TreeFam:
Gene Tree for MIR1914 (if available)

Paralogs for MIR1914 Gene

Paralogs for MIR1914 Gene

genes like me logo Genes that share paralogs with MIR1914: view

Variants for MIR1914 Gene

Sequence variations from dbSNP and Humsavar for MIR1914 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111545918 -- 63,942,199(+) GCCGG(A/G)AATGG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs111873930 -- 63,943,307(+) ATGTC(C/T)GTAGT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs112363030 -- 63,942,073(+) CGGGG(C/T)CGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs112538127 -- 63,942,195(+) CGGGG(C/T)CGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs112709026 -- 63,942,256(+) CGGGG(C/T)CGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR1914 Gene

Variant ID Type Subtype PubMed ID
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv586695 CNV loss 21841781
nsv953309 CNV deletion 24416366

Relevant External Links for MIR1914 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1914

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1914 Gene

Disorders for MIR1914 Gene

Relevant External Links for MIR1914

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1914

No disorders were found for MIR1914 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1914 Gene

Publications for MIR1914 Gene

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for MIR1914 Gene

Sources for MIR1914 Gene

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