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Aliases for MIR191 Gene

Subcategory (RNA class) for MIR191 Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR191 Gene

  • MicroRNA 191 2 3
  • Hsa-Mir-191 3
  • MiR-191 3
  • MIRN191 3

External Ids for MIR191 Gene

Previous Symbols for MIR191 Gene

  • MIRN191

Summaries for MIR191 Gene

Entrez Gene Summary for MIR191 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR191 Gene

MIR191 (MicroRNA 191) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR191 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR191

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR191 Gene

Genomics for MIR191 Gene

Genomic Location for MIR191 Gene

Start:
49,020,602 bp from pter
End:
49,020,714 bp from pter
Size:
113 bases
Orientation:
Minus strand

Genomic View for MIR191 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR191 Gene

ORGUL Member Location for MIR191 Gene

ORGUL Member Location for MIR191 gene

No data available for Regulatory Elements for MIR191 Gene

Proteins for MIR191 Gene

Post-translational modifications for MIR191 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR191 Gene

Domains for MIR191 Gene

Gene Families for MIR191 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR191: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR191 Gene

Function for MIR191 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR191 Gene

Localization for MIR191 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR191 Gene

Pathways for MIR191 Gene

SuperPathways for MIR191 Gene

No Data Available

Interacting Proteins for MIR191 Gene

Gene Ontology (GO) - Biological Process for MIR191 Gene

None

No data available for Pathways by source for MIR191 Gene

Transcripts for MIR191 Gene

fRNAdb Secondary structures for MIR191 Gene

  • FR166793
  • FR327653
  • hsa-mir-191_MI0000465_Homo_sapiens_miR-191_stem-loop_hairpin

mRNA/cDNA for MIR191 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR191 Gene

No ASD Table

Relevant External Links for MIR191 Gene

GeneLoc Exon Structure for
MIR191
ECgene alternative splicing isoforms for
MIR191

Expression for MIR191 Gene

mRNA expression in normal human tissues for MIR191 Gene

genes like me logo Genes that share expressions with MIR191: view

Orthologs for MIR191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-191 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-191 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-191 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm24083 37
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-191 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-191 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-191 37
  • 57 (a)
OneToOne
Species with no ortholog for MIR191:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR191 Gene

ENSEMBL:
Gene Tree for MIR191 (if available)
TreeFam:
Gene Tree for MIR191 (if available)

Paralogs for MIR191 Gene

No data available for Paralogs for MIR191 Gene

Variants for MIR191 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR191 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Relevant External Links for MIR191 Gene

HapMap Linkage Disequilibrium report
MIR191
Human Gene Mutation Database (HGMD)
MIR191

No data available for Sequence variations from dbSNP and Humsavar for MIR191 Gene

Disorders for MIR191 Gene

Relevant External Links for MIR191

Genetic Association Database (GAD)
MIR191
Human Genome Epidemiology (HuGE) Navigator
MIR191
genes like me logo Genes that share disorders with MIR191: view

No data available for UniProtKB/Swiss-Prot for MIR191 Gene

Publications for MIR191 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 49
  3. microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. (PMID: 19954774) Hezova R. … Michalek J. (Cell. Immunol. 2010) 3
  4. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 3
  5. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3

Products for MIR191 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR191
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR191
    • Block miRNA regulation of MIR191 using miScript Target Protectors

    Sources for MIR191 Gene

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