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Aliases for MIR1908 Gene

Subcategory (RNA class) for MIR1908 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR1908 Gene

  • MicroRNA 1908 2 3
  • FADS1 4 5
  • Delta(5) Fatty Acid Desaturase 4
  • Fatty Acid Desaturase 1 5
  • Delta(5) Desaturase 4
  • Delta-5 Desaturase 4
  • Hsa-Mir-1908 3
  • EC 1.14.19.- 4
  • EC 1.14.19 61
  • Mir-1908 3
  • MIRN1908 3
  • FADSD5 4
  • D5D 4

External Ids for MIR1908 Gene

Previous HGNC Symbols for MIR1908 Gene

  • MIRN1908

Previous GeneCards Identifiers for MIR1908 Gene

  • GC00U923135
  • GC11M061340
  • GC11M061582

Summaries for MIR1908 Gene

Entrez Gene Summary for MIR1908 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR1908 Gene

MIR1908 (MicroRNA 1908) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. An important paralog of this gene is FADS2.

UniProtKB/Swiss-Prot for MIR1908 Gene

  • Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR1908 Gene

Genomics for MIR1908 Gene

Regulatory Elements for MIR1908 Gene

Enhancers for MIR1908 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F062104 1.5 FANTOM5 Ensembl ENCODE 10.8 -276.1 -276124 2.5 HDAC1 ATF1 TBL1XR1 SIN3A ZBTB40 ELK1 CEBPB NR2F2 POLR2H MEF2D FTH1 INCENP RAB3IL1 FADS3 BEST1 FADS1 MIR1908 MYRF DKFZP434K028 DAGLA
GH11F061921 1.5 FANTOM5 Ensembl ENCODE 10.6 -94.3 -94344 4.5 TBP ATF1 CBX3 KLF17 ARID4B ZNF48 RARA ETV6 CREM EGR2 RAB3IL1 FADS3 BEST1 FADS1 MIR1908 FTH1 DKFZP434K028 MYRF GC11P061939 PIR40157
GH11F061910 1.2 Ensembl ENCODE 11.6 -82.4 -82391 3.4 ARID4B SIN3A ZNF143 ZNF207 ZNF263 REST SMARCA4 RFX3 ETV4 GLIS1 B3GAT3 TMEM109 BEST1 RAB3IL1 FADS1 MIR1908 LRRN4CL FTH1 AHNAK MIR611
GH11F061791 1.1 ENCODE 12.2 +36.6 36593 3.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FADS2 LRRN4CL TMEM109 FADS1 MIR1908 EEF1G TAF6L BEST1 MIR611 AHNAK
GH11F062054 1.2 Ensembl ENCODE 11.1 -225.1 -225143 0.9 ATF1 ARNT ARID4B SIN3A FEZF1 BRCA1 ZNF2 CBX5 REST PPARG INCENP TTC9C HNRNPUL2 BEST1 FTH1 RAB3IL1 FADS3 MIR1908 FADS1 GC11P062053
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR1908 on UCSC Golden Path with GeneCards custom track

Promoters for MIR1908 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769019 918 2801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 YY1 GLIS2 KLF7 SP3
ENSR00000109548 -1182 1001 WRNIP1

Genomic Location for MIR1908 Gene

Chromosome:
11
Start:
61,799,625 bp from pter
End:
61,829,318 bp from pter
Size:
29,694 bases
Orientation:
Minus strand

Genomic View for MIR1908 Gene

Genes around MIR1908 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR1908 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR1908 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR1908 Gene

Proteins for MIR1908 Gene

  • Protein details for MIR1908 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60427-FADS1_HUMAN
    Recommended name:
    Fatty acid desaturase 1
    Protein Accession:
    O60427
    Secondary Accessions:
    • A8K0I7
    • B2RAI0
    • Q53GM5
    • Q8N3A6
    • Q8NCC7
    • Q8NCG0
    • Q96I39
    • Q96SV3
    • Q96T10
    • Q9NRP8
    • Q9NYX1

    Protein attributes for MIR1908 Gene

    Size:
    444 amino acids
    Molecular mass:
    51964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11182.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11229.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR1908 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR1908 Gene

Selected DME Specific Peptides for MIR1908 Gene

O60427:
  • PASWWNHMHFQHHAKPNCF
  • LWLDAYL
  • FVIGHLKG
  • TQMNHIP
  • QAGWLQHD
  • WFSGHLNFQIEHHLFP

Post-translational modifications for MIR1908 Gene

  • Ubiquitination at Lys 41, Lys 83, Lys 106, and Lys 398
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR1908 Gene

Gene Families for MIR1908 Gene

Protein Domains for MIR1908 Gene

Graphical View of Domain Structure for InterPro Entry

O60427

UniProtKB/Swiss-Prot:

FADS1_HUMAN :
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Belongs to the fatty acid desaturase type 1 family.
Domain:
  • The histidine box domains may contain the active site and/or be involved in metal ion binding.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with MIR1908: view

No data available for Suggested Antigen Peptide Sequences for MIR1908 Gene

Function for MIR1908 Gene

Molecular function for MIR1908 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated upon differentiation in a neuroblastoma cell line (at protein level).

Enzyme Numbers (IUBMB) for MIR1908 Gene

Gene Ontology (GO) - Molecular Function for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA --
GO:0045485 omega-6 fatty acid desaturase activity TAS --
genes like me logo Genes that share ontologies with MIR1908: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR1908 Gene

Localization for MIR1908 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR1908 Gene

Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion.
Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR1908: view

No data available for Subcellular locations from COMPARTMENTS for MIR1908 Gene

Pathways & Interactions for MIR1908 Gene

genes like me logo Genes that share pathways with MIR1908: view

UniProtKB/Swiss-Prot O60427-FADS1_HUMAN

  • Pathway: Lipid metabolism; polyunsaturated fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for MIR1908 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006636 unsaturated fatty acid biosynthetic process IEA --
genes like me logo Genes that share ontologies with MIR1908: view

No data available for SIGNOR curated interactions for MIR1908 Gene

Transcripts for MIR1908 Gene

mRNA/cDNA for MIR1908 Gene

(22) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR1908 Gene

No ASD Table

Relevant External Links for MIR1908 Gene

GeneLoc Exon Structure for
MIR1908
ECgene alternative splicing isoforms for
MIR1908

Expression for MIR1908 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR1908 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR1908 Gene:

MIR1908

mRNA Expression by UniProt/SwissProt for MIR1908 Gene:

O60427-FADS1_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
genes like me logo Genes that share expression patterns with MIR1908: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR1908 Gene

Orthologs for MIR1908 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR1908 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FADS1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FADS1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FADS1 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fads1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FADS1 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADS1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FADS1 35
  • 78 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fat-3 35
  • 25 (a)
ManyToMany
fat-4 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for MIR1908 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MIR1908 Gene

ENSEMBL:
Gene Tree for MIR1908 (if available)
TreeFam:
Gene Tree for MIR1908 (if available)

Paralogs for MIR1908 Gene

Paralogs for MIR1908 Gene

Pseudogenes.org Pseudogenes for MIR1908 Gene

genes like me logo Genes that share paralogs with MIR1908: view

Variants for MIR1908 Gene

Sequence variations from dbSNP and Humsavar for MIR1908 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs113305638 -- 61,816,858(+) CCCAG(A/C)GCCAG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs113766438 -- 61,816,855(+) GCGCC(A/C)AGAGC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs11548150 -- 61,816,728(-) AGACC(A/G)CGGCT intron-variant, upstream-variant-2KB, reference, missense
rs115698269 -- 61,816,071(+) GCTCC(C/T)TCTCC intron-variant, upstream-variant-2KB
rs116080656 -- 61,817,229(+) TTTTC(C/T)GTGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR1908 Gene

Variant ID Type Subtype PubMed ID
nsv528697 CNV loss 19592680

Relevant External Links for MIR1908 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR1908

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR1908 Gene

Disorders for MIR1908 Gene

Relevant External Links for MIR1908

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR1908

No disorders were found for MIR1908 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR1908 Gene

Publications for MIR1908 Gene

  1. MicroRNA-1908 is a biomarker for poor prognosis in human osteosarcoma. (PMID: 27097944) Lian D. … Liu N.S. (Eur Rev Med Pharmacol Sci 2016) 3 64
  2. The biological effects of hsa-miR-1908 in human adipocytes. (PMID: 25421647) Yang L. … Ji C.B. (Mol. Biol. Rep. 2015) 3 64
  3. MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway. (PMID: 26265437) Xia X. … He S. (Mol. Cancer 2015) 3 64
  4. MicroRNA-1908 is upregulated in human osteosarcoma and regulates cell proliferation and migration by repressing PTEN expression. (PMID: 26328886) Yuan H. … Gao Y. (Oncol. Rep. 2015) 3 64
  5. [Transfected miR-1908 inhibits renal fibrosis via targeting transforming growth factor beta 1]. (PMID: 26648305) Xie F. … Shan Z. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2015) 3 64

Products for MIR1908 Gene

Sources for MIR1908 Gene

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