Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR18B Gene

Subcategory (RNA class) for MIR18B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR18B Gene

  • MicroRNA 18b 2 3
  • MicroRNA 19b-2 5
  • Hsa-Mir-18b 3
  • MIR19B2 5
  • Mir-18b 3
  • MIRN18B 3

External Ids for MIR18B Gene

Previous HGNC Symbols for MIR18B Gene

  • MIRN18B

Previous GeneCards Identifiers for MIR18B Gene

  • GC0XM133149
  • GC0XM133156
  • GC0XM133304
  • GC0XM134174
  • GC0XM134179

Summaries for MIR18B Gene

Entrez Gene Summary for MIR18B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18B Gene

MIR18B (MicroRNA 18b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR18B Gene

Genomics for MIR18B Gene

Regulatory Elements for MIR18B Gene

Enhancers for MIR18B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF134171 1.4 FANTOM5 Ensembl ENCODE 0.8 +0.5 455 4.8 MAX ZNF76 ZIC2 ZNF664 ZFHX2 GLIS2 POLR2A PATZ1 ZNF143 PRDM10 CCDC160 GPC3 PHF6 GC0XM134196 GC0XM134201 MIR106A MIR19B2 MIR20B MIR363 MIR92A2
GH0XF134179 0.4 ENCODE 0.4 -6.9 -6879 2.4 ZNF133 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134187 0.4 Ensembl 0.4 -13.2 -13212 0.2 CBX8 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134186 0.4 ENCODE 0.4 -12.9 -12857 0.2 CBX8 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
GH0XF134188 0.2 Ensembl 0.4 -12.4 -12412 0.2 CCDC160 MIR106A MIR18B MIR19B2 MIR20B MIR363 MIR92A2 LARP1BP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR18B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR18B Gene

Chromosome:
X
Start:
134,168,911 bp from pter
End:
134,174,089 bp from pter
Size:
5,179 bases
Orientation:
Minus strand

Genomic View for MIR18B Gene

Genes around MIR18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR18B Gene

Proteins for MIR18B Gene

Post-translational modifications for MIR18B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18B Gene

Domains & Families for MIR18B Gene

Gene Families for MIR18B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR18B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR18B Gene

Function for MIR18B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18B Gene

Localization for MIR18B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR18B Gene

Pathways & Interactions for MIR18B Gene

SuperPathways for MIR18B Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR18B: view

Pathways by source for MIR18B Gene

1 BioSystems pathway for MIR18B Gene

Interacting Proteins for MIR18B Gene

Gene Ontology (GO) - Biological Process for MIR18B Gene

None

No data available for SIGNOR curated interactions for MIR18B Gene

Transcripts for MIR18B Gene

mRNA/cDNA for MIR18B Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18B Gene

No ASD Table

Relevant External Links for MIR18B Gene

GeneLoc Exon Structure for
MIR18B
ECgene alternative splicing isoforms for
MIR18B

Expression for MIR18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR18B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR18B Gene:

MIR18B
genes like me logo Genes that share expression patterns with MIR18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR18B Gene

Orthologs for MIR18B Gene

Evolution for MIR18B Gene

ENSEMBL:
Gene Tree for MIR18B (if available)
TreeFam:
Gene Tree for MIR18B (if available)

No data available for Orthologs for MIR18B Gene

Paralogs for MIR18B Gene

No data available for Paralogs for MIR18B Gene

Variants for MIR18B Gene

Sequence variations from dbSNP and Humsavar for MIR18B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs113658998 -- 134,170,166(+) CACAA(A/G)CTACA downstream-variant-500B, upstream-variant-2KB
rs137881717 -- 134,171,170(+) TAAAC(A/G)AGTGA upstream-variant-2KB
rs142112727 -- 134,171,521(+) TCTGG(C/T)ATCCC upstream-variant-2KB
rs146939378 -- 134,170,567(+) TATGT(A/C)TAAGC upstream-variant-2KB
rs180944931 -- 134,170,957(+) AAGTA(A/G)GCAGA upstream-variant-2KB

Relevant External Links for MIR18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR18B Gene

Disorders for MIR18B Gene

Relevant External Links for MIR18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR18B

No disorders were found for MIR18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR18B Gene

Publications for MIR18B Gene

  1. MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways. (PMID: 26851511) Wu J.H. … Chen C.M. (Int. J. Biochem. Cell Biol. 2016) 3 64
  2. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R. … Chaganti R.S. (Stem Cells Dev. 2014) 3 64
  3. The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. (PMID: 23365201) Dar A.A. … Kashani-Sabet M. (J. Natl. Cancer Inst. 2013) 3 64
  4. Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. (PMID: 23681229) Yu X. … Fang W. (Cell Death Dis 2013) 3 64
  5. miR-18b inhibits TGF-I^1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2. (PMID: 23916701) Liu X. … Li Y. (Biochem. Biophys. Res. Commun. 2013) 3 64

Products for MIR18B Gene

Sources for MIR18B Gene

Content
Loading form....