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Aliases for MIR18B Gene

Subcategory (RNA class) for MIR18B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR18B Gene

  • MicroRNA 18b 2 3 5
  • Hsa-Mir-18b 3
  • Mir-18b 3
  • MIRN18B 3

External Ids for MIR18B Gene

Previous HGNC Symbols for MIR18B Gene

  • MIRN18B

Previous GeneCards Identifiers for MIR18B Gene

  • GC0XM133149
  • GC0XM133156
  • GC0XM133304
  • GC0XM134174
  • GC0XM134179
  • GC0XM134185
  • GC0XM134191

Summaries for MIR18B Gene

Entrez Gene Summary for MIR18B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18B Gene

MIR18B (MicroRNA 18b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR18B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR18B Gene

Genomics for MIR18B Gene

Genomic Location for MIR18B Gene

Chromosome:
X
Start:
134,170,041 bp from pter
End:
134,170,111 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR18B Gene

Genes around MIR18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR18B Gene

No data available for Regulatory Elements for MIR18B Gene

Proteins for MIR18B Gene

Post-translational modifications for MIR18B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18B Gene

Domains & Families for MIR18B Gene

Gene Families for MIR18B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR18B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR18B Gene

Function for MIR18B Gene

Gene Ontology (GO) - Molecular Function for MIR18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24383669
genes like me logo Genes that share ontologies with MIR18B: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR18B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18B Gene

Localization for MIR18B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR18B Gene

Pathways & Interactions for MIR18B Gene

SuperPathways for MIR18B Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR18B: view

Pathways by source for MIR18B Gene

1 BioSystems pathway for MIR18B Gene

Interacting Proteins for MIR18B Gene

Gene Ontology (GO) - Biological Process for MIR18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030857 negative regulation of epithelial cell differentiation IMP 24383669
GO:0035195 gene silencing by miRNA IDA 24383669
genes like me logo Genes that share ontologies with MIR18B: view

No data available for SIGNOR curated interactions for MIR18B Gene

Drugs & Compounds for MIR18B Gene

No Compound Related Data Available

Transcripts for MIR18B Gene

mRNA/cDNA for MIR18B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR18B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18B Gene

No ASD Table

Relevant External Links for MIR18B Gene

GeneLoc Exon Structure for
MIR18B
ECgene alternative splicing isoforms for
MIR18B

Expression for MIR18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR18B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR18B Gene:

MIR18B
genes like me logo Genes that share expression patterns with MIR18B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR18B Gene

Orthologs for MIR18B Gene

Evolution for MIR18B Gene

ENSEMBL:
Gene Tree for MIR18B (if available)
TreeFam:
Gene Tree for MIR18B (if available)

No data available for Orthologs for MIR18B Gene

Paralogs for MIR18B Gene

No data available for Paralogs for MIR18B Gene

Variants for MIR18B Gene

Sequence variations from dbSNP and Humsavar for MIR18B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000692193 -- 134,172,082(+) CCCCT(C/T)CCACC upstream-variant-2KB
rs1003822325 -- 134,171,007(+) AAACC(C/T)TCTCC upstream-variant-2KB
rs1004871742 -- 134,171,563(+) CCTTA(A/G)ATTGC upstream-variant-2KB
rs1004902717 -- 134,170,953(+) ACCAA(A/G)GTAGG upstream-variant-2KB
rs1005828091 -- 134,169,983(+) ATGTG(G/T)CCTAT downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR18B Gene

Disorders for MIR18B Gene

Relevant External Links for MIR18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR18B

No disorders were found for MIR18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR18B Gene

Publications for MIR18B Gene

  1. MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis. (PMID: 27220837) Chen Y … Zhou J (Oncology reports 2016) 3 60
  2. MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways. (PMID: 26851511) Wu JH … Chen CM (The international journal of biochemistry & cell biology 2016) 3 60
  3. miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator. (PMID: 25736311) Husby S … Grønbæk K (Blood 2015) 3 60
  4. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R … Chaganti RS (Stem cells and development 2014) 3 60
  5. microRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration. (PMID: 23970382) Fonseca-Sanchéz MA … López-Camarillo C (Oncology reports 2013) 3 60

Products for MIR18B Gene

Sources for MIR18B Gene

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