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Aliases for MIR1909 Gene

Subcategory (RNA class) for MIR1909 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1909 Gene

  • MicroRNA 1909 2 3
  • REXO1 4 5
  • Transcription Elongation Factor B Polypeptide 3-Binding Protein 1 4
  • Elongin-A-Binding Protein 1 4
  • RNA Exonuclease 1 Homolog 5
  • Hsa-Mir-1909 3
  • EC 3.1.-.- 4
  • Mir-1909 3
  • MIRN1909 3
  • EloA-BP1 4
  • KIAA1138 4
  • TCEB3BP1 4
  • ELOABP1 4

External Ids for MIR1909 Gene

Previous HGNC Symbols for MIR1909 Gene

  • MIRN1909

Previous GeneCards Identifiers for MIR1909 Gene

  • GC00U922852
  • GC19M001769
  • GC19M001817

Summaries for MIR1909 Gene

Entrez Gene Summary for MIR1909 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1909 Gene

MIR1909 (MicroRNA 1909) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is LOC81691.

UniProtKB/Swiss-Prot for MIR1909 Gene

  • Seems to have no detectable effect on transcription elongation in vitro.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1909 Gene

Genomics for MIR1909 Gene

Regulatory Elements for MIR1909 Gene

Enhancers for MIR1909 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001744 1.6 FANTOM5 Ensembl ENCODE 12.4 +100.6 100624 7.1 HDGF PKNOX1 ARNT ZNF2 YY1 ZNF766 CBX5 FOS KLF13 ZNF263 SCAMP4 CIRBP ENSG00000266990 LINC01775 C19orf24 ATP8B3 MIR1909 REXO1 TMEM259 TCF3
GH19F001667 1.5 FANTOM5 Ensembl ENCODE 11.8 +180.0 180034 2.5 HDGF GLI4 YBX1 ZBTB40 ZNF48 ZNF155 ZEB1 ZNF335 GLIS2 ZNF366 SF3A2 TMEM259 CIRBP LOC100288123 RNU6-1223P ATP8B3 MIR1909 REXO1 RPS15 GRIN3B
GH19F001725 1.5 FANTOM5 Ensembl ENCODE 11.8 +122.6 122621 1.3 ELF3 ZNF133 ZFP64 DEAF1 ARID4B ZNF48 ZBTB40 KAT2B ZNF335 ZNF121 ONECUT3 ATP8B3 MIR1909 REXO1 RNU6-1223P TCF3 APC2 MUM1 CBARP ENSG00000275642
GH19F001671 1.3 Ensembl ENCODE 11.8 +176.3 176304 1.1 HDGF ATF1 PKNOX1 ARNT ARID4B GLI4 ZNF2 GLIS2 ZNF143 KLF7 CFD RNU6-1223P ATP8B3 MIR1909 REXO1 MIDN GC19P001669 GC19P001681 GC19P001682
GH19F001928 1.2 Ensembl ENCODE 12.3 -81.3 -81327 1.7 PKNOX1 ZNF133 ARID4B SIN3A ZSCAN9 ZNF2 RAD21 ZNF48 ZNF335 ZNF766 BTBD2 TMEM259 SF3A2 MIR1909 REXO1 KLF16 ATP8B3 LOC100288123 ENSG00000267317 CSNK1G2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1909 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1909 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341628 263 2001 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for MIR1909 Gene

Chromosome:
19
Start:
1,815,246 bp from pter
End:
1,848,463 bp from pter
Size:
33,218 bases
Orientation:
Minus strand

Genomic View for MIR1909 Gene

Genes around MIR1909 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1909 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1909 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1909 Gene

Proteins for MIR1909 Gene

  • Protein details for MIR1909 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G1-REXO1_HUMAN
    Recommended name:
    RNA exonuclease 1 homolog
    Protein Accession:
    Q8N1G1
    Secondary Accessions:
    • Q9ULT2

    Protein attributes for MIR1909 Gene

    Size:
    1221 amino acids
    Molecular mass:
    131510 Da
    Quaternary structure:
    • Interacts with TCEA2 and TCEB3.
    • Interacts with TCEA2 and TCEB3.
    SequenceCaution:
    • Sequence=BAA86452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MIR1909 Gene

Post-translational modifications for MIR1909 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR1909 Gene

No data available for DME Specific Peptides for MIR1909 Gene

Domains & Families for MIR1909 Gene

Gene Families for MIR1909 Gene

Protein Domains for MIR1909 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G1

UniProtKB/Swiss-Prot:

REXO1_HUMAN :
  • Contains 1 exonuclease domain.
  • Belongs to the REXO1/REXO3 family.
Domain:
  • Contains 1 exonuclease domain.
Family:
  • Belongs to the REXO1/REXO3 family.
genes like me logo Genes that share domains with MIR1909: view

No data available for Suggested Antigen Peptide Sequences for MIR1909 Gene

Function for MIR1909 Gene

Molecular function for MIR1909 Gene

UniProtKB/Swiss-Prot Function:
Seems to have no detectable effect on transcription elongation in vitro.

Enzyme Numbers (IUBMB) for MIR1909 Gene

Gene Ontology (GO) - Molecular Function for MIR1909 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MIR1909: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1909 Gene

Localization for MIR1909 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1909 Gene

Gene Ontology (GO) - Cellular Components for MIR1909 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR1909: view

No data available for Subcellular locations from COMPARTMENTS for MIR1909 Gene

Pathways & Interactions for MIR1909 Gene

SuperPathways for MIR1909 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR1909 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with MIR1909: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1909 Gene

Transcripts for MIR1909 Gene

mRNA/cDNA for MIR1909 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1909 Gene

No ASD Table

Relevant External Links for MIR1909 Gene

GeneLoc Exon Structure for
MIR1909
ECgene alternative splicing isoforms for
MIR1909

Expression for MIR1909 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1909 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1909 Gene:

MIR1909

mRNA Expression by UniProt/SwissProt for MIR1909 Gene:

Q8N1G1-REXO1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MIR1909: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1909 Gene

Orthologs for MIR1909 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR1909 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia REXO1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia REXO1 35
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia REXO1 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rexo1 35
  • 78 (a)
OneToMany
Gm7104 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rexo1 35
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12877 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.33 35
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 35
  • 17 (a)
OneToMany
Species where no ortholog for MIR1909 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR1909 Gene

ENSEMBL:
Gene Tree for MIR1909 (if available)
TreeFam:
Gene Tree for MIR1909 (if available)

Paralogs for MIR1909 Gene

Variants for MIR1909 Gene

Sequence variations from dbSNP and Humsavar for MIR1909 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111599606 -- 1,815,961(+) GCCTC(A/G)GCCAG downstream-variant-500B, reference, utr-variant-3-prime, stop-gained
rs112302325 -- 1,816,990(+) AAGCC(C/T)TCCTG intron-variant, upstream-variant-2KB
rs112410147 -- 1,815,759(+) GGGCC(G/T)GGCAG downstream-variant-500B, reference, missense, utr-variant-3-prime
rs112646518 -- 1,817,866(+) CGAGC(C/T)CTACT intron-variant, upstream-variant-2KB
rs113647181 -- 1,817,344(+) GAGAA(A/G)GCAGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1909 Gene

Variant ID Type Subtype PubMed ID
dgv567n67 CNV gain 20364138
esv32942 CNV gain+loss 17666407
esv3893156 CNV loss 25118596
nsv1160560 CNV deletion 26073780
nsv470107 CNV loss 18288195
nsv578337 CNV gain 21841781
nsv828384 CNV gain 20364138
nsv953942 CNV deletion 24416366

Relevant External Links for MIR1909 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1909

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1909 Gene

Disorders for MIR1909 Gene

Relevant External Links for MIR1909

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1909

No disorders were found for MIR1909 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1909 Gene

Publications for MIR1909 Gene

  1. MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors. (PMID: 26698155) Braoudaki M. … Kanavakis E. (Med. Oncol. 2016) 3 64
  2. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64

Products for MIR1909 Gene

Sources for MIR1909 Gene

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