Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR18B Gene

Subcategory (RNA class) for MIR18B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR18B Gene

  • MicroRNA 18b 2 3 5
  • Hsa-Mir-18b 3
  • Mir-18b 3
  • MIRN18B 3

External Ids for MIR18B Gene

Previous HGNC Symbols for MIR18B Gene

  • MIRN18B

Previous GeneCards Identifiers for MIR18B Gene

  • GC0XM133149
  • GC0XM133156
  • GC0XM133304
  • GC0XM134174
  • GC0XM134179

Summaries for MIR18B Gene

Entrez Gene Summary for MIR18B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18B Gene

MIR18B (MicroRNA 18b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR18B Gene

Genomics for MIR18B Gene

Genomic Location for MIR18B Gene

Chromosome:
X
Start:
134,170,017 bp from pter
End:
134,170,125 bp from pter
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR18B Gene

Genes around MIR18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR18B Gene

No data available for Regulatory Elements for MIR18B Gene

Proteins for MIR18B Gene

Post-translational modifications for MIR18B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18B Gene

Domains & Families for MIR18B Gene

Gene Families for MIR18B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR18B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR18B Gene

Function for MIR18B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18B Gene

Localization for MIR18B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR18B Gene

Pathways & Interactions for MIR18B Gene

SuperPathways for MIR18B Gene

No Data Available

Interacting Proteins for MIR18B Gene

Gene Ontology (GO) - Biological Process for MIR18B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR18B Gene

Drugs & Compounds for MIR18B Gene

No Compound Related Data Available

Transcripts for MIR18B Gene

mRNA/cDNA for MIR18B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18B Gene

No ASD Table

Relevant External Links for MIR18B Gene

GeneLoc Exon Structure for
MIR18B
ECgene alternative splicing isoforms for
MIR18B

Expression for MIR18B Gene

mRNA expression in normal human tissues for MIR18B Gene

genes like me logo Genes that share expression patterns with MIR18B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR18B Gene

Orthologs for MIR18B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR18B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-18b 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-18b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-18b 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir18b 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-18 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-18a 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-18b 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-18b 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-18c 36
  • 68 (a)
OneToOne
Species with no ortholog for MIR18B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR18B Gene

ENSEMBL:
Gene Tree for MIR18B (if available)
TreeFam:
Gene Tree for MIR18B (if available)

Paralogs for MIR18B Gene

No data available for Paralogs for MIR18B Gene

Variants for MIR18B Gene

Relevant External Links for MIR18B Gene

HapMap Linkage Disequilibrium report
MIR18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR18B Gene

Disorders for MIR18B Gene

Relevant External Links for MIR18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR18B

No disorders were found for MIR18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR18B Gene

Publications for MIR18B Gene

  1. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R. … Chaganti R.S. (Stem Cells Dev. 2014) 3
  2. The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. (PMID: 23365201) Dar A.A. … Kashani-Sabet M. (J. Natl. Cancer Inst. 2013) 3
  3. miR-18b inhibits TGF-I^1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2. (PMID: 23916701) Liu X. … Li Y. (Biochem. Biophys. Res. Commun. 2013) 3
  4. microRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration. (PMID: 23970382) Fonseca-SanchAcz M.A. … LA^pez-Camarillo C. (Oncol. Rep. 2013) 3
  5. Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. (PMID: 23681229) Yu X. … Fang W. (Cell Death Dis 2013) 3

Products for MIR18B Gene

Sources for MIR18B Gene

Back to Top

Content