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Aliases for MIR1908 Gene

Subcategory (RNA class) for MIR1908 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1908 Gene

  • MicroRNA 1908 2 3
  • FADS1 4 5
  • Delta(5) Fatty Acid Desaturase 4
  • Fatty Acid Desaturase 1 5
  • Delta(5) Desaturase 4
  • Delta-5 Desaturase 4
  • Hsa-Mir-1908 3
  • EC 1.14.19.- 4
  • EC 1.14.19 61
  • Mir-1908 3
  • MIRN1908 3
  • FADSD5 4
  • D5D 4

External Ids for MIR1908 Gene

Previous HGNC Symbols for MIR1908 Gene

  • MIRN1908

Previous GeneCards Identifiers for MIR1908 Gene

  • GC00U923135
  • GC11M061340
  • GC11M061582

Summaries for MIR1908 Gene

Entrez Gene Summary for MIR1908 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1908 Gene

MIR1908 (MicroRNA 1908) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is FADS2.

UniProtKB/Swiss-Prot for MIR1908 Gene

  • Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1908 Gene

Genomics for MIR1908 Gene

Regulatory Elements for MIR1908 Gene

Enhancers for MIR1908 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR1908 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1908 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR1908 Gene

Chromosome:
11
Start:
61,799,625 bp from pter
End:
61,829,318 bp from pter
Size:
29,694 bases
Orientation:
Minus strand

Genomic View for MIR1908 Gene

Genes around MIR1908 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1908 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1908 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1908 Gene

ORGUL Member Location for MIR1908 Gene

ORGUL Member Location for MIR1908 gene

Proteins for MIR1908 Gene

  • Protein details for MIR1908 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60427-FADS1_HUMAN
    Recommended name:
    Fatty acid desaturase 1
    Protein Accession:
    O60427
    Secondary Accessions:
    • A8K0I7
    • B2RAI0
    • Q53GM5
    • Q8N3A6
    • Q8NCC7
    • Q8NCG0
    • Q96I39
    • Q96SV3
    • Q96T10
    • Q9NRP8
    • Q9NYX1

    Protein attributes for MIR1908 Gene

    Size:
    444 amino acids
    Molecular mass:
    51964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11182.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11229.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR1908 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1908 Gene

Selected DME Specific Peptides for MIR1908 Gene

Post-translational modifications for MIR1908 Gene

  • Ubiquitination at Lys 41, Lys 83, Lys 106, and Lys 398
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR1908 Gene

Gene Families for MIR1908 Gene

Protein Domains for MIR1908 Gene

Graphical View of Domain Structure for InterPro Entry

O60427

UniProtKB/Swiss-Prot:

FADS1_HUMAN :
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Belongs to the fatty acid desaturase type 1 family.
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with MIR1908: view

No data available for Suggested Antigen Peptide Sequences for MIR1908 Gene

Function for MIR1908 Gene

Molecular function for MIR1908 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated upon differentiation in a neuroblastoma cell line (at protein level).

Enzyme Numbers (IUBMB) for MIR1908 Gene

Gene Ontology (GO) - Molecular Function for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IDA --
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA --
GO:0045485 omega-6 fatty acid desaturase activity TAS --
genes like me logo Genes that share ontologies with MIR1908: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1908 Gene

Localization for MIR1908 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1908 Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane NAS --
GO:0016021 integral component of membrane NAS --
genes like me logo Genes that share ontologies with MIR1908: view

No data available for Subcellular locations from COMPARTMENTS for MIR1908 Gene

Pathways & Interactions for MIR1908 Gene

SuperPathways for MIR1908 Gene

No Data Available

UniProtKB/Swiss-Prot O60427-FADS1_HUMAN

  • Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0006636 unsaturated fatty acid biosynthetic process IEA --
GO:0007267 cell-cell signaling NAS --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with MIR1908: view

No data available for Pathways by source and SIGNOR curated interactions for MIR1908 Gene

Drugs & Compounds for MIR1908 Gene

No Compound Related Data Available

Transcripts for MIR1908 Gene

mRNA/cDNA for MIR1908 Gene

(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1908 Gene

No ASD Table

Relevant External Links for MIR1908 Gene

GeneLoc Exon Structure for
MIR1908
ECgene alternative splicing isoforms for
MIR1908

Expression for MIR1908 Gene

mRNA expression in normal human tissues for MIR1908 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1908 Gene:

MIR1908

mRNA Expression by UniProt/SwissProt for MIR1908 Gene:

O60427-FADS1_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
genes like me logo Genes that share expression patterns with MIR1908: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1908 Gene

Orthologs for MIR1908 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1908 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FADS1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FADS1 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADS1 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fads1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FADS1 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FADS1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 68 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
FADS1 35
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fat-3 35
  • 25 (a)
ManyToMany
fat-4 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for MIR1908 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MIR1908 Gene

ENSEMBL:
Gene Tree for MIR1908 (if available)
TreeFam:
Gene Tree for MIR1908 (if available)

Paralogs for MIR1908 Gene

Paralogs for MIR1908 Gene

Pseudogenes.org Pseudogenes for MIR1908 Gene

genes like me logo Genes that share paralogs with MIR1908: view

Variants for MIR1908 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR1908 Gene

Variant ID Type Subtype PubMed ID
nsv528697 CNV loss 19592680

Relevant External Links for MIR1908 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1908

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR1908 Gene

Disorders for MIR1908 Gene

Relevant External Links for MIR1908

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1908

No disorders were found for MIR1908 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1908 Gene

Publications for MIR1908 Gene

  1. The biological effects of hsa-miR-1908 in human adipocytes. (PMID: 25421647) Yang L. … Ji C.B. (Mol. Biol. Rep. 2015) 3 65
  2. MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway. (PMID: 26265437) Xia X. … He S. (Mol. Cancer 2015) 3 65
  3. MicroRNA-1908 is upregulated in human osteosarcoma and regulates cell proliferation and migration by repressing PTEN expression. (PMID: 26328886) Yuan H. … Gao Y. (Oncol. Rep. 2015) 3 65
  4. [Transfected miR-1908 inhibits renal fibrosis via targeting transforming growth factor beta 1]. (PMID: 26648305) Xie F. … Shan Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015) 3 65
  5. Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. (PMID: 23142051) Pencheva N. … Tavazoie S.F. (Cell 2012) 3 65

Products for MIR1908 Gene

Sources for MIR1908 Gene

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