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Aliases for MIR191 Gene

Subcategory (RNA class) for MIR191 Gene


Quality Score for this RNA gene is


Aliases for MIR191 Gene

  • MicroRNA 191 2 3 5
  • Hsa-Mir-191 3
  • MiR-191 3
  • MIRN191 3

External Ids for MIR191 Gene

Previous HGNC Symbols for MIR191 Gene

  • MIRN191

Previous GeneCards Identifiers for MIR191 Gene

  • GC03M049050
  • GC03M049054
  • GC03M049058
  • GC03M049025
  • GC03M049031
  • GC03M049078
  • GC03M049083
  • GC03M049088

Summaries for MIR191 Gene

Entrez Gene Summary for MIR191 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR191 Gene

MIR191 (MicroRNA 191) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR191 include Familial Breast Cancer.

fRNAdb sequence ontologies for MIR191 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR191

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR191 Gene

Genomics for MIR191 Gene

Regulatory Elements for MIR191 Gene

Enhancers for MIR191 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049338 1.9 FANTOM5 ENCODE dbSUPER 10.5 -325.3 -325341 14.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AMT QRICH1 IMPDH2 DALRD3 RHOA WDR6 NICN1 USP4 ENSG00000230454 RHOA-IT1
GH03G048971 0.5 dbSUPER 10.9 +48.7 48664 1.1 GLIS1 ZNF394 PRDM10 ZIC2 WDR6 MIR191 MIR425 NDUFAF3 DALRD3 IMPDH2 QRICH1 QARS NICN1 PIR49221
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR191 on UCSC Golden Path with GeneCards custom track

Promoters for MIR191 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303946 -891 2801 MLX CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZFP41
ENSR00000303947 1209 201 BCOR MLLT1 REST

Genomic Location for MIR191 Gene

49,020,618 bp from pter
49,020,709 bp from pter
92 bases
Minus strand

Genomic View for MIR191 Gene

Genes around MIR191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR191 Gene

ORGUL Member Location for MIR191 Gene

ORGUL Member Location for MIR191 gene

Proteins for MIR191 Gene

Post-translational modifications for MIR191 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR191 Gene

Domains & Families for MIR191 Gene

Gene Families for MIR191 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR191: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR191 Gene

Function for MIR191 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR191 Gene

Localization for MIR191 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR191 Gene

Pathways & Interactions for MIR191 Gene

SuperPathways for MIR191 Gene

No Data Available

Interacting Proteins for MIR191 Gene

Gene Ontology (GO) - Biological Process for MIR191 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR191 Gene

Drugs & Compounds for MIR191 Gene

No Compound Related Data Available

Transcripts for MIR191 Gene

fRNAdb Secondary structures for MIR191 Gene

  • FR166793
  • FR327653
  • hsa-mir-191_MI0000465_Homo_sapiens_miR-191_stem-loop_hairpin

mRNA/cDNA for MIR191 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR191 Gene

No ASD Table

Relevant External Links for MIR191 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR191 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR191 Gene:

genes like me logo Genes that share expression patterns with MIR191: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR191 Gene

Orthologs for MIR191 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR191 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-191 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-191 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-191 35
  • 99 (a)
(Monodelphis domestica)
Mammalia mdo-mir-191 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-191 35
  • 70 (a)
(Mus musculus)
Mammalia Gm24083 35
  • 48 (a)
(Anolis carolinensis)
Reptilia aca-mir-191 35
  • 57 (a)
Species where no ortholog for MIR191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR191 Gene

Gene Tree for MIR191 (if available)
Gene Tree for MIR191 (if available)

Paralogs for MIR191 Gene

No data available for Paralogs for MIR191 Gene

Variants for MIR191 Gene

Sequence variations from dbSNP and Humsavar for MIR191 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918134 Pathogenic 49,022,497(+) TGCTC(A/C/G)GCCCC upstream-variant-2KB, reference, missense
rs121918136 Pathogenic 49,022,146(+) AGCCA(C/T)GGCCA intron-variant, upstream-variant-2KB, reference, missense
rs567032648 Likely pathogenic 49,022,175(+) GCTTG(C/G/T)ACCGA intron-variant, upstream-variant-2KB, reference, missense
rs527954570 Likely benign 49,022,377(+) CGCCG(A/G)CGGAT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs146340094 Uncertain significance 49,022,706(+) GGTGG(G/T)ATCCC upstream-variant-2KB, reference, missense

Relevant External Links for MIR191 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR191 Gene

Disorders for MIR191 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR191 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR191

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR191: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR191 Gene

Publications for MIR191 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  3. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 1 3 64
  4. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 1 3 64
  5. New microRNAs from mouse and human. (PMID: 12554859) Lagos-Quintana M. … Tuschl T. (RNA 2003) 1 3 64

Products for MIR191 Gene

Sources for MIR191 Gene

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