Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR18A Gene

Subcategory (RNA class) for MIR18A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR18A Gene

  • MicroRNA 18a 2 3
  • MiR-17-92a-1 Cluster Host Gene 5
  • MicroRNA 18 2
  • Hsa-Mir-18a 3
  • Hsa-Mir-18 3
  • MiRNA18A 3
  • MIR17HG 5
  • Mir-18a 3
  • MIRN18A 3
  • MiR-18 3
  • MIRN18 3
  • MIR18 3

External Ids for MIR18A Gene

Previous HGNC Symbols for MIR18A Gene

  • MIRN18
  • MIRN18A

Previous GeneCards Identifiers for MIR18A Gene

  • GC13P090866
  • GC13P090876
  • GC13P092015
  • GC13P092023
  • GC13P092030
  • GC13P092038
  • GC13P092047
  • GC13P092057
  • GC13P092066
  • GC13P092076
  • GC13P092084
  • GC13P092098
  • GC13P092112
  • GC13P091351
  • GC13P091356

Summaries for MIR18A Gene

Entrez Gene Summary for MIR18A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR18A Gene

MIR18A (MicroRNA 18a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR18A Gene

Genomics for MIR18A Gene

Regulatory Elements for MIR18A Gene

Enhancers for MIR18A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F091346 1 ENCODE 0.8 +1.2 1213 4.8 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5 GPC5 GC13P091376 MIR17 MIR17HG MIR18A MIR19A MIR19B1 MIR20A MIR92A1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR18A on UCSC Golden Path with GeneCards custom track

Promoters for MIR18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000667089 780 3601 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ELK1 CBX5

Genomic Location for MIR18A Gene

Chromosome:
13
Start:
91,347,820 bp from pter
End:
91,354,579 bp from pter
Size:
6,760 bases
Orientation:
Plus strand

Genomic View for MIR18A Gene

Genes around MIR18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR18A Gene

Proteins for MIR18A Gene

Post-translational modifications for MIR18A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR18A Gene

Domains & Families for MIR18A Gene

Gene Families for MIR18A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR18A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR18A Gene

Function for MIR18A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR18A Gene

Localization for MIR18A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR18A Gene

Pathways & Interactions for MIR18A Gene

genes like me logo Genes that share pathways with MIR18A: view

Pathways by source for MIR18A Gene

1 KEGG pathway for MIR18A Gene

Interacting Proteins for MIR18A Gene

Gene Ontology (GO) - Biological Process for MIR18A Gene

None

No data available for SIGNOR curated interactions for MIR18A Gene

Transcripts for MIR18A Gene

mRNA/cDNA for MIR18A Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR18A Gene

No ASD Table

Relevant External Links for MIR18A Gene

GeneLoc Exon Structure for
MIR18A
ECgene alternative splicing isoforms for
MIR18A

Expression for MIR18A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR18A Gene:

MIR18A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR18A Gene

Orthologs for MIR18A Gene

Evolution for MIR18A Gene

ENSEMBL:
Gene Tree for MIR18A (if available)
TreeFam:
Gene Tree for MIR18A (if available)

No data available for Orthologs for MIR18A Gene

Paralogs for MIR18A Gene

No data available for Paralogs for MIR18A Gene

Variants for MIR18A Gene

Sequence variations from dbSNP and Humsavar for MIR18A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112107109 -- 91,350,002(+) GTTTA(C/T)GAAAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs113832160 -- 91,350,575(+) AGAAC(A/C)TCACC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs12865889 -- 91,350,726(+) GTGCA(G/T)GGCCT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs138661876 -- 91,349,698(+) TCCAG(A/C/T)CATAC nc-transcript-variant, upstream-variant-2KB
rs140053713 -- 91,350,393(+) ATTGC(C/G)TTCTG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR18A Gene

Variant ID Type Subtype PubMed ID
nsv832679 CNV gain 17160897

Relevant External Links for MIR18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR18A Gene

Disorders for MIR18A Gene

Relevant External Links for MIR18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR18A

No disorders were found for MIR18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR18A Gene

Publications for MIR18A Gene

  1. High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer. (PMID: 26672767) Leidinger P. … Keller A. (Oncotarget 2016) 3 64
  2. Angiomirs expression profiling in diffuse large B-Cell lymphoma. (PMID: 26683099) Borges N.M. … Colleoni G.W. (Oncotarget 2016) 3 64
  3. MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients. (PMID: 26173586) Chen Y.J. … Shen X.Z. (J. Gastroenterol. Hepatol. 2016) 3 64
  4. Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer. (PMID: 24626859) Tsujiura M. … Otsuji E. (Gastric Cancer 2015) 3 64
  5. Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-I+ in female hepatocellular carcinoma. (PMID: 24975878) Li C.L. … Yeh S.H. (Int. J. Cancer 2015) 3 64

Products for MIR18A Gene

Sources for MIR18A Gene

Content
Loading form....